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Male hypogonadism

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https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#1
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#2
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28992710/-male-hypogonadism-and-its-treatment
#3
Václav Hána, Mikuláš Kosák, Václav Hána
Male hypogonadism can be of various etiology and that reflects its clinical manifestation, diagnostics and treatment. Male hypogonadism leads not only to decreased fertility, but influences the cardiovascular system, mood changes, bone fragility, lipids and other metabolic functions. Diagnosis of hypogonadism can be cumbersome, as well as the choice of optimal hormonal supplementation. The aim of this article is to summarize the basics from symptoms, diagnosis and treatment of male hypogonadism.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28989874/metabolic-status-and-hypogonadism-in-human-immunodeficiency-virus-infected-males
#4
Sarita Bajaj, Yashaswi Pathak, Sharad Varma, Sujit Verma
AIMS AND OBJECTIVES: The aim of this study is to determine the prevalence of hypogonadism in human immunodeficiency virus (HIV)-infected males and to study its relation to age, CD4 count, body mass index (BMI), duration of highly active antiretroviral therapy (HAART), and metabolic status. METHODOLOGY: Eighty-one HIV positive cases and 82 healthy controls were included in this case-control study. Each case underwent a complete physical examination and serum fasting plasma glucose, A1c, lipid profile, total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were estimated...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28984502/the-association-between-hypogonadism-symptoms-with-serum-testosterone-fsh-and-lh-in-men
#5
Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Mojtaba Mehrdad
OBJECTIVES: This study aimed to determine the relationship of hypogonadism symptoms with the levels of sex hormones in men. METHODS: This cross-sectional study was conducted on 140 men aged above 40 years. Data collections were conducted by Aging Male Scales (AMS) questionnaire and some sociodemographic variables. Then, 3 ml blood serum was sampled for testosterone (free and total), FSH and LH. Data were analyzed by descriptive and analytical statistics. RESULTS: Mean age score was 52...
October 6, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28980739/serum-testosterone-levels-in-male-hypogonadism-why-and-when-to-check-a-review
#6
REVIEW
Mark Livingston, Anura Kalansooriya, Andrew J Hartland, Sudarshan Ramachandran, Adrian Heald
AIM: Although "late onset hypogonadism", a condition that includes low testosterone and symptoms, is common in men over the age of 40 years, diagnosis is not clear cut amongst non-specialists. It is the aim of this review to provide an up to date picture of how this state should be diagnosed and managed. METHODS: We aim to describe how primary and secondary hypogonadism should be excluded before the diagnosis of late onset hypogonadism is reached. As laboratory testosterone measurements are essential the current pitfalls such as inappropriate sample collection and the use of population derived reference ranges are expanded...
October 5, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28979746/the-prevalence-of-zinc-deficiency-in-6-month-to-12-year-old-children-in-bandar-abbas-in-2013
#7
Mohammadbagher Rahmati, Fateme Safdarian, Mohadese Zakeri, Shahram Zare
BACKGROUND: Zinc deficiency is an important problem in children, especially in developing countries. Zinc supplements have beneficial effects on multiple factors, including treatment of growth retardation and hypogonadism, and they can be used as therapeutic and prophylactic agents against infection in children. OBJECTIVE: To determine the prevalence of zinc deficiency in 6-month to 12-year-old children in Bandar Abbas. METHODS: This study was done in Bandar Abbas in 2013...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28967604/-neonatal-presentation-of-prader-willi-syndrome-a-report-of-five-cases
#8
B Richard-De Ceaurriz, C Leymarie, A Godefroy, P Collignon, S Sigaudy, P Truc
Prader-Willi syndrome (PWS) is a fingerprint disease caused by the loss of paternally inherited chromosome 15q11.2-q13. In several populations studied, prevalence is estimated to be from 1/10,000 to 1/25,000 births. The disease initially manifests by neonatal hypotonia associated with orality disorders. Secondly, hyperphagia appears with significant obesity and hypogonadism. Motor milestones and language development are delayed, and all individuals have variable degrees of cognitive disability during childhood...
September 26, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28954982/androgen-replacement-therapy-for-cancer-related-symptoms-in-male-advanced-cancer-patients-study-protocol-for-a-randomised-prospective-trial-artform-study
#9
Kouji Izumi, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Yoshifumi Kadono, Shigeki Nanjo, Tadaaki Yamada, Koushiro Ohtsubo, Seiji Yano, Atsushi Mizokami
Recent studies reveal that hypogonadism with low serum androgen levels is associated with advanced cancer and induction of most cancer-related symptoms. We designed an ARTFORM study to evaluate the efficacy of androgen replacement therapy in male advanced cancer patients. The ARTFORM study is an investigator-initiated, randomised controlled trial comparing intramuscle injection of testosterone enanthate with non-administration in male advanced cancer patients with non-curative locally advanced or metastatic lesions...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28941963/effects-of-androgen-deprivation-therapy-on-pain-perception-quality-of-life-and-depression-in-men-with-prostate-cancer
#10
Thiago Gagliano-Jucá, Thomas G Travison, Paul L Nguyen, Philip W Kantoff, Mary-Ellen Taplin, Adam S Kibel, Robert Manley, Kathleen Hally, Richelle Bearup, Yusnie M Beleva, Grace Huang, Robert R Edwards, Shehzad Basaria
CONTEXT: Previous animal and human research suggests that testosterone has anti-nociceptive properties. Castration in male rodents increases pain perception which is reversed by testosterone replacement. Pain perception also improves in hypogonadal men with testosterone therapy. However, it remains unclear whether androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an increase in pain perception. METHODS: Thirty-seven men with PCa about to undergo ADT with leuprolide acetate (ADT group) were followed prospectively for 6 months to evaluate changes in clinical and experimental pain...
September 20, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28941925/dynamic-patterns-of-testosterone-levels-within-individuals-and-risk-of-prostate-cancer-among-hypogonadal-men-a-longitudinal-study
#11
Xiaohui Xu, Xiao Zhang, Yan Zhong, Farid Saad, Maria J Perez-Patron, Karim Haider, Ahmad Haider
PURPOSE: We proposed to investigate whether dynamic patterns of testosterone (T) levels contribute to risk of prostate cancer (PCa). MATERIALS AND METHODS: We used data from 376 untreated hypogonadal men (T ≤ 12.1 nmol/L) recruited from a urology office in Germany. Study entry age was used as a surrogate for age at first detecting T below 12.1 nmol/L; three indicators, the coefficient of variation (CV), the ratio of the largest decline relative to the mean (MMDRM), and the median of the maximum declines (MMD) were derived to measure the dynamic patterns of T within an individual...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28931393/successful-pregnancy-and-live-birth-from-a-hypogonadotropic-hypogonadism-woman-with-low-serum-estradiol-concentrations-despite-numerous-oocyte-maturations-a-case-report
#12
Kaori Matsumoto, Kazuhiko Imakawa, Chuyu Hayashi
BACKGROUND: The increase in serum estradiol (E2) concentrations during the follicular phase becomes the index of oocyte maturation in vivo. When ovarian stimulation is performed to hypogonadotropic hypogonadism (HH) patients with only follicle stimulating hormone (FSH), proper increase in serum E2 concentrations is not observed. Even if oocytes are obtained, which usually have low fertilization rate. In this report, we would like to present an unique case, in which under low E2 concentrations and without luteinizing hormone (LH) administration, numerous mature oocytes could be obtained and a healthy baby delivered...
September 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28924487/a-novel-stop-mutation-p-gln22-of-dax1-nr0b1-results-in-late-onset-x-linked-adrenal-hypoplasia-congenita
#13
Judith Gerards, Michael M Ritter, Elke Kaminsky, Andreas Gal, Wolfgang Hoeppner, Marcus Quinkler
DAX1 (NR0B1) is an orphan nuclear receptor, which plays an important role in development and function of the adrenal glands and gonads. Mutations in DAX1 cause X-linked adrenal hypoplasia congenita (X-linked AHC), which is characterized by adrenal insufficiency (AI) and hypogonadotropic hypogonadism (HHG). Affected boys present with adrenal failure usually in childhood and, later in life, with delayed puberty. However, patients with a late-onset form of X-linked AHC have also been described in the past years...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28924480/remission-of-type-2-diabetes-in-a-hypogonadal-man-under-long-term-testosterone-therapy
#14
Ahmad Haider, Karim S Haider, Farid Saad
In daily practice, clinicians are often confronted with obese type 2 diabetes mellitus (T2DM) patients for whom the treatment plan fails and who show an inadequate glycemic control and/or no sustainable weight loss. Untreated hypogonadism can be the reason for such treatment failure. This case describes the profound impact testosterone therapy can have on a male hypogonadal patient with metabolic syndrome, resulting in a substantial and sustained loss of body weight, pronounced improvement of all critical laboratory values and finally complete remission of diabetes...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28920756/sleep-disturbance-as-a-clinical-sign-for-severe-hypogonadism-efficacy-of-testosterone-replacement-therapy-on-sleep-disturbance-among-hypogonadal-men-without-obstructive-sleep-apnea
#15
Kazuyoshi Shigehara, Hiroyuki Konaka, Kazuhiro Sugimoto, Takahiro Nohara, Koji Izumi, Yoshifumi Kadono, Mikio Namiki, Atsushi Mizokami
OBJECTIVE: The present subanalysis of the EARTH study investigates the effects of one year testosterone replacement therapy (TRT) on sleep disturbance among hypogonadal men without obstructive sleep apnea. METHODS: Sleep disturbance was defined as three or more points in question 4 of the aging males symptoms (AMS) questionnaire. All participants completed the AMS scale, International Prostatic Symptoms Score (IPSS), Sexual Health Inventory for Men (SHIM) and Short Form 36 (SF-36) health survey at baseline and after 12 months...
September 18, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28914501/andrology-of-male-to-female-transsexuals-influence-of-cross-sex-hormone-therapy-on-testicular-function
#16
REVIEW
F Schneider, S Kliesch, S Schlatt, N Neuhaus
Patients with gender dysphoria are offered cross-sex hormone therapy and sex reassignment surgery to achieve the transition between the sex assigned at birth and gender identity. According to international guidelines, cross-sex hormone therapy in trans-women should lead to a psychologically and physiologically healthy body with feminized serum hormone levels, resulting in suppression of spermatogenesis. However, in a recently published multi-center study, we discovered a high proportion of patients with male serum hormone levels and qualitatively intact spermatogenesis on the day of sex reassignment surgery...
September 2017: Andrology
https://www.readbyqxmd.com/read/28903836/reconsidering-a-lower-level-of-follicle-stimulating-hormone-as-abnormal-in-sub-fertile-males-of-pakistan
#17
Shehla Arif, Ayesha Khan
OBJECTIVE: To assess the association between Follicle-Stimulating Hormone (FSH) and semen parameters in order to evaluate whether the current laboratory reference for abnormal FSH levels should be readjusted. STUDY DESIGN: Observational, cross-sectional study. PLACE AND DURATION OF STUDY: Infertility Clinic of Gynecology Unit 1, Civil Hospital, Karachi, from May 2015 to April 2016. METHODOLOGY: The study included 100 sub-fertile males inducted from the clinic...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28883919/a-case-of-klinefelter-syndrome-with-hypersexual-desire
#18
Kingsley Okolie, Sumathy Perampalam, Anthony Barker, Christopher J Nolan
Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28882981/characteristics-of-a-nationwide-cohort-of-patients-presenting-with-isolated-hypogonadotropic-hypogonadism-ihh
#19
Marco Bonomi, Valeria Vezzoli, Csilla Gabriella Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzoccaro, Gianni Russo, Mirella Moro, Letizia Maria Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvatore Cannavò, Andrea M Isidori, Angela I Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Francesca Pregnolato, Mohammad Maghnie, Mario Maggi, Luca Persani
OBJECTIVE: IHH is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present altough information on their frequency are scanty, particularly according to the age of presentation. DESIGN: Observational cohort study carried out between January 2008-June 2016 within a national network of academic or general hospitals Methods: We performed a detailed phenotyping of 503 IHH patients with: 1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; 2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects...
September 7, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28869721/the-utility-and-feasibility-of-assessing-sleep-disruption-in-a-men-s-health-clinic-using-a-mobile-health-platform-device-a-pilot-study
#20
Hai H Le, Rachel Marie E Salas, Alyssa Gamaldo, Kevin L Billups, Peter Dziedzic, Seulah Choi, Neftali Bermudez, Roland J Thorpe, Charlene E Gamaldo
INTRODUCTION: Evidence linking sleep disruption and sexual dysfunction in men is mounting; yet the characterisation of sleep patterns and complaints utilising a clinically feasible method within this patient population remain largely under-reported. AIM: A pilot study aiming to demonstrate a clinically feasible method to characterise the sleep patterns and complaints in a representative sample of patients treated in a men's health clinic. METHODS: Male patients (n = 48) completed a battery of validated sleep questionnaires using an mHealth mobile platform, MySleepScript, at the Johns Hopkins Men's Health and Vitality Center...
September 4, 2017: International Journal of Clinical Practice
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