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Male hypogonadism

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https://www.readbyqxmd.com/read/28816715/testosterone-therapy-improves-erectile-function-and-libido-in-hypogonadal-men
#1
Paul J Rizk, Taylor P Kohn, Alexander W Pastuszak, Mohit Khera
PURPOSE OF REVIEW: Erectile dysfunction and decreased libido are common complaints in the older male population. Recent studies have elucidated the role testosterone therapy (TTh) can play in men with low testosterone levels. The aim of this review is to provide an overview of these findings and the utility of TTh. We specifically examine the role of TTh on erectile function, coadministration with phosphodiesterase type 5 inhibitors, and libido. RECENT FINDINGS: Recent publications suggest that TTh improves mild erectile dysfunction, though may be less useful in men with more severe erectile dysfunction...
August 14, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28807822/does-long-term-androgen-deficiency-lead-to-metabolic-syndrome-in-middle-aged-rats
#2
Veronika Borbélyová, Emese Domonkos, Janka Bábíčková, Ľubomíra Tóthová, Mária Kačmárová, Oľga Uličná, Daniela Ostatníková, Július Hodosy, Peter Celec
Evidence from clinical observational studies and animal experiments suggests that hypogonadism is associated with the metabolic syndrome. In most of the experiments, androgen deficiency is induced by gonadectomy in the adulthood and relatively short-term effects of hypogonadism on metabolic parameters are usually observed. The purpose of this study was to evaluate the metabolic effects of long-term androgen deficiency starting before puberty in middle-aged male rats. The components of the metabolic syndrome were examined in male, female and gonadectomized male rats at the age of 18months...
August 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28795962/testosterone-therapy-improves-well-being-and-psychological-health
#3
Jason Akerman, Jason R Kovac, Larry I Lipshultz
PURPOSE OF REVIEW: To ascertain whether testosterone therapy (TTh) improves psychological health and a sense of overall well being in a number of clinical domains. RECENT FINDINGS: Recent work suggests small but durable and replicable improvements in the components of male health and well being. SUMMARY: Symptomatic hypogonadism is frequently associated with decreased libido and fatigue that contributes to lowered overall quality-of-life and worsening psychological health...
August 8, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28791186/a-case-of-male-osteoporosis-a-37-year-old-man-with-multiple-vertebral-compression-fractures
#4
Suhaib Radi, Andrew C Karaplis
While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and improving psychosocial wellbeing, the goals of testosterone replacement therapy in male hypogonadism also include attainment of age-specific bone mineral density. We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28782309/study-of-seminal-fluid-parameters-and-fertility-of-male-sickle-cell-disease-patients-and-potential-impact-of-hydroxyurea-treatment
#5
Lulup Kumar Sahoo, Bipin Kishore Kullu, Siris Patel, Nayan Kumar Patel, Pragyan Rout, Prasanta Purohit, Satyabrata Meher
INTRODUCTION: Male Sickle cell disease (SCD) patients often have moderate to severe hypogonadism resulting in abnormal seminal fluid parameters due to testicular dysfunction. Hydroxyurea (HU), the only drug found to be effective in preventing morbidity and mortality in sickle cell disease patients has been found to further aggravate the testicular dysfunction. MATERIAL AND METHODS: This was a prospective study done at a tertiary care hospital over 26 months between September 2011 to October 2013...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28781213/quality-of-life-and-sexual-function-benefits-of-long-term-testosterone-treatment-longitudinal-results-from-the-registry-of-hypogonadism-in-men-rhyme
#6
Raymond C Rosen, Frederick Wu, Hermann M Behre, Hartmut Porst, Eric J H Meuleman, Mario Maggi, Javier Romero-Otero, Juan I Martinez-Salamanca, Thomas Hugh Jones, Frans M J Debruyne, Karl-Heinz Kurth, Geoff I Hackett, Richard Quinton, Peter Stroberg, Yacov Reisman, Edoardo S Pescatori, Antonio Morales, Lluis Bassas, Natalio Cruz, Glenn R Cunningham, Olivia A Wheaton
BACKGROUND: The benefits and risks of long-term testosterone administration have been a topic of much scientific and regulatory interest in recent years. AIM: To assess long-term quality of life (QOL) and sexual function benefits of testosterone replacement therapy (TRT) prospectively in a diverse, multinational cohort of men with hypogonadism. METHODS: A multinational patient registry was used to assess long-term changes associated with TRT in middle-age and older men with hypogonadism...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28770686/body-composition-changes-with-testosterone-replacement-therapy-following-spinal-cord-injury-and-aging-a-mini-review
#7
Tom E Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S Gill, Teodoro Castillo, Robert A Adler, Ashraf S Gorgey
Context Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood, erythropoiesis, cognition and quality of life. Hypogonadism can occur due to several underlying pathologies during aging and in men with physical disabilities, such as spinal cord injury (SCI). This condition is often under diagnosed and as a result, symptoms undertreated. Methods In this mini-review, we propose that testosterone replacement therapy (TRT) may be a viable strategy to improve lean body mass (LBM) and fat mass (FM) in men with SCI...
August 3, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28760247/psychometric-evaluation-of-the-hypogonadism-impact-of-symptoms-questionnaire-short-form-his-q-sf
#8
Heather L Gelhorn, Laurie J Roberts, Nikhil Khandelwal, Dennis A Revicki, Leonard R DeRogatis, Adrian Dobs, Zsolt Hepp, Michael G Miller
BACKGROUND: The Hypogonadism Impact of Symptoms Questionnaire Short Form (HIS-Q-SF) is a patient-reported outcome measurement designed to evaluate the symptoms of hypogonadism. The HIS-Q-SF is an abbreviated version including17 items from the original 28-item HIS-Q. AIM: To conduct item analyses and reduction, evaluate the psychometric properties of the HIS-Q-SF, and provide guidance on score interpretation. METHODS: A 12-week observational longitudinal study of hypogonadal men was conducted as part of the original HIS-Q psychometric evaluation...
August 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28747541/obesity-a-serious-etiologic-factor-for-male-subfertility-in-modern-society
#9
Yue Liu, Zhide Ding
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder resulting from behavioral, environmental and heritable causes. Such malfunction increases the risk of developing hypertension, diabetes, cardiovascular disease, respiratory problems, osteoarthritis and cancer. Meanwhile, the negative impact of obesity on male reproduction is gradually being recognized. According to clinical investigations and animal experiments, obesity is correlated with reductions in sperm concentration and motility, increases in sperm DNA damage and changes in reproductive hormonal levels...
July 26, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28728990/long-term-testosterone-therapy-improves-urinary-and-sexual-function-and-quality-of-life-in-men-with-hypogonadism-results-from-a-propensity-matched-subgroup-of-a-controlled-registry-study
#10
Karim Sultan Haider, Ahmad Haider, Gheorghe Doros, Abdulmaged Traish
OBJECTIVES: To investigate the effects of long-term testosterone (T) therapy (TTh) on urinary and sexual functions and quality of life (QoL) in hypogonadal men. PATIENTS AND METHODS: Observational, prospective, cumulative registry study in 656 men (age: 60.7 ± 7.2 years) with total T levels ≤12.1 nmol/L and symptoms of hypogonadism. In the T-treated group, men (n = 360) received parenteral T undecanoate (TU) 1000 mg/12 weeks for up to 10 years. Men who opted against TTh (n= 296) served as controls...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28717276/testosterone-versus-clomiphene-citrate-in-managing-symptoms-of-hypogonadism-in-men
#11
Pranav Dadhich, Ranjith Ramasamy, Jason Scovell, Nathan Wilken, Larry Lipshultz
INTRODUCTION: Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS: 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. These men were also compared to eugonadal men who were not on CC or TST during the same period...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#12
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28704095/sarcopenia-an-endocrine-disorder
#13
Alexis McKee, John E Morley, Alvin M Matsumoto, Aaron Vinik
Sarcopenia is defined as low muscle function (walking speed or grip strength) in the presence of low muscle mass. A simple screening test - the SARC-F - is available to identify persons with sarcopenia. The major endocrine causes of sarcopenia are diabetes mellitus and male hypogonadism. Other causes are decreased physical activity, loss of motor neuron units, weight loss, inflammatory cytokines, reduced blood flow to muscles, very low 25(OH) vitamin D levels and decreased growth hormone and IGF-1. Treatment for sarcopenia includes resistance and aerobic exercise, leucine enriched essential amino acids, and vitamin D...
July 13, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28698282/circulating-sex-steroids-co-regulate-adipose-tissue-immune-cell-populations-in-healthy-men
#14
Katya B Rubinow, Jing Chao, Derek Hagman, Mario Kratz, Brian Van Yserloo, Nilesh W Gaikwad, John K Amory, Stephanie T Page
Male hypogonadism results in changes in body composition characterized by increases in fat mass. Resident immune cells influence energy metabolism in adipose tissue and could promote increased adiposity through paracrine effects. We hypothesized that manipulation of circulating sex steroid levels in healthy men would alter adipose tissue immune cell populations. Subjects (n=44 men, 19-55 years of age) received 4 weeks of treatment with the GnRH receptor antagonist acyline with daily administration of 1) placebo gel, 2) 1...
July 11, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28694969/hypogonadotropic-hypogonadism-in-men-with-hereditary-hemochromatosis
#15
Rabih El Osta, Nicolas Grandpre, Nicolas Monnin, Jacques Hubert, Isabelle Koscinski
Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28683157/growth-impairment-and-gonadal-axis-abnormalities-are-common-in-survivors-of-paediatric-brain-tumours
#16
Sari Pietilä, Anne Mäkipernaa, Anna-Maija Koivisto, Hanna L Lenko
AIM: Childhood brain tumour survivors have a high risk of endocrine morbidity. This study evaluated the growth, pubertal development and gonadal function in survivors of childhood brain tumours and identified factors associated with the problems we observed. METHODS: The 52 subjects (52% male) were diagnosed in 1983-1997 and treated for brain tumours at Tampere University Hospital, Finland. They were followed up at a mean age of 14.2 (3.8-28.7) years, a mean of 7...
July 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28679145/the-effect-of-aromatase-on-the-reproductive-function-of-obese-males
#17
Xiaolin Xu, Mingqi Sun, Jifeng Ye, Dandan Luo, Xiaohui Su, Dongmei Zheng, Li Feng, Ling Gao, Chunxiao Yu, Qingbo Guan
Obesity has increased dramatically worldwide, which is associated with male infertility. Androgen deficiency, impaired spermatogenesis, and erectile dysfunction are characteristics of male infertility. The balance of androgens and estrogens is essential for maintaining normal reproductive function in males. Aromatase, the rate-limiting enzyme in the conversion of androgens into estrogens, is present in various tissues. The expression of aromatase is proportional to body fat mass and causes more fat accumulation, thus forming a vicious cycle...
August 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28670553/does-testosterone-replacement-therapy-promote-an-augmented-risk-of-thrombotic-events-in-thalassemia-major-male-patients-with-hypogonadism
#18
Vincenzo De Sanctis, Shahina Daar, Ashraf T Soliman, Heba Elsedfy, Doaa Khater, Salvatore Di Maio
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28661897/obesity-and-male-infertility
#19
Barbara E Kahn, Robert E Brannigan
PURPOSE OF REVIEW: The prevalence of obesity has risen steadily for the past 35 years and presently affects more than a third of the US population. A concurrent decline in semen parameters has been described, and a growing body of literature suggests that obesity contributes to the male infertility. The purpose of this review is to examine the effects of obesity on male fertility, the mechanisms by which impaired reproductive health arise, and the outcomes of treatment. RECENT FINDINGS: Obesity alters the hypothalamic-pituitary-gonadal axis both centrally and peripherally, resulting in hypogonadotropic, hyperestrogenic hypogonadism...
September 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28659543/sox2-nonsense-mutation-in-a-patient-clinically-diagnosed-with-non-syndromic-hypogonadotropic-hypogonadism
#20
Hirohito Shima, Akira Ishii, Yasunori Wada, Junya Kizawa, Tadashi Yokoi, Noriyuki Azuma, Yoichi Matsubara, Erina Suzuki, Akie Nakamura, Satoshi Narumi, Maki Fukami
Hypogonadotropic hypogonadism (HH) is a genetically heterogeneous condition that occurs either as an isolated disorder or as a component of congenital malformation syndromes. SOX2 is a causative gene of syndromic HH characterized by anophthalmia, microphthalmia, or coloboma and other neurological defects such as epilepsy. To date, the causal relationship between SOX2 abnormalities and non-syndromic HH remains speculative. Here, we identified a nonsense mutation of SOX2 in a male patient clinically diagnosed with non-syndromic HH...
June 28, 2017: Endocrine Journal
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