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Stella Stabouli, Euthymia Vargiami, Olga Maliachova, Nikoleta Printza, John Dotis, Maria Kyriazi, Konstantinos O Papazoglou, Dimitrios Zafeiriou
Arterial hypertension is a common finding in patients with neurofibromatosis (NF) type 1. Renovascular hypertension due to renal artery stenosis or midaortic syndrome could be the underlying cause. We report the case of a 4-year-old girl with NF type 1 and midaortic syndrome whose changes in blood pressure and pulse wave velocity suggested the evolution of vasculopathy, diagnosis of renovascular hypertension, and provided insights of response to treatment. Hypertension persisted after percutaneous transluminal angioplasty in the abdominal aorta, requiring escalation of antihypertensive treatment, while arterial stiffness demonstrated a mild decrease...
2018: Case Reports in Pediatrics
Sercin Ozkok, Ahmet Aslan, Yildiz Gulseren, Gonul Kutlu Aciksari, Mehmet Ali Agirbasli
A 23-year-old female patient with factor VII (FVII) deficiency was admitted with severe hypertension and renal failure. Brachial arterial pressures were 230/120 and 220/115 mm/Hg on the right and left arms, respectively. There was no blood pressure difference between the arms. Renal artery Doppler ultrasonography revealed bilateral severe renal artery stenosis (RAS). Contrast-enhanced magnetic resonance imaging angiography (CE-MRA) revealed severe mural irregularities, contrast enhancement in the aorta and its branches, and long-segment stenosis starting in the abdominal aorta and extending into the proximal renal arteries...
October 2018: Eurasian Journal of Medicine
Jianming Guo, Lianrui Guo, Gao Zeng, Zhu Tong, Xixiang Gao, Yongquan Gu
Guo J, Guo L, Zeng G, Tong Z, Gao X, Gu Y. An infant case of renovascular hypertension in moyamoya disease treated by angioplasty. Turk J Pediatr 2018; 60: 331-334. Here we report the treatment experience of an 18-month-old female infant case of renovascular hypertension due to moyamoya disease by angioplasty. Although renal blood flow was recovered immediately after operation, 12 months follow-up found severe restenosis which required us to perform a right renal autotransplantation.
2018: Turkish Journal of Pediatrics
Maysa Isernhagen Schaedler, Rhanany Alan Calloi Palozi, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Valdinei de Oliveira Araújo, Emerson Luiz Botelho Lourenço, Lauro Mera de Souza, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior
BACKGROUND: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Macbr. (Lythraceae), popularly known as 'sete sangrias', being found in Brazil, Hawaii and in South Pacific Islands. Despite the widespread use of this species by the population, its long-term antihypertensive and cardioprotective activities have not yet been scientifically evaluated. PURPOSE: To evaluate the possible cardioprotective effects of an ethanol-soluble fraction obtained from C...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Misako Nagatsuma, Kei Takasawa, Takeru Yamauchi, Ryuichi Nakagawa, Tomoko Mizuno, Eriko Tanaka, Kouhei Yamamoto, Noriko Uemura, Kenichi Kashimada, Tomohiro Morio
Schimmelpenning syndrome is a rare neurocutaneous disorder categorized as a mosaic RASopathy due to postzygotic HRAS or KRAS mutations. We report a 6-year-old girl diagnosed with Schimmelpenning syndrome due to a postzygotic KRAS G12D mutation. The patient had three atypical symptoms of Schimmelpenning syndrome: renovascular hypertension, congenital lipomatosis, and diabetes mellitus. The first two symptoms may overlap with phenotypes of other neurocutaneous syndromes or congenital lipomatous overgrowth syndrome due to mosaic RASopathies or other somatic mosaic mutations...
November 16, 2018: Journal of Human Genetics
Brian R Lane, Stephen K Babitz, Katerina Vlasakova, Allen Wong, Sabrina L Noyes, William Boshoven, Pam Grady, Cindy Zimmerman, Susan Engerman, Maureen Gebben, Michael Tanen, Warren E Glaab, Frank D Sistare
BACKGROUND: Partial nephrectomy (PN) is the gold standard for the treatment of small renal masses. Urinary biomarkers (UBMs) may serve as early indicators of acute kidney injury (AKI) following PN. OBJECTIVE: To evaluate the timing, specificity, and sensitivity of several candidate UBMs after PN to determine the most promising UBMs in this setting. We hypothesize that some UBMs will have utility as early markers of AKI. DESIGN, SETTING, AND PARTICIPANTS: Twenty-two patients undergoing on-clamp robotic or open PN underwent paired urine collection via ureteral catheterization of the affected kidney and Foley catheterization for the unaffected kidney obtained preoperatively, after anesthesia, and at several points in time after renovascular occlusion...
November 10, 2018: European Urology Focus
Pei Lin Chan, Florence Hui Sieng Tan
Background: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants in the vascular anatomy which are often thought to be innocuous but in some circumstances can cause renovascular hypertension leading to secondary hyperaldosteronism. Case presentation: We report 2 cases of hypertension with secondary hyperaldosteronism associated with accessory renal arteries...
2018: Clinical Hypertension
Ryuji Okamoto, Masaya Taniguchi, Yuki Onishi, Naoto Kumagai, Junji Uraki, Naoki Fujimoto, Eitaro Fujii, Yutaka Yano, Toru Ogura, Masaaki Ito
It remains unknown which surrogate markers can predict diagnostic test results for primary hyperaldosteronism (PA). The Secondary Hypertension Registry Investigation in Mie Prefecture (SHRIMP) study has sequentially and prospectively recruited 128 patients with hypertension with an aldosterone-to-renin ratio (ARR) greater than 20, evaluated the differences among essential hypertension (EHT), idiopathic hyperaldosteronism (IHA), and aldosterone-producing adenoma (APA), and analyzed the predictors for the confirmatory tests...
November 6, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Rajesh Vijayvergiya, Ankur K Jindal, Rakesh K Pilania, Deepti Suri, Anju Gupta, Ashish Sharma, Saroj K Sinha, Manphool Singhal, Ajay Bahl, Surjit Singh
AIM: To report our experience on complex percutaneous interventions of the abdominal aorta and its branches in six children with Takayasu arteritis (TA). METHODS: A review of records of children with TA, who underwent percutaneous interventions of the abdominal aorta and its major branches. RESULTS: In this analysis, we included six children with TA who underwent intervention of the abdominal aorta and its major branches. The endovascular interventions were performed mostly for treatment-resistant renovascular hypertension and mesentery artery ischemia...
November 5, 2018: International Journal of Rheumatic Diseases
Harshal Deshmukh, Emma Barker, Thineshkrishna Ambarasan, Daniel Levin, Samira Bell, Miles D Witham, Jacob George
BACKGROUND AND OBJECTIVE: Results of interventional trials in renovascular hypertension have been disappointing and medical therapy is the current recommended gold standard. However, the comparative long-term benefits of different antihypertensive drug classes in atherosclerotic renal artery stenosis are not known. We aim to assess the effect of different antihypertensive drug classes on outcomes in renovascular hypertension DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Using Tayside Health Informatics Centre database, anonymised data over a 6-year period was analysed...
October 29, 2018: Cardiovascular Therapeutics
Ana Carolina de Bragança, Daniele Canale, Janaína Garcia Gonçalves, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro, Rildo Aparecido Volpini
The pathogenesis of chronic kidney disease (CKD) involves a very complex interaction between hemodynamic and inflammatory processes, leading to glomerular/vascular sclerosis, and fibrosis formation with subsequent evolution to end-stage of renal disease. Despite efforts to minimize the progression of CKD, its incidence and prevalence continue to increase. Besides cardiovascular diseases and infections, several studies demonstrate that vitamin D status could be considered as a non-traditional risk factor for the progression of CKD...
2018: Frontiers in Medicine
Qi Zhang, Ying-Ying Tan, Xiao-Hua Liu, Fan-Rong Yao, Dong-Yuan Cao
Electroacupuncture (EA) has been reported to benefit hypertension, but the underlying mechanisms are still unclear. We hypothesized that EA attenuates hypertension, in part, through modulation of γ -aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS). In the present study, the long-term effect of EA on GABA receptor function and expression was examined in the NTS of two-kidney, one-clip (2K1C) renovascular hypertensive rats. EA (0.1-0.4 mA, 2 and 15 Hz) was applied at Zusanli (ST36) acupoints overlying the deep fibular nerve for 30 min once a day for two weeks...
2018: Neural Plasticity
Willian S Korim, Khalid Elsaafien, Jeremy R Basser, Anthony Setiadi, Clive N May, Song T Yao
Aims: Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are unclear. Here we investigated whether TNF-α stimulates neurons in the area postrema, a circumventricular organ, to elicit sympathetic excitation and increases in blood pressure...
October 25, 2018: Cardiovascular Research
Raquel González-Blázquez, Beatriz Somoza, Marta Gil-Ortega, Miriam Martín Ramos, David Ramiro-Cortijo, Elena Vega-Martín, Angela Schulz, Luis Miguel Ruilope, Peter Kolkhof, Reinhold Kreutz, María S Fernández-Alfonso
Albuminuria is an early marker of renovascular damage associated to an increase in oxidative stress. The Munich Wistar Frömter (MWF) rat is a model of chronic kidney disease (CKD), which exhibits endothelial dysfunction associated to low nitric oxide availability. We hypothesize that the new highly selective, non-steroidal mineralocorticoid receptor (MR) antagonist, finerenone, reverses both endothelial dysfunction and microalbuminuria. Twelve-week-old MWF (MWF-C; MWF-FIN) and aged-matched normoalbuminuric Wistar (W-C; W-FIN) rats were treated with finerenone (FIN, 10 mg/kg/day p...
2018: Frontiers in Pharmacology
In O Sun, Adrian Santelli, Abdelrhman Abumoawad, Alfonso Eirin, Christopher M Ferguson, John R Woollard, Amir Lerman, Stephen C Textor, Amrutesh S Puranik, Lilach O Lerman
Hypertension, an important cause of chronic kidney disease, is characterized by peritubular capillary (PTC) loss. Circulating levels of endothelial microparticles (EMPs) reflect systemic endothelial injury. We hypothesized that systemic and urinary PTC-EMPs levels would reflect renal microvascular injury in hypertensive patients. We prospectively measured by flow cytometry renal vein, inferior vena cava, and urinary levels of EMPs in essential (n=14) and renovascular (RVH; n=24) hypertensive patients and compared them with peripheral blood and urinary levels in healthy volunteers (n=14)...
November 2018: Hypertension
Johnny Steuer, David Bergqvist, Martin Björck
OBJECTIVE/BACKGROUND: To study functional outcome, mortality, and dialysis free survival in patients undergoing open primary surgical repair of renal artery stenosis (RAS) or aneurysm (RAA). METHODS: This was a retrospective single centre study of patients undergoing open surgical renal artery reconstruction from 1993 to 2007. Blood pressure, renal function, dialysis dependence, vessel patency, and mortality were registered. Survival was investigated by cross matching with the population registry, yielding up to 20 years of follow up...
October 18, 2018: European Journal of Vascular and Endovascular Surgery
Dolores Ferrara, Francesco Esposito, Roberta Blasio, Rosanna Mamone, Rosa Severino, Marco Di Serafino, Carmine Pecoraro, Massimo Zeccolini
Percutaneous renal biopsy (PRB) is an important procedure in the diagnostic and prognostic evaluation of renal disorders. Despite the relative simplicity, it can be a possible cause of iatrogenic renovascular injury. We describe two cases of iatrogenic pseudoaneurysm, a major post-biopsy complication, in two pediatric patients with persistent micro- and macro-hematuria, promptly diagnosed using color Doppler ultrasound, confirmed with renal arteriography and treated with embolization.
December 2018: Journal of Ultrasound
L Qin, Z L Wang, Y Feng, Z Z Chen, H Yu
Objective: To characterize the gut microbial community structure of two-kidney-one-clip (2K1C) hypertensive rats, provide new evidences for prevention and treatment of hypertension. Methods: Adult male SD rats were divided into 2K1C hypertensive model group and sham operation group ( n= 8 each). Blood pressure was recorded by tail-cuff technique weekly for 4 weeks. Then, the total fecal DNA of rats in 2K1C model group and sham operation group were extracted. The structure and principal components of intestinal flora in 2K1C model rats and sham operated rats were analyzed using Hiseq3000 sequencing platform...
September 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Joseph J Bookstein
No abstract text is available yet for this article.
November 2018: Journal of Vascular and Interventional Radiology: JVIR
Burcin Atak, Gulali Aktas, M Zahid Kocak, Tuba Duman, Edip Erkus, Kamil Gurel, Haluk Savli
Hydatid cyst is a parasitic infection which causes enormous morbidity and mortality worldwide. The pathogenic organism responsible for hydatid cyst is Echinococcus granulosus. Despite the fact that the characteristic cysts of the disease usually occur in liver and lungs, they may also occur in aberrant localisations. Subjects either present with symptoms of infection itself or local complications due to compressive mass effect of the cyst. Here, we report a case of secondary hypertension due to extrinsic compression of the right renal artery by a giant hepatic hydatid cyst...
October 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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