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Dolores Ferrara, Francesco Esposito, Roberta Blasio, Rosanna Mamone, Rosa Severino, Marco Di Serafino, Carmine Pecoraro, Massimo Zeccolini
Percutaneous renal biopsy (PRB) is an important procedure in the diagnostic and prognostic evaluation of renal disorders. Despite the relative simplicity, it can be a possible cause of iatrogenic renovascular injury. We describe two cases of iatrogenic pseudoaneurysm, a major post-biopsy complication, in two pediatric patients with persistent micro- and macro-hematuria, promptly diagnosed using color Doppler ultrasound, confirmed with renal arteriography and treated with embolization.
October 11, 2018: Journal of Ultrasound
L Qin, Z L Wang, Y Feng, Z Z Chen, H Yu
Objective: To characterize the gut microbial community structure of two-kidney-one-clip (2K1C) hypertensive rats, provide new evidences for prevention and treatment of hypertension. Methods: Adult male SD rats were divided into 2K1C hypertensive model group and sham operation group ( n= 8 each). Blood pressure was recorded by tail-cuff technique weekly for 4 weeks. Then, the total fecal DNA of rats in 2K1C model group and sham operation group were extracted. The structure and principal components of intestinal flora in 2K1C model rats and sham operated rats were analyzed using Hiseq3000 sequencing platform...
September 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Joseph J Bookstein
No abstract text is available yet for this article.
September 28, 2018: Journal of Vascular and Interventional Radiology: JVIR
Burcin Atak, Gulali Aktas, M Zahid Kocak, Tuba Duman, Edip Erkus, Kamil Gurel, Haluk Savli
Hydatid cyst is a parasitic infection which causes enormous morbidity and mortality worldwide. The pathogenic organism responsible for hydatid cyst is Echinococcus granulosus. Despite the fact that the characteristic cysts of the disease usually occur in liver and lungs, they may also occur in aberrant localisations. Subjects either present with symptoms of infection itself or local complications due to compressive mass effect of the cyst. Here, we report a case of secondary hypertension due to extrinsic compression of the right renal artery by a giant hepatic hydatid cyst...
October 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Gregory J Weber, Biswa Purkayastha, Lu Ren, Sathnur Pushpakumar, Utpal Sen
OBJECTIVE: Hypertension at advanced age damages microvasculature and initiates many disease conditions including chronic kidney disease (CKD). In the present study, we sought to determine molecular alterations occurring in angiotensin-II (Ang-II)-induced aged kidney. METHODS: Old (75-80 weeks) and young (12-14 weeks) wild-type mice (C57BL/6J) were infused with Ang-II (1000 ng/kg per min) for 4 weeks using osmotic minipumps to induce hypertension. Blood pressure, renovascular density, and renal vascular resistance were measured by telemetry, barium angiography, and renal ultrasound, respectively...
November 2018: Journal of Hypertension
Hong Jiang, Chen Zhang, Wen He
BACKGROUND Dracocephalum heterophyllum Benth flavonoid (DHBF) is a Tibetan and Uighur traditional medicine used to treat various disorders such as hypertension, lung heat, cough, and bronchitis; it has good antioxidant activity. Previous studies have shown that DHBF can reduce blood pressure in renovascular hypertensive rats, improve left ventricular systolic and diastolic function, and improve myocardial contractility. Therefore, we aimed to study the effect of DHBF on cardiomyocyte hypertrophy in cultured cells...
September 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Pradyumna Kumar Singh, Rajesh Rajput, Saurav Banerjee, Keshav Garg
Renovascular hypertension is one of the common causes of secondary hypertension. Here we report a case of patient of renal artery stenosis presenting to the emergency department as a case of acute flaccid paralysis. Renal artery stenosis has been associated with hypokalaemia, but rarely reported to be symptomatic. Initial correction of hypokalaemia leads to improvement of weakness and aetiological work up for hypokalaemia with hypertension revealed hypokalaemia due to hyperaldosteronism secondary to unilateral renal artery stenosis...
August 31, 2018: BMJ Case Reports
Erick Bryan de Sousa Lima, Lúcia Castro Santos de Oliveira, Geovane da Silva Cardoso, Pedro Victor Nogueira Telles, Lara da Costa Lima, Jessica Fernanda Reis E Sousa, Ruan Pablo Nunes Araújo, Aldeidia Pereira de Oliveira, Rosimeire Ferreira Dos Santos, Armenio Aguiar Dos Santos, Moisés Tolentino Bento da Silva
Actually, arterial hypertension is a major public health concern, which involves the renin angiotensin aldosterone system (RAS), via activation of the angiotensin receptors AT1 and AT2 of the cardiovascular system. Although angiotensin is an important stimulant of the gut permeability to sodium and water, little is known about the effects of arterial hypertension on gut motor behavior. Thus, we evaluated in rats the effect of hypertension induced by two-kidney one-clip (2K1C) model on the gastric motility, as well as the influence of exercise and RAS blockers treatment in such phenomenon...
October 1, 2018: Life Sciences
Gioacchino Li Cavoli, Giuseppe Mulè, Mario Giuseppe Vallone, Flavia Caputo
Takayasu arteritis (TA) is a chronic vasculitis disease of unknown etiology. Clinically significant renal disease is relatively common, and renovascular hypertension is the major renal problem. The assessment of TA activity is usually challenging because vascular inflammation may progress to fixed vascular injury without findings of active disease. Until now, the best therapeutic options have not been identified. This review highlights the current perspectives of renal involvement in TA.
2018: International Journal of Nephrology and Renovascular Disease
Fang-Da Li, Zhi-Gang Ji, Chang-Wei Liu, Jiang Shao, Yi Xie, Yue-Hong Zheng
OBJECTIVE: In this article, we aim to prove the safety and effectiveness of orthotopic renal autotransplantation using ex vivo repair for the treatment of complex renovascular hypertension (RVH). METHODS: We retrospectively reviewed five consecutive patients (three women, two men) with young-onset RVH from January 2009 to August 2014. Orthotopic renal autotransplantation using ex vivo repair was performed and perioperative data were collected for statistical analysis...
July 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
Karel Decaestecker, Benjamin Van Parys, Jeroen Van Besien, Nicolas Doumerc, Liesbeth Desender, Caren Randon, Frederic De Ryck, Thomas Tailly, Matthias Beysens, Carl Van Haute, Diederik Ponette, Kathia De Man, Piet Hoebeke, Frank Vermassen
BACKGROUND: Kidney autotransplantation (KAT) is the ultimate way to salvage kidneys with complex renovascular, ureteral, or malignant pathologies that are not amenable to in situ reconstruction. A minimally invasive approach could broaden its adoption. OBJECTIVE: To describe operative technique, perioperative complications, and early functional outcomes of robot-assisted kidney autotransplantation (RAKAT). DESIGN, SETTING, AND PARTICIPANTS: Retrospective review of prospectively collected data regarding consecutive patients undergoing RAKAT between March 2017 and February 2018 at two university hospitals...
March 2018: European Urology Focus
Jun-Li Tsai, Shang-Feng Tsai
Renal transplant is the preferred choice of treatment for end-stage renal diseases. To avoid rejection, increasingly potent immunosuppressants are administered to recipients of kidney transplants. Complications, when there is excess immunosuppression, include possible lethal infections, which reduce allograft survival and compromise patient survival. When there is insufficient immunosuppression, rejections could impair allograft outcomes. Moreover, recurrent primary diseases could also threaten allograft outcomes...
July 31, 2018: Experimental and Clinical Transplantation
Aspasia I Tzani, Ilias P Doulamis, Panagiotis S Konstantopoulos, Ermioni D Pasiou, Afrodite Daskalopoulou, Dimitrios C Iliopoulos, Ioannis V Georgiadis, Nikolaos Kavantzas, Stavros K Kourkoulis, Despina N Perrea
Chios mastic gum (CMG) exerts robust anti-inflammatory and antioxidant properties and it affects pathways that are implicated in the pathophysiology of endothelial and vascular inflammation. Aim of this study was to test the hypothesis that CMG administration lowers blood pressure (BP) and improves hypertension-induced target organ damage. 2-kidney, 1-clip (2K1C) hypertensive rats were treated with CMG (40 mg/kg body weight/day) for 2-weeks after the establishment of hypertension. Acute CMG administration lowered systolic, diastolic and mean arterial BP, while these hemodynamic effects were sustained throughout the 2-week administration period...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Maria Florencia Albertoni Borghese, Sandra Hope, Maria Del Carmen Ortiz, Magalí Barchuk, Camila Kessler, Carlos Davio, Marcelo Vatta, Mónica Majowicz
AIMS: The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model). In addition, some mechanisms that underlie the role of AQP2 in the Goldblatt-1 model were evaluated. MAIN METHODS: Sprague-Dawley rats were divided in three groups: control two-kidney, no clip (C, 2 K-NC); nephrectomized one-kidney, no clip (N, 1 K-NC) and Goldblatt one-kidney, one-clip (G, 1 K-1C)...
September 1, 2018: Life Sciences
A Gromotowicz-Poplawska, A Stankiewicz, J Mikita, M Aleksiejczuk, N Marcinczyk, J Szemraj, E Chabielska
A strong correlation between raised aldosterone levels and increased risk of thrombotic disorders has been provided. Clinical studies have demonstrated the benefits of the addition of the aldosterone receptor antagonist to the standard therapy with angiotensin-converting enzyme inhibitor in the reduction of cardiovascular events in patients. We suggest that the benefits of this dual renin-angiotensin-aldosterone system (RAAS) blockade may be related to the drug's effects on the hemostatic and oxidative balance...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Rui Tan, You Mee Ahn, Hye Yoom Kim, Yun Jung Lee, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee
In the present study, the change in secretion of atrial natriuretic peptide (ANP) from the atria was defined in hypertension accompanied by ventricular hypertrophy and increased synthesis of ANP. To identify the change of the secretion and mechanisms involved, experiments were performed in isolated perfused beating atria from sham-operated normotensive and renovascular hypertensive rats. Expression of ANP, natriuretic peptide receptor (NPR)-C, components of the renin-angiotensin system, and muscarinic signaling pathway was measured in cardiac tissues...
September 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Matthew W Harer, Alison L Kent
Hypertension is encountered in up to 3% of neonates and occurs more frequently in neonates requiring hospitalization in the neonatal intensive care unit (NICU) than in neonates in newborn nurseries or outpatient clinics. Former NICU neonates are at higher risk of hypertension secondary to invasive procedures and disease-related comorbidities. Accurate measurement of blood pressure (BP) remains challenging, but new standardized methods result in less measurement error. Multiple factors contribute to the rapidly changing BP of a neonate: gestational age, postmenstrual age (PMA), birth weight, and maternal factors are the most significant contributors...
July 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Alfonso Eirin, Xiang-Yang Zhu, Sreela Jonnada, Amir Lerman, Andre J van Wijnen, Lilach O Lerman
BACKGROUND: Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease (RVD) complicated by metabolic syndrome (MetS), we tested the hypothesis that EVs would attenuate renal microvascular loss. METHODS: Four groups of pigs ( n = 7 each) were studied after 16 weeks of diet-induced MetS and RVD (MetS+RVD), MetS+RVD treated 4 weeks earlier with a single intra-renal delivery of EVs harvested from autologous adipose tissue-derived MSCs, and Lean and MetS Sham controls...
July 2018: Cell Transplantation
Gonzalo I Gómez, Victoria Velarde
Boldine, a major aporphine alkaloid found in the Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimental role in the pathogenesis of kidney damage in renovascular hypertension (RVH). The activation of the renin-angiotensin system (RAS) is crucial to the development and progression of hypertensive renal damage and TGF-β is closely associated with the activation of RAS. In the present study, we assessed the effect of boldine on the progression of kidney disease using the 2K1C hypertension model and identifying mediators in the RAS, such as TGF-β, that could be modulated by this alkaloid...
June 25, 2018: International Journal of Molecular Sciences
Irina Iuliana Costache, Claudia Florida Costea, Vasile Fotea, Victor Laurian Rusu, Viviana Aursulesei, Razan Al Namat, Dan Alexandru Costache, Nicoleta Dumitrescu, Cătălin Mihai Buzdugă, Gabriela Florenţa Dumitrescu, Anca Sava, Camelia Margareta Bogdănici
Resistant hypertension is defined by the inability to maintain within normal limits the blood pressure values of an individual, while he is under treatment with maximal tolerated doses of three antihypertensive agents. One of the most common types of resistant hypertension is renovascular hypertension (RVH), which is caused by the narrowing of the renal arteries, in the context of existing atherosclerotic plaques at that level. We are presenting the case of a hypertensive 56-year-old man admitted in the Clinic of Cardiology for a sudden rise of his blood pressure values, despite undergoing the scheduled treatment...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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