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https://www.readbyqxmd.com/read/30513396/hemodynamic-and-neuronal-responses-to-cocaine-differ-in-awake-versus-anesthetized-animals-optical-brain-imaging-study
#1
Kicheon Park, Wei Chen, Nora D Volkow, Craig P Allen, Yingtian Pan, Congwu Du
Cocaine is a highly addictive drug with complex pharmacological effects. Most preclinical imaging studies investigating the effects of cocaine in the brain have been performed under anesthesia, which confounds findings. To tackle this problem, we used optical imaging to compare the effects of cocaine in the awake versus the anesthetized state. For this purpose, we customized an air floating mobile cage to fit the multi-wavelength spectral and laser speckle optical imaging system and implanted a multi-layer cranial window over the mouse somatosensory cortex...
December 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/30502086/emulsan-based-nanoparticles-for-in-vivo-drug-delivery-to-tumors
#2
Gawon Yi, Jihwan Son, Jihye Yoo, Changhee Park, Heebeom Koo
Nanoparticles have been widely used as drug carriers, and finding new materials for them is important for efficient drug delivery. Herein, we developed a new nanoparticle using emulsan and flax seed oil. Emulsan is one of the representative biosurfactants obtained from Acinetobacter calcoaceticus RAG-1. The resulting nanoparticles have an emulsan shell and a hydrophobic oil core, into which pheophorbide a (Pba) was loaded as a model drug. The nanoparticles were about 165.7 nm and were stably dispersed in an aqueous condition for more than one week...
November 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30501583/a-survey-of-vascular-specialists-practice-patterns-of-inferior-vena-cava-filter-placement-and-retrieval
#3
Anand Brahmandam, Laura Skrip, Bauer Sumpio, Jeffrey Indes, Alan Dardik, Timur Sarac, John Rectenwald, Cassius Iyad Ochoa Chaar
OBJECTIVES: The placement of inferior vena cava filters (IVCF) continues to rise. Vascular specialists adopt different practices based on local expertise. This study was performed to assess the attitudes of vascular specialists towards the placement and retrieval of IVCF. METHODS: An online survey of 28 questions related to practice patterns regarding IVCF was administered to 1429 vascular specialists. Vascular specialists were categorized as low volume if they place less than three IVCF per month and high volume if they place at least three IVCF per month...
December 1, 2018: Vascular
https://www.readbyqxmd.com/read/30499483/-the-application-of-combined-low-intensity-laser-therapy-for-the-treatment-of-the-patients-presenting-with-trophic-ulcers-associated-with-chronic-venous-insufficiency-of-the-lower-extremities
#4
E V Askhadulin, T V Konchugova, S V Moskvin
AIM: The objective of the present study was the evaluation of the effectiveness of the combined treatment of the patients presenting with trophic ulcers associated with chronic venous insufficiency of the lower extremities of venous etiology with the application of low-intensity laser therapy (LILT) at different wavelengths. MATERIAL AND METHODS: The study included the patients presenting with chronic venous insufficiency (CVI) (class C6 in accordance with the CEAP clinical classification)...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/30485331/evaluation-of-flicker-induced-hyperemia-in-the-retina-and-optic-nerve-head-measured-by-laser-speckle-flowgraphy
#5
Klemens Fondi, Ahmed M Bata, Nikolaus Luft, Katarzyna J Witkowska, René M Werkmeister, Doreen Schmidl, Matthias Bolz, Leopold Schmetterer, Gerhard Garhöfer
PURPOSE: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation. METHODS: Twenty healthy subjects were included in this cross sectional study...
2018: PloS One
https://www.readbyqxmd.com/read/30479878/noninvasive-assessment-of-retinal-blood-flow-using-a-novel-handheld-laser-speckle-contrast-imager
#6
Abhishek Rege, Samantha I Cunningham, Yusi Liu, Karan Raje, Sachin Kalarn, M Jason Brooke, Lisa Schocket, Sunni Scott, Asifa Shafi, Luis Toledo, Osamah J Saeedi
Purpose: We assessed the image quality and reproducibility of blood flow measurements from a novel handheld laser speckle imager in handheld and stabilized use cases. Methods: Eleven dilated human subjects were imaged with the XyCAM Handheld Retinal Imager investigational device (XyCAM HRI) in the handheld and stabilized use case in nine consecutive imaging sessions. Subjects then underwent standard color fundus photography using a Topcon TRC 50DX. The vessel-to-background contrast of the XyCAM HRI red-free photo was compared to the fundus photograph, while the coefficient of variation of blood flow measurements in specific arteries and veins also was determined...
November 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/30477732/argon-laser-photocoagulation-for-macular-edema-in-branch-vein-occlusion
#7
(no author information available yet)
The Branch Vein Occlusion Study is a multi-center, randomized, controlled clinical trial designed to answer several questions regarding the management of complications of branch vein occlusion. This report discusses the question, "Is argon laser photocoagulation useful in improving visual acuity in eyes with branch vein occlusion and macular edema reducing vision to 20/40 or worse?" One hundred thirty-nine eligible eyes were assigned randomly to either a treated or an untreated control group. Comparing treated patients to control patients (mean follow-up 3...
December 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30476208/visualization-and-quantification-of-mitochondrial-structure-in-the-endothelium-of-intact-arteries
#8
Matthew J Durand, Karima Ait-Aissa, Vladislav Levchenko, Alexander Staruschenko, David D Gutterman, Andreas M Beyer
Aims: To quantify the mitochondrial structure of ECs in intact arteries vs. cultured cells. Methods and Results: Cre-stop mito-Dendra2 mice, expressing the fluorescent protein Dendra2 in the mitochondrial matrix only, were used to label EC mitochondria using Cre-recombinase under the control of the VE-cadherin promoter. Conduit arteries, resistance arterioles and veins were fixed, mounted on glass slides and fluorescent images were obtained using a laser scanning confocal microscope (ex 488 nm; em 550 nm)...
November 22, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30472075/the-potent-small-molecule-integrin-antagonist-thr-687-is-a-promising-next-generation-therapy-for-retinal-vascular-disorders
#9
Tjing-Tjing Hu, Marc Vanhove, Michaël Porcu, Inge Van Hove, Tine Van Bergen, Bart Jonckx Bart, Philippe Barbeaux, Elke Vermassen, Jean H M Feyen
Integrins are associated with various eye diseases such as diabetic retinopathy (DR) and wet age-related macular degeneration (AMD) and implicated in main pathologic disease hallmarks like neovascularization, inflammation, fibrosis and vascular leakage. Targeting integrins has the potential to attenuate these vision-threatening processes, independent of anti-vascular endothelial growth factor (VEGF) responsiveness. The current investigation characterized THR-687 as a novel pan RGD (arginylglycylaspartic acid) integrin receptor antagonist able to compete for binding with the natural ligand with nanomolar potency (e...
November 22, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30466354/patient-reported-outcomes-of-endovenous-superficial-venous-ablation-for-lower-extremity-swelling
#10
William Shutze, Ryan Shutze, Paul Dhot, Gerald O Ogola
OBJECTIVE: To evaluate the effect of endovenous ablation in patients presenting with leg swelling. METHODS: We identified Clinical, Etiology, Anatomy, Pathophysiology (CEAP) clinical class 3 (C3) patients undergoing endovenous ablation from 21 January 2005 to 19 March 2015 with an 810-nm or 1470-nm laser. Patients were surveyed regarding the degree of edema, use of compression stockings, and satisfaction with the procedure. RESULTS: A total of 1634 limbs were treated by endovenous ablation for incompetent saphenous veins with or without adjunctive segmental varicose vein microphlebectomy...
November 22, 2018: Phlebology
https://www.readbyqxmd.com/read/30461460/endovenous-photocoagulation-using-a-diode-laser-for-complicated-varicose-veins-related-to-stasis-ulcers
#11
Jing-Syuan Lee, Yen-Chang Hsiao, Cheng-Jen Chang
BACKGROUND: The objective of this study was to assess the efficacy and safety of endovenous laser photocoagulation (EVLP) at a wavelength of 810 nm for treating complicated venous insufficiency associated with venous ulcers. MATERIALS AND METHODS: A retrospective review of 110 patients with 180 legs having chronic venous insufficiencies associated with varicose veins treated over an 8-year period was conducted. Patients ranged from 16 to 80 years of age and included 85 women and 25 men...
November 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/30461034/heartlight-guided-pure-pulmonary-vein-isolation-regardless-of-concomitant-atrial-substrate-heureca-study
#12
Takahiko Nagase, Stefano Bordignon, Laura Perrotta, Fabrizio Bologna, Nikolaos Tsianakas, Shaojie Chen, Athanasios Konstantinou, Julian K R Chun, Boris Schmidt
BACKGROUND: It remains unclear whether left atrial low-voltage area (LALVA) affects atrial tachyarrhythmia recurrence after laser balloon pulmonary vein isolation (PVI) for atrial fibrillation (AF). We prospectively evaluated the outcome of laser balloon PVI in patients with and without LALVA (≤ 0.5 mV) together with surface/intracardiac electrophysiological criteria. METHODS: One hundred consecutive paroxysmal/persistent AF patients underwent laser balloon PVI...
November 20, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/30460761/retinal-oximetry-and-systemic-arterial-oxygen-levels
#13
Thorunn Scheving Eliasdottir
PURPOSE: Continuous peripheral pulse oximetry for monitoring adequacy of oxygenation is probably the most important technological advance for patients' monitoring and safety in the last decades. Pulse oximetry has the disadvantage of measuring the peripheral circulation, and the only mean to measure oxygen content of the central circulation is by invasive technology. Determination of blood oxyhaemoglobin saturation in the retinal vessels of the eye can be achieved noninvasively through spectrophotometric retinal oximetry which provides access to the central nervous system circulation...
November 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30460242/activation-of-toll-like-receptor-9-impairs-blood-flow-recovery-after-hind-limb-ischemia
#14
Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
Background: Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. However, the role of TLR9, which was originally known as a sensor for bacterial DNA, remains unknown. This study investigated the role of TLR9 in blood flow recovery in the ischemic limb using a mouse hind-limb ischemia model. Methods and Results: Unilateral femoral artery ligation was performed in TLR9-deficient ( Tlr9 -/- ) mice and wild-type mice...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30458678/bone-marrow-mesenchymal-stem-cells-bmscs-restore-functional-endometrium-in-the-rat-model-for-severe-asherman-syndrome
#15
Lufen Gao, Zhongwei Huang, Haiyingjie Lin, Yuke Tian, Ping Li, Shaoqiang Lin
OBJECTIVE: To investigate the feasibility to restore functional endometrium using bone marrow mesenchymal stem cells (BMSCs) in the Sprague Dawley (SD["SD" has been defined as both "Sprague Dawley" and "standard deviation." Please clarify which one is to be followed.]) rat model for Asherman syndrome (AS). DESIGN: Basic research on treatment of AS utilizing an optimized rat model. SETTING: University research laboratories...
November 20, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/30457641/impact-of-time-to-anti-vascular-endothelial-growth-factor-intervention-on-visual-outcomes-for-patients-diagnosed-with-retinal-vein-occlusion
#16
Jessica Hsueh, Karen M Wai, Felipe F Conti, Thais F Conti, Rishi P Singh
BACKGROUND AND OBJECTIVES: To analyze the impact of time to treatment with anti-vascular endothelial growth factor (VEGF) for patients with macular edema (ME) secondary to retinal vein occlusions (RVO) in routine clinical practice. PATIENTS AND METHODS: One hundred fifty-five eyes with ME secondary to RVO were identified. Patients were divided into initiation of anti-VEGF treatment at 28 days or fewer after symptom onset (Group A), between 28 and 84 days (Group B), and 84 days or more (Group C)...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30448152/the-relative-roles-of-power-linear-endovenous-energy-density-and-pullback-velocity-in-determining-short-term-success-after-endovenous-laser-ablation-of-the-truncal-saphenous-veins
#17
Sanjay S Srivatsa, Steve Chung, Vikramjit Sidhu
OBJECTIVE: The objective of this study was to describe the relative contributions of power output, linear endovenous energy density (LEED), and pullback rate (PBR) in determining successful long-term occlusion of the truncal saphenous veins after endovenous laser ablation (EVLA). METHODS: A consecutive 203 patients (336 ablated veins) with reflux of the great saphenous vein or small saphenous vein (Clinical, Etiology, Anatomy, and Pathophysiology class C2-C6) defined by duplex ultrasound and clinical criteria were treated with 1470-nm EVLA at a power of 6 to 12 W...
November 14, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/30444191/combination-of-grid-laser-photocoagulation-and-a-single-intravitreal-ranibizumab-as-an-efficient-and-cost-effective-treatment-option-for-macular-edema-secondary-to-branch-retinal-vein-occlusion
#18
Wei Cao, Hongping Cui, Ewelina Biskup
Purpose Our prospective, comparative study of 60 patients aimed to compare the efficacy and feasibility of a single injection ranibizumab vs a single grid laser photocoagulation and vs. a combined treatment in macular edema secondary to branch retinal vein occlusion in Asian population. Methods Patients were randomized 1:1:1 (n=20/group) into laser (LAS), the ranibizumab (RAN) and the combination (COM) group. Outcomes were measured as best-corrected visual acuity (BCVA) and central macular thickness (CMT). Results There were significant differences in mean BCVA between the three groups at 1 week and 1 month (P<0...
November 16, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/30441951/results-of-the-first-12-months-treatment-of-macular-edema-complicating-brvo-in-patients-treated-with-ranibizumab
#19
L Lalinská, J Krásný, P Studený, M Veith
THE AIM OF THE STUDY: Retrospective evaluation of the first 12 months treatment of macular edema in BRVO with ranibizumab based on anatomical and functional parameters. METHODS: 54 eyes with macular edema complicating BRVO were included in the study, with an average initial best corrected visual acuity 4/16 ETDRS charts, an average central retinal thickness 512.3 μm, and in average 4 months till the beginning of treatment with ranibizumab. After 3 initial injections of 0...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30441683/the-importance-of-posture-and-skin-site-selection-on-remote-measurements-of-neck-pulsations-an-ultrasonographic-study
#20
Andreia Moco, Paul Hamelmann, Sander Stuijk, Gerard de Haan
Laser Doppler vibrometry (LDV) and camerabased vibrocardiography imaging (cVCGI) systems can sense cardiac-related displacements of the skin. This allows that carotid artery (CA) or jugular vein (JV) wall movements are acquired, non-obtrusively, at the neck and used for assessing cardiovascular health. However, skin-neck measurements are invalid if the CA and JV pulsations overlap. The concern is plausible since these vessels are anatomically close to one another until the carotid sinus. In this paper, we build on ultrasonographic (US) insights to verify whether trunk posture and skin-site variability within the neck influence cVCGI outcomes...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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