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https://www.readbyqxmd.com/read/30114305/choriocapillaris-hypoperfusion-artifact-in-oct-angiography
#1
Kim Vieira Kayat, Luiz Roisman, Claudio Zett, Eduardo A Novais, Michel Eid Farah
BACKGROUND AND OBJECTIVE: To illustrate how optical coherence tomography (OCT) angiography (OCTA) can be misinterpreted if not evaluated along with structural en face OCT to analyze the signal intensity. PATIENTS AND METHODS: Patients with different macular diseases associated with suspicious flow impairment in the choriocapillaris were recruited to be imaged on the RTVue XR Avanti device (Optovue, Fremont, CA) with the Angio Retina mode. En face OCT angiograms, structural en face OCT, and corresponding OCT B-scans with flow signal overlaid were compared to evaluate the correspondence of signal strength to areas of flow reduction in the choriocapillaris...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30110008/-effect-of-temperature-for-tumescence-anesthesia-solution-on-intraoperative-and-postoperative-pain-of-endovenous-laser-ablation-of-lower-extremity-varicose-vein
#2
Lihua Luo, Zhu Chen, Enhua Xiao, Cong Ma
To compare the effect of cold or room temperature of tumescence anesthesia solution on pain perception during and after endovenous laser ablation (EVLA) for varicose veins of lower limb.
 Methods: A total of 51 patients with lower extremity varicose vein were treated by EVLA with tumescence anesthesia solution. All patients were used for local anesthesia and randomly divided into 2 groups according to the temperature of tumescence anesthesia solution: Group A (n=26) with room temperature (24 ℃) of tumescence anesthesia solution and Group B (n=25) with cold (4 ℃) tumescence anesthesia solution...
June 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/30098668/cost-effectiveness-of-current-and-emerging-treatments-of-varicose-veins
#3
David Epstein, Sarah Onida, Roshan Bootun, Marta Ortega-Ortega, Alun H Davies
OBJECTIVES: To analyze the cost-effectiveness of current technologies (conservative care [CONS], high-ligation surgery [HL/S], ultrasound-guided foam sclerotherapy [UGFS], endovenous laser ablation [EVLA], and radiofrequency ablation [RFA]) and emerging technologies (mechanochemical ablation [MOCA] and cyanoacrylate glue occlusion [CAE]) for treatment of varicose veins over 5 years. METHODS: A Markov decision model was constructed. Effectiveness was measured by re-intervention on the truncal vein, re-treatment of residual varicosities, and quality-adjusted life-years (QALYs) over 5 years...
August 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/30075939/cationic-peptides-from-enzymatic-hydrolysates-of-soybean-proteins-exhibit-lps-neutralizing-and-angiogenic-activities
#4
Masayuki Taniguchi, Yusuke Noda, Ryousuke Aida, Kazuki Saito, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
In this study, we prepared fractions containing multifunctional cationic peptides by separating the commercial soybean protein hydrolysate Hinute-AM into 20 fractions. These fractions contained peptides with various isoelectric points (pI), as indicated by ampholyte-free isoelectric focusing (autofocusing). Thus, we purified and identified the cationic peptides from fractions 19 and 20, which had pH values greater than 10, using reversed-phase high-performance liquid chromatography and matrix-assisted laser/desorption ionization-time-of-flight mass spectroscopy...
July 31, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/30064962/men-present-with-higher-clinical-class-of-chronic-venous-disease-before-endovenous-catheter-ablation
#5
Yasaman Kavousi, Ziad Al Adas, Efstathios Karamanos, Nicole Kennedy, Loay S Kabbani, Judith C Lin
BACKGROUND: Risk factors for chronic venous disease (CVD) have been widely reported in population health management. However, predisposing factors associated with patients treated for advanced stages of CVD have yet to be established. We examined the demographics and risk factors associated with advanced clinical presentation of CVD for patients referred for vein ablation. METHODS: Retrospective analysis of our institutional Vascular Quality Initiative Varicose Vein Registry included endovenous laser treatment and radiofrequency ablation procedures at our tertiary institution, community hospital, and outpatient vein clinic between January 2015 and December 2016...
July 28, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/30056450/a-novel-intraoperative-laser-light-imaging-system-to-simultaneously-visualize-visible-light-and-near-infrared-fluorescence-for-indocyanine-green-videoangiography
#6
Taku Sato, Mudathir Bakhit, Kyouichi Suzuki, Jun Sakuma, Masazumi Fujii, Yuta Murakami, Yuhei Ito, Ulrich Sure, Kiyoshi Saito
BACKGROUND: Intraoperative indocyanine green videoangiography (ICG-VA) has been reported to be utilized in various cerebrovascular surgeries, wherein the blood flow is noticeably shown in white with a black background. ICG flow alone, but not other structures, can be observed using ICG-VA. We developed a novel high-resolution intraoperative imaging system using laser light source for simultaneously visualizing both visible light and near-infrared (NIR) fluorescence images of ICG-VA. METHODS: We used a novel system for 14 cerebrovascular cases...
July 27, 2018: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/30046816/lactic-acid-upregulates-vegf-expression-in-macrophages-and-facilitates-choroidal-neovascularization
#7
Juha Song, Kihwang Lee, Sung Wook Park, Hyewon Chung, Daun Jung, Yi Rang Na, Hailian Quan, Chang Sik Cho, Jeong-Hwan Che, Jeong Hun Kim, Jae-Hak Park, Seung Hyeok Seok
Purpose: Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes to the disease pathogenesis of choroidal neovascularization (CNV) and to investigate the role of macrophages in CNV pathogenesis. Methods: CNV was induced by laser photocoagulation in C57BL/6J mice. Lactic acid concentration was measured in the RPE-choroid region. Macrophage infiltration and VEGF were quantified by flow cytometry...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30046164/effects-of-light-emitting-diodes-irradiation-on-human-vascular-endothelial-cells
#8
Kyung-Jin Oh, Jinju Park, Hyun-Suk Lee, Kwangsung Park
Endothelial cell proliferation is a hallmark of angiogenesis and plays a key role in the process of tissue repair. Low-intensity (670 nm) laser irradiation influences endothelial cell proliferation in vitro. Light in the near infrared spectrum may have clinical applications in erectile dysfunction. The purpose of this study was to investigate the effects of irradiation with light-emitting diodes (LEDs) at different wavelengths on human vascular endothelial cells in vitro. Human umbilical vein endothelial cells (HUVECs) were irradiated with LEDs at 410, 480, 595, and 630 nm in doses of 1, 2...
July 25, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30042039/a-randomised-clinical-trial-comparing-n-butyl-cyanoacrylate-radiofrequency-ablation-and-endovenous-laser-ablation-for-the-treatment-of-superficial-venous-incompetence-two-year-follow-up-results
#9
Erdinc Eroglu, Alptekin Yasim
OBJECTIVE: To compare early and two year results for N-butyl cyanoacrylate (NBCA), radiofrequency ablation (RFA), and endovenous laser ablation (EVLA) in the treatment of varicose veins. METHODS: This was a randomised clinical trial. Five hundred and twenty five patients were blindly randomised into NBCA, RFA, and EVLT groups (175 patients to each group; block randomisation using sealed envelopes). Four hundred and fifty six patients were monitored for 2 years (ultrasound at 2 days, and 6, 12, and 24 months)...
July 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/30039229/spatio-temporal-visualization-of-the-distribution-of-acetaminophen-as-well-as-its-metabolites-and-adducts-in-mouse-livers-by-maldi-msi
#10
Selahaddin Sezgin, Reham Hassan, Sebastian Zühlke, Lars Kuepfer, Jan G Hengstler, Michael Spiteller, Ahmed Ghallab
Acetaminophen (APAP) is one of the most intensively studied compounds that causes hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal information on the distribution of APAP, its metabolites and GSH adducts in the liver tissue is not yet available. Here, we addressed the question, whether APAP-GSH adducts and GSH depletion show a zonated pattern and whether the distribution of APAP and its glucuronide as well as sulfate conjugates in liver lobules are zonated. For this purpose, a matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) technique was established, where the MSI images were superimposed onto CYP2E1 immunostained tissue...
July 23, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30039133/homing-of-icg-loaded-liposome-inlaid-with-tumor-cellular-membrane-to-the-homologous-xenografts-glioma-eradicates-the-primary-focus-and-prevents-lung-metastases-through-phototherapy
#11
He-Lin Xu, Bi-Xin Shen, Meng-Ting Lin, Meng-Qi Tong, Ya-Wen Zheng, Xue Jiang, Wai-Geng Yang, Jian-Dong Yuan, Qing Yao, Ying-Zheng Zhao
Currently, phototherapy initiated by local irradiation with a near-infrared (NIR) laser has emerged as a promising strategy for cancer treatment owing to its low toxicity. However, a key problem for effective phototherapy is how to specifically deliver a sufficient dose of photosensitizers to a tumor focus. Herein, indocyanine green (ICG), a United States Food and Drug Administration (US FDA)-approved photosensitizer, was first encapsulated in an inner aqueous compartment of liposome (ICG-LIP) to improve its stability...
July 24, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30028309/natural-melanin-loaded-nanovesicles-for-near-infrared-mediated-tumor-ablation-by-photothermal-conversion
#12
Min Ah Kim, Soon Do Yoon, Eun-Min Kim, Hwan-Jeong Jeong, Chang-Moon Lee
Photothermal therapy requires a biocompatible material to absorb near-infrared (NIR) light and generate sufficient heat. Herein, we suggest natural melanin-loaded nanovesicles (melasicles) as photothermal therapeutic agents (PTA) for NIR mediated cancer therapy in vivo. The mean size of these melasicles was 140 ± 15 nm. They showed excellent colloidal stability. After irradiation from 808 nm NIR laser at 1.5 W cm-2 , the melasicles showed good photothermal conversion efficiencies both in vitro and in vivo...
October 12, 2018: Nanotechnology
https://www.readbyqxmd.com/read/30025919/vasoactivity-of-retinal-veins-a-potential-involvement-of-endothelin-1-et-1-in-the-pathogenesis-of-retinal-vein-occlusion-rvo
#13
Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie, Tsunehiko Ikeda
PURPOSE: Whilst the pathogenesis of retinal vein occlusion (RVO) is still unclear, systemic hypertension and increased level of endothelin-1 (ET-1) are known risk factors. Therefore, we studied the influence of ET-1 on the retinal veins in hypertensive rats. METHODS: We focused on the behavior of retinal veins in spontaneous hypertensive rats (SHR). To determine whether ET-1 was associated with the blood flow in eyes of SHRs, the chorioretinal blood flow in the rats was assessed using laser speckle flowgraphy (LSFG-Micro, Softcare, Fukuoka, Japan) before and after an intravenous injection of ET-1 under general anesthesia...
July 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30025072/aldosterone-exposure-causes-increased-retinal-edema-and-severe-retinopathy-following-laser-induced-retinal-vein-occlusion-in-mice
#14
Michael J Allingham, Nomingerel Tserentsoodol, Peter Saloupis, Priyatham S Mettu, Scott W Cousins
Purpose: To determine the effects of aldosterone exposure on retinal edema and retinopathy in a mouse model of retinal vein occlusion (RVO). Methods: RVO was induced immediately following intravenous injection of Rose bengal (66 mg/kg) using a 532-nm wavelength laser to place three to seven applications at 80 mW and 50-μm spot size directed at the superior retinal vein one disc diameter away from the nerve. Negative control consisted of placing an equal number of laser spots without targeting the vein...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30020324/evidence-for-varicose-vein-treatment-an-overview-of-systematic-reviews
#15
Ricardo de Ávila Oliveira, Andréa Castro Porto Mazzucca, Daniela Vianna Pachito, Rachel Riera, José Carlos da Costa Baptista-Silva
BACKGROUND: Varicose veins affect nearly 30% of the world's population. This condition is a social problem and needs interventions to improve quality of life and reduce risks. Recently, new and less invasive methods for varicose vein treatment have emerged. There is a need to define the best treatment options and to reduce the risks and costs. Since there are cosmetic implications, treatments for which effectiveness remains unproven present risks to consumers and higher costs for stakeholders...
July 16, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/30016008/laser-balloon-ablation-for-af-a-systematic-review-and-meta-analysis
#16
Matthew R Reynolds, Qi Zheng, Gheorghe Doros
INTRODUCTION: The HeartLight laser balloon ablation system was FDA approved in 2016 for the treatment of paroxysmal AF, but there have been numerous single and multicenter studies published reporting its outcomes, in addition to a few randomized trials. We aimed to systematically review and synthesize currently published outcome data on AF ablation using the laser balloon ablation system. METHODS AND RESULTS: We performed a systematic review and meta-analysis of published studies of AF ablation performed using the laser balloon ablation system...
July 17, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/30007118/small-molecule-targeting-the-rac1-nox2-interaction-prevents-collagen-related-peptide-and-thrombin-induced-reactive-oxygen-species-generation-and-platelet-activation
#17
H Akbar, X Duan, R Piatt, S Saleem, A K Davis, N N Tandon, W Bergmeier, Y Zheng
BACKGROUND: Platelets from patients with X-linked chronic granulomatous disease or mice deficient in NADPH oxidase isoform NOX2 exhibit diminished reactive oxygen species (ROS) generation and platelet activation. Binding of Rac1 GTPase to p67phox plays a critical role in NOX2 activation by facilitating the assembly of the NOX2 enzyme complex. OBJECTIVE: We tested the hypothesis that Phox-I, a rationally designed small molecule inhibitor of Rac-p67phox interaction, may serve as an anti-thrombosis agent by suppressing ROS production and platelet activation...
July 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/30003175/spontaneous-retinal-choroidal-anastomosis-in-a-case-of-branch-retinal-vein-occlusion
#18
Alessandro Arrigo, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Giuseppe Querques, Francesco Bandello
Purpose: To report a case of a patient affected by branch retinal vein occlusion (BRVO) showing a possible spontaneous retinal-choroidal anastomosis (RCA) at the level of the fovea. Observations: A 72 years old male patient with diagnosis of BRVO of left eye (LE) one year before came to our observation for a follow-up visit.The patient underwent a complete ophthalmologic examination, including fluorescein angiography, structural optical coherence tomography (OCT), OCT-Angiography (OCT-A)...
September 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29998207/retinal-racemose-hemangioma-with-retinal-artery-macroaneurysm-optical-coherence-tomography-angiography-octa-findings
#19
Raval Vishal, Oli Avadesh, Rao Srinivas, Das Taraprasad
Purpose: To describe a rare case of retinal racemose hemangioma (RRH) with retinal artery macroaneurysm (RAM) and its optical coherence tomography angiography (OCT-A) finding before and after treatment. Observations: Congenital arteriovenous (AV) communications or RRH is a rare developmental anomaly associated with various ocular conditions. RRH alone is usually asymptomatic, and vision loss occurs when associated with other ocular complications like retinal vein occlusion, hemmorage, macular edema and macroaneurysm...
September 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29988869/histological-and-immunofluorescent-analysis-of-a-large-tributary-of-the-great-saphenous-vein-treated-with-a-1920-nm-endovenous-laser-preliminary-findings
#20
H F Ashpitel, E B Dabbs, J L Nemchand, R M La Ragione, F J Salguero, M S Whiteley
Objectives: To analyse the biological effects of a 1920 nm endovenous laser (EVL) on extra-fascial great saphenous vein (GSV) in vitro . Methods: A 10 cm length of a large tributary bypassing a hypoplastic segment of the GSV (sometimes called an "extra-fascial GSV") was obtained during routine varicose vein surgery. The length was treated in five sections with different LEEDs (0 (control), 20, 40, 60, and 80 J/cm) with a 1920 nm EVL at 4W power, in a novel in vitro treatment model...
2018: EJVES short reports
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