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https://www.readbyqxmd.com/read/27923416/charles-georges-thibault-1919-2003-inspirational-leader-in-french-reproductive-biology
#1
R H F Hunter
The contribution of Charles Thibault in creating and developing a major international centre of animal research at Jouy-en-Josas (near Versailles) in post Second World War France is recorded in detail. Not only did he select a team of gifted young chercheurs, but he stimulated and supported their research in diverse ways. The projects covered were not only primarily of significance to animal reproduction, but they also became relevant to human infertility studies and to IVF treatments. Members of the team in Physiologie Animale gained international research reputations and seasoned overseas researchers were attracted to Jouy-en-Josas for their sabbaticals...
December 7, 2016: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/27908082/objective-and-perceptual-evaluation-of-distance-dependent-scattered-sound-effects-in-a-small-variable-acoustics-hall
#2
Louena Shtrepi, Arianna Astolfi, Gianluca D'Antonio, Martin Guski
Performance spaces are characterized by a complex sound field, due to the presence of absorptive and diffusive surfaces. In situ evaluations of the acoustic effects that these surfaces have on the objective acoustic parameters and on sound perception have not yet been fully understood. To this aim, acoustic measurements have been performed in a variable-acoustic concert hall, the Espace de Projection, at the Institut de Recherche et Coordination Acoustique/Musique. These measurements have allowed the effects of one single wall to be determined...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27888000/enhanced-laboratory-capacity-development-a-boost-for-effective-tuberculosis-control-in-resource-limited-settings
#3
Abraham Sunday Alabi, Afsatou Ndama Traoré, Marguerite Massinga Loembe, Ulysse Ateba-Ngoa, Matthias Frank, Ayola Akim Adegnika, Bertrand Lell, Jocelyn Mahoumbou, Carsten Köhler, Peter Gottfried Kremsner, Martin Peter Grobusch
Both routine and research tuberculosis (TB) laboratory capacity urgently need to be expanded in large parts of Sub-Saharan Africa. In 2009, the Centre de Recherches Médicales de Lambaréné (CERMEL) took a strategic decision to expand its activities by building TB laboratory capacity to address research questions and to improve routine diagnostic and treatment capacity. Over the past 7 years, a standard laboratory has been developed that is contributing significantly to TB diagnosis, treatment, and control in Gabon; training has also been provided for TB research staff in Central Africa...
November 22, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27882718/catching-up-or-falling-behind-continuing-wealth-disparities-for-immigrants-to-canada-by-region-of-origin-and-cohort
#4
Michelle Maroto, Laura Aylsworth
This paper investigates wealth disparities among first-generation immigrants using data from the 2012 Survey of Financial Security. We apply logistic and linear regression models to estimate disparities in homeownership and household equivalent net worth by immigrant status, region of origin, and time since arrival. By focusing on immigrant families from different regions who entered Canada at different points in time, this research applies theories related to assimilation, human capital, and structural barriers to wealth...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27873356/nail-psoriasis-a-systematic-evaluation-in-313-children-with-psoriasis
#5
Diane Pourchot, Christine Bodemer, Alice Phan, Anne-Claire Bursztejn, Smaïl Hadj-Rabia, Franck Boralevi, Juliette Miquel, Thomas Hubiche, Eve Puzenat, Anne-Laure Souillet, Ingrid Kupfer, Maryam Piram, Alain Beauchet, Emmanuel Mahé
BACKGROUND/OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27866639/innovation-within-a-university-setting
#6
Elisabeth K Wynne, Thomas M Krummel
Elisabeth K. Wynne, MD, completed her undergraduate degree in bioengineering and is currently a surgical resident in training at the University of Washington. From 2014-2016, she served as a Biodesign Fellow at Stanford University. She plans to pursue a career of innovation as an academic surgeon. Thomas M. Krummel, MD, is the Emile Holman Professor and Chair Emeritus of the Department of Surgery at Stanford University School of Medicine. Throughout his career, Dr Krummel has been a pioneer and an innovator...
December 2016: Surgery
https://www.readbyqxmd.com/read/27836513/anticoagulant-therapy-for-symptomatic-calf-deep-vein-thrombosis-cactus-a-randomised-double-blind-placebo-controlled-trial
#7
Marc Righini, Jean-Philippe Galanaud, Hervé Guenneguez, Dominique Brisot, Antoine Diard, Pascale Faisse, Marie-Thérèse Barrellier, Claudine Hamel-Desnos, Christine Jurus, Olivier Pichot, Myriam Martin, Lucia Mazzolai, Clarisse Choquenet, Sandrine Accassat, Helia Robert-Ebadi, Marc Carrier, Grégoire Le Gal, Bernadette Mermilllod, Jean-Pierre Laroche, Henri Bounameaux, Arnaud Perrier, Susan R Kahn, Isabelle Quere
BACKGROUND: The efficacy and safety of anticoagulant treatment is not established for patients with acute symptomatic deep vein thrombosis (DVT) of the calf. We aimed to assess whether therapeutic anticoagulation is superior to placebo in patients with symptomatic calf DVT. METHODS: In this randomised, double-blind, placebo-controlled trial, we enrolled low-risk outpatients (without active cancer or previous venous thromboembolic disease) with a first acute symptomatic DVT in the calf from 23 university medical centres or community medical clinics in Canada, France, and Switzerland...
November 7, 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27823843/-setting-up-a-pediatric-emergency-medicine-research-network
#8
F Angoulvant, I Claudet, S Dauger, F Dubos, V Gajdos, Y Gillet, C Gras-Le Guen, H Haas, P Minodier, A Portefaix
No abstract text is available yet for this article.
November 4, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27818097/a-surrogate-marker-of-piperaquine-resistant-plasmodium-falciparum-malaria-a-phenotype-genotype-association-study
#9
Benoit Witkowski, Valentine Duru, Nimol Khim, Leila S Ross, Benjamin Saintpierre, Johann Beghain, Sophy Chy, Saorin Kim, Sopheakvatey Ke, Nimol Kloeung, Rotha Eam, Chanra Khean, Malen Ken, Kaknika Loch, Anthony Bouillon, Anais Domergue, Laurence Ma, Christiane Bouchier, Rithea Leang, Rekol Huy, Grégory Nuel, Jean-Christophe Barale, Eric Legrand, Pascal Ringwald, David A Fidock, Odile Mercereau-Puijalon, Frédéric Ariey, Didier Ménard
BACKGROUND: Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance and is facing high rates of dihydroartemisinin-piperaquine treatment failures. Genetic tools to detect the multidrug-resistant parasites are needed. Artemisinin resistance can be tracked using the K13 molecular marker, but no marker exists for piperaquine resistance. We aimed to identify genetic markers of piperaquine resistance and study their association with dihydroartemisinin-piperaquine treatment failures...
November 3, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27807221/la-bio%C3%A3-thique-la-r%C3%A3-%C3%A3-valuation-des-technologies-de-la-sant%C3%A3-et-la-gestion
#10
REVIEW
Lesley J J Soril, Fiona M Clement, Tom W Noseworthy
La réévaluation des technologies de la santé (RTS), ce domaine émergent des services de santé et des recherches stratégiques, favorise la prise en charge optimale des technologies pendant toute leur vie utile. La RTS, qui est une évaluation structurée et fondée sur des données probantes des effets cliniques, économiques, sociaux et éthiques des technologies en place, permet de faire une utilisation optimale de ces technologies, d'en prévoir le retrait progressif et de mieux rentabiliser celles qui sont utilisées dans le milieu de la santé...
November 2016: Healthcare Management Forum
https://www.readbyqxmd.com/read/27799605/le-partenariat-en-recherche-un-v%C3%A3-hicule-pour-atteindre-les-plus-hauts-sommets
#11
Isabelle Gélinas
Les partenariats en ergothérapie entre les praticiens et les chercheurs sont importants pour produire des connaissances pertinentes pour la pratique clinique et pour favoriser la pratique fondée sur les données probantes au sein de la profession. BUT: Dans ce discours Muriel Driver, l'auteure discute des raisons pour lesquelles nous devons favoriser la participation des praticiens à la recherche et elle examine les conditions essentielles à la réussite des partenariats de recherche en collaboration. QUESTIONS CLÉS: Les partenariats de collaboration peuvent réduire les obstacles empêchant les praticiens de participer à la recherche et permettre de veiller à ce que les initiatives de recherche soient plus pertinentes pour la pratique clinique...
October 2016: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/27789083/patterns-of-recurrence-and-outcomes-in-surgically-treated-women-with-endometrial-cancer-according-to-esmo-esgo-estro-consensus-conference-risk-groups-results-from-the-francogyn-study-group
#12
Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Cyril Touboul, Pierre Collinet, Emile Daraï, Marcos Ballester
OBJECTIVES: The purpose of this study was to analyse the endometrial cancer (EC) patterns of recurrence based on a large French multicentre database according to ESMO-ESGO-ESTRO classification. METHODS: Data of women with histologically proven EC who received primary surgical treatment between January 2001 and December 2012 were retrospectively abstracted from seven institutions with prospectively maintained databases. The endpoints were recurrence, recurrence free survival (RFS) and overall survival (OS)...
October 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27783381/increased-mortality-in-hematological-malignancy-patients-with-acute-respiratory-failure-from-undetermined-etiology-a-groupe-de-recherche-en-r%C3%A3-animation-respiratoire-en-onco-h%C3%A3-matologique-grrr-oh-study
#13
Adrien Contejean, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Michael Darmon, Mercé Jourdain, Anne Renault, Benoît Schlemmer, Elie Azoulay
BACKGROUND: Acute respiratory failure (ARF) is the most frequent complication in patients with hematological malignancies and is associated with high morbidity and mortality. ARF etiologies are numerous, and despite extensive diagnostic workflow, some patients remain with undetermined ARF etiology. METHODS: This is a post-hoc study of a prospective multicenter cohort performed on 1011 critically ill hematological patients. Relationship between ARF etiology and hospital mortality was assessed using a multivariable regression model adjusting for confounders...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27773665/pulmonary-effects-of-immediate-versus-deferred-antiretroviral-therapy-in-hiv-positive-individuals-a-nested-substudy-within-the-multicentre-international-randomised-controlled-strategic-timing-of-antiretroviral-treatment-start-trial
#14
Ken M Kunisaki, Dennis E Niewoehner, Gary Collins, Bitten Aagaard, Nafisah B Atako, Elzbieta Bakowska, Amanda Clarke, Giulio Maria Corbelli, Ernest Ekong, Sean Emery, Elizabeth B Finley, Eric Florence, Rosa M Infante, Cissy M Kityo, Juan Sierra Madero, Daniel E Nixon, Ellen Tedaldi, Jørgen Vestbo, Robin Wood, John E Connett
BACKGROUND: Observational data have been conflicted regarding the potential role of HIV antiretroviral therapy (ART) as a causative factor for, or protective factor against, COPD. We therefore aimed to investigate the effect of immediate versus deferred ART on decline in lung function in HIV-positive individuals. METHODS: We did a nested substudy within the randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial at 80 sites in multiple settings in 20 high-income and low-to-middle-income countries...
October 20, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27751553/early-diaphragm-pacing-in-patients-with-amyotrophic-lateral-sclerosis-respistimals-a-randomised-controlled-triple-blind-trial
#15
Jésus Gonzalez-Bermejo, Capucine Morélot-Panzini, Marie-Laure Tanguy, Vincent Meininger, Pierre-François Pradat, Timothée Lenglet, Gaëlle Bruneteau, Nadine Le Forestier, Philippe Couratier, Nathalie Guy, Claude Desnuelle, Hélène Prigent, Christophe Perrin, Valérie Attali, Catherine Fargeot, Marie-Cécile Nierat, Catherine Royer, Fabrice Ménégaux, François Salachas, Thomas Similowski
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with respiratory muscle weakness and respiratory failure. Non-invasive ventilation alleviates respiratory symptoms and prolongs life, but is a palliative intervention. Slowing the deterioration of diaphragm function before respiratory failure would be desirable. We aimed to assess whether early diaphragm pacing could slow down diaphragm deterioration and would therefore delay the need for non-invasive ventilation...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27742172/the-scalp-hair-collar-and-tuft-signs-a-retrospective-multicenter-study-of-78-patients-with-a-systematic-review-of-the-literature
#16
Didier Bessis, Michèle Bigorre, Nausicaa Malissen, Guillaume Captier, Christine Chiaverini, Claire Abasq, Sébastien Barbarot, Olivia Boccara, Emmanuelle Bourrat, Hassan El Fertit, Catherine Eschard, Thomas Hubiche, Jean-Philippe Lacour, Nicolas Leboucq, Emmanuel Mahé, Stéphanie Mallet, Myriam Marque, Ludovic Martin, Juliette Mazereeuw-Hautier, Nathalie Milla, Alice Phan, Patrice Plantin, Marie-Christine Picot, Eve Puzenat, Valérie Rigau, Pierre Vabres, Sylvie Fraitag, Franck Boralevi
BACKGROUND: Hair collar sign (HCS) and hair tuft of the scalp (HTS) are cutaneous signs of an underlying neuroectodermal defect, but most available data are based on case reports. OBJECTIVE: We sought to define the clinical spectrum of HCS and HTS, clarify the risk for underlying neurovascular anomalies, and provide imaging recommendations. METHODS: A 10-year multicenter retrospective and prospective analysis of clinical, radiologic, and histopathologic features of HCS and HTS in pediatric patients was performed...
October 11, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27739129/anti-pd1-induced-psoriasis-a-study-of-21-patients
#17
Julie Bonigen, Christine Raynaud-Donzel, José Hureaux, Nora Kramkimel, Astrid Blom, Géraldine Jeudy, Anne-Laure Breton, Thomas Hubiche, Christophe Bedane, Delphine Legoupil, Anne Pham-Ledard, Julie Charles, Maurice Pérol, Emilie Gérard, Patrick Combemale, Daphné Bonnet, Michèle-Léa Sigal, Emmanuel Mahé
Nivolumab (Opdivo(®) ), pembrolizumab (Keytruda(®) ), atezolizumab, and pidilizumabab are anti-PD1 monoclonal antibodies. Nivolumab is licensed in advanced melanoma and second-line therapy of advanced or metastatic non-small cell lung cancer. When activated, the programmed cell death (PD)-1 is implicated in the inhibition of the immune system. Anti-PD1 removes this inhibition and allows the immune system to control tumour cell progression.(1-4) Immune-mediated toxicity of this treatment have been reported, either organ-specific toxicities - i...
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27720101/%C3%A3-valuation-%C3%A3-chographique-des-complications-au-premier-trimestre-de-grossesse
#18
Lucie Morin, Yvonne M Cargill, Phyllis Glanc
OBJECTIFS: RéSULTATS: SOURCES DE DONNéES: Nous avons effectué des recherches dans MEDLINE et un examen de la bibliographie des articles recensés. VALEURS: Le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada a passé en revue les données probantes recueillies. Les recommandations reposent sur les lignes directrices élaborées par le Groupe d'étude canadien sur les soins de santé préventifs (tableau 1). AVANTAGES, DéSAVANTAGES ET COûTS: Les femmes qui présentent des saignements durant le premier trimestre peuvent recevoir un diagnostic incorrect d'avortement manqué...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27704167/efficacy-of-single-hormone-and-dual-hormone-artificial-pancreas-during-continuous-and-interval-exercise-in-adult-patients-with-type-1-diabetes-randomised-controlled-crossover-trial
#19
Nadine Taleb, Ali Emami, Corinne Suppere, Virginie Messier, Laurent Legault, Martin Ladouceur, Jean-Louis Chiasson, Ahmad Haidar, Rémi Rabasa-Lhoret
AIMS/HYPOTHESIS: The aim of this study was to assess whether the dual-hormone (insulin and glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (insulin alone) artificial pancreas during two types of exercise. METHODS: An open-label randomised crossover study comparing both systems in 17 adults with type 1 diabetes (age, 37.2 ± 13.6 years; HbA1c, 8.0 ± 1.0% [63.9 ± 10.2 mmol/mol]) during two exercise types on an ergocycle and matched for energy expenditure: continuous (60% [Formula: see text] for 60 min) and interval (2 min alternating periods at 85% and 50% [Formula: see text] for 40 min, with two 10 min periods at 45% [Formula: see text] at the start and end of the session)...
October 4, 2016: Diabetologia
https://www.readbyqxmd.com/read/27676935/perceived-effectiveness-tolerance-of-cares-in-children-and-adults-with-cerebral-palsy
#20
Laetitia Houx, Hélène Saudreau, Philippe Galien, Christelle Pons, Marion Roquet, Ronan Garlantezec, Sylvain Brochard
OBJECTIVE: A better understanding of the perception of the rehabilitative and medical care's by persons with cerebral palsy (CP) and their families may help in providing better adherence to these cares. The main objective of this study was to assess overall satisfaction, self-perception of effectiveness and tolerance of the rehabilitative and medical cares in individuals with CP. MATERIAL AND METHODS: This was a cross-sectional questionnaire-based study. A total of 950 questionnaires were sent to French Britain children and adults with CP...
September 2016: Annals of Physical and Rehabilitation Medicine
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