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https://www.readbyqxmd.com/read/29153586/non-specific-effects-of-childhood-vaccinations-a-case-control-study-nested-into-a-health-and-demographic-surveillance-system-in-rural-burkina-faso
#1
G Pfeiffer, A B Fisker, E Nebié, J Hengelbrock, A Sié, H Becher, O Müller
INTRODUCTION: Previous studies in African countries have been suggestive of non-specific effects (NSE) of vaccination on child survival. Live vaccines (e.g. measles, MV) have been found to reduce child mortality while inactivated vaccines (e.g. diphtheria-tetanus-pertussis, DTP) have been associated with increased mortality; NSE were often found to be sex-specific. METHODS: A case-control study nested into the Health and Demographic Surveillance System (HDSS) cohort of the Centre de Recherche en Santé de Nouna (CRSN) was conducted in northwestern Burkina Faso...
November 15, 2017: Vaccine
https://www.readbyqxmd.com/read/29151047/interpretation-of-health-news-items-reported-with-or-without-spin-protocol-for-a-prospective-meta-analysis-of-16-randomised-controlled-trials
#2
Romana Haneef, Amélie Yavchitz, Philippe Ravaud, Gabriel Baron, Ivan Oranksy, Gary Schwitzer, Isabelle Boutron
INTRODUCTION: We aim to compare the interpretation of health news items reported with or without spin. 'Spin' is defined as a misrepresentation of study results, regardless of motive (intentionally or unintentionally) that overemphasises the beneficial effects of the intervention and overstates safety compared with that shown by the results. METHODS AND ANALYSIS: We have planned a series of 16 randomised controlled trials (RCTs) to perform a prospective meta-analysis...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146007/-psoriatic-arthritis-in-france-from-infants-to-the-elderly-findings-from-two-cross-sectional-multicenter-studies
#3
A Galezowski, F Maccari, S Hadj-Rabia, M-L Sigal, A Phan, M Lahfa, A-C Bursztejn, H Barthélémy, F Boralévi, Z Reguiai, C Chiavérini, E Estève, E Bourrat, M Ruer-Mulard, A Beauchet, E Mahé
BACKGROUND: Psoriatic arthritis affects 20-30% of patients with psoriasis. Few epidemiological data are available in France about its prevalence and its association with skin lesions and comorbidities. OBJECTIVES: To assess the epidemiological aspects and the risk factors for psoriatic arthritis in children and adults in France. METHODS: Two cross-sectional studies were conducted in France in children (χ-Psocar, 23 pediatric dermatology centers belonging to the SFDP, 1 year) and adults (Resopsocar, 29 dermatology centers belonging to GEM RESOPSO, 4 months) to study the link between psoriasis and cardiovascular and metabolic comorbidities...
November 13, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29145594/wellbeing-of-gay-fathers-with-children-born-through-surrogacy-a-comparison-with-lesbian-mother-families-and-heterosexual-ivf-parent-families
#4
L Van Rijn-van Gelderen, H W M Bos, T D Jorgensen, K Ellis-Davies, A Winstanley, S Golombok, B Rubio, M Gross, O Vecho, M E Lamb
STUDY QUESTION: Are there differences in levels of parental wellbeing (parental stress, psychological adjustment and partner relationship satisfaction) between gay-father families with infants born through surrogacy, lesbian-mother families with infants born through donor insemination, and heterosexual-parent families with infants born through IVF? SUMMARY ANSWER: There were no differences in parental wellbeing. WHAT IS KNOWN ALREADY: The only other study of parental wellbeing in gay-father families formed through surrogacy (mean age children: 4 years old) found no difference in couple relationship satisfaction between these families and lesbian-mother families formed through donor insemination and heterosexual-parent families formed without assisted reproductive technologies...
November 14, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29120321/une-sant%C3%A3-mondiale-repens%C3%A3-e-la-perspective-de-futures-chercheuses-praticiennes
#5
Muriel Mac-Seing, Cielo Perez Osorio, Stella Tine, Charity Oga Omenka, Rolande Chegno Gueutue
 L'étude des conséquences de la mondialisation sur la santé des populations est au coeur de la santé mondiale. Ce faisant, la mondialisation conditionne également la mise en oeuvre des projets de recherche et des interventions en santé mondiale, et les rapports sociaux inégalitaires qui s'y perpétuent. Le présent commentaire propose des réflexions sur des défis épistémologiques et politiques auxquels se confronte la santé mondiale. Celles-ci sont issues d'observations et de discussions pendant et après la Conférence canadienne sur la santé mondiale, tenue en novembre 2015...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29107324/daytime-variation-of-perioperative-myocardial-injury-in-cardiac-surgery-and-its-prevention-by-rev-erb%C3%AE-antagonism-a-single-centre-propensity-matched-cohort-study-and-a-randomised-study
#6
David Montaigne, Xavier Marechal, Thomas Modine, Augustin Coisne, Stéphanie Mouton, Georges Fayad, Sandro Ninni, Cédric Klein, Staniel Ortmans, Claire Seunes, Charlotte Potelle, Alexandre Berthier, Celine Gheeraert, Catherine Piveteau, Rebecca Deprez, Jérome Eeckhoute, Hélène Duez, Dominique Lacroix, Benoit Deprez, Bruno Jegou, Mohamed Koussa, Jean-Louis Edme, Philippe Lefebvre, Bart Staels
BACKGROUND: On-pump cardiac surgery provokes a predictable perioperative myocardial ischaemia-reperfusion injury which is associated with poor clinical outcomes. We determined the occurrence of time-of-the-day variation in perioperative myocardial injury in patients undergoing aortic valve replacement and its molecular mechanisms. METHODS: We studied the incidence of major adverse cardiac events in a prospective observational single-centre cohort study of patients with severe aortic stenosis and preserved left ventricular ejection fraction (>50%) who were referred to our cardiovascular surgery department at Lille University Hospital (Lille, France) for aortic valve replacement and underwent surgery in the morning or afternoon...
October 26, 2017: Lancet
https://www.readbyqxmd.com/read/29067906/the-age-of-blood-evaluation-able-randomised-controlled-trial-description-of-the-uk-funded-arm-of-the-international-trial-the-uk-cost-utility-analysis-and-secondary-analyses-exploring-factors-associated-with-health-related-quality-of-life-and-health-care-costs
#7
Timothy S Walsh, Simon Stanworth, Julia Boyd, David Hope, Sue Hemmatapour, Helen Burrows, Helen Campbell, Elena Pizzo, Nicholas Swart, Stephen Morris
BACKGROUND: At present, red blood cells (RBCs) are stored for up to 42 days prior to transfusion. The relative effectiveness and safety of different RBC storage times prior to transfusion is uncertain. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of transfusing fresher RBCs (stored for ≤ 7 days) compared with current standard-aged RBCs in critically ill patients requiring blood transfusions. DESIGN: The international Age of BLood Evaluation (ABLE) trial was a multicentre, randomised, blinded trial undertaken in Canada, the UK, the Netherlands and France...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29040471/endometriosis-fertility-index-predicts-live-births-following-surgical-resection-of-moderate-and-severe-endometriosis
#8
S Maheux-Lacroix, E Nesbitt-Hawes, R Deans, H Won, A Budden, D Adamson, J A Abbott
STUDY QUESTION: Can live birth be accurately predicted following surgical resection of moderate-severe (Stage III-IV) endometriosis? SUMMARY ANSWER: Live births can accurately be predicted with the endometriosis fertility index (EFI), with adnexal function being the most important factor to predict non-assisted reproductive technology (non-ART) fertility or the requirement for ART (www.endometriosisefi.com). WHAT IS KNOWN ALREADY: Fertility prognosis is important to many women with severe endometriosis...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29027488/global-health-promotion-et-la-recherche-interventionnelle-en-sant%C3%A3-des-populations
#9
Suzanne F Jackson
No abstract text is available yet for this article.
September 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28984527/corrigendum-to-analgesic-effect-of-maternal-human-milk-odor-on-premature-neonates-a-randomized-controlled-trial
#10
(no author information available yet)
Baudesson de Chanville, A., Brevaut-Malaty, V., Garbi, A., Tosello, B., Baumstarck, K., Gire, C., & Le Cozannet, R. (2017). Analgesic effect of maternal human milk odor on premature neonates: A randomized controlled trial. Journal of Human Lactation, 33(2), 300-308. (Original DOI: 10.1177/0890334417693225) In this article that appeared in the May 2017 issue of Journal of Human Lactation, the following corrections are required due to an inadvertent omission by the research team authoring the paper. 1) Dr. Romain Le Cozannet has been added as an author...
November 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28975832/systemic-and-adjuvant-therapies-for-intrahepatic-cholangiocarcinoma
#11
Yun Shin Chun, Milind Javle
Intrahepatic cholangiocarcinoma represents the second most common primary liver cancer and is increasing in incidence. Most patients are diagnosed at an advanced, nonsurgical stage and only about 1 in 5 cases are surgically resectable. Despite surgery, the 5-year survival is low at only 30%. Multifocal, node- or margin-positive disease is at a higher risk of recurrence after resection. There is no level 1 evidence in support of postoperative adjuvant therapy. A recent adjuvant therapy phase III trial from the Partenariat de Recherche en Oncologie Digestive-Actions Concertées dans les Cancers Colo-Rectaux et Digestifs (PRODIGE) group reported no survival advantage with adjuvant gemcitabine and oxaliplatin therapy...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28967199/levels-and-determinants-of-breast-and-cervical-cancer-screening-uptake-in-hiv-infected-women-compared-with-the-general-population-in-france
#12
L Tron, F Lert, B Spire, R Dray-Spira
OBJECTIVES: Cancer is a growing concern for HIV-infected people, and screening plays a major role in alleviating the burden it causes. We sought to investigate the levels and determinants of breast cancer screening (BCS) and cervical cancer screening (CCS) in HIV-infected women as compared with the general population. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study was conducted in 2011 in a national representative sample of 3022 HIV-infected hospital out-patients in France...
March 2017: HIV Medicine
https://www.readbyqxmd.com/read/28963775/clinical-and-hemodynamic-risk-factors-associated-with-discrepancies-in-lower-limb-length-with-capillary-malformations-data-from-the-national-paediatric-french-cohort-conape
#13
M Samimi, M Durieux-Verde, A Caille, J Mazereeuw-Hautier, O Boccara, L Martin, C Chiaverini, C Eschard, N Beneton, P Vabres, X Balguerie, P Plantin, D Bessis, S Barbarot, A Dadban, C Droitcourt, S Leducq, G Lorette, B Morel, A Maruani
BACKGROUND: Genetics discoveries have allowed for better understanding capillary malformations (CMs) with overgrowth syndrome. However, molecular analyses are still not easy to perform or interpret. Other analytical methods are needed. OBJECTIVE: We aimed to identify clinical and hemodynamic factors associated with leg length discrepancy (LLD) in children with CM of lower limbs. METHODS: Data were obtained from the multicentre French national cohort CONAPE (COhorte Nationale d'enfants atteints d'Angiome Plan de membrE inférieur), including children from 2 to 12 years old with CM of lower limbs...
September 30, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28943471/childhood-chronic-prurigo-interest-in-patch-tests-and-delayed-reading-skin-prick-tests-to-environmental-allergens
#14
Claire Maridet, Martin Perromat, Juliette Miquel, Christine Chiaverini, Didier Bessis, Audrey Lasek, Maryam Piram, Anne-Claire Bursztejn, Claire Abasq, Alice Phan, Ludovic Martin, Bérénice Bréchat, Jin Ho Chong, Julien Seneschal, Alain Taïeb, Franck Boralevi
No abstract text is available yet for this article.
September 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28935558/immediate-interruption-of-sedation-compared-with-usual-sedation-care-in-critically-ill-postoperative-patients-sos-ventilation-a-randomised-parallel-group-clinical-trial
#15
Gerald Chanques, Matthieu Conseil, Claire Roger, Jean-Michel Constantin, Albert Prades, Julie Carr, Laurent Muller, Boris Jung, Fouad Belafia, Moussa Cissé, Jean-Marc Delay, Audrey de Jong, Jean-Yves Lefrant, Emmanuel Futier, Grégoire Mercier, Nicolas Molinari, Samir Jaber
BACKGROUND: Avoidance of excessive sedation and subsequent prolonged mechanical ventilation in intensive care units (ICUs) is recommended, but no data are available for critically ill postoperative patients. We hypothesised that in such patients stopping sedation immediately after admission to the ICU could reduce unnecessary sedation and improve patient outcomes. METHODS: We did a randomised, parallel-group, clinical trial at three ICUs in France. Stratified randomisation with minimisation (1:1 via a restricted web platform) was used to assign eligible patients (aged ≥18 years, admitted to an ICU after abdominal surgery, and expected to require at least 12 h of mechanical ventilation because of a critical illness defined by a Sequential Organ Failure Assessment score >1 for any organ, but without severe acute respiratory distress syndrome or brain injury) to usual sedation care provided according to recommended practices (control group) or to immediate interruption of sedation (intervention group)...
October 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28935058/n-o-349-consommation-de-substances-psychoactives-pendant-la-grossesse
#16
Alice Ordean, Suzanne Wong, Lisa Graves
OBJECTIFS: Accroître la sensibilisation à la consommation problématique de substances psychoactives pendant la grossesse et les connaissances à ce sujet, et formuler des recommandations factuelles relatives à la prise en charge de cet épineux problème clinique à l'intention de l'ensemble des fournisseurs de soins. OPTIONS: La présente directive clinique analyse l'utilisation d'outils de dépistage, l'approche générale de soins et les recommandations pour la prise en charge clinique de la consommation problématique de substances psychoactives pendant la grossesse...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28929896/une-analyse-%C3%A3-thique-appropri%C3%A3-e-s-impose
#17
Don Flaming
Les leaders en santé gèrent de nombreux types de risques. Le risque éthique associé aux multiples projets et activités, réalisés régulièrement hors du secteur de la recherche, est probablement négligé (p. ex., évaluation de programmes, amélioration de la qualité et innovation en santé). La mise en application de l'éthique clinique, personnelle, professionnelle et organisationnelle peut contribuer à atténuer les risques, mais ensemble ou séparément, ces divers types d'éthique ne suffisent pas...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929854/l-%C3%A3-thique-de-la-modification-du-g%C3%A3-nome-en-clinique-une-dose-de-r%C3%A3-alisme-pour-les-leaders-en-sant%C3%A3
#18
Tania Bubela, Yael Mansour, Dianne Nicol
Les technologies de modification du génome promettent des avancées dans le traitement des maladies génétiques. Les auteurs abordent les enjeux éthiques et sociaux que soulèvent ces technologies, y compris leur utilisation dans des recherches précliniques, leur potentiel à résoudre les mutations somatiques et leur potentiel à modifier les lignées germinales qui peuvent être transmises aux prochaines générations. Ils demandent une réponse modérée de la part des leaders en santé, reposant sur une évaluation réaliste des avantages, des risques et des délais d'application clinique...
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28901791/determinants-of-1-year-survival-in-critically-ill-acute-leukemia-patients-a-grrr-oh-study
#19
Márcio Tavares, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs...
September 13, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28879788/development-of-an-epitope-based-hiv-1-vaccine-strategy-from-hiv-1-lipopeptide-to-dendritic-based-vaccines
#20
Mathieu Surenaud, Christine Lacabaratz, Gérard Zurawski, Yves Lévy, Jean-Daniel Lelièvre
Development of a safe, effective and globally affordable Human Immunodeficiency Virus strain 1 (HIV-1) vaccine offers the best hope for future control of the HIV-1 pandemic. However, with the exception of the recent RV144 trial, which elicited a modest level of protection against infection, no vaccine candidate has shown efficacy in preventing HIV-1 infection or in controlling virus replication in humans. There is also a great need for a successful immunotherapeutic vaccine since combination antiretroviral therapy (cART) does not eliminate the reservoir of HIV-infected cells...
September 7, 2017: Expert Review of Vaccines
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