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https://www.readbyqxmd.com/read/28901791/determinants-of-1-year-survival-in-critically-ill-acute-leukemia-patients-a-grrr-oh-study
#1
Márcio Tavares, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs...
September 13, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28879788/development-of-an-epitope-based-hiv-1-vaccine-strategy-from-hiv-1-lipopeptide-to-dendritic-based-vaccines
#2
Mathieu Surenaud, Christine Lacabaratz, Gérard Zurawski, Yves Lévy, Jean-Daniel Lelièvre
Development of a safe, effective and globally affordable Human Immunodeficiency Virus strain 1 (HIV-1) vaccine offers the best hope for future control of the HIV-1 pandemic. However, with the exception of the recent RV144 trial, which elicited a modest level of protection against infection, no vaccine candidate has shown efficacy in preventing HIV-1 infection or in controlling virus replication in humans. There is also a great need for a successful immunotherapeutic vaccine since combination antiretroviral therapy (cART) does not eliminate the reservoir of HIV-infected cells...
September 7, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28870426/prognostic-value-of-local-relapse-for-patients-with-endometrial-cancer
#3
Y Dabi, J Uzan, S Bendifallah, L Ouldamer, V Lavoué, G Canlorbe, E Raimond, C Coutant, O Graesslin, P Collinet, A Bricou, E Daraï, M Ballester, B Haddad, C Touboul
BACKGROUND: The objective of our study was to determine survival and prognostic factors associated with isolated local recurrence of endometrial cancer. METHODS: Data of 1229 patients with endometrial carcinoma treated between 2000 and 2012 were extracted from maintained databases of nine French University Hospitals as well as from the Senti-Endo trial. Patients with isolated central pelvic and vaginal recurrence were selected for further analysis. RESULTS: Two hundreds and twenty five patients recurred during the inclusion period, 20 with isolated central pelvic recurrence and 23 with vaginal recurrence...
August 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28856560/ensemble-classifiers-for-predicting-hiv-1-resistance-from-three-rule-based-genotypic-resistance-interpretation-systems
#4
Letícia M Raposo, Flavio F Nobre
Resistance to antiretrovirals (ARVs) is a major problem faced by HIV-infected individuals. Different rule-based algorithms were developed to infer HIV-1 susceptibility to antiretrovirals from genotypic data. However, there is discordance between them, resulting in difficulties for clinical decisions about which treatment to use. Here, we developed ensemble classifiers integrating three interpretation algorithms: Agence Nationale de Recherche sur le SIDA (ANRS), Rega, and the genotypic resistance interpretation system from Stanford HIV Drug Resistance Database (HIVdb)...
August 30, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28849428/topical-corticosteroid-concerns-among-parents-of-children-with-psoriasis-versus-atopic-dermatitis-a-french-multicenter-cross-sectional-study
#5
Sandra Moawad, Emmanuel Mahé, Hélène Aubert-Wastiaux, Alice Phan, Annabel Maruani, Christine Chiaverini, Christine Bodemer, Juliette Mazereeuw-Hautier, Audrey Lasek-Duriez, Catherine Droitcourt, Sébastien Barbarot, Alain Beauchet, Anne-Claire Bursztejn
BACKGROUND: Atopic dermatitis (AD) and psoriasis are chronic inflammatory cutaneous disorders for which the gold standard treatment is topical corticosteroids. Although fears about topical corticosteroids are known to be a primary cause of poor therapeutic adherence in AD, this has not been evaluated in psoriasis. TOPICOP is a helpful and easy-to-use tool for the evaluation of topical corticosteroid concerns (TCC). It may help clinicians improve adherence to treatment and correct misconceptions...
August 28, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28840783/the-challenges-of-mobilizing-workers-on-gender-issues-lessons-from-two-studies-on-the-occupational-health-of-teachers-in-qu%C3%A3-becles-d%C3%A3-fis-de-mobiliser-les-travailleur-ses-sur-la-question-du-genre-constats-issus-de-deux-recherches-portant-sur-la-sant%C3%A3-au-travail
#6
Jessica Riel, Marie-Eve Major
In partnership with the largest teachers' union confederation in Québec ( Centrale des syndicats du Québec), two qualitative research studies that integrate gender were conducted in the teaching community. These ergonomic studies advocated a participatory approach involving interviews and observations with high school teachers (thirty-five) and female teachers responsible for vocational training in trades with predominantly male clientele (twelve). The results revealed that gender influences work success by reducing the operational leeway available for female teachers to carry out their work and protect their health...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28817602/exploring-the-potential-of-a-structural-alphabet-based-tool-for-mining-multiple-target-conformations-and-target-flexibility-insight
#7
Leslie Regad, Jean-Baptiste Chéron, Dhoha Triki, Caroline Senac, Delphine Flatters, Anne-Claude Camproux
Protein flexibility is often implied in binding with different partners and is essential for protein function. The growing number of macromolecular structures in the Protein Data Bank entries and their redundancy has become a major source of structural knowledge of the protein universe. The analysis of structural variability through available redundant structures of a target, called multiple target conformations (MTC), obtained using experimental or modeling methods and under different biological conditions or different sources is one way to explore protein flexibility...
2017: PloS One
https://www.readbyqxmd.com/read/28807040/management-of-upper-gastrointestinal-bleeding-in-emergency-departments-from-bleeding-symptoms-to-diagnosis-a-prospective-multicenter-observational-study
#8
Pierre-Clément Thiebaud, Youri Yordanov, Jacques-Emmanuel Galimard, Pierre-Alexis Raynal, Sébastien Beaune, Laurent Jacquin, François-Xavier Ageron, Dominique Pateron
BACKGROUND: Upper gastrointestinal bleeding (UGB) is common in emergency departments (EDs) and can be caused by many eso-gastro-duodenal lesions. Most available epidemiological data and data on the management of UGB comes from specialized departments (intensive care units or gastroenterology departments), but little is known from the ED perspective. We aimed to determine the distribution of symptoms revealing UGB in EDs and the hemorrhagic lesions identified by endoscopy. We also describe the characteristics of patients consulting for UGB, UGB management in the ED and patients outcomes...
August 14, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28803518/a-feminist-intervention-that-hurt-women-biological-differences-ergonomics-and-occupational-health-une-intervention-f%C3%A3-ministe-qui-a-nui-aux-femmes-diff%C3%A3-rences-biologiques-%C3%A3-galit%C3%A3-ergonomie-et-sant%C3%A3-au-travail
#9
Karen Messing
The University of Québec in Montréal has agreements with trade unions providing access to university resources. Researchers involved in this program worked in partnership with union women's and health and safety committees for more than twenty years. Not all studies succeeded in improving women's working conditions. One joint project involved observational studies of tasks done by health-care workers, complemented by interviews and questionnaires. We found that task assignments, movements, postures, and work-related musculoskeletal disorders varied by gender/sex and made recommendations for change...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28796457/precarity-in-the-nonprofit-employment-services-sector
#10
Carlo Fanelli, Debbie Laliberté Rudman, Rebecca M Aldrich
Drawing on interview and focus group data, this article explores research undertaken as part of a larger research project exploring precarity in the nonprofit employment services sector in a mid-sized Canadian city. We critically survey major legislative changes to Canadian employment and income security policies and programs, including the restructuring of work and labor relations, growth of performance-based contracting-out, erosion of intergovernmental transfers, worker stress, and emotional tolls. Our study's results demonstrate how employment precarity in the nonprofit employment services sector is amplified by top-down and centralized relationships with funding partners and policymaking divorced from the employment experiences of frontline staff...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28796452/in-praise-of-sociology
#11
Raewyn Connell
This reflection on the relevance of sociology starts with the different forms of social knowledge, and some autobiographical reflection on my engagement with the discipline. A research-based social science is made urgent by the prevalence of distortion and pseudoscience in the public realm. However, the research-based knowledge formation is embedded in a global economy of knowledge that centers on a privileged group of institutions and produces major imbalances on a world scale. Sociological data collection has important uses in policy and public discussion...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28753865/prognostic-biomarkers-used-for-localised-prostate-cancer-management-a-systematic-review
#12
REVIEW
Pierre-Jean Lamy, Yves Allory, Anne-Sophie Gauchez, Bernard Asselain, Philippe Beuzeboc, Patricia de Cremoux, Jacqueline Fontugne, Agnès Georges, Christophe Hennequin, Jacqueline Lehmann-Che, Christophe Massard, Ingrid Millet, Thibaut Murez, Marie-Hélène Schlageter, Olivier Rouvière, Diana Kassab-Chahmi, François Rozet, Jean-Luc Descotes, Xavier Rébillard
CONTEXT: Prostate cancer stratification is based on tumour size, pretreatment PSA level, and Gleason score, but it remains imperfect. Current research focuses on the discovery and validation of novel prognostic biomarkers to improve the identification of patients at risk of aggressive cancer or of tumour relapse. OBJECTIVE: This systematic review by the Intergroupe Coopérateur Francophone de Recherche en Onco-urologie (ICFuro) analysed new evidence on the analytical validity and clinical validity and utility of six prognostic biomarkers (PHI, 4Kscore, MiPS, GPS, Prolaris, Decipher)...
March 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#13
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
September 2017: Lancet HIV
https://www.readbyqxmd.com/read/28730983/-vers-un-%C3%A2-mouvement-de-l-%C3%A3-ducation-nouvelle-%C3%A2-de-recherche-en-chirurgie
#14
Vivian McAlister
No abstract text is available yet for this article.
August 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28729109/n-o-211-d%C3%A3-pistage-et-prise-en-charge-de-la-vaginose-bact%C3%A3-rienne-pendant-la-grossesse
#15
Mark H Yudin, Deborah M Money
OBJECTIF: Analyser les résultats et fournir des recommandations au sujet du dépistage et de la prise en charge de la vaginose bactérienne pendant la grossesse. OPTIONS: Les options de pratique clinique prises en considération au moment de formuler la présente directive clinique. ISSUES: Parmi les issues évaluées, on trouve les taux d'efficacité et de guérison de l'antibiothérapie, et l'influence de la prise en charge de la vaginose bactérienne sur les taux d'issues de grossesse indésirables (tels que le travail et l'accouchement prétermes, et la rupture prématurée des membranes préterme)...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28729105/n-o-223-tenue-syst%C3%A3-matique-d%C3%A2-un-examen-%C3%A3-chographique-obst%C3%A3-trical-au-cours-du-deuxi%C3%A3-me-trimestre-contenu-d%C3%A2-un-examen-et-d%C3%A2-un-rapport-exhaustifs
#16
Yvonne Cargill, Lucie Morin
OBJECTIF: Analyser les avantages d'un examen échographique exhaustif au cours du deuxième trimestre et les conditions nécessaires à sa tenue, ainsi que la documentation requise. ISSUES: Un examen échographique exhaustif au cours du deuxième trimestre offre des renseignements au sujet du nombre de fœtus, de l'âge gestationnel, de l'emplacement du placenta et de l'anatomie fœtale et maternelle. RéSULTATS: Dans le cadre de la rédaction du présent document, le document « Practice Guideline for the Performance of Obstetric Ultrasound Examinations » du American Institute of Ultrasound in Medicine, le bulletin de pratique « Ultrasound in Pregnancy » du American College of Obstetricians and Gynaecologists et le rapport de groupe de travail « Ultrasound Screening » du Royal College of Obstetricians and Gynaecologists ont été analysés...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28729103/n-o-225-lignes-directrices-quant-%C3%A3-la-prise-en-charge-des-patientes-en-obst%C3%A3-trique-chez-lesquelles-la-pr%C3%A3-sence-du-syndrome-respiratoire-aigu-s%C3%A3-v%C3%A3-re-sras-est-soup%C3%A3-onn%C3%A3-e-ou-probable-et-des-nouveau-n%C3%A3-s-issus-de-ces-patientes
#17
Cynthia Maxwell, Alison McGeer, Kin Fan Young Tai, Mathew Sermer
OBJECTIF: Le présent document résume notre expérience limitée quant à la présence du SRAS pendant la grossesse et suggère des lignes directrices quant à sa prise en charge. ISSUES: Les exposés de cas issus d'Asie laissent entendre que les issues maternelles et fœtales sont aggravées par la présence du SRAS pendant la grossesse. RéSULTATS: Des recherches ont été menées dans Medline afin d'en tirer les articles pertinents publiés en anglais entre 2000 et 2007...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28714863/dna-methylation-based-immune-response-signature-improves-patient-diagnosis-in-multiple-cancers
#18
Jana Jeschke, Martin Bizet, Christine Desmedt, Emilie Calonne, Sarah Dedeurwaerder, Soizic Garaud, Alexander Koch, Denis Larsimont, Roberto Salgado, Gert Van den Eynden, Karen Willard Gallo, Gianluca Bontempi, Matthieu Defrance, Christos Sotiriou, François Fuks
BACKGROUND: The tumor immune response is increasingly associated with better clinical outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating lymphocytes (TILs) relies on histopathological measurements with limited accuracy and reproducibility. Here, we profiled DNA methylation markers to identify a methylation of TIL (MeTIL) signature that recapitulates TIL evaluations and their prognostic value for long-term outcomes in breast cancer (BC). METHODS: MeTIL signature scores were correlated with clinical endpoints reflecting overall or disease-free survival and a pathologic complete response to preoperative anthracycline therapy in 3 BC cohorts from the Jules Bordet Institute in Brussels and in other cancer types from The Cancer Genome Atlas...
August 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28693492/barriers-to-publishing-in-biomedical-journals-perceived-by-a-sample-of-french-researchers-results-of-the-diazepam-study
#19
Martin Duracinsky, Christophe Lalanne, Laurence Rous, Aichata Fofana Dara, Lesya Baudoin, Claire Pellet, Alexandre Descamps, Fabienne Péretz, Olivier Chassany
BACKGROUND: As publishing is essential but competitive for researchers, difficulties in writing and submitting medical articles to biomedical journals are disabling. The DIAzePAM (Difficultés des Auteurs à la Publication d'Articles Médicaux) survey aimed to assess the difficulties experienced by researchers in the AP-HP (Assistance Publique - Hôpitaux de Paris, i.e., Paris Hospitals Board, France), the largest public health institution in Europe, when preparing articles for biomedical journals...
July 10, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28651997/endovascular-treatment-of-asymptomatic-abdominal-aortic-aneurysms-in-octogenarians-factors-influencing-long-term-survival
#20
Valentin Crespy, Lucie Salomon du Mont, Adrien Kaladji, Michel Bartoli, Yann Gouëffic, Nicolas Abello, Pierre-Edouard Magnan, Alain Cardon, Philippe Chaillou, Eric Steinmetz
BACKGROUND: Beyond the age of 80 years, the preventive treatment of an asymptomatic abdominal aortic aneurysm (AAA) has to be decided in light of the life expectancy which it is difficult to evaluate, but it is important to determine who in this population will benefit from it. The objective of our study was to determine the factors influencing short-term mortality and long-term survival in patients aged 80 years and older after the endovascular treatment of AAAs (EVAR). MATERIAL AND METHODS: We present a retrospective analysis of the prospective databases of 4 French academic departments of vascular surgery, bringing together the data of all the patients presenting an AAA who were treated by EVAR between 1998 and 2011...
June 24, 2017: Annals of Vascular Surgery
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