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https://www.readbyqxmd.com/read/29776895/islet-transplantation-versus-insulin-therapy-in-patients-with-type-1-diabetes-with-severe-hypoglycaemia-or-poorly-controlled-glycaemia-after-kidney-transplantation-trimeco-a-multicentre-randomised-controlled-trial
#1
Sandrine Lablanche, Marie-Christine Vantyghem, Laurence Kessler, Anne Wojtusciszyn, Sophie Borot, Charles Thivolet, Sophie Girerd, Domenico Bosco, Jean-Luc Bosson, Cyrille Colin, Rachel Tetaz, Sophie Logerot, Julie Kerr-Conte, Eric Renard, Alfred Penfornis, Emmanuel Morelon, Fanny Buron, Kristina Skaare, Gwen Grguric, Coralie Camillo-Brault, Harald Egelhofer, Kanza Benomar, Lionel Badet, Thierry Berney, François Pattou, Pierre-Yves Benhamou
BACKGROUND: Islet transplantation is indicated for patients with type 1 diabetes with severe hypoglycaemia or after kidney transplantation. We did a randomised trial to assess the efficacy and safety of islet transplantation compared with insulin therapy in these patients. METHODS: In this multicentre, open-label, randomised controlled trial, we randomly assigned (1:1) patients with type 1 diabetes at 15 university hospitals to receive immediate islet transplantation or intensive insulin therapy (followed by delayed islet transplantation)...
May 15, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29773283/tongue-psoriasis-clinical-aspects-and-analysis-of-epidemiological-associations-in-313-children-with-a-systematic-literature-review
#2
D Pourchot, C Chiaverini, E Bourrat, S Barbarot, P Vabres, T Hubiche, C Droicourt, M Piram, I Kupfer-Bessaguet, M Ferneiny, E Puzenat, X Balguérie, A Beauchet, A-C Bursztejn, E Mahé
BACKGROUND: Little information is available on the prevalence and clinical aspects of tongue involvement in children with psoriasis. The aim was to evaluate the prevalence, clinical aspects and risk factors concerning tongue involvement in children with psoriasis. PATIENTS AND METHODS: This study was carried out in two stages. We performed a multicentre, cross-sectional study in 23 French dermatology centers. All children seen for psoriasis during the one-year study were systematically included...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29754777/international-validation-of-the-consensus-immunoscore-for-the-classification-of-colon-cancer-a-prognostic-and-accuracy-study
#3
Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, P Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E Church, Helen K Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Jeffrey P Meyers, Christopher Paustian, Zipei Feng, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Daniel J Sargent, Bernard A Fox, Jérôme Galon
BACKGROUND: The estimation of risk of recurrence for patients with colon carcinoma must be improved. A robust immune score quantification is needed to introduce immune parameters into cancer classification. The aim of the study was to assess the prognostic value of total tumour-infiltrating T-cell counts and cytotoxic tumour-infiltrating T-cells counts with the consensus Immunoscore assay in patients with stage I-III colon cancer. METHODS: An international consortium of 14 centres in 13 countries, led by the Society for Immunotherapy of Cancer, assessed the Immunoscore assay in patients with TNM stage I-III colon cancer...
May 10, 2018: Lancet
https://www.readbyqxmd.com/read/29731199/circonstances-particuli%C3%A3-res-l-%C3%A3-re-de-la-comp%C3%A3-tence-par-conception-aura-t-elle-raison-de-la-recherche-chez-les-r%C3%A3-sidents
#4
EDITORIAL
Roxana Geoffrion, Jane Schulz
No abstract text is available yet for this article.
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29729123/trends-in-hospitalization-rates-for-psoriasis-flares-since-the-introduction-of-biologics-a-time-series-in-france-between-2005-and-2015
#5
L Polivka, N Oubaya, H Bachelez, C Paul, M A Richard, M Beylot-Barry, J L Schmutz, N Beneton, E Mahé, M Viguier, O Chosidow, F Canoui-Poitrine, E Sbidian
BACKGROUND: In the late 2000s, the introduction of biologics transformed the prognosis for patients with moderate-to-severe psoriasis. We hypothesized that treatment with biologics may associate with a reduction in the hospitalization rate for psoriasis flares. OBJECTIVE: To analyze changes over time in the hospitalization rate for psoriasis flares. METHODS: We included inpatient stays in any of nine French hospitals between 2005 and 2015 for a psoriasis flare, as documented in the national inpatient database...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29722601/asym%C3%A3-trie-de-pouvoir-dans-les-partenariats-de-recherche-en-sant%C3%A3-mondiale-%C3%A3-tude-qualitative-aupr%C3%A3-s-de-chercheurs-en-c%C3%A3-te-d-ivoire
#6
Patrick Gogognon, Béatrice Godard
Résumé : Contexte : L'asymétrie de pouvoir dans les partenariats de recherche en santé mondiale constitue un enjeu de justice et d'équité pour les institutions de recherche, les chercheurs et les communautés, en particulier dans les pays en développement. Pour les chercheurs, l'asymétrie de pouvoir peut constituer un obstacle pour une recherche efficiente et équitable et ils sont à risque d'être en situation de vulnérabilité. Objectifs : Ces enjeux sont largement discutés dans la littérature mais ce phénomène reste encore étudié au plan théorique et peu de données empiriques sont disponibles, particulièrement dans les pays en développement...
May 1, 2018: Global Health Promotion
https://www.readbyqxmd.com/read/29718247/emerging-resistance-mutations-in-pi-naive-patients-failing-an-atazanavir-based-regimen-anrs-multicentre-observational-study
#7
S Lambert-Niclot, M Grude, M L Chaix, C Charpentier, S Reigadas, H Le Guillou-Guillemette, A Rodallec, C Amiel, A Maillard, J Dufayard, T Mourez, A Mirand, J Guinard, B Montes, S Vallet, A G Marcelin, D Descamps, P Flandre, C Delaugerre, L Morand-Joubert
Background: Atazanavir is a PI widely used as a third agent in combination ART. We aimed to determine the prevalence and the patterns of resistance in PI-naive patients failing on an atazanavir-based regimen. Methods: We analysed patients failing on an atazanavir-containing regimen used as a first line of PI therapy. We compared the sequences of reverse transcriptase and protease before the introduction of atazanavir and at failure [two consecutive viral loads (VLs) >50 copies/mL]...
April 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29715355/effect-of-glyburide-vs-subcutaneous-insulin-on-perinatal-complications-among-women-with-gestational-diabetes-a-randomized-clinical-trial
#8
Marie-Victoire Sénat, Helene Affres, Alexandra Letourneau, Magali Coustols-Valat, Marie Cazaubiel, Helene Legardeur, Julie Fort Jacquier, Nathalie Bourcigaux, Emmanuel Simon, Anne Rod, Isabelle Héron, Virginie Castera, Loic Sentilhes, Florence Bretelle, Catherine Rolland, Mathieu Morin, Philippe Deruelle, Celine De Carne, François Maillot, Gael Beucher, Eric Verspyck, Raoul Desbriere, Sandrine Laboureau, Delphine Mitanchez, Jean Bouyer
Importance: Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes. Objective: To compare oral glyburide vs subcutaneous insulin in prevention of perinatal complications in newborns of women with gestational diabetes. Design, Settings, and Participants: The Insulin Daonil trial (INDAO), a multicenter noninferiority randomized trial conducted between May 2012 and November 2016 (end of participant follow-up) in 13 tertiary care university hospitals in France including 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation...
May 1, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29703972/critically-ill-allogenic-hsct-patients-in-the-intensive-care-unit-a-systematic-review-and-meta-analysis-of-prognostic-factors-of-mortality
#9
Colombe Saillard, Michael Darmon, Magali Bisbal, Antoine Sannini, Laurent Chow-Chine, Marion Faucher, Etienne Lengline, Norbert Vey, Didier Blaise, Elie Azoulay, Djamel Mokart
Outcome of patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT) has improved. To investigate if this improvement can be transposed to the ICU setting, we conducted a systematic review and meta-analysis to assess short-term mortality of critically ill allo-HSCT patients admitted to the ICU and to identify prognostic factors of mortality. Public-domain electronic databases, including Medline via PubMed and the Cochrane Library were searched. All full-text articles written-English studies published from 2006 to 2016, including allo-HSCT adults transferred to the ICU were included...
April 27, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29687359/does-apneic-oxygenation-prevent-desaturation-during-emergency-airway-management-a-systematic-review-and-meta-analysis
#10
Edmund Tan, Osama Loubani, Nelofar Kureshi, Robert S Green
RéSUMé: OBJECTIF: L'oxygénation apnéique (OA) par lunettes nasales est une méthode de prévention de la désaturation en oxygène au cours des intubations en urgence. L'objectif de cette revue systématique était de déterminer l'efficacité de l'OA sur la prévention de la désaturation en oxygène au cours des intubations en urgence. SOURCE: Des recherches systématiques ont été effectuées dans trois bases de données électroniques (MEDLINE, EMBASE et CINAHL) pour identifier les études portant sur la prévention de la désaturation en oxygène au moyen de l'OA par lunettes nasales...
April 23, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29675758/the-prognostic-impact-of-abdominal-surgery-in-cancer-patients-with-neutropenic-enterocolitis-a-systematic-review-and-meta-analysis-on-behalf-the-groupe-de-recherche-en-r%C3%A3-animation-respiratoire-du-patient-d-onco-h%C3%A3-matologie-grrr-oh
#11
REVIEW
Colombe Saillard, Lara Zafrani, Michael Darmon, Magali Bisbal, Laurent Chow-Chine, Antoine Sannini, Jean-Paul Brun, Jacques Ewald, Olivier Turrini, Marion Faucher, Elie Azoulay, Djamel Mokart
Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. This review and meta-analysis aimed to determine the prognostic impact of abdominal surgery on outcome of neutropenic cancer patients presenting with NE, versus medical conservative treatment...
April 19, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29673905/-cardiovascular-adverse-effects-of-antimuscarinics-used-in-the-treatment-of-overactive-bladder-in-the-elderly-a-review
#12
C Chesnel, A Charlanes, C Hentzen, N Turmel, X Biardeau, C Brochard, S Campagne, G Capon, X Deffieux, B Fatton, X Gamé, R Haddad, C Jeandel, J Kerdraon, P Manceau, P Mares, M Mezzadri, P Mongiat-Artus, A-C Petit, B Peyronnet, J-M Soler, C Thuillier, J-M Vetel, G Robain, G Amarenco
AIM: The aim of this study was to review the evidence regarding the cardiovascular effects of urinary anticholinergic drugs in the elderly. METHODS: A literature review was conducted in October 2017 using the Medline/Pubmed database limiting the search to works in English or French. RESULTS: In total, 602 articles between March 1964 and October 2017 have been reported, 60 studies were analyzed, 19 were prospective trials. Geriatric population has a high prevalence of cardiovascular diseases (24...
April 16, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29667597/much-work-remains-to-be-done-in-the-intensive-care-of-patients-with-malignant-haemopathies
#13
S Yaacoubi, S Ayed, C Bornstain, F Vincent, For The Grrr-Oh Groupe de Recherche Respiratoire En Réanimation En Onco-Hématologie Http/Www Grrroh Com/
No abstract text is available yet for this article.
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29625873/-lower-uterine-segment-trial-a-pragmatic-open-multicenter-randomized-trial
#14
P Rozenberg, P Deruelle, M-V Sénat, R Desbrière, N Winer, E Simon, Y Ville, G Kayem, I Boutron
BACKGROUND: The data from literature show that trial of labor and elective repeat cesarean delivery after a prior cesarean delivery both present significant risks and benefits, and these risks and benefits differ for the woman and her fetus. The benefits to the woman can be at the expense of her fetus and vice-versa. This uncertainty is compounded by the scarcity of high-level evidence that preclude accurate quantification of the risks and benefits that could help provide a fair counseling about a trial of labor and elective repeat cesarean delivery...
April 4, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29609425/lower-urinary-tract-symptoms-in-elderly-population-with-multiple-sclerosis
#15
Camille Chesnel, Audrey Charlanes, Claire Hentzen, Nicolas Turmel, Frédérique Le Breton, Samer Sheikh Ismael, Gérard Amarenco
PURPOSE: The aim of this study is to compare the clinical and urodynamic characteristics of urinary disorders in multiple sclerosis (MS) patients in a geriatric population with a nongeriatric population. METHODS: This study was conducted retrospectively between 2010 and 2016. Each patient with MS aged 65 and older was matched with 2 patients with MS aged less than 65 in sex, form of MS, and Expended Disability Status Scale (EDSS). Demographic data, urinary symptoms, treatment, quality of life, repercussion of lower urinary tract symptoms on daily life activities and psychological state and urodynamic parameters were collected...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29606364/pyronaridine-artesunate-or-dihydroartemisinin-piperaquine-versus-current-first-line-therapies-for-repeated-treatment-of-uncomplicated-malaria-a-randomised-multicentre-open-label-longitudinal-controlled-phase-3b-4-trial
#16
(no author information available yet)
BACKGROUND: Artemether-lumefantrine and artesunate-amodiaquine are used as first-line artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine-artesunate and dihydroartemisinin-piperaquine are potentially useful for diversification of ACTs in this region, but further safety and efficacy data are required on malaria retreatment. METHODS: We did a randomised, multicentre, open-label, longitudinal, controlled phase 3b/4 clinical trial at seven tertiary centres in Burkina Faso, Guinea, and Mali...
March 29, 2018: Lancet
https://www.readbyqxmd.com/read/29594973/clinical-and-therapeutic-aspects-of-linear-psoriasis-a-study-of-30-cases
#17
Matthieu Say, Franck Boralévi, Cédric Lenormand, Anne-Claire Bursztejn, Eric Estève, Alice Phan, Emmanuelle Bourrat, Jean-Philippe Lacour, Marie-Aleth Richard, Aurélie Acher, Denis Jullien, Nathalie Beneton, Vincent Descamps, Christine Bodemer, Marion Lagaude, Christine Chiaverini, Emmanuel Mahé
BACKGROUND: Psoriasis affects 2-4% of the population, with the most common clinical type being plaque psoriasis. The linear form of psoriasis is very rare. The literature on linear psoriasis (LP) consists of only case reports, and data are few. OBJECTIVE: This study aimed to better understand LP in a large-scale study. PATIENTS AND METHODS: We retrospectively retrieved the medical records from 14 French medical centers of patients newly diagnosed clinically with LP, with or without the support of histology, between 1 February and 31 July 2015...
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29582210/in-hospital-and-day-120-survival-of-critically-ill-solid-cancer-patients-after-discharge-of-the-intensive-care-units-results-of-a-retrospective-multicenter-study-a-groupe-de-recherche-respiratoire-en-r%C3%A3-animation-en-onco-h%C3%A3-matologie-grrr-oh-study
#18
François Vincent, Marcio Soares, Djamel Mokart, Virginie Lemiale, Fabrice Bruneel, Marouane Boubaya, Frédéric Gonzalez, Yves Cohen, Elie Azoulay, Michaël Darmon
OBJECTIVES: To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN: International, multicenter, retrospective study. SETTING: Five ICUs in France and Brazil, two located in cancer centers, two in university affiliated and one in general hospitals...
March 27, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29578847/development-of-quality-indicators-to-assess-oral-anticoagulant-management-in-community-pharmacies-for-patients-with-atrial-fibrillation
#19
Mylène Chartrand, Line Guénette, Denis Brouillette, Stéphane Côté, Roger Huot, Jérôme Landry, Josée Martineau, Sylvie Perreault, Brian White-Guay, David Williamson, Élisabeth Martin, Marie-Mireille Gagnon, Lyne Lalonde
BACKGROUND: Few studies have evaluated the quality of oral anticoagulant management by community pharmacists. There is no complete set of quality indicators available for this purpose. OBJECTIVE: To develop a set of specific quality indicators to assess oral anticoagulant management by community pharmacists for patients with atrial fibrillation (AF). METHODS: Quality indicators were developed in 3 phases. In phase 1, potential quality indicators were generated based on clinical guidelines and a literature review...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29576324/prevalence-of-nail-scabies-a-french-prospective-multicenter-study
#20
Marie Chinazzo, Guillaume Desoubeaux, Sophie Leducq, Didier Bessis, Catherine Droitcourt, Emmanuel Mahe, Elisa Goujon, Anne-Claire Bursztejn, Alice Phan, Annabel Maruani
INTRODUCTION: To assess the prevalence of nail involvement in children <16 years old with a confirmed diagnosis of scabies. STUDY DESIGN: Observational, prospective study in 7 French dermatology departments between June 2015 and January 2017. Children were included if they had scabies confirmed by dermoscopy and/or microscopy and if nails could be sampled. The first toenails and thumbnails as well as clinically affected nails were systematically sampled for microscopic examination...
March 23, 2018: Journal of Pediatrics
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