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https://www.readbyqxmd.com/read/30096722/exercise-training-induced-modulation-in-microenvironment-of-rat-mammary-neoplasms
#1
Ana Cristina Corrêa Figueira, Mafalda Corrêa Figueira, Carina Silva, Ana Padrão, Paula Alexandra Oliveira, Rita Pinho Ferreira, Jose Alberto Duarte
Despite the importance attributed to exercise training in the breast cancer (BC) continuum, the underlying mechanisms modulating tumor behavior are unknown. We evaluated the effects of long-term moderate-exercise in the development of mammary tumors, and studied the microenvironment of infiltrative lesions, the amount of connective tissue, and balance between cellular proliferation/death.Fifty Sprague-Dawley rats, randomly assigned into four groups: two control groups (sedentary and exercised) and two models of BC groups (sedentary and exercised) induced by N-methyl-N-nitrosoureia (MNU), were sacrificed after 35 weeks of moderate-exercise, and all perceptible tumors were removed for histological and immunohistochemistry analysis...
August 10, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/30092011/pancreatic-cancer-survival-analysis-defines-a-signature-that-predicts-outcome
#2
Pichai Raman, Ravikanth Maddipati, Kian Huat Lim, Aydin Tozeren
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the US. Despite multiple large-scale genetic sequencing studies, identification of predictors of patient survival remains challenging. We performed a comprehensive assessment and integrative analysis of large-scale gene expression datasets, across multiple platforms, to enable discovery of a prognostic gene signature for patient survival in pancreatic cancer. PDAC RNA-Sequencing data from The Cancer Genome Atlas was stratified into Survival+ (>2-year survival) and Survival-(<1-year survival) cohorts (n = 47)...
2018: PloS One
https://www.readbyqxmd.com/read/30087703/serum-and-exosome-long-non-coding-rnas-as-potential-biomarkers-for-hepatocellular-carcinoma
#3
Li Sun, Yingying Su, Xiangxiang Liu, Mu Xu, Xiaoxiang Chen, Yefei Zhu, Zhirui Guo, Tingting Bai, Lin Dong, Chenchen Wei, Xiaoxiao Cai, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang
Background: Hepatocellular carcinoma (HCC) is one of the most aggressive cancers, with limited new diagnostic and therapeutic measures. This study aimed to investigate the utility of specific serum and exosome lncRNAs as biomarkers for early diagnosis of HCC. Methods : The relative expression levels of eight selected lncRNAs in serum were evaluated by quantitative reverse transcription-PCR (qRT-PCR) in the training and validation sets of HCC patients and matched healthy controls. Additionally, the stability, specificity and diagnostic efficiency of these lncRNAs were evaluated to determine their potential as biomarkers...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30081863/effect-of-virtual-reality-aggression-prevention-training-for-forensic-psychiatric-patients-vrapt-study-protocol-of-a-multi-center-rct
#4
Stéphanie Klein Tuente, Stefan Bogaerts, Sarah van IJzendoorn, Wim Veling
BACKGROUND: Many patients residing in forensic psychiatric centers have difficulties regulating their aggression in an adequate manner. Therefore, they are frequently involved in conflicts. Evidenced-based aggression therapies in forensic psychiatry are scarce, and due to the highly secured environment, it is hard to practice real-life provocations. We have developed a Virtual Reality aggression prevention training (VRAPT), providing safe virtual environments, in which patients can practice controlling their aggressive behaviors in an adequate way...
August 6, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/30071907/restraint-in-mental-health-settings-is-it-time-to-declare-a-position
#5
Faisil Sethi, John Parkes, Eric Baskind, Brodie Paterson, Aileen O'Brien
SummaryThe emergence of a drive to reduce restrictive interventions has been accompanied particularly in the UK by a debate focussing on restraint positions. Any restraint intervention delivered poorly can potentially lead to serious negative outcomes. More research is required to reliably state the risk attached to a particular position in a particular clinical circumstance.Declaration of interestF.S. is a consultant psychiatrist in Psychiatric Intensive Care at the Maudsley Hospital, London. He is on the Executive Committee of the National Association of Psychiatric Intensive Care and Low Secure Units, and was a member of the National Institute for Health and Care Excellence Guideline Development Group for the Short-Term Management of Aggression and Violence (2015)...
March 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/30071690/aberrant-driving-behaviour-risk-involvement-and-their-related-factors-among-taxi-drivers
#6
Javadreza Vahedi, Afshin Shariat Mohaymany, Zahra Tabibi, Milad Mehdizadeh
The current study aims to investigate the aberrant driving behaviour and risk involvement of Iranian taxi drivers. The sample comprised 405 Iranian taxi drivers, who were recruited with a cross-sectional design, using a self-completion questionnaire survey during October and November 2016. We contribute to the literature by understanding how and to what extent the socioeconomic, demographic, driving, and aberrant driving behaviours influence risk involvement (accident involvement and traffic tickets). The validated 27-item Driver Behaviour Questionnaire (DBQ) was applied to measure aberrant driving behaviour...
August 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30067417/co-creation-of-the-safewards-model-in-a-forensic-mental-health-care-facility
#7
Sarah M Kipping, Jen L De Souza, Lisa A Marshall
Violence and aggression are highly complex problems in mental health care facilities; thus, multi-faceted conflict-reduction strategies are required to mitigate and reduce violence. Safewards is an evidence-informed model aimed at preventing events that have the capacity to trigger aggression and violence. Effectiveness studies of the implementation of Safewards have shown mixed results, including that implementation strategies failed to engage staff and fidelity was low. The objective of this study was to examine the effectiveness of implementing the Safewards model with an approach that embedded co-creation principles in the staff training...
August 1, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/30061360/circulating-cell-free-mir-375-as-surrogate-marker-of-tumor-burden-in-merkel-cell-carcinoma
#8
Kaiji Fan, Cathrin Ritter, Paul Nghiem, Astrid Blom, Monique E Verhaegen, Andrzej Dlugosz, Niels Odum, Anders Woetmann, Richard W Tothill, Rodney J Hicks, Michael Sand, David Schrama, Dirk Schadendorf, Selma Ugurel, Jurgen C Becker
PURPOSE: Merkel cell carcinoma (MCC) is an aggressive skin cancer with neuroendocrine differentiation. There is an unmet need for MCC-specific blood-based surrogate biomarkers of tumor burden; circulating cell-free micro(mi)RNA may serve this purpose. EXPERIMENTAL DESIGN: Expression of miR-375 was quantified in 24 MCC and 23 non-MCC cell lines, 67 MCC and 58 non-MCC tumor tissues, sera of two preclinical MCC models, sera of 109 MCC patients and 30 healthy controls by nCounter® human-v2-miRNA expression or miR-375 specific real-time PCR assays...
July 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30045770/the-effectiveness-of-rock-and-water-in-improving-students-socio-emotional-adjustment-and-social-safety-study-protocol-for-a-randomized-controlled-trial
#9
E C A Mertens, M Deković, M van Londen, E Reitz
BACKGROUND: Students following a low education track have an increased risk for developing problem behaviors. Rock and Water is a widespread, but still poorly evaluated, intervention that aims to improve students' socio-emotional adjustment and social safety. The aims of this study are to evaluate (1) the effectiveness of Rock and Water on socio-emotional adjustment (i.e., psychosocial wellbeing, sexual autonomy, and resilience) and social safety (i.e., perceived social security in the classroom, aggression, and bullying) and to examine (2) moderators and (3) mediators of its effects...
July 25, 2018: BMC Psychology
https://www.readbyqxmd.com/read/30045160/autism-spectrum-disorder-and-mental-health-comorbidity-leading-to-prolonged-inpatient-admission
#10
Surbhi Gupta, Andrea Caskey, Neelkamal Soares, Marilyn Augustyn
Sam is a 6-year-old boy with a diagnosis of autism spectrum disorder (ASD) who recently relocated and has an appointment with you, his new pediatric clinician, to establish care. He was previously followed by a psychiatrist for 2 years for additional diagnoses of insomnia, bipolar disorder, anxiety, attention deficit hyperactivity disorder, and intellectual disability. He has tried and (apparently) failed multiple psychotropic trials including stimulants, nonstimulants, mood stabilizers, atypical antipsychotics, and nonbenzodiazepine hypnotics...
July 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/30033747/patient-indications-for-mohs-micrographic-surgery-a-systematic-review
#11
Christian Murray, Duvaraga Sivajohanathan, Timothy P Hanna, Scott Bradshaw, Nowell Solish, Benvon Moran, Robert Hekkenberg, Alice C Wei, Teresa Petrella
The purpose of the present review was to describe evidence-based indications for Mohs micrographic surgery (MMS) in patients with a diagnosis of skin cancer. Relevant studies were identified from a systematic MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews search of studies published from 1970 to 2017. Randomized controlled trials (RCTs), prospective and retrospective comparative studies with greater than 30 patients, and single-arm retrospective studies with multivariate analyses were included...
July 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/30033655/who-s-challenging-who-training-for-staff-empathy-towards-adults-with-challenging-behaviour-cluster-randomised-controlled-trial
#12
R P Hastings, D Gillespie, S Flynn, R McNamara, Z Taylor, R Knight, E Randell, L Richards, G Moody, A Mitchell, P Przybylak, B Williams, P H Hunt
BACKGROUND: One in five adults with intellectual disabilities (ID) known to services display challenging behaviours (CBs), and these individuals are at risk for restrictive practices and poor care. Staff attitudes may contribute to the development and/or maintenance of CBs. We investigated the effectiveness of co-produced Who's Challenging Who? training delivered by people with ID to staff. METHOD: This study involved a cluster randomised controlled trial (RCT) of Who's Challenging Who? training with follow-up at six and 20 weeks post-randomisation...
July 23, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/30031089/steps-to-effective-problem-solving-in-group-homes
#13
Sarah H Ailey, Arlene M Miller, Olimpia Paun, Michael Schoeny, Tricia Johnson, Teresa Moro, Arthur Nezu, Tamar Heller, Janet Melby
Aggressive/challenging behaviors (A/CB) are a major public health problem for individuals with intellectual disabilities (ID). A leading reason for psychiatric hospitalizations and incarcerations, such behaviors are costly to the health care system, agencies, and families. Social problem-solving (SPS) training programs for individuals with ID have had positive behavioral results, but most were conducted in clinical or forensic settings. None was a community-based preventive intervention, none examined whether the behaviors decreased in residential and work settings, and none addressed cost-effectiveness...
July 18, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/30021586/does-special-education-in-palliative-medicine-make-a-difference-in-end-of-life-decision-making
#14
Reetta P Piili, Juho T Lehto, Tiina Luukkaala, Heikki Hinkka, Pirkko-Liisa I Kellokumpu-Lehtinen
BACKGROUND: Characteristics of the physician influence the essential decision-making in end-of-life care. However, the effect of special education in palliative medicine on different aspects of decision-making in end-of-life care remains unknown. The aim of this study was to explore the decision-making in end-of-life care among physicians with or without special competency in palliative medicine (cPM). METHODS: A questionnaire including an advanced lung cancer patient-scenario with multiple decision options in end-of-life care situation was sent to 1327 Finnish physicians...
July 18, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/30019165/management-of-subdural-hematomas-part-ii-surgical-management-of-subdural-hematomas
#15
REVIEW
Elena I Fomchenko, Emily J Gilmore, Charles C Matouk, Jason L Gerrard, Kevin N Sheth
PURPOSE OF REVIEW: Management of patients with subdural hematomas starts with Emergency Neurological Life Support guidelines. Patients with acute or chronic subdural hematomas (SDHs) associated with rapidly deteriorating neurologic exam, unilaterally or bilaterally dilated nonreactive pupils, and extensor posturing are considered imminently surgical; likewise, SDHs more than 10 mm in size or those associated with more than 5-mm midline shift are deemed operative. RECENT FINDINGS: While twist drill craniostomy and placement of subdural evacuating vport system (SEPS) are quick, bedside procedures completed under local anesthesia and appropriate for patients with chronic SDH or patients that cannot tolerate anesthesia, these techniques are not optimal for patients with acute SDH or chronic SDH with septations...
July 18, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/30009632/af-cbt-for-families-experiencing-physical-aggression-or-abuse-served-by-the-mental-health-or-child-welfare-system-an-effectiveness-trial
#16
David J Kolko, Amy D Herschell, Barbara L Baumann, Jonathan A Hart, Stephen R Wisniewski
The Partnerships for Families project is a randomized clinical trial to evaluate the effectiveness of Alternatives for Families: A Cognitive Behavioral Therapy (AF-CBT), an evidence-based treatment (EBT) for families who are at risk of or have histories of child physical abuse. Across 10 agencies whose programs were supported by referrals from the mental health or child welfare system, individual providers were randomized to receive AF-CBT training ( n = 90) in a 6-month learning community or treatment as usual (TAU; n = 92) which provided trainings per agency routine...
January 1, 2018: Child Maltreatment
https://www.readbyqxmd.com/read/30009541/corpora-amylacea-in-prostatectomy-tissue-and-associations-with-molecular-histological-and-lifestyle-factors
#17
Natalie C DuPre, Richard Flavin, Karen S Sfanos, Robert H Unger, Samantha To, Elizaveta Gazeeva, Michelangelo Fiorentino, Angelo M De Marzo, Jennifer R Rider, Lorelei A Mucci
BACKGROUND: Corpora amylacea are amyloid bodies commonly found adjacent to damaged prostate epithelium. Little is known about their formation or function. The current study sought to characterize corpora amylacea in prostate tissue and to describe their relationship with clinical, histological, molecular, and lifestyle factors, especially with chronic inflammation which is associated with aggressive disease. METHODS: We studied a cohort of 355 men with prostate cancer and tissue specimens from the Health Professionals Follow-Up Study...
July 15, 2018: Prostate
https://www.readbyqxmd.com/read/30006931/a-comprehensive-methylation-signature-identifies-lymph-node-metastasis-in-esophageal-squamous-cell-carcinoma
#18
Roshni Roy, Raju Kandimalla, Fuminori Sonohara, Masahiko Koike, Yasuhiro Kodera, Naoki Takahashi, Yasuhide Yamada, Ajay Goel
Treatment modalities in esophageal squamous cell carcinoma (ESCC) depend largely on lymph node metastasis (LNM) status. With sub-optimal detection sensitivity of existing imaging techniques, we propose a methylation signature which identifies patients with LNM with greater accuracy. This would allow precise stratification of high-risk patients requiring more aggressive treatment from low-risk ESCC patients who can forego radical surgery. An unbiased genome-wide methylation signature for LNM detection was established from an initial in-silico discovery phase...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29999246/a-successful-standardized-academic-inter-professional-post-licensure-education-program-exists-to-train-msk-professionals-to-become-advanced-practitioners-in-arthritis-care-lessons-learned-from-the-acpac-program
#19
Katie Lundon, Rachel Shupak
We read with interest the article in the most recent issue of Arthritis Care & Research "Core Curriculum to Facilitate the Expansion of a Rheumatology Practice to Include Nurse Practitioners and Physician Assistants" by Benjamin J. Smith et al., Vol 70(5) May 2018: pp 672-678. We can all agree that rapid access to rheumatology care has become increasingly important as early aggressive treatment with disease modifying anti-rheumatic drugs (DMARDs) and/or biologic agents can prevent irreversible joint damage and long-term disability in patients with inflammatory arthritis (IA)...
July 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29994494/lifelong-metric-learning
#20
Gan Sun, Yang Cong, Ji Liu, Lianqing Liu, Xiaowei Xu, Haibin Yu
The state-of-the-art online learning approaches are only capable of learning the metric for predefined tasks. In this paper, we consider a lifelong learning problem to mimic ``human learning,'' i.e., endowing a new capability to the learned metric for a new task from new online samples and incorporating the previous experiences. Therefore, we propose a new metric learning framework: lifelong metric learning (LML), which only utilizes the data of the new task to train the metric model while preserving the original capabilities...
June 21, 2018: IEEE Transactions on Cybernetics
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