keyword
https://read.qxmd.com/read/38532357/profile-of-non-tuberculous-mycobacteria-amongst-tuberculosis-presumptive-people-in-cameroon
#1
JOURNAL ARTICLE
Valerie Flore Donkeng Donfack, Thierry Anicet Zemo Fokou, Lazare Eric Noche Wadje, Yves Le Grand Napa Tchuedji, Yvonne Josiane Djieugoue, Sorelle Nguimfack Teagho, Brenda Shile Takong, Yannick Patrick Assolo, Suzanne Magloire Ongboulal, Yannick Willy Kamdem Simo, Stanley Nkemnji Awungafac, Sara Eyangoh
BACKGROUND: Cameroon is a tuberculosis (TB) burden country with a 12% positivity among TB presumptive cases. Of the presumptive cases with a negative TB test, some are infected with Non-tuberculous Mycobacteria (NTM). However, the diagnosis of NTM infections remains difficult due to the lack of tools in many laboratories, particularly in resource limited laboratories and remote setting. The present study was undertaken to determine NTM profile and associated comorbidities among TB presumptive people...
March 26, 2024: BMC Microbiology
https://read.qxmd.com/read/38054150/unveiling-the-clinical-diversity-in-nontuberculous-mycobacteria-ntm-infections-a-comprehensive-review
#2
REVIEW
Jay Bhanushali, Ulhas Jadhav, Babaji Ghewade, Pankaj Wagh
Once considered rare, nontuberculous mycobacterial (NTM) infections have garnered increasing attention in recent years. This comprehensive review provides insights into the epidemiology, clinical diversity, diagnostic methods, treatment strategies, prevention, and emerging research trends in NTM infections. Key findings reveal the global prevalence of NTM infections, their diverse clinical presentations affecting respiratory and extra-pulmonary systems, and the diagnostic challenges addressed by advances in microbiological, radiological, and immunological methods...
November 2023: Curēus
https://read.qxmd.com/read/38018256/database-resources-of-the-national-genomics-data-center-china-national-center-for-bioinformation-in-2024
#3
JOURNAL ARTICLE
(no author information available yet)
The National Genomics Data Center (NGDC), which is a part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support the global academic and industrial communities. With the rapid accumulation of multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands and updates core database resources through big data archiving, integrative analysis and value-added curation. Importantly, NGDC collaborates closely with major international databases and initiatives to ensure seamless data exchange and interoperability...
November 29, 2023: Nucleic Acids Research
https://read.qxmd.com/read/37747253/complete-genome-sequence-of-candidatus-mycobacterium-wuenschmannii-a-nontuberculous-mycobacterium-isolated-from-a-captive-population-of-amazon-milk-frogs
#4
JOURNAL ARTICLE
Mohamed Zeineldin, Jessica Hicks, Hilary J Ward, Arno Wünschmann, Patrick Camp, David Farrell, Kimberly Lehman, Tyler C Thacker, Elizabeth Cuthbert
A slow growing species of nontuberculous mycobacteria (NTM) was isolated from the liver of an Amazon milk frog. The complete genome of this isolate comprises 5,102,433 bp, exhibiting 66.86% GC content, 4,940 protein-coding sequences, 52 predicted RNA genes, and 39 repeat regions.
September 25, 2023: Microbiology Resource Announcements
https://read.qxmd.com/read/37721238/cumulative-antimicrobial-susceptibilities-for-respiratory-clinical-isolates-of-mycobacterium-avium-complex-mycobacterium-kansasii-and-mycobacterium-abscessus-from-pakistan-2018-to-2022
#5
JOURNAL ARTICLE
Sadia Shakoor, Samreen Shafiq, Asima Shahid, Fatima Mir, Rashid Ali, Rumina Hasan
BACKGROUND: Nontuberculous mycobacteria (NTM) are increasingly identified as causes of protracted pulmonary infections. Antibiotic susceptibility testing requires microdilution methods, which are often unavailable in laboratories in resource-poor settings. We report cumulative antibiograms for the most frequently isolated clinical pulmonary NTM from Pakistan to inform empiric antibiotic management of initial NTM infections. METHODS: We analyzed data from 2018 to 2022 for the most frequently isolated and clinically relevant NTM isolated from respiratory specimens, i...
2023: International Journal of Mycobacteriology
https://read.qxmd.com/read/37541804/reducing-unnecessary-testing-on-sputum-specimens-from-patients-with-cystic-fibrosis-pathology-stewardship-in-microbiology
#6
JOURNAL ARTICLE
Grace Butel-Simoes, Despina Kotsanas, Richard Streitberg, Kylie Horne, Paul Finlay, John Hamblin, Michelle Francis, Beena Kumar, David Armstrong, Maryza Graham
Chronic respiratory tract infection by Pseudomonas aeruginosa is the hallmark of established lung disease in patients with cystic fibrosis (CF). Antibiotic therapy can usually only suppress but not eradicate infection. In recent years, pulmonary infection with non-tuberculous Mycobacteria (NTM) species has also been increasing. These patients are often colonised with multiple isolates and determination of clinical significance of each isolate is difficult. The clinical value of frequent routine susceptibility testing of individual isolates is unproven, particularly since a delay in susceptibility testing is inevitable when purification of multiple cultured isolates is required to test each isolate separately...
July 17, 2023: Pathology
https://read.qxmd.com/read/37532873/manoeuvring-across-academia-in-national-socialist-germany-the-life-and-work-of-devendra-nath-bannerjea
#7
JOURNAL ARTICLE
Maria Framke
The article investigates the possibilities and limits for the academic Devendra Nath Bannerjea to find employment in National Socialist Germany by producing-what he imagined to be-useful knowledge for the state. Bannerjea, who came from the Punjab in northwestern India via London, Geneva and Rome to Berlin, defies neat categorization. He was neither a National Socialist scholar, nor can he be solely understood as an Indian anticolonial nationalist. In the more than four decades he spent in Europe, Bannerjea appeared in many different roles-as an anticolonial rebel, false diplomat, researcher, and endeavouring professor...
August 2, 2023: NTM
https://read.qxmd.com/read/37532872/knowledge-of-india-as-an-instrument-of-nazi-politics-ludwig-alsdorf-german-indology-and-indian-anti-colonialism
#8
JOURNAL ARTICLE
Baijayanti Roy
Ludwig Alsdorf (1904-1978) is primarily remembered as a scholar of ancient and medieval India. This paper examines a little known aspect of Alsdorf's career: his role as an expert of modern India in Nazi Germany. Alsdorf, who was in India from 1930 to 1932, joined the NSDAP and a few of its subsidiaries after 1933. Political contacts as well as his claims of having "first-hand experience" of India secured Alsdorf writing assignments that aimed to fulfil the regime's political objectives. In return, he gained professional advancement and the reputation of being an authority on modern India...
August 2, 2023: NTM
https://read.qxmd.com/read/37488500/incidence-of-nontuberculous-mycobacteria-infections-among-persons-with-cystic-fibrosis-in-the-united-states-2010-2019
#9
JOURNAL ARTICLE
Julia E Marshall, Rachel A Mercaldo, Ettie M Lipner, D Rebecca Prevots
BACKGROUND: Nontuberculous mycobacteria (NTM) are ubiquitous, environmental bacteria that can cause chronic lung disease. Persons with cystic fibrosis (pwCF) are at high risk for NTM. Approximately 1 in 5 pwCF in the United States (U.S.) is affected by pathogenic NTM species, and incidence rates of NTM have been increasing among pwCF as well as in the general population. Prevalence of NTM pulmonary infections (PI) varies widely across the United States because of geographic variation in environmental exposures...
July 24, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37437716/a-strip-based-assay-for-detection-of-crfa-enzyme-activity-to-differentiate-mycobacterium-tuberculosis-and-non-tuberculous-mycobacteria
#10
JOURNAL ARTICLE
Rushna Wazahat, Pallavi Juneja, Varsha Chauhan, Rana Zaidi, Gyanu Lamichhane, Urvashi B Singh, Mehvash Haider, Pankaj Kumar
There is an unmet need for tools that permit diagnosis of Tuberculosis (TB) that are affordable, low-tech, and can differentiate Mycobacterium tuberculosis (M.tb) from non-tuberculous mycobacteria (NTM). In this study, we have developed a strip-based assay to detect the activity of a unique Carbapenem Resistance Factor A (CrfA) enzyme present only in M.tb. The strip comprises of PVDF (Polyvinylidene fluoride) membrane that has an immobilized anti-CrfA antibody to capture the CrfA enzyme from M.tb lysate. Lysate of mycobacteria is applied to the strip, washed, and incubated in the presence of chromogenic reporter dye which is a substrate for CrfA...
July 10, 2023: Journal of Microbiological Methods
https://read.qxmd.com/read/37278639/novel-synergies-and-isolate-specificities-in-the-drug-interaction-landscape-of-mycobacterium-abscessus
#11
JOURNAL ARTICLE
Nhi Van, Yonatan N Degefu, Pathricia A Leus, Jonah Larkins-Ford, Jacob Klickstein, Florian P Maurer, David Stone, Husain Poonawala, Cheleste M Thorpe, Trever C Smith, Bree B Aldridge
Mycobacterium abscessus infections are difficult to treat and are often considered untreatable without tissue resection. Due to the intrinsic drug-resistant nature of the bacteria, combination therapy of three or more antibiotics is recommended. A major challenge in treating M. abscessus infections is the absence of a universal combination therapy with satisfying clinical success rates, leaving clinicians to treat infections using antibiotics lacking efficacy data. We systematically measured drug combinations in M...
June 6, 2023: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/37189598/rapid-detection-of-mycobacterium-tuberculosis-using-a-novel-point-of-care-bz-tb-ntm-nalf-assay-integrating-lamp-and-lfia-technologies
#12
JOURNAL ARTICLE
Ha Nui Kim, Junmin Lee, Soo-Young Yoon, Woong Sik Jang, Chae Seung Lim
Tuberculosis (TB) is one of the leading causes of infectious mortality from a single infectious agent, Mycobacterium tuberculosis (MTB). This study evaluated the performance of the newly developed BZ TB/NTM NALF assay, which integrated loop-mediated isothermal amplification and lateral flow immunochromatographic assay technologies, for the detection of MTB. A total of 80 MTB-positive samples and 115 MTB-negative samples were collected, all of which were confirmed by TB real-time PCR (RT-PCR) using either AdvanSureTM TB/NTM RT-PCR Kit or Xpert® MTB/RIF Assay...
April 21, 2023: Diagnostics
https://read.qxmd.com/read/37147556/molecular-identification-of-non-tuberculous-mycobacterial-species-isolated-from-extrapulmonary-samples-using-real-time-pcr-and-rpob-sequence-analysis
#13
JOURNAL ARTICLE
Mohammad Hashemzadeh, Aram Asarehzadegan Dezfuli, Azar Dokht Khosravi, Maryam Moradi Bandbal, Atousa Ghorbani, Mahtab Hamed, Soolmaz Khandan Dezfuli
Tuberculosis (TB) is one of the leading causes of mortality among infectious diseases and accounts for a serious health hazard wordwide. Apart from TB, the members of non-tuberculous mycobacteria (NTM), which includes around 170 species, may also cause different diseases in humans. Therefore this study aimed to investigate the distribution of NTM strains isolated from extrapulmonary (EP) samples by Real-Time PCR and PCR-sequencing methods in Southwest Iran. Three hundred and twenty-five suspected EP samples were collected from patients referred to the referral hospitals in Ahvaz, Iran...
May 5, 2023: AMB Express
https://read.qxmd.com/read/36740317/the-clinician-the-lab-and-the-patient-understanding-lab-diagnostics-to-eradicate-tuberculosis
#14
JOURNAL ARTICLE
Bhavini Shah, S C Shah, P Kakadia, Shah Parth, Nidhi Shah, H Toshniwal
BACKGROUND: Diagnostic modalities for diagnosing Tuberculosis caused by Mycobacterium group of organisms include mainly AFB smear by Ziehl Neelsen carbol fuchsin smear microscopy, GeneXpert (CB NAAT) molecular method, Line probe assay (Molecular method) and AFB culture (Liquid automated systems and solid media) methods. METHODS: This study was initiated to understand and prioritize TB lab diagnosis, with reference to selection of lab diagnostic tests and its order of preference for MTC and NTM/MOTT closely associating it with the TB irradication program initiated by the Government of India...
January 2023: Indian Journal of Tuberculosis
https://read.qxmd.com/read/36627190/evaluation-of-a-novel-elisa-test-using-synthetic-mycolic-acid-antigens-for-serodiagnosis-of-non-tuberculous-mycobacterial-ntm-infections
#15
JOURNAL ARTICLE
Julia Bashford, William Flowers, Charles Haworth, Judy Ryan, Anna Cervi, J R Al Dulayymi, Paul S Mason, Ashley Plank, Mark Baird, Andres Floto
The diagnosis of non-tuberculous mycobacteria (NTM) is a particular challenge in people with cystic fibrosis. Current standard diagnostic approaches rely on serial sputum culture, which is resource demanding, dependent on patient expectoration and may be compromised by excessive decontamination, conventional bacterial overgrowth and masking by concomitant oral and nebulised antibiotics. An alternative rapid, reliable and inexpensive diagnostic method is therefore urgently needed. Serum of patients with Mycobacterium abscessus infection and chronic suppurative lung disease without NTM infection was tested against an array of novel synthetic mycolic acids, identical or similar to natural components of mycobacterial cell walls, and glycopeptidolipid (GPL)-core antigen, which has previously been investigated in Mycobacterium avium pulmonary infection...
March 2023: Thorax
https://read.qxmd.com/read/35880173/virulence-associated-secretion-in-mycobacterium-abscessus
#16
REVIEW
Michal Bar-Oz, Michal Meir, Daniel Barkan
Non-tuberculous mycobacteria (NTM) are a heterogeneous group of originally environmental organi3sms, increasingly recognized as pathogens with rising prevalence worldwide. Knowledge of NTM's mechanisms of virulence is lacking, as molecular research of these bacteria is challenging, sometimes more than that of M. tuberculosis (Mtb), and far less resources are allocated to their investigation. While some of the virulence mechanisms are common to several mycobacteria including Mtb, others NTM species-specific...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35699468/evaluation-of-aptamer-fluorescence-microscopy-in-the-diagnosis-of-pulmonary-tuberculosis
#17
JOURNAL ARTICLE
Ruijuan Zheng, Feifan Xu, Xiaochen Huang, Jie Wang, Yonghong Feng, Jin Huang, Lianhua Qin
Sputum smear microscopy for tuberculosis diagnosis has stood the test of time. However, due to its low sensitivity, the positive detection rate for tuberculosis in clinical specimens is not high. To improve the sensitivity of microscopic observation in Mycobacterium tuberculosis (MTB) detection, we developed the MTB-specific aptamer MA1. To further improve the binding reactivity of MA1 with MTB, we constructed a new derivative aptamer with a pocket-stem-loop-structure, MA1-39, and identified it to have high binding reactivity with the MTB reference strain...
August 31, 2022: Microbiology Spectrum
https://read.qxmd.com/read/35696783/-mycobacterium-abscessus-insights-from-a-bioinformatic-perspective
#18
JOURNAL ARTICLE
Saubashya Sur, Tanushree Patra, Mistu Karmakar, Anindita Banerjee
Mycobacterium abscessus is a nontuberculous mycobacterium, associated with broncho-pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and pulmonary diseases. The risk factors for transmission include biofilms, contaminated water resources, fomites, and infected individuals. M. abscessus is extensively resistant to antibiotics. To date, there is no vaccine and combination antibiotic therapy is followed. However, drug toxicities, low cure rates, and high cost of treatment make it imperfect...
June 13, 2022: Critical Reviews in Microbiology
https://read.qxmd.com/read/35587637/successful-direct-whole-genome-sequencing-and-revivification-of-freeze-dried-nontuberculous-mycobacteria-after-more-than-half-a-century-of-storage
#19
JOURNAL ARTICLE
Xenia Emilie Sinding Iversen, Anders Norman, Dorte Bek Folkvardsen, Erik Svensson, Erik Michael Rasmussen, Troels Lillebaek
In this study, 28 "historical" clinical freeze-dried nontuberculous mycobacterial isolates collected from 1948 to 1957, were analyzed by investigating their viability and performing whole genome sequencing (WGS) on DNA extracted (i) directly from freeze-dried cells versus (ii) after culturing, to determine cell properties and DNA quality after centuries of freeze-dried storage. The isolated DNA was sequenced on the Illumina MiSeq platform and data quality evaluated analyzing the per-base quality scores of paired-end sequencing reads as well as the overall contiguity of resulting de novo assemblies...
May 19, 2022: Microbiology Spectrum
https://read.qxmd.com/read/35536307/radiation-risk-in-cold-war-mexico-local-and-global-networks
#20
JOURNAL ARTICLE
Ana Barahona
After WWII, global concerns about the uses of nuclear energy and radiation sources in agriculture, medicine, and industry brought about calls for radiation protection. At the beginning of the 1960s radiation protection involved the identification and measurement of all sources of radiation to which a population was exposed, and the evaluation and assessment of populations in terms of the biological hazard their exposure posed. Mexico was not an exception to this international trend. This paper goes back to the origins of the first studies on the effects of radiation and on radioprotective compounds in the Genetics and Radiobiology Program of the National Commission of Nuclear Energy founded in 1960, at a time when the effects of radiation on living beings and radiation protection demanded the attention of highly localized groups of scientists and the creation of international as well as national institutions, and its connection to dosimetry and radiation protection until the 1990s...
June 2022: NTM
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