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JOURNAL ARTICLE
Tricia Templet, Roger Rholdon, Ansley Bienvenu
The purpose of this study is to evaluate the effectiveness of SafeBoard, a Food and Drug Administration-approved extremity stabilization device, as an assistive method in performing peripherally inserted central catheter procedures on children 0 to 3 years of age. This is a retrospective chart review ( n = 59) of vascular access procedures where SafeBoard was utilized ( n = 32 ) in comparison to those procedures which utilized a traditional approach to placement ( n = 27)...
March 2024: Journal of Pediatric Intensive Care
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JOURNAL ARTICLE
Sebastian Rodrigo, Stefania Costi, Pierre Ellul, Melodie Aubart, Nathalie Boddaert, Stephane Auvin, Monique Elmaleh, Alexandra Ntorkou, Brigitte Bader-Meunier, Vincent Lebon, Isabelle Melki, Catherine Chiron
BACKGROUND: In juvenile systemic lupus erythematosus (j-SLE) with neuropsychiatric (NP) symptoms, there is a lack of diagnostic biomarkers. Thus, we study whether PET-FDG may identify any metabolic dysfunction in j-NPSLE. METHODS: A total of 19 18 FDG-PET exams were consecutively performed using PET-MRI system in 11 non-sedated patients presenting with j-NPSLE (11-18y) for less than 18 months (m) and without any significant lesion at MRI. Psychiatric symptoms were scored from 0 (none) to 3 (severe) at PET time...
April 2, 2024: EJNMMI Research
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JOURNAL ARTICLE
Yair Katzir, Lior Ganor, Ron Berant, Keren Shahar-Nissan
OBJECTIVE: We describe a case series of regional nerve blocks, which comprise an adapted framework for the pediatric emergency setting and were performed by pediatric emergency medicine physicians. METHODS: A case series of 8 different ultrasound-guided nerve blocks and 1 anatomical block, performed in 11 pediatric patients, aged 7 weeks to 17 years. RESULTS: All blocks resulted in adequate analgesia. No procedural complications were observed...
April 2, 2024: Pediatric Emergency Care
#24
JOURNAL ARTICLE
Julio Fernandez-Mendoza, Susan L Calhoun, Edward O Bixler
What an honor to write about Dr. Edward O. Bixler's contributions to the sleep field. In 1967, Dr. Bixler published a case report on a chimpanzee with implanted brain electrodes while working at an Air Force base in New Mexico. A few years later, in 1971, he published on the sleep effects of flurazepam in individuals with insomnia together with Dr. Anthony Kales, data that he had collected when the Sleep Research & Treatment Center (SRTC) was housed at the University of California Los Angeles. Dr. Bixler, a meticulous scientist, learned from Dr...
2024: Sleep advances: a journal of the Sleep Research Society
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JOURNAL ARTICLE
Cong-Hui Fu, Yan Li, Yu-Cai Zhang, Xiao-Ya Yang, Ji Liu, Min-Jie Ju, Ting-Ting Xu
INTRODUCTION: Children receiving extracorporeal membrane oxygenation are prone to delirium. This case report describes the nursing care of a child with delirium who received venoarterial extracorporeal membrane oxygenation. Relevant interventions and precautions are also discussed. CLINICAL FINDINGS: A 6-year-old girl was admitted to the pediatric intensive care unit with a 2-day history of vomiting and fever. The child underwent cannulation for venoarterial extracorporeal membrane oxygenation...
April 1, 2024: Critical Care Nurse
#26
JOURNAL ARTICLE
Patrícia Corrêa-Faria, Saul Martins Paiva, Luciane Rezende Costa
INTRODUCTION: Little is known regarding the impact of dental treatment under sedation on distressed young children's oral health-related quality of life (OHRQoL). AIM: To evaluate the impact of dental treatment under sedation on the OHRQoL of children and their families. METHODS: Caregivers of two-to-six-year-old children answered the Brazilian version of the Early Childhood Oral Health Impact Scale (B-ECOHIS): (1) before treatment under sedation (T0), (2) two weeks (T1) and (3) 3 months after the completion of treatment (T2)...
March 30, 2024: Special Care in Dentistry
#27
Eline Hermans, Jozefien Meersschaut, Isis Van Herteryck, Mathias Devreese, Johan Vande Walle, Peter De Paepe, Pieter A De Cock
BACKGROUND AND OBJECTIVE: Drug dosing should ideally be based on the drug concentrations at the target site, which, for most drugs, corresponds to the tissue. The exact influence of growth and development on drug tissue distribution is unclear. This systematic review compiles the current knowledge on the tissue distribution of systemically applied drugs in children, with the aim to identify priorities in tissue pharmacokinetic (PK) research in this population. METHODS: A systematic literature search was performed in the MEDLINE and Embase databases...
March 29, 2024: Clinical Pharmacokinetics
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JOURNAL ARTICLE
Jinying Zhu, Sufeng Zhou, Lu Wang, Yuqing Zhao, Jie Wang, Tangping Zhao, Tongtong Li, Feng Shao
This study aims to explore and characterize the role of pediatric sedation via rectal route. A pediatric physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) model of midazolam gel was built and validated to support dose selection for pediatric clinical trials. Before developing the rectal PBPK model, an intravenous PBPK model was developed to determine drug disposition, specifically by describing the ontogeny model of the metabolic enzyme. Pediatric rectal absorption was developed based on the rectal PBPK model of adults...
March 29, 2024: Molecular Pharmaceutics
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JOURNAL ARTICLE
Sean McCann, Victória E Helfer, Stephen J Balevic, Chi D Hornik, Stuart L Goldstein, Julie Autmizguine, Marisa Meyer, Amira Al-Uzri, Sarah G Anderson, Elizabeth H Payne, Sitora Turdalieva, Daniel Gonzalez
Dexmedetomidine is a sedative used in both adults and off-label in children with considerable reported pharmacokinetic (PK) interindividual variability affecting drug exposure across populations. Several published models describe the population PKs of dexmedetomidine in neonates, infants, children, and adolescents, though very few have been externally evaluated. A prospective PK dataset of dexmedetomidine plasma concentrations in children and young adults aged 0.01-19.9 years was collected as part of a multicenter opportunistic PK study...
March 28, 2024: Journal of Clinical Pharmacology
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JOURNAL ARTICLE
Pilar Carrasco-Garrido, Isabel Jiménez-Trujillo, Valentín Hernández-Barrera, Lidiane Lima Florencio, Spencer Yeamans, Domingo Palacios-Ceña
Adolescence is a critical developmental stage for the initiation of substance use worldwide, which is one of the main risk-taking behaviors that may impact adolescents' physical and mental well-being. The aims of this study were to (1) assess the prevalence of the co-use of tranquilizers, sedatives, and sleeping pills with alcohol (TSSp&AC) by gender in the Spanish adolescent population in 2018 and (2) identify the variables associated with TSSp&AC. An observational cross-sectional study following STROBE guidelines was conducted...
March 13, 2024: Children
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JOURNAL ARTICLE
Jonah M Hill, Daphne Y S Vogel, Bea Spek, Catharine J de Jong, Janneke B Krikken, Jaap S J Veerkamp
Background : Dental fear and uncooperative behavior can hinder dental treatment quality. Pediatric Procedural Sedation and Analgesia (PPSA) is used to facilitate treatment when the coping capacity is exceeded. Out-of-hospital PPSA has been associated with more adverse outcomes compared to when it is used in hospital-based settings. The updated Dutch PPSA guidelines have increased costs and raised concerns about the accessibility of specialized high-quality dental care for children in the Netherlands. This study aimed to investigate the impact of the updated 2017 guidelines on the occurrence rate of adverse events during PPSA in twelve Dutch dental clinics...
March 5, 2024: Dentistry Journal
#32
JOURNAL ARTICLE
Claci Ayers, David P Johnson, Lacey Noffsinger, S Barron Frazier
BACKGROUND AND OBJECTIVE: Inadequate postintubation sedation (PIS) can lead to unplanned extubations, conscious paralysis, and overall unsafe care of patients. From 2018 to 2020, we realized at our hospital that ∼25% of children received sedation in an adequate time frame in the pediatric emergency department, with 2 unplanned dislodgements of the endotracheal tube. Our objective was to reduce time to initiating PIS from a mean of 39 minutes to less than 15 minutes in our pediatric emergency department by September 2021...
March 27, 2024: Pediatrics
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JOURNAL ARTICLE
Ahila Manivannan, Shailender Madani, Michael Woodall, George McKelvey, Sharon Kemper
Background and aims Propofol combined with fentanyl is a commonly used sedative for pediatric upper endoscopies (UEs). The primary aim was to study the association between propofol dose and procedure and sedation time. The secondary aims were to assess the pharmacodynamics of propofol use with fentanyl and evaluate if gastroenterologists' and anesthesiologists' years of experience or the presence of supervised participants (such as students, residents, and fellows) have any influence on the procedure and sedation time...
February 2024: Curēus
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JOURNAL ARTICLE
Alexis Ball, Scott Hadland, Jonathan Rodean, Matt Hall, Jason Mendoza, Kym Ahrens
PURPOSE: This study evaluates recent trends in substance-related visits among youth visiting children's hospitals. METHODS: We conducted a cross-sectional study of substance-related visits to pediatric hospitals within the Pediatric Health Information System database of youth aged 12-21 years from 2016 through 2021. Substance-related visits were defined as acute visits for International Classification of Diseases, 10th Revision Clinical Modification codes related to substance 'use', dependence, or overdoses for alcohol, cannabis, nicotine, opioids, sedatives, stimulants, hallucinogens, or other substances...
March 25, 2024: Journal of Adolescent Health
#35
JOURNAL ARTICLE
Hasan Alzoubi, Samar Kabbani, Ahmad Taleb, Nada Bshara, Mohamed K Altinawi, Mohammed Bashier Almonakel, Saleh Al Kurdi
Background In pediatric dentistry, sedation aims to eliminate anxiety to facilitate the completion of dental procedures. Sedation in children is a multidimensional field that includes the child, parents/guardians, and the health care team. The rectal route is generally painless, making it suitable for children who are afraid of needles. This route has several advantages over the oral route, including reduced patient cooperation requirements, a faster and more predictable onset, and less physical trauma than the intravenous and intramuscular routes...
February 2024: Curēus
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JOURNAL ARTICLE
Caroline Melhado, Rachelle Durand, Katie W Russell, Natalya E Polukoff, John Rampton, Rajiv R Iyer, Shannon N Acker, Richele Koehler, Connor Prendergast, Nicholas Stence, Brent O'Neill, Benjamin E Padilla, Ramin Jamshidi, Jennifer A Vaughn, Jennifer S Ronecker, Leigh Selesner, Katrine Lofberg, Michael Regner, Jaclyn Thiessen, Christine Sayama, Ryan G Spurrier, Erin E Ross, Chia-Shang Jason Liu, Jason Chu, Kathryn McNevin, Catherine Beni, Bryce R H Robinson, Ken Linnau, Robert T Buckley, Stephanie D Chao, Akanksha Sabapaty, Elizabeth Tong, Laura M Prolo, Romeo Ignacio, Gretchen Floan Sachs, Peter Kruk, David Gonda, Mark Ryan, Samir Pandya, Korgun Koral, Bruno P Braga, Kurtis Auguste, Aaron R Jensen
INTRODUCTION: Clinical clearance of a child's cervical spine after trauma is often challenging due to impaired mental status or an unreliable neurologic examination. Magnetic resonance imaging (MRI) is the gold standard for excluding ligamentous injury in children but is constrained by long image acquisition times and frequent need for anesthesia. Limited-sequence MRI (LSMRI) is used in evaluating the evolution of traumatic brain injury and may also be useful for cervical spine clearance while potentially avoiding the need for anesthesia...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#37
RANDOMIZED CONTROLLED TRIAL
Hao Xie, Jialian Zhao, Haiya Tu, Wenyang Wang, Yaoqin Hu
BACKGROUND: The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their combination. METHODS: This is a prospective dose-finding study. A total of 53 children aged from 2 months to 6 years scheduled for MRI examination from February 2023 to April 2023 were randomly divided into group D (to determine the ED50 of intranasal dexmedetomidine) and group M (to determine the ED50 of oral midazolam)...
March 23, 2024: BMC Anesthesiology
#38
REVIEW
Dong X Chen, Zhi M Tan, Xue M Lin
PURPOSE: Heated discussions have divided health care providers and policymakers on the risks versus benefits of general anesthesia in pediatric populations. We conducted this study to provide a comprehensive bibliometric analysis of general anesthesia in this specific population over the past decade. DESIGN: We summarized and quantitatively analyzed the studies related to general anesthesia in children and infants over the past decade. METHODS: Using the Web of Science Core Collection as the data source, we analyzed the literature using CiteSpace software, focusing on authors, countries, institutions, keywords, and references to identify hotspots and predict research trends...
March 21, 2024: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
#39
JOURNAL ARTICLE
Michal Čečrle, Daniela Pelclová, Navrátil Tomáš, Sergej Zacharov
Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16...
March 23, 2024: Basic & Clinical Pharmacology & Toxicology
#40
JOURNAL ARTICLE
Yuqi Huang, Chao Yang, Jingjing Nie, Manman Zeng, Huifang Kuang, Kaiyue Zheng, Honglan Sun, Xi Xie, Xiaoning He, Hai-Bin Luo, Wen Luo
Oral behavior management methods include basic behavior management methods and drug behavior management methods. In many cases, dental treatment that cannot be done simply through basic behavior management is not possible. The uncooperative behavior of children with dental fear in oral treatment has increased the demand for medication based behavior management methods. Drug sedation can provide more effective analgesic and anti-anxiety effects, thereby helping to provide comfortable, efficient, and high-quality dental services...
March 22, 2024: Medicine (Baltimore)
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