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Sedation children

Sedat Işıkay, Nurgül Işıkay, Hüseyin Per, Kürşat Bora Çarman, Halil Kocamaz
Işıkay S, Işıkay N, Per H, Çarman KB, Kocamaz H. Restless leg syndrome in children with celiac disease. Turk J Pediatr 2018; 60: 70-75. Celiac disease (CD) is an immune-mediated enteropathy triggered by ingestion of dietary gluten in genetically predisposed individuals. The aim of the study was to determine the prevalence of restless leg syndrome (RLS) in children with CD and to investigate the associated factors for RLS. Totally 494 children with the ages ranging between 11-18 years were included. Among those, 226 were under follow-up with CD and constituted the study group while other 268 children did not have any symptoms or signs associated with CD and established the control group...
2018: Turkish Journal of Pediatrics
Ali Mohamed Elnabtity, Mohamed Ibrahim
Background and Aims: Intraperitoneal local anesthetic is an effective analgesic approach in laparoscopic appendectomy in adults. The aim of the study was to compare the postoperative pain when intraperitoneal bupivacaine is administered alone versus the addition of dexmedetomidine to it in children undergoing a laparoscopic appendectomy. Methods: In this prospective randomized trial, 52 children were randomly allocated to Group B who received intraperitoneal bupivacaine 0...
July 2018: Saudi Journal of Anaesthesia
Mary K Dahmer, Michael W Quasney, Anil Sapru, Ginny Gildengorin, Martha A Q Curley, Michael A Matthay, Heidi Flori
OBJECTIVES: To test whether plasma interleukin-1 receptor antagonist or variants within the gene encoding for interleukin-1ra (IL1RN), or proteins involved in regulating interleukin-1β levels or interleukin-1β response, are associated with pediatric acute respiratory distress syndrome or outcomes in mechanically ventilated children with parenchymal lung disease. DESIGN: Prospective cohort study. SETTING: Twenty-two PICUs participating in the multisite clinical trial, Randomized Evaluation of Sedation Titration for Respiratory Failure (U01 HL086622)...
August 7, 2018: Pediatric Critical Care Medicine
A Gunes, E Bulut, A Uzumcugil, K K Oguz
BACKGROUND AND PURPOSE: Brachial plexus birth injury is caused by traction on the neck during delivery and results in flaccid palsy of an upper extremity commonly involving C5-C6 nerve roots. MR imaging and MR myelography help to assess the anatomic location, extent, and severity of brachial plexus injuries which influence the long-term prognosis along with the surgical decision making. Recently, sonography has been increasingly used as the imaging modality of choice for brachial plexus injuries...
August 9, 2018: AJNR. American Journal of Neuroradiology
Kanika Singh, Anju Aggarwal, M M A Faridi, Sangeeta Sharma
Objectives: To compare the efficacy of IV phenytoin and IV levetiracetam in acute seizures. Design: Randomized controlled trial. Setting: Tertiary care hospital, November 2012 to April 2014. Patients: 100 children aged 3-12 yrs of age presenting with acute seizures. Intervention: Participants randomly received either IV phenytoin 20 mg/kg ( n = 50) or IV levetiracetam 30 mg/kg ( n = 50). Patients who were had seizures at presentation received IV diazepam prior to these drugs...
April 2018: Journal of Pediatric Neurosciences
Fang Chen, Chengyu Wang, Yi Lu, Mengmeng Huang, Zhijian Fu
BACKGROUND: Dexmedetomidine (DEX), a highly sensitive α2 -adrenoceptor agonist that possesses anxiolytic, sedative, and analgesic effects, has been documented as a preventative and treatment for emergence agitation (EA). The therapeutic should be given as a loading dose that is infused during a 10 min period, but if a rapid bolus injection is deemed to be hemodynamically appropriate, it would be a more opportune route of administration. So we studied the efficacy of different doses of DEX as a rapid bolus for children to prevent and treat EA...
August 7, 2018: BMC Anesthesiology
Anna Sidorchuk, Kayoko Isomura, Yasmina Molero, Clara Hellner, Paul Lichtenstein, Zheng Chang, Johan Franck, Lorena Fernández de la Cruz, David Mataix-Cols
BACKGROUND: Pharmacoepidemiological studies have long raised concerns on widespread use of benzodiazepines and benzodiazepine-related drugs (BZDs), in particular long-term use, among adults and the elderly. In contrast, evidence pertaining to the rates of BZD use at younger ages is still scarce, and the factors that influence BZD utilisation and shape the different prescribing patterns in youths remain largely unexplored. We examined the prevalence rates, relative changes in rates over time, and prescribing patterns for BZD dispensation in young people aged 0-24 years in Sweden during the period January 1, 2006-December 31, 2013, and explored demographic, clinical, pharmacological, and prescriber-related attributes of BZD prescribing in this group...
August 2018: PLoS Medicine
Sigalit Blumer, Rabea Iraqi, Roly Bercovich, Benjamin Peretz
OBJECTIVE: We aimed to examine if changes in oxygen saturation and pulse rate of pediatric patients during conscious sedation with midazolam and nitrous oxide are associated with child's behavior, midazolam dose, the type and duration of the treatment and demographic parameters. STUDY DESIGN: This study was a retrospective chart review of consecutive pediatric patients, aged 2.5-12.5 years, who had undergone conscious sedation for dental treatment with oral midazolam (with or without nitrous oxide) between January 2011 and September 2015 at the Department of Pediatric Dentistry of Tel Aviv University...
August 7, 2018: Journal of Clinical Pediatric Dentistry
Susan E Warrington, Hailey K Collier, Adam S Himebauch, Heather A Wolfe
OBJECTIVES: To evaluate if institutionally established calculations for transitioning continuous IV midazolam to enteral benzodiazepines maintain Withdrawal Assessment Tool-Version 1 scores equal to or less than preconversion values. DESIGN: Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients...
August 3, 2018: Pediatric Critical Care Medicine
Mary-Louise C Greer
Pediatric cancer predisposition syndromes comprise a group of diseases characterized by specific tumors or a concomitance of tumors in infants, children and adolescents, suggesting a genetic cancer susceptibility condition. Most but not all have germline pathogenic variants on genetic testing. For some children with cancer predisposition syndromes, this diagnosis is based on their own or a family history of related neoplasms, or associated clinical manifestations. These tumors have variable incidence and age of onset...
August 2018: Pediatric Radiology
Camilo Jaimes, John E Kirsch, Michael S Gee
Magnetic resonance imaging (MRI) is the preferred imaging modality in children with complex medical issues. Patient motion and respiration remain major challenges in pediatric abdominal MRI. Young children ages 3 months to 6 years are unable to cooperate or perform breath-holding and frequently require deep sedation or general anesthesia to undergo MRI. Given the growing concerns associated with the use of sedation and anesthesia as well as the adverse impact on workflow, developing and implementing fast and motion-resistant MRI sequences are of great interest...
August 2018: Pediatric Radiology
B U K Li
Cyclic vomiting syndrome (CVS) in children is characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. In the absence of robust data, the treatment of CVS remains largely empiric starting with the 2008 NASPGHAN Consensus Statement recommendations of cyproheptadine for children < 5 years of age and amitriptyline for those ≥ 5 years with propranolol serving as the second-line agent. Comprehensive management begins with lifestyle alterations, and extends to medications, supplements, and stress reduction therapies...
August 3, 2018: European Journal of Pediatrics
Michael J Moss, Robert G Hendrickson
BACKGROUND: Amanita muscaria (AM) and A. pantherina (AP) contain ibotenic acid and muscimol and may cause both excitatory and sedating symptoms. Gastrointestinal (GI) symptoms are not classically described but have been reported. There are relatively few reported cases of poisoning with these mushrooms in North America. METHODS: This is a retrospective review of ingestions of ibotenic acid and muscimol containing mushrooms reported to a United States regional poison center from 2002-2016...
August 3, 2018: Clinical Toxicology
Michael Huss, Keith McBurnett, Andrew J Cutler, Amaia Hervás, Caleb Bliss, Joseph Gao, Bryan Dirks, Jeffrey H Newcorn
The present study investigated whether symptom reduction in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with guanfacine extended release (GXR) can be explained by sedative effects of the medication. Data from four double-blind, randomized, placebo-controlled, phase 3 trials of GXR monotherapy (1-7 mg/day; morning administration) in children (aged 6-12 years) and adolescents (aged 13-17 years) with ADHD were analyzed post hoc. Two studies used forced-dose titration and two used flexible-dose titration...
July 29, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Roger K Harned, Manraj K S Heran, Manish Patel, Alex Barnacle, Anne Marie Cahill, Leah Braswell, G Peter Feola, Sergio Sierre, Francis Marshalleck
OBJECTIVE: Pediatric interventional radiology (PIR) is a dynamic and growing subspecialty. We will detail our need to evolve like the emerging therapies and innovative imaging options that we provide to children. CONCLUSION: New interventional radiology training pathways, maintaining competency with small volumes of complex procedures, limited availability of pediatric-specific equipment, questions about the safety of sedation in the developing brain, and the dearth of PIR opportunities outside of North America provide challenges and opportunities for the vibrant community of PIR practitioners...
July 31, 2018: AJR. American Journal of Roentgenology
Steven Kecskemeti, Alexey Samsonov, Julia Velikina, Aaron S Field, Patrick Turski, Howard Rowley, Janet E Lainhart, Andrew L Alexander
Purpose To develop and evaluate a retrospective method to minimize motion artifacts in structural MRI. Materials and Methods The motion-correction strategy was developed for three-dimensional radial data collection and demonstrated with MPnRAGE, a technique that acquires high-resolution volumetric magnetization-prepared rapid gradient-echo, or MPRAGE, images with multiple tissue contrasts. Forty-four pediatric participants (32 with autism spectrum disorder [mean age ± standard deviation, 13 years ± 3] and 12 age-matched control participants [mean age, 12 years ± 3]) were imaged without sedation...
July 31, 2018: Radiology
S Arcari, M Moscati
AIM: Pain experienced during dental treatment increases the risk of developing dental anxiety in children who will became anxious adults, avoiding dental care. It is therefore essential to provide pain-free dental treatment. The strongest fears are often associated with injections: being able to successfully complete painless restorative treatment without the need for local anesthesia injection is therefore an important goal. Nitrous oxide administration by means of Langa's Relative Analgesia (RA) technique has been demonstrated to have both sedative and bland analgesic properties: the mechanism by which N2O exerts its analgesic effects is now understood...
September 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Jochen Meyburg, Mona-Lisa Dill, Rebecca von Haken, Susanne Picardi, Jens Hendrik Westhoff, Gabrielle Silver, Chani Traube
OBJECTIVES: To determine and quantify risk factors for postoperative pediatric delirium. DESIGN: Single-center prospective cohort study. SETTING: Twenty-two bed PICU in a tertiary care academic medical center in Germany. PATIENTS: All children admitted after major elective surgery (n = 93; 0-17 yr). INTERVENTIONS: After awakening, children were screened for delirium using the Cornell Assessment of Pediatric Delirium bid over a period of 5 days...
July 27, 2018: Pediatric Critical Care Medicine
Varshini Varadaraj, Beatriz Munoz, Mohammed Karaoui, Megan E Collins, Leyla Ali Aljasim, Essam Al Naji, Karam Hamweyah, Mohammed Al Shamrani, Earl Randy Craven, David S Friedman
PURPOSE: To determine the effect of oral chloral hydrate (CH) sedation on intraocular pressure (IOP) in an outpatient pediatric population. DESIGN: Prospective, non-comparative case series METHODS: Children aged 1 month-5 years undergoing CH sedation for ocular imaging/evaluation at a tertiary eye hospital were included. IOP was measured using an Icare tonometer prior to sedation (in some, not all), at 25 minutes after sedation, and then every 10 minutes until sedation completion...
July 25, 2018: American Journal of Ophthalmology
Julia S Kimbell, Saikat Basu, Guilherme J M Garcia, Dennis O Frank-Ito, Frances Lazarow, Erica Su, Dimitry Protsenko, Zhongping Chen, John S Rhee, Brian J Wong
OBJECTIVES: Adenotonsillectomy (AT) is commonly used to treat upper airway obstruction in children, but selection of patients who will benefit most from AT is challenging. The need for diagnostic evaluation tools without sedation, radiation, or high costs has motivated the development of long-range optical coherence tomography (LR-OCT), providing real-time cross-sectional airway imaging during endoscopy. Since the endoscope channel location is not tracked in conventional LR-OCT, airway curvature must be estimated and may affect predicted airway resistance...
July 26, 2018: Lasers in Surgery and Medicine
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