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Glaucoma , cataract,

Sunee Chansangpetch, Kevin Lau, Claudio I Perez, Ngoc Nguyen, Travis C Porco, Shan C Lin
PURPOSE: To evaluate the effectiveness of trabecular microbypass stent (iStent) implantation in combined mechanism glaucoma (CMG). DESIGN: Retrospective cohort study METHODS: We reviewed the medical charts of patients with the following scenarios: (1) primary open angle glaucoma (POAG) undergoing phacoemulsification (PE), (2) POAG undergoing PE with iStent (POAG-PE/iStent), (3) CMG undergoing PE (CMG-PE), and (4) CMG undergoing PE with iStent (CMG-PE/iStent). CMG was defined as narrow angle glaucoma patients whose angle had opened after iridotomy...
August 8, 2018: American Journal of Ophthalmology
Jost B Jonas, Wen Bin Wei, Liang Xu, Marcella Rietschel, Fabian Streit, Ya Xing Wang
PURPOSE: To assess the prevalence of depression in the general population of Beijing and its association with ocular diseases. METHODS: The population-based Beijing Eye Study was conducted in a rural and an urban region of Greater Beijing. The study participants underwent a detailed ophthalmological examination and an interview including questions on the socioeconomic background. Depressive symptoms were evaluated using a Chinese depression scale adapted from Zung´s self-rated depression scale...
2018: PloS One
Avrey Thau, Maureen Lloyd, Sharon Freedman, Allen Beck, Alana Grajewski, Alex V Levin
PURPOSE OF REVIEW: The Childhood Glaucoma Research Network (CGRN) has created a new classification system for childhood glaucoma that has become the first International Consensus Classification. The purpose of this review is to present this classification system and share its use to date. RECENT FINDINGS: The diagnoses of the classification system include glaucoma and glaucoma suspect. The primary glaucomas include: primary congenital glaucoma and juvenile open-angle glaucoma...
September 2018: Current Opinion in Ophthalmology
Rosanna Dammacco, Pasquale Procaccio, Vito Racanelli, Angelo Vacca, Franco Dammacco
PURPOSE: To assess the prevalence of the ocular manifestations related to the disease and/or ascribable to the administration of potentially toxic drugs in a cohort of 98 patients with systemic lupus erythematosus (SLE). METHODS: Retrospective, observational study reporting the experience of two tertiary referral centers. RESULTS: Overall, an ocular involvement was detected in 29 patients (29.6%), sometimes preceding of months the diagnosis of SLE, more often revealed at diagnosis or throughout its course...
August 10, 2018: Ocular Immunology and Inflammation
Kaweh Mansouri, Kevin Gillmann, Harsha L Rao, Jacopo Guidotti, André Mermoud
PURPOSE: To compare the safety and efficacy of XEN gel implant surgery (Allergan Inc., Irvine, USA) in patients with pseudoexfoliative glaucoma (PEXG) and primary open angle glaucoma (POAG). SETTING: Prospective, interventional study in a tertiary glaucoma center. METHODS: Fifty-seven eyes (43 patients) with POAG and 53 eyes (42 patients) with PEXG with uncontrolled intraocular pressure (IOP) despite medical treatment underwent combined XEN+cataract surgery or standalone XEN surgery...
August 7, 2018: Journal of Glaucoma
Megan Cann, Athimalaipet V Ramanan, Andrew Crawford, Andrew D Dick, Sarah L N Clarke, Fatima Rashed, Catherine M Guly
BACKGROUND: There is a paucity of data on the ocular outcomes in paediatric non-infectious uveitis since the introduction of the biologic agents. The purpose of this study was to outline the clinical characteristics of children with non-infectious uveitis and determine the visual outcomes and ocular complication rates in the modern era. METHODS: Children with non-infectious uveitis from January 2011 to December 2015 were identified. Data was collected at baseline, 1, 3, 5, and 10 years post diagnosis...
August 6, 2018: Pediatric Rheumatology Online Journal
Cristobal Loezar, Eva Madrid, Catalina Jahr, Antonio Daviu, Herman Ahumada, Hector Pardo-Hernandez, Eva Keller, Xavier Bonfill
PURPOSE: Properly conducted controlled clinical trials (CCTs) provide the highest level of evidence for optimising decision-making in healthcare. Electronic search strategies do not exhaustively retrieve them, because of issues related to indexing, exclusion of journals in languages other than English, among others. A handsearch approach is therefore warranted. We aimed to identify all CCTs published in Ophthalmology journals in Spain, to describe their main features, and to submit them to the Cochrane Register of CCTs (CENTRAL)...
August 6, 2018: Ophthalmic Epidemiology
Antonio Lopez-Ramos, Pedro Arnulfo Gomez-Bastar, Van Charles Lansingh, Jaime Arturo Rodriguez-Gomez, Veronica Vargas-Fragoso, Felipe Andres Soria-Arellano, Santos Horacio Silva-Camacho, Javier Castillo-Velazquez, Luz Consuelo Zepeda-Romero, Hans Limburg
PURPOSE: To estimate the prevalence of blindness, visual impairment, diabetes mellitus, and diabetic retinopathy in patients aged 50 years and older in the State of Nuevo León, Mexico. METHODS: Ninety-one clusters of 60 people aged 50+ were selected randomly and a rapid assessment of avoidable blindness (RAAB) was conducted. Participants had their visual acuity and cause of visual impairment assessed, underwent a random glucose test and fundoscopy under mydriasis if they had diabetes...
August 6, 2018: Ophthalmic Epidemiology
Shweta Reddy, Prity Sahay, Debananda Padhy, Sarada Sarangi, Mrutyunjay Suar, Rahul Modak, Aparna Rao
PURPOSE: Prostaglandin analogues (PGA's) are the mainstay and first line of treatment in current glaucoma practise. Though latanoprost and bimatoprost are the most commonly used PGA's with minimal side effects at lower concentrations like bimaotoprost 0.01%, direct comparison of their cytokine/MMP profile in tears has not been evaluated earlier. The study intends to ascribe PGA to the upregulation of MMPs, Cytokines and Chemokines mediating varied pathways to result in side effects of the drugs...
2018: PloS One
Syril K Dorairaj, Leonard K Seibold, Nathan M Radcliffe, Ahmad A Aref, Jesús Jimenez-Román, Gabriel S Lazcano-Gomez, Jason K Darlington, Kaweh Mansouri, John P Berdahl
INTRODUCTION: To describe the 12-month efficacy and safety of goniotomy performed using the Kahook Dual Blade (KDB) in combination with cataract surgery in eyes with medically treated open-angle glaucoma (OAG). METHODS: This was a prospective, interventional case series conducted at seven centers in North America. Consecutive patients with medically treated OAG and visually significant cataract underwent phacoemulsification combined with goniotomy (PE + goniotomy) using KDB...
August 4, 2018: Advances in Therapy
Dandan Zhang, Zhigang Fan, Xinbo Gao, Wenmin Huang, Qiongman Yang, Zhongwen Li, Mingkai Lin, Huiming Xiao, Jian Ge
This study evaluated illness uncertainty, anxiety and depression among glaucoma patients and cataract patients in China. 263 patients with primary glaucoma and 100 patients with age-related cataract were recruited sequentially from Zhongshan Ophthalmic Center between October 2013 and March 2016. All the participants completed questionnaires for socio-demographic information, Mishel Uncertainty in Illness Scale (MUIS) and Hospital Anxiety and Depression Scale (HADS). 25 of the 263 glaucoma patients and 21 of the100 cataract patients finished two copies of the same questionnaires before and after surgery...
August 3, 2018: Scientific Reports
Neelima Aron, Rajesh Sinha, Namrata Sharma, Tushar Agarwal
Iridodialysis is commonly encountered after blunt trauma to the eye. Most iris detachments are small, superior, and asymptomatic and require no surgical intervention. However, large areas of iridodialysis require early surgical repair to prevent the onset of iris necrosis, pigment dispersion, and secondary glaucoma. Suture fixation of iris to the sclera is the most commonly used method for iris repair; however, this technique becomes difficult in cases of near-total iris disinsertion, even in expert hands. We describe a case of posttraumatic near-total iris disinsertion with subluxated cataract managed with phacoemulsification and iris preservation with the help of intracameral injection of isoexpansile sulfur hexafluoride...
July 27, 2018: Journal of Cataract and Refractive Surgery
Samir Nazarali, Stephanie L Cote, Patrick Gooi
Glaucoma following penetrating keratoplasty (PKP) remains the leading cause of blindness following PKP. Patients with post-PKP glaucoma can be managed medically and surgically. Evidence studying glaucoma surgical techniques following PKP is limited, but suggests the possibility for high risk complications, including graft failure. Minimally invasive glaucoma surgeries (MIGS) offer an alternative. We report the first case of post-PKP glaucoma managed with GATT. The patient was a 33-year-old male with a history of keratoconus who underwent PKP in his right eye...
July 27, 2018: Journal of Glaucoma
Mateusz Nowak, Piotr Chaniecki, Paulina Renke, Łukasz Szmuksta, Agnieszka Ścisłowicz, Aneta Taranek, Agnieszka Mierzwińska, Michał Baćko
Congenital cataracts are lens opacities that are already present at birth or are developing in the first years of life. Treatment consists of the surgical removal of the lens. Bilateral cataract deeply impairs vision, preventing the development of physiological reflex fixation and causes the development of nystagmus about 3 months of age. This nystagmus persists even after the surgical removal of cataracts without allowing often >0,1 visual acuity despite adequate aperture correction. Intraocular lens implants in children under the age of 1 are subject to discussion...
June 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Michael Smith, Daniel Byles, Lei-Ai Lim
PURPOSE: To describe the 3-year outcomes of combined cataract surgery and 360-degree endocyclophotocoagulation (ECP) in eyes with uncontrolled glaucoma and no previous glaucoma drainage surgery. SETTING: University Hospital Eye Department, Exeter, United Kingdom. DESIGN: Retrospective case series. METHODS: The study included patients who had combined cataract surgery and 360-degree ECP. The primary outcome measure was intraocular pressure (IOP) reduction at 3 years postoperatively...
July 25, 2018: Journal of Cataract and Refractive Surgery
Preethi S Ganapathy, Careen Y Lowder, Sruthi Arepalli, Kimberly Baynes, Manshi Li, James Bena, Sunil K Srivastava
PURPOSE: Non-infectious uveitis has been treated historically with corticosteroid therapy in varying doses and routes. Triesence® , a preservative-free sterile formulation of triamcinolone acetonide, has been used in a wide spectrum of ocular pathologies, but there have been few large studies validating its dosing or detailing long-term side-effects in uveitic disease. The primary aim of this study was to describe the relative duration of action and side-effects of two doses of preservative-free intravitreal triamcinolone acetonide (PF-IVTA) in uveitis...
July 24, 2018: American Journal of Ophthalmology
Ofira Zloto, Emmanuel Schwalb
The Uveitis Glaucoma Hyphema (UGH) syndrome is a triad that in the new era of phacoemulsification cataract surgeries is considered uncommon. One of the risk factor for this complication is implant a one piece intra ocular lens in the anterior chamber. We present a case of one piece intraocular lens that was implanted in the anterior chamber and caused to UGH. The lens chafing the iris and created an unusual appearance of iris transillumination defects in the shape of intra ocular lens.
September 2018: American Journal of Ophthalmology Case Reports
Daniel Laroche, Andrea Nortey, Chester Ng
PURPOSE: We describe a novel technique comprising the use of trypan blue to confirm aqueous outflow to collector channels and aqueous veins after goniotomy with the Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA, USA). Intraocular dyes have been safely used during ophthalmic surgery to evaluate the patency of the trabecular meshwork and collector channels. Further, trypan blue has been safely used to stain the anterior capsule of the lens in cataract surgery, in order to enhance visualization for capsulorhexis; similarly, trypan blue has been safely used to stain the trabecular meshwork for enhanced visualization during glaucoma angle surgery...
July 24, 2018: Journal of Glaucoma
Paul Nderitu, Paul Ursell
PURPOSE: To devise a comprehensive cataract surgery complexity score system for the selection of appropriate cases for trainees using evidence-based, validated risk factors for posterior capsule rupture, patient-specific factors, and complexity stratification recommendations to minimize complications, optimize outcomes, and maximize patient safety. SETTING: Epsom and St. Helier University National Health Service Trust, London, United Kingdom. DESIGN: Retrospective cohort study...
June 2018: Journal of Cataract and Refractive Surgery
Joshua S Hardin, Christopher I Lee, Lydia F Lane, Christian C Hester, R Grant Morshedi
PURPOSE: Corneal hysteresis (CH) is a corneal biomechanical property measured by the ocular response analyzer (ORA). It is associated with primary open-angle glaucoma development, progression, and severity as well as intraocular pressure (IOP) measurement. Decreases in CH and changes in IOP measurements have been described for laser-assisted refractive surgery; however, patients with prior radial keratotomy (RK) have not been examined. We have performed a cohort study examining CH and intraocular pressure measurements (Goldmann applanation and ORA values including Goldmann-correlated and cornea-compensated IOP [adjusted for corneal hysteresis]) in RK patients and myopic controls with POAG...
July 23, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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