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https://www.readbyqxmd.com/read/30108546/contribution-of-neurochemical-inputs-to-the-decrease-of-motoneuron-excitability-during-non-rem-and-rem-sleep-a-systematic-review
#1
Victor B Fenik
The sleep-related depression of excitability of upper airway motoneurons is a major neurological cause of obstructive sleep apnea whereas a disruption in the inhibition of spinal motoneurons during rapid eye movement (REM) sleep causes the REM sleep behavioral disorder. The large amount of experimental data has been obtained that deal with neurochemical mechanisms that are responsible for sleep-related depression of various motoneuron groups. However, there is a disagreement regarding the outcome of these studies primarily due to the use of different animal models and approaches, as well as due to differences in quantification and interpretation of obtained results...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30098033/first-successful-mechanical-splint-for-obstructive-sleep-apnea-with-an-orally-administrable-pharyngeal-stenting-device
#2
Daniel Neu, Grégory Nawara, Johan Newell, David Bouchez, Olivier Mairesse
We report the case of obstructive sleep apnea in a 19-year-old, otherwise healthy male presenting with persistent daytime sleepiness and nonrestorative sleep after velo- and uvuloplasty. An individually tailored prototype of an orally inserted pharyngeal stenting device was proposed in the framework of a first clinical feasibility trial. The noninvasive, easily self-administered device is mounted on a simple inferior dental guard. Baseline total apnea-hypopnea index (AHI) was 15.5 and 24.4 per hour of rapid eye movement (REM) sleep...
August 10, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30093262/difference-in-severity-of-sleep-apnea-in-patients-with-rapid-eye-movement-sleep-behavior-disorder-with-or-without-parkinsonism
#3
Dae Lim Koo, Jee Young Lee, Hyunwoo Nam
OBJECTIVE: Rapid eye movement sleep behavior disorder (RBD) is a common sleep disturbance in patients with neurodegenerative disorders. We aimed to compare sleep parameters among the different types of RBD patients. METHODS: A total of 122 patients with dream enactment behavior were screened. Of these, 92 patients who were diagnosed with RBD by polysomnography were included in this study. Enrolled patients with RBD were classified into four groups based on the following diagnoses: idiopathic RBD (iRBD); RBD with Parkinson disease (PD-RBD); multiple system atrophy (MSA) with RBD (MSA-RBD); and dementia with Lewy bodies (DLB) with RBD (DLB-RBD)...
June 28, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/30050500/determinants-of-slow-wave-activity-in-overweight-and-obese-adults-roles-of-sex-obstructive-sleep-apnea-and-testosterone-levels
#4
Lisa L Morselli, Karla A Temple, Rachel Leproult, David A Ehrmann, Eve Van Cauter, Babak Mokhlesi
Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple studies have documented that SWA levels are higher in lean women, compared to age-matched lean men, but whether these differences persist in obese subjects is unclear. Obstructive sleep apnea (OSA), a condition associated with obesity, is more prevalent in men than in women...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30037585/cyclic-alternating-pattern-in-infants-with-congenital-hypothyroidism
#5
Rafael Santana-Miranda, Chiharu Murata, Oliveiro Bruni, Agostinho Rosa, Gerardo Alberto Alvarado Ruiz, Carlos Raúl Castillo Montoya, José Ángel Rojas-Zamorano, Enrique Esqueda-León, Emilio Dominguez-Salazar, Adrian Poblano, Javier Velazquez-Moctezuma
Congenital hypothyroidism is defined as thyroid hormone deficiency present at birth which is crucial for brain development. Recently, the cyclic alternating pattern, a rhythm present in electroencephalography recordings in non-Rapid eye movement sleep, has been related to brain development and cognition in different pediatric conditions. Therefore, we evaluated the cyclic alternating pattern rate in infants with congenital hypothyroidism, thyroxine supplementation, and healthy controls. The parameters of the cyclic alternating pattern were evaluated in 19 healthy infants (10 female, mean age 25...
July 20, 2018: Brain & Development
https://www.readbyqxmd.com/read/30027514/sleep-disturbances-can-be-prospectively-observed-in-patients-with-an-inactive-inflammatory-bowel-disease
#6
Ariella Bar-Gil Shitrit, Chen Chen-Shuali, Tomer Adar, Benjamin Koslowsky, Shimon Shteingart, Kalman Paz, Sorina Grisaru-Granovsky, Eran Goldin, Gali Epstein Shochet, David Shitrit
BACKGROUND: Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and inflammatory processes. Little is known about sleep disturbances in patients with inflammatory bowel disease (IBD), while not in flare, i.e., inactive. AIMS: To prospectively explore the sleep quality of patients with an inactive IBD. METHODS: This pilot study included 36 consecutive patients with IBD and 27 healthy volunteers...
July 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29993405/sleep-dependent-directional-coupling-of-cardiorespiratory-system-in-patients-with-obstructive-sleep-apnea
#7
Hee Nam Yoon, Sang Ho Choi, Hyun Bin Kwon, Sang Kyong Kim, Su Hwan Hwang, Sung Min Oh, Jae Won Choi, Yu Jin Lee, Do Un Jeong, Kwang Suk Park
OBJECTIVE: Cardiorespiratory interactions have been widely investigated in different physiological states and conditions. Various types of coupling characteristics have been observed in the cardiorespiratory system; however, it is difficult to identify and quantify details of their interaction. In this study, we investigate directional coupling of the cardiorespiratory system in different physiological states (sleep stages) and conditions, i.e., severity of obstructive sleep apnea (OSA)...
March 26, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29991423/craniofacial-phenotyping-in-chinese-and-caucasian-patients-with-sleep-apnea-influence-of-ethnicity-and-sex
#8
Kate Sutherland, Richard W W Lee, Tat On Chan, Susanna Ng, David S Hui, Peter A Cistulli
STUDY OBJECTIVES: Craniofacial abnormalities are a risk factor for obstructive sleep apnea (OSA). We have previously shown that phenotypic information derived from craniofacial photographs predict OSA in sleep clinic populations. However, there are likely ethnic and sex differences in craniofacial phenotypes related to OSA. We aimed to assess the use of craniofacial photography to identify interactions between OSA, ethnicity, and sex in craniofacial phenotype. METHODS: Frontal and profile craniofacial photographs were analyzed from two sleep clinic populations of different ethnicity (Hong Kong Chinese, Australian Caucasians)...
July 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29991418/changes-in-sleep-characteristics-and-breathing-parameters-during-sleep-in-early-and-late-pregnancy
#9
Bilgay Izci-Balserak, Brendan T Keenan, Charles Corbitt, Beth Staley, Michael Perlis, Grace W Pien
STUDY OBJECTIVES: Few studies have objectively evaluated sleep characteristics during pregnancy or investigated the relationship between altered spectral electroencephalogram (EEG) bands and sleep-disordered breathing (SDB). The study aimed to describe changes in sleep as measured by polysomnography (PSG) and spectral EEG bands during pregnancy and to examine the relationship between delta power in non-rapid eye movement (NREM) sleep and SDB. METHODS: This is a secondary analysis of a prospective study...
July 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29991414/quantitative-analysis-of-thoracoabdominal-asynchrony-in-pediatric-polysomnography
#10
Jason Z Bronstein, Li Xie, Thomas H Shaffer, Aaron Chidekel, Robert Heinle
STUDY OBJECTIVES: Objective measurements of thoracoabdominal asynchrony (TAA), such as average phase angle (θavg), can quantify airway obstruction. This study demonstrates and evaluates use of θavg for predicting obstructive sleep apnea (OSA) in pediatric polysomnography (PSG). METHODS: This prospective observational study recruited otherwise healthy 3- to 8-year-old children presenting for PSG due to snoring, behavioral problems, difficulty sleeping, and/or enlarged tonsils...
July 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29958805/sleep-characteristics-that-predict-atrial-fibrillation
#11
Matthew A Christensen, Shalini Dixit, Thomas A Dewland, Isaac R Whitman, Gregory Nah, Eric Vittinghoff, Kenneth J Mukamal, Susan Redline, John A Robbins, Anne B Newman, Sanjay R Patel, Jared W Magnani, Bruce M Psaty, Jeffrey E Olgin, Mark J Pletcher, Susan R Heckbert, Gregory M Marcus
BACKGROUND: The relationship between sleep disruption, independent of obstructive sleep apnea (OSA), and atrial fibrillation (AF) is unknown. OBJECTIVE: The purpose of this study was to determine whether poor sleep itself is a risk factor for AF. METHODS: We first performed an analysis of participants in the Health eHeart Study and validated those findings in the longitudinal Cardiovascular Health Study, including a subset of patients undergoing polysomnography...
June 20, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29936617/anti-iglon-5-disease
#12
REVIEW
Anna Heidbreder, Konstanze Philipp
PURPOSE OF REVIEW: This review aims to give an overview about the current knowledge of this novel neurological disorder associated to IgLON-5 antibodies and its treatment. RECENT FINDINGS: Anti-IgLON5 disease was first formally described in 2014. This newly discovered disorder recaps a complex neurological disorder with sleep, movement, and neuroimmunological and neurodegenerative aspects. The clinical manifestation of the anti-IgLON5 disease is very heterogeneous mostly including a sleep disorder with non-rapid eye movement (REM) sleep parasomnia and REM behavior disorder besides obstructive sleep apnea syndrome and stridor...
June 23, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29907796/a-recurrent-de-novo-missense-pathogenic-variant-in-smarcb1-causes-severe-intellectual-disability-and-choroid-plexus-hyperplasia-with-resultant-hydrocephalus
#13
Illja J Diets, Trine Prescott, Neena L Champaigne, Grazia M S Mancini, Bård Krossnes, Radek Frič, Kristina Kocsis, Marjolijn C J Jongmans, Tjitske Kleefstra
PURPOSE: SMARCB1 encodes a subunit of the SWI/SNF complex involved in chromatin remodeling. Pathogenic variants (PV) in this gene can give rise to three conditions. Heterozygous loss-of-function germline PV cause rhabdoid tumor predisposition syndrome and schwannomatosis. Missense PV and small in-frame deletions in exons 8 and 9 result in Coffin-Siris syndrome, which is characterized by intellectual disability (ID), coarse facial features, and fifth digit anomalies. METHODS: By a gene matching approach, individuals with a similar SMARCB1 PV were identified...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29902844/-the-impact-of-arousal-on-sleep-related-deglutition-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#14
Y R Li, X Ding, C Y Wang, D M Han
Objective: To investigate the sleep-related deglutition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with sleep stage and cortical arousals. Methods: From December 2015 to September 2017, simultaneous polysomnography and pharyngeal pressure monitoring were performed in 23 adult patients with OSAHS, Mann-Whitney U test were employed to analyze the following parameters: (1) the relationship between arousal and deglutition; (2) the effect of sleep stage on deglutition; (3) The relationship between the frequency of deglutition and the severity of OSAHS...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29859364/do-diurnal-cortisol-levels-mediate-the-association-between-sleep-disturbances-and-cognitive-impairment
#15
José Haba-Rubio, Sami Ouanes, Yannick Franc, Pedro Marques-Vidal, Gerard Waeber, Peter Vollenweider, Armin von Gunten, Martin Preisig, Christine Kuehner, Enrique Castelao, Raphaël Heinzer, Julius Popp
Previous research found an association between sleep disturbances and cognitive deficits on the one hand, and between increased cortisol levels and poor cognitive performance on the other hand. We hypothesized that cortisol may, at least partially, mediate the link between sleep disturbances and cognitive impairment (CI). We analyzed data from 440 nondemented subjects aged ≥65 years (72.4 ± 4.5 years old, 55.7% women) participating at the population-based CoLaus/PsyCoLaus study, who underwent cognitive evaluation, complete polysomnography and cortisol measures during the day...
September 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29798125/-relationship-of-symptoms-with-sleep-stage-abnormalities-in-obstructive-sleep-apnea-hypopnea-syndrome
#16
H J Liu, N Zhao, A F Zhang
Objective: To study the relationship between symptoms and sleep staging in OSAHS patients. Method: A cross-sectional study. Adult subjects who attended a sleep laboratory for diagnostic polysomnography for a period of 1 month were recruited consecutively.OSAHS was diagnosed using American Academy of Sleep Medicine criteria.Subjects filled a questionnaire for symptoms prior to polysomnography. Result: Thirty subjects, of whom 83.3% were obese, met diagnostic criteria, with males constituting 46.7% and females constituting 53%...
November 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29745973/the-prevalence-of-obstructive-sleep-apnea-in-patients-with-atrial-fibrillation
#17
Asmaa M Abumuamar, Paul Dorian, David Newman, Colin M Shapiro
BACKGROUND: Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play a role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine the prevalence and clinical predictors of OSA in patients with AF. HYPOTHESIS: OSA is underdiagnosed in a large number of patients with AF and may not be predicted by conventional clinical indices. METHODS: Consecutive nonselected patients with AF were recruited from different arrhythmia clinics in Toronto, Ontario, Canada...
May 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29741725/ventilatory-control-sensitivity-in-patients-with-obstructive-sleep-apnea-is-sleep-stage-dependent
#18
Shane A Landry, Christopher Andara, Philip I Terrill, Simon A Joosten, Paul Leong, Dwayne L Mann, Scott A Sands, Garun S Hamilton, Bradley A Edwards
Study Objectives: The severity of obstructive sleep apnea (OSA) is known to vary according to sleep stage; however, the pathophysiology responsible for this robust observation is incompletely understood. The objective of the present work was to examine how ventilatory control system sensitivity (i.e. loop gain) varies during sleep in patients with OSA. Methods: Loop gain was estimated using signals collected from standard diagnostic polysomnographic recordings performed in 44 patients with OSA...
May 1, 2018: Sleep
https://www.readbyqxmd.com/read/29735000/value-and-payment-in-sleep-medicine
#19
Emerson M Wickwire, Tilak Verma
Value, like beauty, exists in the eye of the beholder. This article places the value of clinical sleep medicine services in historical context and presents a vision for the value-based sleep of the future. First, the history of value and payment in sleep medicine is reviewed from the early days of the field, to innovative disruption, to the widespread adoption of home sleep apnea testing. Next, the importance of economic perspective is discussed, with emphasis on cost containment and cost-shifting between payers, employers, providers, and patients...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29734991/violent-parasomnia-with-recurrent-biting-and-surgical-interventions-case-report-and-differential-diagnosis
#20
Nilam Danish, Imran S Khawaja, Carlos H Schenck
A case is reported of recurrent, injurious self-biting during sleep, requiring surgical interventions, in a 55-year-old obese man with a 20-year history of violent complex parasomnia, with greatly increased frequency and severity of episodes induced by work stress during the preceding 3 years. After clinical evaluation and overnight, hospital-based video-polysomnography, the cause of the chronic injurious parasomnia was deemed to be a non-rapid eye movement (NREM) sleep parasomnia comorbid with severe obstructive sleep apnea...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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