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Sleep apnea eye

Jason H Mateika, Dragana Komnenov, Alexandru Pop, Donald M Kuhn
PURPOSE: We examined the impact of serotonin (5HT) on the frequency and duration of central apneic events, and the frequency of accompanying arousals, during non-rapid and rapid eye movement (NREM and REM) sleep across the light-dark cycle. METHODS: Electroencephalography, electromyography, core body temperature and activity were recorded for 24 hours following implantation of telemeters in wild type (Tph2+/+ ) and tryptophan hydroxylase 2 knockout (Tph2-/- ) male mice...
October 18, 2018: Journal of Applied Physiology
Shahrokh Javaheri, Scott W McKane, Nathan Cameron, Robin E Germany, Atul Malhotra
Study Objectives: Periodic breathing with central sleep apnea (CSA) is common in patients with left ventricular systolic dysfunction. Based on the pathophysiological mechanisms underlying CSA, we hypothesized that the frequency of CSA episodes would increase in the late hours of non-rapid eye movement (NREM) of sleep. Methods: Forty-one patients with left ventricular ejection fraction <40% underwent full-night-attended polysomnography scored by a central core lab...
October 16, 2018: Sleep
Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain, Paul Linkowski
BACKGROUND: Since few studies have investigated the risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression, the aim of this study was to examine this risk in a large sample of individuals with major depression. METHODS: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. High blood pressure status was defined by the presence of one of the following: self-reports at interview of either a physician-diagnosis or taking antihypertensive medication; or an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg during at least two medical examinations...
October 10, 2018: Clinical and Experimental Hypertension: CHE
Melinda Y Chang, John L Keltner
BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye. METHODS: We performed a retrospective chart review of patients with "ischemic optic neuropathy" (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017...
October 8, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Brendon Wong, Clare L Fraser
BACKGROUND: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. EVIDENCE ACQUISITION: We conducted a search of the literature using the Ovid Medline database and Google Scholar, focusing on articles that explored the association between OSA and ophthalmic conditions...
October 8, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Panagis Drakatos, Lucy Marples, Rexford Muza, Sean Higgins, Alexander Nesbitt, Eptehal M Dongol, Raluca Macavei, Valentina Gnoni, Laura Perez Carbonell, Iain Duncan, Adam Birdseye, Sakina Dastagir, Ivana Rosenzweig, David O'Regan, Adrian J Williams, Guy D Leschziner, Brian D Kent
Although video polysomnography (vPSG) is not routinely recommended for the evaluation of typical cases of non-rapid eye movement (NREM) parasomnias, it can aid diagnosis of unusual cases, other sleep disorders and complicated cases with REM behaviour disorder (RBD), and in differentiating parasomnias from epilepsy. In this study, we aimed to assess vPSG findings in consecutive patients with a clinical diagnosis of NREM-parasomnia covering the whole phenotypic spectrum. Five hundred and twelve patients with a final diagnosis of NREM parasomnia who had undergone vPSG were retrospectively identified...
October 8, 2018: Journal of Sleep Research
Sophie G Carter, Jayne C Carberry, Ronald R Grunstein, Danny J Eckert
Pharyngeal and oesophageal manometry is used clinically and in research to quantify respiratory effort, upper-airway mechanics and the pathophysiological contributors to obstructive sleep apnea. However, the effects of this equipment on respiratory events and sleep in obstructive sleep apnea are unclear. As part of a clinical trial (ANZCTRN12613001106729), data from 28 participants who successfully completed a physiology night with an epiglottic catheter and nasal mask followed by a standard in-laboratory polysomnography were compared...
October 1, 2018: Journal of Sleep Research
Alessandra Zanatta, Carlos Henrique Ferreira Camargo, Francisco Manoel Branco Germiniani, Salmo Raskin, Ana Chrystina de Souza Crippa, Hélio Afonso Ghizoni Teive
Spinocerebellar ataxia type 2 (SCA2) is characterized by a progressive cerebellar syndrome, and additionally saccadic slowing, cognitive dysfunction, and sleep disorders. The aim of this study was to assess the frequency of abnormal findings in sleep recordings of patients with SCA2. Seventeen patients with genetically confirmed SCA2 from the Movement Disorders Outpatient group of the Hospital de Clínicas da UFPR were evaluated with a structured medical interview and the Scale for the Assessment and Rating of Ataxia (SARA)...
September 28, 2018: Cerebellum
Irma Rukhadze, Victor B Fenik
Obstructive Sleep Apnea (OSA) is a common sleep-related respiratory disorder that is associated with cognitive, cardiovascular, and metabolic morbidities. The major cause of OSA is the sleep-related reduction of upper airway muscle tone that leads to airway obstructions in individuals with anatomically narrow upper airway. This reduction is mainly due to the suppressant effect of sleep on hypoglossal motoneurons that innervate upper airway muscles. The hypoglossal motoneurons have state-dependent activity, which is decreased during the transition from wakefulness to non-rapid eye movement sleep and is further suppressed during rapid eye movement sleep...
2018: Frontiers in Neurology
Andrew W Varga, Babak Mokhlesi
Rapid eye movement (REM) sleep was discovered nearly 60 years ago. This stage of sleep accounts for approximately a quarter of total sleep time in healthy adults, and it is mostly concentrated in the second half of the sleep period. The majority of research on REM sleep has focused on neurocognition. More recently, however, there has been a growing interest in understanding whether obstructive sleep apnea (OSA) during the two main stages of sleep (REM and non-REM sleep) leads to different cardiometabolic and neurocognitive risk...
September 19, 2018: Sleep & Breathing, Schlaf & Atmung
Raj C Dedhia, Amit J Shah, Donald L Bliwise, Arshed A Quyyumi, Patrick J Strollo, Qiao Li, Giulia Da Poian, Gari D Clifford
Objective Hypoglossal nerve stimulation represents a novel therapy for the treatment of moderate-severe obstructive sleep apnea; nonetheless, its cardiovascular effects are not known. We examine the effects of hypoglossal nerve stimulation on heart rate variability, a measure of autonomic function. Study Design Substudy of the STAR trial (Stimulation Therapy for Apnea Reduction): a multicenter prospective single-group cohort. Setting Academic and private practice centers in the United States and Europe. Subjects and Methods A subset of responder participants (n = 46) from the STAR trial was randomized to therapy withdrawal or therapy maintenance 12 months after surgery...
September 18, 2018: Otolaryngology—Head and Neck Surgery
Karri T Utriainen, Juhani K Airaksinen, Olli J Polo, Harry Scheinin, Ruut M Laitio, Kari A Leino, Tero J Vahlberg, Tom A Kuusela, Timo T Laitio
OBJECTIVE: Obstructive sleep apnea (OSA) is common in peripheral arterial disease (PAD) and associates with high mortality after surgery. Since abnormal heart rate variability (HRV) is predictive of postoperative complications, we investigated the relations of HRV with PAD, OSA and major adverse cardiovascular and cerebrovascular events (MACCE). MATERIALS AND METHODS: Seventy-five patients (67±9 years) scheduled for sub-inguinal revascularization and 15 controls (63±6 years) underwent polysomnography and HRV analyses...
2018: PloS One
Jeong-Whun Kim, Taehoon Kim, Jaeyoung Shin, Goun Choe, Hyun Jung Lim, Chae-Seo Rhee, Kyogu Lee, Sung-Woo Cho
Objectives: To develop a simple algorithm for prescreening of obstructive sleep apnea (OSA) on the basis of respiratory sounds recorded during polysomnography during all sleep stages between sleep onset and offset. Methods: Patients who underwent attended, in-laboratory, full-night polysomnography were included. For all patients, audio recordings were performed with an air-conduction microphone during polysomnography. Analyses included all sleep stages (i.e., N1, N2, N3, rapid eye movement, and waking)...
September 8, 2018: Clinical and Experimental Otorhinolaryngology
Morgane Pradines, Marc Rey, Rémy Dumas, Wadih Rhondali, Patrick Lemoine, Jean-Michel Azorin, Christian Vedie
STUDY OBJECTIVES: The aim of this study was to assess the frequency of past and current psychiatric disorders among patients referred to a sleep unit for polysomnography. METHODS: A total of 152 patients referred to the Sleep Center of Timone Hospital in Marseille were included from January 12 to March 31, 2015. Clinical data were collected using the Mini International Neuropsychiatric Interview. RESULTS: The final sample consisted of 102 patients...
September 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
K Al Oweidat, S A AlRyalat, M Al-Essa, N Obeidat
Obstructive sleep apnea (OSA) is a common disorder that includes an intermittent mechanical obstruction of the upper airway during sleep, which can occur either during rapid eye movement (REM) phase or non-REM (NREM) phase. In this study, we aim to evaluate the differences in demographic and polysomnographic features between REM- and NREM-related OSA in a Jordanian sample, using both the broad and the restricted definitions of REM-related OSA. All patients who were referred due to clinical suspicion of OSA and underwent sleep study were screened...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Dong-Mei Zhang, Xing-Long Pang, Rong Huang, Feng-Ying Gong, Xu Zhong, Yi Xiao
Objectives: Obstructive sleep apnea (OSA) is closely associated with obesity, insulin resistance, and inflammation. Adiponectin, omentin, ghrelin, and visfatin are adipokines involved in insulin sensitivity or regulation of inflammatory disease. This study aims to clarify the relationship between OSA and associated adipokines. Patients and Methods: Thirty overweight male patients with severe OSA and twenty controls underwent standard diagnostic polysomnography (PSG), and 10 patients underwent overnight continuous positive airway pressure (CPAP) treatment...
2018: BioMed Research International
Helena Martynowicz, Joanna Smardz, Tomasz Wieczorek, Grzegorz Mazur, Rafal Poreba, Robert Skomro, Marek Zietek, Anna Wojakowska, Monika Michalek, Mieszko Wieckiewicz
BACKGROUND: Sleep sex also known as sexsomnia or somnambulistic sexual behavior is proposed to be classified as NREM (non-rapid eye movement) parasomnia (as a clinical subtype of disorders of arousal from NREM sleep-primarily confusional arousals or less commonly sleepwalking), but it has also been described in relation to REM (rapid eye movement) parasomnias. METHODS: The authors searched the PubMed database to identify relevant publications and present the co-occurrence of sexsomnia and other sleep disorders as a non-systematic review with case series...
August 23, 2018: Journal of Clinical Medicine
Larissa A Habib, Kyle J Godfrey, Priya Mathews, Joaquin De Rojas, Michael Kazim
PURPOSE: To evaluate the association of risk of obstructive sleep apnea (OSA) and thyroid eye disease-compressive optic neuropathy (TED-CON). METHODS: The authors performed a retrospective observational study. All TED patients evaluated by the principal investigator over the past 5 years were screened with the snoring tired observed pressure (STOP)-Bang questionnaire to assess their risk for OSA. Patients were grouped into 2 age-matched cohorts based on the presence (TED-CON) or absence of CON...
August 21, 2018: Ophthalmic Plastic and Reconstructive Surgery
Kate B Herr, Graziella L Mann, Leszek Kubin
In both nocturnal and diurnal mammals, sleep and wake states differentially aggregate during the rest and active phases of circadian cycle. Closely associated with this rhythm are prominent changes in motor activity. Here, we quantified the magnitudes of electromyographic activity (EMG) measured separately during different sleep-wake states across the rest-activity cycle, thereby separating amplitude measurements from the known dependance of the timing of wake and sleep on the phase of circadian rest-activity cycle...
2018: Frontiers in Integrative Neuroscience
Victor B Fenik
The sleep-related depression of excitability of upper airway motoneurons is a major neurological cause of obstructive sleep apnea whereas a disruption in the inhibition of spinal motoneurons during rapid eye movement (REM) sleep causes the REM sleep behavioral disorder. The large amount of experimental data has been obtained that deal with neurochemical mechanisms that are responsible for sleep-related depression of various motoneuron groups. However, there is a disagreement regarding the outcome of these studies primarily due to the use of different animal models and approaches, as well as due to differences in quantification and interpretation of obtained results...
2018: Frontiers in Neurology
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