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Sleep apnea eye

Masahiko Ayaki, Kazuo Tsubota, Motoko Kawashima, Taishiro Kishimoto, Masaru Mimura, Kazuno Negishi
Purpose: Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis...
November 1, 2018: Investigative Ophthalmology & Visual Science
Harleen Kaur, Muhammad Umair Jahngir, Junaid H Siddiqui
Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson's disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Parasomnias can affect the quality of life of the patients as well as the night time sleep of their bed partners. Hence, it is important for physicians to recognize the occurrence of parasomnias in PD...
September 22, 2018: Curēus
Andrée-Ann Baril, Katia Gagnon, Pauline Brayet, Jacques Montplaisir, Julie Carrier, Jean-Paul Soucy, Chantal Lafond, Hélène Blais, Caroline d'Aragon, Jean-François Gagnon, Nadia Gosselin
Obstructive sleep apnea (OSA) predominantly during rapid eye movement (REM) sleep may have impacts on brain health, even in milder OSA cases. Here, we evaluated whether REM sleep OSA is associated with abnormal daytime cerebral functioning using high-resolution single-photon emission computed tomography (SPECT). We tested 96 subjects (25 F, age: 65.2 ± 6.4) with a wide range of OSA severity from no OSA to severe OSA (apnea-hypopnea index: 0-97 events/h). More respiratory events during REM sleep were associated with reduced daytime regional cerebral blood flow (rCBF) in the bilateral ventromedial prefrontal cortex and in the right insula extending to the frontal cortex...
November 22, 2018: Journal of Cerebral Blood Flow and Metabolism
K Fricke, H Schneider, P Biselli, N N Hansel, Z G Zhang, M O Sowho, L Grote
Introduction: Patients with COPD have increased respiratory loads and altered blood gases, both of which affect vascular function and sympathetic activity. Sleep, particularly rapid eye movement (REM) sleep, is known to exacerbate hypoxia and respiratory loads. Therefore, we hypothesize that nasal high flow (NHF), which lowers ventilatory loads, reduces sympathetic activity during sleep and that this effect depends on COPD severity. Methods: We performed full polysomnography in COPD patients (n=17; FEV1 , 1...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Hasim Uslu, Ayşe Yağmur Kanra, Gulgun Cetintas, Mehmet Gurkan Tatar
BACKGROUND AND OBJECTIVE: To evaluate effect of continuous positive airway pressure (CPAP) therapy on choroidal thickness in patients with obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS: Thirty distinct eyes of 30 patients with OSAS were evaluated right before and 12 months after CPAP treatment in this prospective observational study. Choroidal thickness was measured at the fovea and with periodic intervals of 500 µm from the foveal center in both temporal and nasal directions using spectral-domain optical coherence tomography in enhanced depth imaging mode...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Sara Mahvash Mohammadi, Majdi Alnowami, Sofia Khan, Derk-Jan Dijk, Adrian Hilton, Kevin Wells
Sleep is a process of rest and renewal that is vital for humans. However, there are several sleep disorders such as rapid eye movement (REM) sleep behaviour disorder (RBD), sleep apnea, and restless leg syndrome (RLS) that can have an impact on a significant portion of the population. These disorders are known to be associated with particular behaviours such as specific body positions and movements. Clinical diagnosis requires patients to undergo polysomnography (PSG) in a sleep unit as a gold standard assessment...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Nobuo Sasaki, Michiaki Nagai, Hiroyuki Mizuno, Mitsuo Kuwabara, Satoshi Hoshide, Kazuomi Kario
Research suggests that oxygen desaturation and sleep stage during obstructive sleep apnea (OSA) are related to the magnitude of high blood pressure (BP) in a laboratory setting. However, in a clinical setting, these associations have not been well studied. We used a noninvasive oscillometric BP measurement device to investigate the association between oxygen-triggered BP levels at the end of each OSA episode and the characteristics of the preceding OSA episode. In 42 newly diagnosed OSA patients (average age, 63...
November 2018: Hypertension
Amit Gupta, Timothy Roehrs, Kenneth Moss, Syed Jaffery, Luisa Bazan, Laura Spear, Larry Darnell, Thomas Roth
We report a case series of four patients where tachypnea was observed during positive airway titration studies, double the baseline breathing rate (tachypnea range 46-68 breaths/min). It happened mainly during non-rapid eye movement to rapid eye movement sleep transitions without significant changes in oxygen saturation or signs of autonomic hyperactivity such as an increased heart rate. The increased respiratory rate may be a normal physiological extreme outlier seen during phasic rapid eye movement sleep triggered by high pressure ventilation and it may also indicate underlying ventilatory instability, making patients predisposed to central sleep apnea...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Sandra Giménez, Laura Videla, Sergio Romero, Bessy Benejam, Susana Clos, Susana Fernández, Maribel Martínez, Maria Carmona-Iragui, Rosa M Antonijoan, Mercedes Mayos, Ana Fortuna, Patricia Peñacoba, Vicente Plaza, Ricardo S Osorio, Ram A Sharma, Ignasi Bardés, Anne-Sophie Rebillat, Alberto Lleó, Rafael Blesa, Sebastian Videla, Juan Fortea
STUDY OBJECTIVES: Sleep problems are often undetected in adults with Down syndrome (DS). Our objective was to determine the prevalence of sleep disorders in adults with DS through self-reported and objective sleep measures. METHODS: We performed a community-based cross-sectional study of 54 adults with DS not referred for sleep disorders. Two polysomnography (PSG) sleep studies were performed. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI); daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS) and the risk for the sleep apnea syndrome (OSA) was identified using the Berlin Questionnaire (BQ)...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Alberto G Distefano, Byron L Lam
BACKGROUND: Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic neuropathy with the exact pathophysiology unknown. Risk factors include advanced age, small optic nerve head, hypertension, diabetes mellitus, and sleep apnea.6 High altitude is considered another risk factor, although only few cases have been reported. No cases of NAION have been reported to occur during flight. CASE REPORT: A 41-yr-old male pilot presented with vision change while performing high G-force maneuvers in an A10 fighter jet...
November 1, 2018: Aerospace Medicine and Human Performance
Michelle Reid, Janice E Maras, Steven Shea, Alexis C Wood, Cecilia Castro-Diehl, Dayna A Johnson, Tianyi Huang, David R Jacobs, Allison Crawford, Marie-Pierre St-Onge, Susan Redline
Rationale: While short sleep duration has been linked to unhealthy dietary patterns, little is known about the association of obstructive sleep apnea (OSA), a disorder characterized by sleep fragmentation, and diet. Objective: Investigate associations between diet quality and OSA in the Multi-Ethnic Study of Atherosclerosis and assess whether reductions in slow wave sleep (stage N3) and rapid eye movement (REM) sleep are potential mediators for these associations...
October 22, 2018: Sleep
Jason H Mateika, Dragana Komnenov, Alexandru Pop, Donald M Kuhn
PURPOSE: We examined the impact of serotonin (5HT) on the frequency and duration of central apneic events, and the frequency of accompanying arousals, during non-rapid and rapid eye movement (NREM and REM) sleep across the light-dark cycle. METHODS: Electroencephalography, electromyography, core body temperature and activity were recorded for 24 hours following implantation of telemeters in wild type (Tph2+/+ ) and tryptophan hydroxylase 2 knockout (Tph2-/- ) male mice...
October 18, 2018: Journal of Applied Physiology
Shahrokh Javaheri, Scott W McKane, Nathan Cameron, Robin E Germany, Atul Malhotra
Study Objectives: Periodic breathing with central sleep apnea (CSA) is common in patients with left ventricular systolic dysfunction. Based on the pathophysiological mechanisms underlying CSA, we hypothesized that the frequency of CSA episodes would increase in the late hours of non-rapid eye movement (NREM) of sleep. Methods: Forty-one patients with left ventricular ejection fraction <40% underwent full-night-attended polysomnography scored by a central core lab...
October 16, 2018: Sleep
Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain, Paul Linkowski
BACKGROUND: Since few studies have investigated the risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression, the aim of this study was to examine this risk in a large sample of individuals with major depression. METHODS: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. High blood pressure status was defined by the presence of one of the following: self-reports at interview of either a physician-diagnosis or taking antihypertensive medication; or an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg during at least two medical examinations...
October 10, 2018: Clinical and Experimental Hypertension: CHE
Melinda Y Chang, John L Keltner
BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye. METHODS: We performed a retrospective chart review of patients with "ischemic optic neuropathy" (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017...
October 8, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Brendon Wong, Clare L Fraser
BACKGROUND: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. EVIDENCE ACQUISITION: We conducted a search of the literature using the Ovid Medline database and Google Scholar, focusing on articles that explored the association between OSA and ophthalmic conditions...
October 8, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Panagis Drakatos, Lucy Marples, Rexford Muza, Sean Higgins, Alexander Nesbitt, Eptehal M Dongol, Raluca Macavei, Valentina Gnoni, Laura Perez Carbonell, Iain Duncan, Adam Birdseye, Sakina Dastagir, Ivana Rosenzweig, David O'Regan, Adrian J Williams, Guy D Leschziner, Brian D Kent
Although video polysomnography (vPSG) is not routinely recommended for the evaluation of typical cases of non-rapid eye movement (NREM) parasomnias, it can aid diagnosis of unusual cases, other sleep disorders and complicated cases with REM behaviour disorder (RBD), and in differentiating parasomnias from epilepsy. In this study, we aimed to assess vPSG findings in consecutive patients with a clinical diagnosis of NREM-parasomnia covering the whole phenotypic spectrum. Five hundred and twelve patients with a final diagnosis of NREM parasomnia who had undergone vPSG were retrospectively identified...
October 8, 2018: Journal of Sleep Research
Sophie G Carter, Jayne C Carberry, Ronald R Grunstein, Danny J Eckert
Pharyngeal and oesophageal manometry is used clinically and in research to quantify respiratory effort, upper-airway mechanics and the pathophysiological contributors to obstructive sleep apnea. However, the effects of this equipment on respiratory events and sleep in obstructive sleep apnea are unclear. As part of a clinical trial (ANZCTRN12613001106729), data from 28 participants who successfully completed a physiology night with an epiglottic catheter and nasal mask followed by a standard in-laboratory polysomnography were compared...
October 1, 2018: Journal of Sleep Research
Alessandra Zanatta, Carlos Henrique Ferreira Camargo, Francisco Manoel Branco Germiniani, Salmo Raskin, Ana Chrystina de Souza Crippa, Hélio Afonso Ghizoni Teive
Spinocerebellar ataxia type 2 (SCA2) is characterized by a progressive cerebellar syndrome, and additionally saccadic slowing, cognitive dysfunction, and sleep disorders. The aim of this study was to assess the frequency of abnormal findings in sleep recordings of patients with SCA2. Seventeen patients with genetically confirmed SCA2 from the Movement Disorders Outpatient group of the Hospital de Clínicas da UFPR were evaluated with a structured medical interview and the Scale for the Assessment and Rating of Ataxia (SARA)...
September 28, 2018: Cerebellum
Irma Rukhadze, Victor B Fenik
Obstructive Sleep Apnea (OSA) is a common sleep-related respiratory disorder that is associated with cognitive, cardiovascular, and metabolic morbidities. The major cause of OSA is the sleep-related reduction of upper airway muscle tone that leads to airway obstructions in individuals with anatomically narrow upper airway. This reduction is mainly due to the suppressant effect of sleep on hypoglossal motoneurons that innervate upper airway muscles. The hypoglossal motoneurons have state-dependent activity, which is decreased during the transition from wakefulness to non-rapid eye movement sleep and is further suppressed during rapid eye movement sleep...
2018: Frontiers in Neurology
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