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Ovarian trigger

Ponsit Sathapondecha, Wilaiwan Chotigeat
In shrimp aquaculture, eyestalk ablation is the only technique that is widely used to accelerate ovarian development. Alternative methods for producing improved ovarian development in broodstock are currently being investigated. Several factors involved in the regulation of ovarian development in shrimp have been investigated. Among these factors, growth factors in the transforming growth factor beta (TGF-β) superfamily have been implicated as playing potential roles in the regulation of gonad development...
October 10, 2018: General and Comparative Endocrinology
Manon Chasles, Didier Chesneau, Chantal Moussu, Kevin Poissenot, Massimiliano Beltramo, José Alberto Delgadillo, Philippe Chemineau, Matthieu Keller
In rodents, early exposure to adult male is well known to induce an early puberty in females (Vandenbergh effect). This phenomenon has been less studied in other mammals. In goats, despite our extensive knowledge about the "male-effect" phenomenon in adults (i.e. ovulation induced by the introduction of the male during the anestrous), there are few data on the consequences of an early exposure of females to males. Here, we evaluated the puberty onset of young alpine goats when raised since weaning with intact bucks (INT), with castrated bucks (CAS) or isolated from bucks (ISOL)...
October 8, 2018: Hormones and Behavior
Minkyung Song, Tito A Sandoval, Chang-Suk Chae, Sahil Chopra, Chen Tan, Melanie R Rutkowski, Mahesh Raundhal, Ricardo A Chaurio, Kyle K Payne, Csaba Konrad, Sarah E Bettigole, Hee Rae Shin, Michael J P Crowley, Juan P Cerliani, Andrew V Kossenkov, Ievgen Motorykin, Sheng Zhang, Giovanni Manfredi, Dmitriy Zamarin, Kevin Holcomb, Paulo C Rodriguez, Gabriel A Rabinovich, Jose R Conejo-Garcia, Laurie H Glimcher, Juan R Cubillos-Ruiz
Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function1-4 . However, it remains unclear how intra-tumoral T cells integrate and interpret metabolic stress signals. Here we report that ovarian cancer-an aggressive malignancy that is refractory to standard treatments and current immunotherapies5-8 -induces endoplasmic reticulum stress and activates the IRE1α-XBP1 arm of the unfolded protein response9,10 in T cells to control their mitochondrial respiration and anti-tumour function...
October 10, 2018: Nature
Shang Li, Junyu Zhai, Jiansheng Liu, Fangfang Di, Yun Sun, Weiping Li, Zi-Jiang Chen, Yanzhi Du
BACKGROUND: The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. And the roles of EPHA7 and EPHA7-regulated pathway factors in the pathogenesis of anovulation remain to be elucidated. METHODS: We used human granulosa cells (hGCs) of PCOS and non-PCOS patients to measure EPHA7 and other target gene expressions. We performed in vitro experiments in KGN cells to verify the molecular mechanisms. Additionally, we conducted in vivo loss- and gain-of-function studies using EPHA7 shRNA lentivirus and recombinant EPHA7-Fc protein injection to identify the ovulation effects of EPHA7...
October 3, 2018: EBioMedicine
I Sfontouris, G Lainas, T Lainas, C Venetis, A Makris, B Tarlatzis, E Kolibianakis
No abstract text is available yet for this article.
October 2018: Ultrasound in Obstetrics & Gynecology
He Li, Hongying Chen, Ruli Li, Juanjuan Xin, Sisi Wu, Jie Lan, Kunyue Xue, Xue Li, Caili Zuo, Wei Jiang, Ling Zhu
Endoplasmic reticulum stress (ERS) is usually involved in tumor development and progression, and anticancer agents have recently been recognized to induce ERS. Cucurbitacin-I showed a potent anticancer action by inducing apoptosis through the inhibition of signal transducer and activator of transcription 3 pathway and triggering autophagic cell death. It is not known whether ERS mediates the cancer cell death induced by cucurbitacin-I. Here, we investigated the role of ERS in cucurbitacin-I-treated SKOV3 ovarian cancer cells and PANC-1 pancreatic cancer cells...
September 11, 2018: Journal of Cellular Biochemistry
Faguang Mu, Ting Liu, Hanrui Zheng, Xiaofang Xie, Tiantian Lei, Xia He, Suya Du, Rongsheng Tong, Yi Wang
Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Previous studies have revealed that mangiferin possesses anti‑neoplastic effects on human lung adenocarcinoma and ovarian cancer. The present study aimed to investigate the role of mangiferin in radio‑sensitivity inhuman GBM...
October 1, 2018: Oncology Reports
Ana Paula Cb Campos, Guilherme P Geber, Rodrigo Hurtado, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate COS and oocyte retrieval results in ART treatment cycles initiated at any stage of the menstrual cycle (random start) in cancer patients, who could not postpone the onset of cancer treatment. METHODS: Prospective observational study of 26 women with cancer, with an indication to start cancer treatment within the next 20 days and wishing to preserve their fertility. Ovarian stimulation started immediately with FSH followed by GnRH antagonist for pituitary suppression and GnRH agonist for oocyte maturation...
September 28, 2018: JBRA Assisted Reproduction
Giovanna Pepe, Massimo Locati, Sara Della Torre, Federica Mornata, Andrea Cignarella, Adriana Maggi, Elisabetta Vegeto
BACKGROUND: Estrogens are known to orchestrate reproductive events and to regulate the immune system during infections and following tissue damage. Recent findings suggest that, in the absence of any danger signal, estrogens trigger the physiological expansion and functional specialization of macrophages, which are immune cells that populate the female reproductive tract (FRT) and are increasingly being recognized to participate in tissue homeostasis beyond their immune activity against infections...
September 19, 2018: Human Reproduction Update
Fangfang Lang, Jinfeng Qu, Haiqin Yin, Lanyu Li, Yuanyuan Zhi, Yanping Liu, Zhenghui Fang, Enkui Hao
Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased...
September 20, 2018: Food and Chemical Toxicology
Gamze Bildik, Ceyda Acılan, Gizem Nur Sahin, Sercin Karahuseyinoglu, Ozgur Oktem
There is a controversy in literature as to whether c-Abl is crucial for the induction of TAp63-mediated apoptosis and whether that inhibition of c-Abl with imatinib, which was designed to inhibit the oncogenic kinase BCR-ABL and c-kit, protects oocytes from chemotherapy-induced apoptosis in mice. No human data are available on this issue. We therefore aimed to explore whether genomic damage induced by chemotherapy drug cisplatin activates c-Abl along with TAp63 and the inhibition of c-Abl with imatinib prevents cisplatin-induced oocyte death and follicle loss in human ovary...
September 20, 2018: Cell Death & Disease
Murat Berkkanoglu, Kevin Coetzee, Hasan Bulut, Kemal Ozgur
Ovarian torsion (OT) in IVF is rare, however, the consequences are significant, which include ovariotomy. In the present study, it was aimed for the first time to compare the incidence of OT between hCG triggered cycles with ICSI and fresh transfer and GnRH-agonist triggered cycles with the ICSI-freeze-all and frozen embryo transfer (FET). In total, 15,577 ICSI cycles performed between 2001 and 2016 were categorised into two groups (Group 1, n: 9978): cycles with controlled ovarian stimulation (COS) and hCG-triggered (Group 2, n: 5599) and COS, with GnRH-agonist only triggered and freeze-all...
September 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Clémence Delcour, Larbi Amazit, Liliana C Patino, Françoise Magnin, Jérôme Fagart, Brigitte Delemer, Jacques Young, Paul Laissue, Nadine Binart, Isabelle Beau
PURPOSE: Primary ovarian insufficiency (POI) is a frequent disorder that affects ~1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels of follicle-stimulating hormone (FSH), leads to infertility. Although various etiological factors have been described, including chromosomal abnormalities and gene variants, most cases remain idiopathic. The aim of the present study was to identify and validate functionally new sequence variants in ATG (autophagy-related genes) leading to POI...
September 17, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Lydia H Pecker, Jacqueline Y Maher, Jennie Y Law, Mary Catherine Beach, Sophie Lanzkron, Mindy S Christianson
OBJECTIVE: To highlight the risk of complications among women with sickle cell anemia (SCA) receiving fertility preservation treatment (FPT) before hematopoietic stem cell transplant (HSCT). DESIGN: Single-center case series. SETTING: Academic fertility center. PATIENT(S): Women aged 15-32 years with SCA undergoing FPT before HSCT. INTERVENTION(S): Retrospective, systematic review. MAIN OUTCOME MEASURE(S): FPT modality, SCA complications during FPT...
September 2018: Fertility and Sterility
Micah J Hill, Mae Wu Healy, Kevin S Richter, Toral Parikh, Kate Devine, Alan H DeCherney, Michael Levy, Eric Widra, George Patounakis
OBJECTIVE: To evaluate methodologies to establish abnormal progesterone (P) levels on the day of trigger for recommending freeze only cycles. DESIGN: Threshold analysis and cost analysis. SETTING: Private ART practice. PATIENT(S): Fresh autologous ART. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Live birth. RESULT(S): Fourteen established statistical methodologies for generating clinical thresholds were evaluated...
September 2018: Fertility and Sterility
Yanling Gao, Shaoyun Chen, Wenjuan Li, Huilin Wang, Kelin Xiao, Lijuan Wu, Yao Li, Huiqin Li, Hongping Li, Yuanfang Zhu
Drug-loaded phase-transformation lipid nanoparticles (NPs) combined with low-intensity focused ultrasound (LIFU) for ultrasound molecular imaging and therapy, which is a very promising drug carrier and can provide both physical and chemical therapeutics, simultaneously. We successfully prepared the paclitaxel (PTX) loaded anti-LHRHR targeted phase-transformation lipid nanoparticles (PTX-anti-LHRHR-PTNPs) for ovarian cancer in this study combined with LIFU has the following characteristics: On the one hand, it showed smaller size and greater stability than blood cells, which significantly prolonged its half-life in the body, and can actively target ovarian cancer OVCAR-3 cells, and smoothly penetrate the endothelial gap into the tumor site for specifically killing the ovarian cancer cells...
September 26, 2018: Biochemical and Biophysical Research Communications
Stéphanie Corgnac, Marie Boutet, Maria Kfoury, Charles Naltet, Fathia Mami-Chouaib
Cancer immunotherapy is aimed at stimulating tumor-specific cytotoxic T lymphocytes and their subsequent trafficking so that they may reach, and persist in, the tumor microenvironment, recognizing and eliminating malignant target cells. Thus, characterization of the phenotype and effector functions of CD8+ T lymphocytes infiltrating human solid tumors is essential for better understanding and manipulating the local antitumor immune response, and for defining their contribution to the success of current cancer immunotherapy approaches...
2018: Frontiers in Immunology
Sumana Gurunath, Sriprada Vinekar, Reeta Biliangady
We report a patient with a history of venous thrombosis following oral contraceptive pills who was planned for in vitro fertilization (IVF)-intracytoplasmic sperm injection for male factor infertility. This article discusses the mechanisms for predisposition to thrombosis during assisted reproduction in patients at high risk. Assessment of risk before commencement of treatment, use of mild stimulation, antagonist protocol, avoiding ovarian hyperstimulation, use of gonadotropin-releasing hormone agonist trigger and avoiding exposure to human chorionic gonadotropin, frozen embryo transfer in a natural cycle, single embryo transfer, avoiding multiple pregnancy, and use of prophylactic or therapeutic anticoagulation are the various risk-reduction strategies that must be adopted during IVF treatment to reduce the risk of thrombosis to that of natural conception...
April 2018: Journal of Human Reproductive Sciences
Hsin-Ling Yang, Ruei-Wan Lin, Peramaiyan Rajendran, Dony Chacko Mathew, Varadharajan Thigarajan, Chuan-Chen Lee, Chih-Jung Hsu, You-Cheng Hseu
Antrodia salmonea is well known in Taiwan as a traditional Chinese medicinal fungus and has demonstrated antioxidant, anti-inflammatory, and anticancer effects. However, the anticancer activity of A. salmonea against human ovarian cancer is still elusive. Therefore, we investigated the antiovarian tumor activity of a fermented culture broth of A. salmonea and exhibits its underlying molecular mechanism. A. salmonea shows a significant effect on cell viability in human ovarian carcinoma (SKOV-3 or A2780) cell lines with an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
August 26, 2018: Journal of Cellular Physiology
Vilawan Payon, Chanaporn Kongsaden, Wannarasmi Ketchart, Apiwat Mutirangura, Piyanuch Wonganan
Cepharanthine (CEP), a medicinal product derived from Stephania cephalantha Hayata, possesses a potent cytotoxicity against several types of cancers. Recently, we have found that CEP could efficiently inhibit the growth of mutated p53 colon cancer cells, which are often resistant to commonly used chemotherapeutic agents. In this study, we evaluated the cytotoxic effect and the underlying mechanisms of CEP on both chemosensitive CaOV-3 and chemoresistant OVCAR-3 ovarian cancer cell lines. The present study demonstrated that CEP significantly inhibited the growth of CaOV-3 and OVCAR-3 cells in a time- and concentration-dependent manner...
August 24, 2018: Planta Medica
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