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https://www.readbyqxmd.com/read/30091425/corrigendum-expanded-curb-65-a-new-score-system-predicts-severity-of-community-acquired-pneumonia-with-superior-efficiency
#1
Jin-Liang Liu, Feng Xu, Hui Zhou, Xue-Jie Wu, Ling-Xian Shi, Rui-Qing Lu, Alessio Farcomeni, Mario Venditti, Ying-Li Zhao, Shu-Ya Luo, Xiao-Jun Dong, Marco Falcone
This corrects the article DOI: 10.1038/srep22911.
August 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30078018/a-novel-tumor-suppressor-cdh18-inhibits-glioma-cell-invasiveness-via-uqcrc2-and-correlates-with-the-prognosis-of-glioma-patients
#2
Ya-Hui Bai, Yun-Bo Zhan, Bin Yu, Wei-Wei Wang, Li Wang, Jin-Qiao Zhou, Ruo-Kun Chen, Feng-Jiang Zhang, Xin-Wei Zhao, Wen-Chao Duan, Yan-Min Wang, Jun Liu, Jian-Ji Bao, Zhen-Yu Zhang, Xian-Zhi Liu
BACKGROUND/AIMS: CDH18 (cadherin 18) is specifically expressed in the central nervous system and associated with various neuropsychiatric disorders. In this study, the role of CDH18 in glioma carcinogenesis and progression was investigated. METHODS: The expression of CDH18 and its prognostic value in patients with gliomas were analyzed in public database and validated by real-time PCR/immunohistochemical staining (IHC) in our cohort. CCK-8 assay, transwell migration assay, wound healing assay, clonogenic assay and tumorigenicity assay were used to compare the proliferation, invasion and migration ability of glioma cells with different expressions of CDH18...
August 3, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30074071/physiological-clearance-of-tau-in-the-periphery-and-its-therapeutic-potential-for-tauopathies
#3
Jun Wang, Wang-Sheng Jin, Xian-Le Bu, Fan Zeng, Zhi-Lin Huang, Wei-Wei Li, Lin-Lin Shen, Zhen-Qian Zhuang, Yuqiang Fang, Bin-Lu Sun, Jie Zhu, Xiu-Qing Yao, Gui-Hua Zeng, Zhi-Fang Dong, Jin-Tai Yu, Zhian Hu, Weihong Song, Hua-Dong Zhou, Jian-Xin Jiang, Yu-Hui Liu, Yan-Jiang Wang
Accumulation of pathological tau is the hallmark of Alzheimer's disease and other tauopathies and is closely correlated with cognitive decline. Clearance of pathological tau from the brain is a major therapeutic strategy for tauopathies. The physiological capacity of the periphery to clear brain-derived tau and its therapeutic potential remain largely unknown. Here, we found that cisterna magna injected 131 I-labelled synthetic tau dynamically effluxed from the brain and was mainly cleared from the kidney, blood, and liver in mice; we also found that plasma tau levels in inferior vena cava were lower than those in femoral artery in humans...
August 3, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/30023877/laser-induced-antibacterial-activity-of-novel-symmetric-carbazole-based-ethynylpyridine-photosensitizers
#4
Lin-Lin Chen, Mei-Ling Zheng, Yong-Chao Zheng, Feng Jin, Qian-Qian Chai, Yuan-Yuan Zhao, Xian-Wei Meng, Yan-Hong Liu, Xuan-Ming Duan
In this study, two kinds of novel carbazole-based ethynylpyridine salts: 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-pentyl-carbazole diiodide (BMEPC) and 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-methyl-carbazole diiodide (BMEMC) have been employed as photosensitizers owing to their excellent antibacterial activity. These molecules possess symmetric A-π-D-π-A-type structures, which would bring in the unique optical properties. The inhibition zone measurement of a gradient concentration from 0 to 100 μM showed BMEPC and BMEMC photoinduced antibacterial activity against Escherichia coli ...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/30016664/characterization-and-molecular-basis-for-the-block-of-kv1-3-channels-induced-by-carvedilol-in-hek293-cells
#5
Jin-Feng Yang, Neng Cheng, Sheng Ren, Xiang-Ming Liu, Xian-Tao Li
Carvedilol is a non-selective β-adrenoreceptor antagonist and exhibits a wide range of biological activities. The voltage-gated K+ (Kv) channel is one of the target ion channels of this compound. The rapidly activating Kv1.3 channel is expressed in several different tissues and plays an important role in the regulation of physiological functions, including cell proliferation and apoptosis. However, little is known about the possible action of carvedilol on Kv1.3 currents. Using the whole-cell configuration of the patch-clamp technique, we have revealed that exposure to carvedilol produced a concentration-dependent blocking of Kv1...
July 26, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30008921/color-doppler-ultrasound-and-contrast-enhanced-ultrasound-in-the-diagnosis-of-lacrimal-apparatus-tumors
#6
Ying-Xian Liu, Yan Liu, Jin-Mei Xu, Qin Chen, Wen Xiong
Color Doppler ultrasound and contrast-enhanced ultrasound (CEUS) in the diagnosis of lacrimal apparatus tumors were investigated. In total, 48 patients undergoing preoperative two-dimensional and color Doppler ultrasound and CEUS examinations were included in this study. Conventional ultrasound and CEUS characteristics of 48 patients pathologically and clinically diagnosed with lacrimal apparatus tumors were retrospectively analyzed. Results of conventional ultrasound of 29 cases with pleomorphic adenoma of lacrimal gland showed moderate-hypoechogenic solid masses in lacrimal gland; CEUS displayed two enhancement modes: High, fast-developed slow-extinct and overall uniform enhancement (20/29, 68...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/29974708/-spatiotemporal-dynamics-and-driving-forces-of-soil-bacterial-communities-on-the-dam-of-shibahe-copper-mine-tailings-in-shanxi-china
#7
Cui Li, Ju Hui Jing, Jin Xian Liu, Bao Feng Chai
The maintaining mechanism of community diversity is the core of community ecology. The mine tailing is a good field for studying on the underlying mechanism of community diversity, as a kind of original bare land with heavy metal pollution, where the physicochemical characteristics of soil change with the restoration periods. We examined the driving forces for bacterial community diversity based on the investigation of edaphic factors, plant community, and bacterial communities in Shibahe copper mine tailing, Shanxi...
June 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29970965/cancer-risk-assessment-in-modern-radiotherapy-workflow-with-medical-big-data
#8
REVIEW
Fu Jin, Huan-Li Luo, Juan Zhou, Ya-Nan He, Xian-Feng Liu, Ming-Song Zhong, Han Yang, Chao Li, Qi-Cheng Li, Xia Huang, Xiu-Mei Tian, Da Qiu, Guang-Lei He, Li Yin, Ying Wang
Modern radiotherapy (RT) is being enriched by big digital data and intensive technology. Multimodality image registration, intelligence-guided planning, real-time tracking, image-guided RT (IGRT), and automatic follow-up surveys are the products of the digital era. Enormous digital data are created in the process of treatment, including benefits and risks. Generally, decision making in RT tries to balance these two aspects, which is based on the archival and retrieving of data from various platforms. However, modern risk-based analysis shows that many errors that occur in radiation oncology are due to failures in workflow...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29965007/-driving-factors-of-the-dynamics-of-microbial-community-in-a-dam-of-copper-mine-tailings
#9
Cui Li, Ju-Hui Jing, Jin-Xian Liu, Bao-Feng Chai
The relative importance of the deterministic versus stochastic processes underlying community dynamics has long been a central theme in community ecology, and is intensively debated in the field. Microbial communities play key roles in nutrient cycling and the flow of energy in ecosystems. The research on the structural dynamics of microbial community will provide data and theoretical support for understanding the assembly mechanisms of community, and for predicting the dynamics of microbial community under environmental stress...
April 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/29956500/a-regulatory-mutant-on-trim26-conferring-the-risk-of-nasopharyngeal-carcinoma-by-inducing-low-immune-response
#10
Xiao-Ming Lyu, Xiao-Wei Zhu, Manli Zhao, Xian-Bo Zuo, Zhong-Xi Huang, Xiao Liu, Tao Jiang, Xue-Xi Yang, Xin Li, Xiao-Bing Long, Jian-Guo Wang, Jin-Bang Li, Ming-Yu Han, Shuang Wang, Teng-Fei Liu, Bo Zhang, Tao Sun, Zhi Cheng, Mo-Chang Qiu, Lei Dong, Lu Zheng, Long-Cheng Zhang, Jia-Hong Wang, Gan-Guan Wei, Kaitai Yao, Qian Wang, Hou-Feng Zheng, Xin Li
The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. We conducted a targeted MHC sequencing in 40 Cantonese NPC patients followed by a two-stage replication in 1065 NPC cases and 2137 controls of Southern Chinese descendent. Quantitative RT-PCR analysis (qRT-PCR) was used to detect gene expression status in 108 NPC and 43 noncancerous nasopharyngeal (NP) samples...
June 28, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29956105/clinical-research-on-alzheimer-s-disease-progress-and-perspectives
#11
REVIEW
Bin-Lu Sun, Wei-Wei Li, Chi Zhu, Wang-Sheng Jin, Fan Zeng, Yu-Hui Liu, Xian-Le Bu, Jie Zhu, Xiu-Qing Yao, Yan-Jiang Wang
Alzheimer's disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease...
June 28, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29946168/author-correction-the-evolutionary-history-of-vertebrate-rna-viruses
#12
Mang Shi, Xian-Dan Lin, Xiao Chen, Jun-Hua Tian, Liang-Jun Chen, Kun Li, Wen Wang, John-Sebastian Eden, Jin-Jin Shen, Li Liu, Edward C Holmes, Yong-Zhen Zhang
Change history: In this Article, author Li Liu should be associated with affiliation number 5 (College of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong, China), rather than affiliation number 4 (Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, China). This has been corrected online.
June 26, 2018: Nature
https://www.readbyqxmd.com/read/29943223/inhibition-of-endoplasmic-reticulum-stress-by-intermedin1-53-attenuates-angiotensin-ii-induced-abdominal-aortic-aneurysm-in-apoe-ko-mice
#13
Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Qing Zhu, Jin-Ling Ren, Yan-Rong Yu, Xiu-Ying Liu, Xiu-Jie Wang, Mei Han, Qing Jing, Jie Du, Chao-Shu Tang, Yong-Fen Qi
Endoplasmic reticulum stress (ERS) is involved in the development of abdominal aortic aneurysm (AAA). Since bioactive peptide intermedin (IMD)1-53 protects against AAA formation, here we investigated whether IMD1-53 attenuates AAA by inhibiting ERS. AAA model was induced by angiotensin II (AngII) in ApoE KO mouse background. AngII-treated mouse aortas showed increased ERS gene transcription of caspase12, eukaryotic translation initiation factor 2a (eIf2a) and activating transcription factor 4(ATF4).The protein level of ERS marker glucose regulated protein 94(GRP94), ATF4 and C/EBP homologous protein 10(CHOP) was also up-regulated by AngII...
June 26, 2018: Endocrine
https://www.readbyqxmd.com/read/29926990/a-simply-modified-lymphocyte-for-systematic-cancer-therapy
#14
Di-Wei Zheng, Jin-Xuan Fan, Xin-Hua Liu, Xue Dong, Pei Pan, Lu Xu, Xian-Zheng Zhang
Cytotherapy has received considerable attention in the field of cancer therapy, and various chemical or genetic methods have been applied to remold natural cells for improved therapeutic outcome of cytotherapy. A simple method to modify lymphocytes for cancer treatment by using a clinically used molecule, δ-aminolevulinic acid (δ-ALA), is reported here. After incubation with this molecule, tumor-targeted lymphocytes spontaneously synthesize anti-neoplastic drug protoporphyrin X (PpIX), and specifically accumulate in cancer tissue...
June 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29926657/-effects-of-soybean-isoflavones-on-the-energy-metabolism-of-swimming-mice
#15
Bing-Nan Deng, Jing-Ran Sun, Hong Jin, Hong-Jing Nie, Rui-Feng Duan, Lie Liu, Zhi-Xian Gao, Zhao-Li Chen
OBJECTIVE: To establish an animal model for loaded swimming, so as to investigate the energy metabolism effects of soybean isoflavones (SI) on swimming mice. METHODS: Thirty male Kunming mice were randomly divided into three groups:normal control, swimming group, and swimming+SI group. The normal control group mice were fed a basic AIN-93M diet, the SI groups were supplied with soybean isoflavones(4 g/kg).Two weeks later, the mice were forced to swim for an hour,and then all the mice were killed, the samples of blood, liver and muscles of hind were collected...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29897018/predicting-malignancy-in-thyroid-nodules-radiomics-score-versus-2017-american-college-of-radiology-thyroid-imaging-reporting-and-data-system
#16
Jinyu Liang, Xiaowen Huang, Hangtong Hu, Yihao Liu, Qian Zhou, Qinghua Cao, Wei Wang, Baoxian Liu, Yanling Zheng, Xin Li, Xiaoyan Xie, Mingde Lu, Sui Peng, Longzhong Liu, Haipeng Xiao
BACKGROUND: Visual interpretation of ultrasound (US) images alone may not be sensitive enough to detect important features of potentially malignant thyroid nodules. The aim of this study was to develop a radiomics score using US imaging to predict the probability for malignancy of thyroid nodules as compared with the Thyroid Imaging, Reporting, and Data System (TI-RADS) scoring criteria proposed by the American College of Radiology (ACR). METHODS: One hundred thirty-seven pathologically proven thyroid nodules from hospital 1 were enrolled as a training cohort, while 95 nodules from hospital 2 served as the validation cohort...
August 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29882235/a-multifunctional-biomimetic-nanoplatform-for-relieving-hypoxia-to-enhance-chemotherapy-and-inhibit-the-pd-1-pd-l1-axis
#17
Mei-Zhen Zou, Wen-Long Liu, Chu-Xin Li, Di-Wei Zheng, Jin-Yue Zeng, Fan Gao, Jing-Jie Ye, Xian-Zheng Zhang
Hypoxia is reported to participate in tumor progression, promote drug resistance, and immune escape within tumor microenvironment, and thus impair therapeutic effects including the chemotherapy and advanced immunotherapy. Here, a multifunctional biomimetic core-shell nanoplatform is reported for improving synergetic chemotherapy and immunotherapy. Based on the properties including good biodegradability and functionalities, the pH-sensitive zeolitic imidazolate framework 8 embedded with catalase and doxorubicin constructs the core and serves as an oxygen generator and drug reservoir...
July 2018: Small
https://www.readbyqxmd.com/read/29867188/the-prongf-p75ntr-pathway-induces-tau-pathology-and-is-a-therapeutic-target-for-ftld-tau
#18
Lin-Lin Shen, Noralyn B Mañucat-Tan, Shi-Hao Gao, Wei-Wei Li, Fan Zeng, Chi Zhu, Jun Wang, Xian-Le Bu, Yu-Hui Liu, Chang-Yue Gao, Zhi-Qiang Xu, Larisa Bobrovskaya, Peng Lei, Jin-Tai Yu, Weihong Song, Hua-Dong Zhou, Xiu-Qing Yao, Xin-Fu Zhou, Yan-Jiang Wang
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin receptor p75NTR plays a critical role in the pathogenesis of FTLD-tau. The expression of p75NTR and the precursor of nerve growth factor (proNGF) were increased in the brains of FTLD-tau patients and mice (P301L transgenic). ProNGF-induced tau phosphorylation via p75NTR in vitro, which was associated with the AKT/glycogen synthase kinase (GSK)3β pathway...
June 4, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29860266/quinalizarin-induces-apoptosis-through-reactive-oxygen-species-ros-mediated-mitogen-activated-protein-kinase-mapk-and-signal-transducer-and-activator-of-transcription-3-stat3-signaling-pathways-in-colorectal-cancer-cells
#19
Ling-Qi Meng, Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Chang Liu, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Nan-Zhu Fang, Cheng-Hao Jin
BACKGROUND Quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) exhibits potentially useful anticancer effects by inducing apoptosis in several types of cancer, but its underlying mechanism of action remains unknown. The present study examined the effects of quinalizarin on the induction of cell cycle arrest, apoptosis, the generation of reactive oxygen species (ROS), other underlying mechanisms, and its role in modifying colorectal cancer cell lines. MATERIAL AND METHODS The MTT assay was used to evaluate the viability of SW480 and HCT-116 cells that had been treated with quinalizarin and 5-fluorouracil (5-FU)...
June 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29845233/matrine-exerts-inhibitory-effects-in-melanoma-through-the-regulation-of-mir-19b-3p-pten
#20
Yan Ping Wei, Xiang Hua Wang, Gang Liu, Jin Feng Zhang, Yong Xian Yang, Juan Zhang, Xiao Li Song, Zhong Dong Li, Lin Dong Zhao
Matrine, one of the main alkaloid components extracted from the traditional Chinese herb, Sophora flavescens Ait, has various pharmacological effects, and has been reported to exert antitumor activity in melanoma. In the current study, the molecular mechanisms underlying the inhibitory effects of matrine were investigated in melanoma cell line. It was initially confirmed that matrine inhibited proliferation, invasion and induced apoptosis in human A375 and SK-MEL-2 melanoma cell lines in vitro. Subsequently, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis demonstrated that the expression of microRNA (miR)-19b-3p was significantly increased in melanoma cells and was downregulated by treatment with matrine...
August 2018: International Journal of Oncology
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