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https://www.readbyqxmd.com/read/30302639/aso-author-reflections-contact-between-t-and-n-classifications-in-pancreatic-neuroendocrine-neoplasms
#1
Jin-Zhi Xu, Wen-Quan Wang, Liang Liu, Xian-Jun Yu
No abstract text is available yet for this article.
October 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30302273/abnormal-gametogenesis-induced-by-p53-deficiency-promotes-tumor-progression-and-drug-resistance
#2
Chunfang Liu, Zhen Cai, Guoxiang Jin, Danni Peng, Bo-Syong Pan, Xian Zhang, Fei Han, Xiaohong Xu, Hui-Kuan Lin
The century-old embryonal/gametogenesis hypothesis of tumors could link diverse tumors' malignant features together likely representing the real "stemness" of tumors. However, the genetic evidence to validate abnormal gametogenesis in tumors remains lacking. Here we show that p53 deficiency elicits abnormal gametogenesis from primordial germ cell-like stage to late oocyte-like stage and subsequent parthenogenetic activation. The similar upregulation of abnormal gametogenesis by p53 deficiency is observed both in p53-/- mouse model and cultured cancer cells...
2018: Cell Discovery
https://www.readbyqxmd.com/read/30291575/three-dimensional-sonographic-minute-structure-analysis-of-fetal-cerebellar-vermis-development-and-malformations-utilizing-volume-contrast-imaging
#3
Jing-Xian Xie, Jian-Hong You, Xiao-Kang Chen, Yi-Ming Su, Jin-Rong Liu, Shan-Shan Su, Min Hou, Guo-Rong Lv
PURPOSE: To obtain three-dimensional ultrasonic (3D US) structural details and biometrics of the fetal cerebellar vermis and evaluate the value of developmental and malformation identification. METHODS: The 3D US minute structure of the fetal cerebellar vermis in mid-sagittal view was detected in normal fetuses (n = 438; 16-41 weeks). Biometric sizes were measured to establish the stage-specific norms and reproducibility analysis. Additionally, 28 fetuses with suspected abnormal posterior fossa contents were assessed to analyze the clinical value...
October 5, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/30281927/b-cell-lymphoma-2-like-protein-12-association-with-t-helper-2-inflammation-in-chronic-rhinosinusitis-with-allergy
#4
Yun-Fang An, Yong-Jin Wu, Xian-Hai Zeng, Li-Juan Song, Fei Ma, Wen-Jing Liao, Zhi-Qiang Liu, Gui Yang, Xiao-Wen Zhang, Zhi-Gang Liu, Chang-Qing Zhao, Ping-Chang Yang
BACKGROUND: T-helper 2 (Th2) polarization plays a critical role in the pathogenesis of chronic rhinosinusitis (CRS) with accompanying nasal allergy. Recent studies indicate that B cell lymphoma-2-like protein-12 (Bcl2L12) is associated with immune dysregulation. The purpose of this study was to elucidate the role of Bcl2L12 in the pathogenesis of Th2 polarization of CRS patients. METHODS: CRS patients with nasal allergy (CRSa) and without nasal allergy (CRSna) were recruited into this study...
October 3, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30280037/tumor-preventing-activity-of-aspirin-in-multiple-cancers-based-on-bioinformatic-analyses
#5
Diangeng Li, Peng Wang, Yi Yu, Bing Huang, Xuelin Zhang, Chou Xu, Xian Zhao, Zhiwei Yin, Zheng He, Meiling Jin, Changting Liu
Background: Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding its mechanism in different biological systems. Methods: The Drugbank and STITCH databases were used to find direct protein targets (DPTs) of aspirin. The Mentha database was used to analyze protein-protein interactions (PPIs) to find DPT-associated genes...
2018: PeerJ
https://www.readbyqxmd.com/read/30271504/the-significance-of-liquid-biopsy-in-pancreatic-cancer
#6
REVIEW
Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer. The 5-year survival rate for PDAC remains low because it is always diagnosed at an advanced stage and it is resistant to therapy. A biomarker, which could detect asymptomatic premalignant or early malignant tumors and predict the response to treatment, will benefit patients with PDAC. However, traditional biopsy has its limitations. There is an urgent need for a tumor biomarker that could easily and repeatedly sample and monitor, in real time, the progress of tumor development...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30267683/two-likely-auto-tetraploidization-events-shaped-kiwifruit-genome-and-contributed-to-establishment-of-the-actinidiaceae-family
#7
Jin-Peng Wang, Ji-Gao Yu, Jing Li, Peng-Chuan Sun, Li Wang, Jia-Qing Yuan, Fan-Bo Meng, Sang-Rong Sun, Yu-Xian Li, Tian-Yu Lei, Yu-Xin Pan, Wei-Na Ge, Zhen-Yi Wang, Lan Zhang, Xiao-Ming Song, Chao Liu, Xue-Qian Duan, Shao-Qi Shen, Yang-Qin Xie, Yue Hou, Jin Zhang, Jian-Yu Wang, Xiyin Wang
The genome of kiwifruit (Actinidia chinensis) was sequenced previously, the first in the Actinidiaceae family. It was shown to have been affected by polyploidization events, the nature of which has been elusive. Here, we performed a reanalysis of the genome and found clear evidence of 2 tetraploidization events, with one occurring ∼50-57 million years ago (Mya) and the other ∼18-20 Mya. Two subgenomes produced by each event have been under balanced fractionation. Moreover, genes were revealed to express in a balanced way between duplicated copies of chromosomes...
September 28, 2018: iScience
https://www.readbyqxmd.com/read/30265911/perceived-stress-and-depression-amongst-older-stroke-patients-sense-of-coherence-as-a-mediator
#8
Li-Na Guo, Yan-Jin Liu, Jacqueline McCallum, Ulrika Söderhamn, Xian-Fei Ding, Su-Yuan Yv, Yi-Ru Zhu, Yv-Ru Guo
OBJECTIVE: This study aimed to explore the relationship between perceived stress, sense of coherence, and depression among older stroke patients. METHODS: A demographic questionnaire, the Perceived Stress Scale (PSS), the Sense of Coherence Scale (SOC) and the Center for Epidemiologic Studies Depression Scale (CES-D) were distributed to 3000 older stroke patients from Neurology wards in six large general hospitals, and 2907 individuals completed the survey. Data analysis consisted of correlation, multiple linear regression, and structural equation modeling...
August 25, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/30241478/tem8-functions-as-a-receptor-for-upa-and-mediates-upa-stimulated-egfr-phosphorylation
#9
Lian-Cheng Zhang, Yong Shao, Li-Hua Gao, Jin Liu, Yong-Yi Xi, Yin Xu, Chutse Wu, Wei Chen, Hui-Peng Chen, You-Liang Wang, Hai-Feng Duan, Xian-Wen Hu
BACKGROUND: TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unknown. RESULTS: Here we identified uPA as an interacting partner of TEM8. Binding of uPA stimulated the phosphorylation of TEM8 and augmented phosphorylation of EGFR and ERK1/2. Finally, TEM8-Fc, a recombinant fusion protein comprising the extracellular domain of human TEM8 linked to the Fc portion of human IgG1, efficiently abrogated the interaction between uPA and TEM8, blocked uPA-induced migration of HepG2 cells in vitro and inhibited the growth and metastasis of human MCF-7 xenografts in vivo...
September 21, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/30240912/the-effect-of-hengduan-mountains-region-hmr-uplift-to-environmental-changes-in-the-hmr-and-its-eastern-adjacent-area-tracing-the-evolutionary-history-of-allium-section-sikkimensia-amaryllidaceae
#10
Chuan Xie, Deng-Feng Xie, Yan Zhong, Xian-Lin Guo, Qing Liu, Song-Dong Zhou, Xing-Jin He
Exploring the effects of orographic events and climatic shifts on geographic distribution of organism in the Hengduan Mountains Region (HMR) and its eastern adjacent area is crucial to the understanding of the environmental changes to organismal evolution. To gain further insight into these processes, we reconstruct evolutionary history of ten species in Allium section Sikkimensia, distributed across regions abovementioned. Using chloroplast and nuclear sequence variation of 79 populations of these ten Allium species with known morphological preferences, we elucidate the phylogenetic relationship, divergence time, ancestral area and genetic structures...
September 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/30222185/the-compound-2-naphthalene-2-thio-5-8-dimethoxy-1-4-naphthoquinone-induces-apoptosis-via-reactive-oxygen-species-regulated-mitogen-activated-protein-kinase-protein-kinase-b-and-signal-transducer-and-activator-of-transcription-3-signaling-in-human-gastric-cancer
#11
Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling-Qi Meng, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Long-Kui Cao, Cheng-Hao Jin
Hit, Lead & Candidate Discovery It is reported that 1,4-naphthoquinones and their derivatives have potent antitumor activity in various cancers, although their clinical application is limited by observed side effects. To improve the therapeutic efficacy of naphthoquinones in the treatment of cancer and to reduce side effects, we synthesized a novel naphthoquinone derivative, 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone (NTDMNQ). In this study, we explored the effects of NTDMNQ on apoptosis in gastric cancer cells with a focus on reactive oxygen species (ROS) production...
September 17, 2018: Drug Development Research
https://www.readbyqxmd.com/read/30217509/bcl2l12-mediates-effects-of-protease-activated-receptor-2-on-the-pathogenesis-of-th2-dominated-responses-of-patients-with-ulcerative-colitis
#12
Bai-Sui Feng, Yong-Jin Wu, Xian-Hai Zeng, Dian Yu, Zhi-Qiang Liu, Cai-Jie Zhou, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
The immune dysregulation plays an important role in the pathogenesis of ulcerative colitis (UC). Bcl2 like protein-12 (Bcl2L12) and mast cells are involved in immune dysregulation of UC. This study aims to elucidate the role of Bcl2L12 in the contribution to the pathogenesis of T helper (Th)2-biased inflammation in UC patients. The results showed that Bcl2L12 was expressed by peripheral CD4+ T cells that was associated with Th2 polarization in UC patients. Bcl2L12 mediated the protease-activated receptor-2 (PAR2)-induced IL-4 expression in CD4+ cells...
September 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30215286/effects-of-brain-temperature-on-the-outcome-of-patients-with-traumatic-brain-injury-a-prospective-observational-study
#13
Wei-Ji Weng, Chun Yang, Xian-Jian Huang, Yong-Ming Zhang, Jin-Fang Liu, Jie-Min Yao, Zi-Heng Zhang, Xue-Song Wu, Tao Mei, Chuan-Dong Zhang, Jun Jia, Xiao-Feng Shi, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang
A prospective observational study collected temperature data from 51 patients in 11 neurosurgical centers and follow-up outcome information at 6 months in 49 patients. Brain temperature (Tbr ) was measured directly by an intraventricular temperature sensor. Axillary temperature (Tax ) and rectal temperature (Tre ) were measured by electric thermometers. Tbr was 0.4 to 1.5°C higher than body temperature. Tre correlated well with the Tbr (coefficient: 0.7378; p < 0.05). Among all patients, Glasgow Coma Scale (GCS) scores on admission were significantly lower in the patients with post-operatively extreme peak temperature (Tpeak , < 37°C or >39°C in first 24 h) and major temperature variation (Tvari > 1°C in first 12 h; p < 0...
October 10, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30198395/security-and-radical-assessment-in-open-laparoscopic-robotic-colorectal-cancer-surgery-a-comparative-study
#14
Shuai-Xi Yang, Zhen-Qiang Sun, Quan-Bo Zhou, Ji-Zhong Xu, Yuan Chang, Kun-Kun Xia, Gui-Xian Wang, Zhen Li, Jun-Min Song, Zhi-Yong Zhang, Wei-Tang Yuan, Jin-Bo Liu
PURPOSE: This retrospective study was designed to assess the safety and effectiveness of open, laparoscopic, robotic colorectal cancer surgery. METHODS: Three hundred patients with colorectal cancer who underwent curative resection in the First Affiliated Hospital of Zhengzhou University between February 2014 and May 2016 were included. Patients were classified into open surgery group, laparoscopic surgery group, and robot-assisted group. RESULTS: The blood loss in laparoscopic surgery group was less than that in open surgery group, and the blood loss in robot-assisted group less was than the open surgery group...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/30196291/novel-polysaccharide-h-1-2-from-pseudostellaria-heterophylla-alleviates-type-2-diabetes-mellitus
#15
Zhao-Hui Fang, Xian-Chun Duan, Jin-Dong Zhao, Yuan-Jie Wu, Meng-Meng Liu
BACKGROUND/AIMS: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms. METHODS: Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. The direct binding of HIF1α on Sirt1 promoter was validated by ChIP assay. The inhibitory regulation of Sirt1 by HIF1α was analyzed using luciferase reporter assay...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30171511/tumor-infiltrating-platelets-predict-postsurgical-survival-in-patients-with-pancreatic-ductal-adenocarcinoma
#16
Shi-Rong Zhang, Lie Yao, Wen-Quan Wang, Jin-Zhi Xu, Hua-Xiang Xu, Wei Jin, He-Li Gao, Chun-Tao Wu, Zi-Hao Qi, Hao Li, Shuo Li, Quan-Xing Ni, Xian-Jun Yu, De-Liang Fu, Liang Liu
BACKGROUND: Platelets are believed to promote tumor growth and metastasis in several tumor types. The prognostic role of blood platelets in pancreatic ductal adenocarcinoma (PDAC) remains controversial, and the prognostic value of tumor-infiltrating platelets (TIPs) remains unknown. METHODS: A total of 303 patients who underwent curative pancreatectomy for PDAC were enrolled from two independent centers in China and divided into three cohorts. Paired preoperative blood samples and surgical specimens from all patients were analyzed...
August 31, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30169494/ultrasound-combined-with-microbubbles-increase-the-delivery-of-doxorubicin-by-reducing-the-interstitial-fluid-pressure
#17
Nina Xiao, Jianhua Liu, Lianlian Liao, Jimei Sun, Wenhui Jin, Xian Shu
The aims of this study were to determine the change of interstitial fluid pressure (IFP) after therapy using pulsed low-frequency ultrasound combined with microbubbles and to determine the change of doxorubicin penetration in VX2 tumor. In this study, all 48 tumor-bearing rabbits were divided randomly into 6 groups (n = 8 per group). These 6 groups include doxorubicin therapy together with ultrasound combined with microbubble treatment group (Ad-US-MB treatment group), US-MB treatment group, US treatment group, MB treatment group, doxorubicin treatment group (Ad treatment group), and blank control group...
August 31, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/30168025/angiogenesis-in-pancreatic-cancer-current-research-status-and-clinical-implications
#18
REVIEW
Shuo Li, Hua-Xiang Xu, Chun-Tao Wu, Wen-Quan Wang, Wei Jin, He-Li Gao, Hao Li, Shi-Rong Zhang, Jin-Zhi Xu, Zi-Hao Qi, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year survival rate of < 5%. Angiogenesis, namely, the formation of new blood vessels from pre-existing vessels, is an important event in tumor growth and hematogenous metastasis. It is a dynamic and complex process involving multiple mechanisms and is regulated by various molecules. Inhibition of angiogenesis has been an established therapeutic strategy for many solid tumors...
August 24, 2018: Angiogenesis
https://www.readbyqxmd.com/read/30128308/family-childcare-types-and-conduct-problem-behaviors-in-young-children-the-mediation-role-of-caregiver-child-interaction
#19
Li Liu, Lijun Fan, Xiang-Yu Hou, Chuan-An Wu, Xiao-Na Yin, Guo-Min Wen, Dengli Sun, Dan-Xia Xian, Hui Jiang, Jin Jing, Yu Jin, Wei-Qing Chen
Background: Previous studies have demonstrated the impacts of genetic, family, and community factors on child conduct problems (CPs). However, little is understood regarding the association between family childcare types and child conduct problem behaviors, as well as whether and to what extent caregiver-child interaction mediates the above association. Methods: 9,289 children first entering kindergartens in the Longhua New District of Shenzhen, China were enrolled in this cross-sectional study. Primary caregivers were invited to fulfill a self-administered structured questionnaire containing data regarding socio-demographics, family childcare types, caregiver-child interaction, and child conduct problem behaviors (measured by the Conners' Conduct Problem Subscale)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30091425/corrigendum-expanded-curb-65-a-new-score-system-predicts-severity-of-community-acquired-pneumonia-with-superior-efficiency
#20
Jin-Liang Liu, Feng Xu, Hui Zhou, Xue-Jie Wu, Ling-Xian Shi, Rui-Qing Lu, Alessio Farcomeni, Mario Venditti, Ying-Li Zhao, Shu-Ya Luo, Xiao-Jun Dong, Marco Falcone
This corrects the article DOI: 10.1038/srep22911.
August 9, 2018: Scientific Reports
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