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https://www.readbyqxmd.com/read/30487699/zinc-finger-e-box-binding-homeobox-1-mediates-aerobic-glycolysis-via-suppression-of-sirtuin-3-in-pancreatic-cancer
#1
Wen-Yan Xu, Qiang-Sheng Hu, Yi Qin, Bo Zhang, Wen-Sheng Liu, Quan-Xing Ni, Jin Xu, Xian-Jun Yu
AIM: To uncover the roles of tumor-promoting gene ZEB1 in aerobic glycolysis regulation and shed light on the underlying molecular mechanism. METHODS: Endogenous zinc finger E-box binding homeobox-1 (ZEB1) was silenced using a lentivirus-mediated method, and the impact of ZEB1 and methyl-CpG binding domain protein 1 (MBD1) on aerobic glycolysis was measured using seahorse cellular flux analyzers, reactive oxygen species quantification, and mitochondrial membrane potential measurement...
November 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30472262/mnp-triggers-nasal-allergy-by-modulating-dendritic-cell-properties
#2
Xiao-Yu Liu, Yong-Jin Wu, Li-Juan Song, Xian-Hai Zeng, Shuai Wang, Jiang-Qi Liu, Li-Hua Mo, Xiao-Rui Geng, Li-Teng Yang, Rui-Di Xie, Xiao-Wen Zhang, Zhi-Gang Liu, Ping-Chang Yang
Exposure to MNP generates Th2 response-inducing dendritic cells. Transfer of OVA/MNP-primed dendritic cells induces nasal allergy. Inhibition of Bcl2L12 prevents nasal allergy development.
November 22, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30469505/molecular-characterization-expression-and-functional-analysis-of-chicken-sting
#3
Jin-Shan Ran, Jie Jin, Xian-Xian Zhang, Ye Wang, Peng Ren, Jing-Jing Li, Ling-Qian Yin, Zhi-Qiang Li, Dan Lan, Yao-Dong Hu, Yi-Ping Liu
Innate immunity is an essential line of defense against pathogen invasion which is gained at birth, and the mechanism involved is mainly to identify pathogen-associated molecular patterns through pattern recognition receptors. STING (stimulator of interferon genes) is a signal junction molecule that hosts the perception of viral nucleic acids and produces type I interferon response, which plays a crucial role in innate immunity. However, relatively few studies have investigated the molecular characterization, tissue distribution, and potential function of STING in chickens...
November 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30448896/development-of-microsatellite-markers-for-the-seagrass-zostera-japonica-using-next-generation-sequencing
#4
Xiaomei Zhang, Yi Zhou, Yu-Long Li, Jin-Xian Liu
The seagrass Zostera japonica Asch. & Graebn. is among the few seagrass species that thrive both in temperate and tropical intertidal zones. The degradation of Z. japonica in its native range and continued expansion in some localities have raised concerns with regard to its conservation and management. Population genetic studies of Z. japonica across its biogeographic range and within meadows are scarce. Previously developed microsatellites via traditional methods are not sufficient in quantity and perform inconsistently between the temperate and tropical populations...
November 17, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30431018/ultrafast-formation-and-dynamics-of-interlayer-exciton-in-a-large-area-cvd-grown-ws-2-wse-2-heterostructure
#5
Yang Yu, Ziyu Wang, Jingle Wei, Wanying Zhao, Xian Lin, Zuanming Jin, Weimin Liu, Guohong Ma
A WS2 /WSe2 heterostructure is constructed by stacking a WS2 monolayer on the top of WSe2 monolayer fabricated with chemical vapor deposition (CVD) method. Ultrafast transient spectroscopy is used to demonstrate the ultrafast charge transfer and interlayer exciton dynamics in the heterostructure. When the WS2 /WSe2 heterostructure was photoexcitated at 617 nm (2.01 eV) to excite the A-exciton transition of WS2 , an ultrafast photobleaching was observed around the WSe2 A-exciton transition at 749 nm. The bleaching signal lasts several nanoseconds, which is much longer than the A-exciton lifetime in both the WS2 and WSe2 monolayer film...
November 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/30416079/arpin-downregulation-is-associated-with-poor-prognosis-in-pancreatic-ductal-adenocarcinoma
#6
Shi-Rong Zhang, Hao Li, Wen-Quan Wang, Wei Jin, Jin-Zhi Xu, Hua-Xiang Xu, Chun-Tao Wu, He-Li Gao, Shuo Li, Tian-Jiao Li, Wu-Hu Zhang, Shuai-Shuai Xu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
INTRODUCTION: Arpin (Arp2/3 complex inhibitor), a novel protein found in 2013, plays a pivotal role in cell motility and migration. However, the prognostic value of Arpin in pancreatic ductal adenocarcinoma (PDAC) remains unknown. MATERIALS AND METHODS: We analyzed the gene expression of ARPIN using the GEO dataset (GSE71989) and validated the results by immunohistochemistry (IHC) and Western blot in our clinical database. Tissue microarray specimens from 214 patients who underwent curative pancreatectomy for PDAC were used...
October 30, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30410937/the-correlations-of-plasma-and-cerebrospinal-fluid-amyloid-beta-levels-with-platelet-count-in-patients-with-alzheimer-s-disease
#7
Hao-Lun Sun, Wei-Wei Li, Chi Zhu, Wang-Sheng Jin, Yu-Hui Liu, Fan Zeng, Yan-Jiang Wang, Xian-Le Bu
Purpose: Recent study shows that blood-derived amyloid-beta (A β ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer's disease (AD). The vast majority of blood A β is generated from platelet. Whether blood A β levels are associated with the count of platelets remains unknown. Methods: 58 clinically diagnosed AD patients, 18 11 C-PIB-PET diagnosed AD patients, and 61 age- and gender-matched cognitively normal controls were included to analyze the correlation of plasma A β levels with platelet count...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30374923/tumor-infiltrating-nets-predict-postsurgical-survival-in-patients-with-pancreatic-ductal-adenocarcinoma
#8
Wei Jin, Hua-Xiang Xu, Shi-Rong Zhang, Hao Li, Wen-Quan Wang, He-Li Gao, Chun-Tao Wu, Jin-Zhi Xu, Zi-Hao Qi, Shuo Li, Quan-Xing Ni, Liang Liu, Xian-Jun Yu
BACKGROUND: Tumor-infiltrating neutrophils (TINs) indicate poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC). Activated neutrophils can generate neutrophil extracellular traps (NETs). Little is known about the presence and prognostic significance of tumor-infiltrating NETs in PDAC. METHODS: This study enrolled 317 patients, in two independent sets (training and validation), who underwent curative pancreatectomy for PDAC in Shanghai Cancer Center...
October 29, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30347920/-effect-of-dingzhi-xiaowan-on-mir-16-expression-and-5-ht-reuptake
#9
Wei-Yu Zhu, Xia Feng, Jin Wang, Yu-Pan Lu, Xian-Zhe Dong, Ping Liu
This study is to investigate the effect of antidepressant medicine prescription Dingzhi Xiaowan (DZ) on miR-16 expression levels in vitro and in vivo, and to explore the mechanism of DZ elevated levels of 5-HT from the perspective of post transcriptional regulation. Firstly, a chronic unpredictable mild moderate stimulation (CUMS) combined with solitary rising depression rat model was established, the behavior changes were detected after different doses of DZ (600, 300, 150 mg·kg⁻¹) given for 3 weeks, high performance liquid chromatography (HPLC) was used to detect 5-HT level in hippocampal, PCR method was used to observe the effect of DZ on the expression of SERT mRNA and miR-16 in hippocampus of CUMS rat...
September 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30341515/a-single-bundle-anterior-cruciate-ligament-reconstruction-acl-r-using-hamstring-tendon-autograft-and-tibialis-anterior-tendon-allograft-a-comparative-study
#10
Saroj Rai, Sheng-Yang Jin, Bimal Rai, Nira Tamang, Wei Huang, Xian-Zhe Liu, Chun-Qing Meng, Hong Wang
The main purpose of this study was to compare the clinical outcomes of patients undergoing a single bundle anterior cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT) autografts and two-strand tibialis anterior (2TA) allografts, and to find out the rate of graft failure and possible causes. We hypothesized that there would be no difference in the clinical outcome, and graft failure would be associated with the use of small sized allograft in young active males with high demand of sports activities...
October 2018: Current medical science
https://www.readbyqxmd.com/read/30302639/aso-author-reflections-contact-between-t-and-n-classifications-in-pancreatic-neuroendocrine-neoplasms
#11
Jin-Zhi Xu, Wen-Quan Wang, Liang Liu, Xian-Jun Yu
No abstract text is available yet for this article.
October 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30302273/abnormal-gametogenesis-induced-by-p53-deficiency-promotes-tumor-progression-and-drug-resistance
#12
Chunfang Liu, Zhen Cai, Guoxiang Jin, Danni Peng, Bo-Syong Pan, Xian Zhang, Fei Han, Xiaohong Xu, Hui-Kuan Lin
The century-old embryonal/gametogenesis hypothesis of tumors could link diverse tumors' malignant features together likely representing the real "stemness" of tumors. However, the genetic evidence to validate abnormal gametogenesis in tumors remains lacking. Here we show that p53 deficiency elicits abnormal gametogenesis from primordial germ cell-like stage to late oocyte-like stage and subsequent parthenogenetic activation. The similar upregulation of abnormal gametogenesis by p53 deficiency is observed both in p53-/- mouse model and cultured cancer cells...
2018: Cell Discovery
https://www.readbyqxmd.com/read/30291575/three-dimensional-sonographic-minute-structure-analysis-of-fetal-cerebellar-vermis-development-and-malformations-utilizing-volume-contrast-imaging
#13
Jing-Xian Xie, Jian-Hong You, Xiao-Kang Chen, Yi-Ming Su, Jin-Rong Liu, Shan-Shan Su, Min Hou, Guo-Rong Lv
PURPOSE: To obtain three-dimensional ultrasonic (3D US) structural details and biometrics of the fetal cerebellar vermis and evaluate the value of developmental and malformation identification. METHODS: The 3D US minute structure of the fetal cerebellar vermis in mid-sagittal view was detected in normal fetuses (n = 438; 16-41 weeks). Biometric sizes were measured to establish the stage-specific norms and reproducibility analysis. Additionally, 28 fetuses with suspected abnormal posterior fossa contents were assessed to analyze the clinical value...
October 5, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/30281927/b-cell-lymphoma-2-like-protein-12-association-with-t-helper-2-inflammation-in-chronic-rhinosinusitis-with-allergy
#14
Yun-Fang An, Yong-Jin Wu, Xian-Hai Zeng, Li-Juan Song, Fei Ma, Wen-Jing Liao, Zhi-Qiang Liu, Gui Yang, Xiao-Wen Zhang, Zhi-Gang Liu, Chang-Qing Zhao, Ping-Chang Yang
BACKGROUND: T-helper 2 (Th2) polarization plays a critical role in the pathogenesis of chronic rhinosinusitis (CRS) with accompanying nasal allergy. Recent studies indicate that B cell lymphoma-2-like protein-12 (Bcl2L12) is associated with immune dysregulation. The purpose of this study was to elucidate the role of Bcl2L12 in the pathogenesis of Th2 polarization of CRS patients. METHODS: CRS patients with nasal allergy (CRSa) and without nasal allergy (CRSna) were recruited into this study...
October 3, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30280037/tumor-preventing-activity-of-aspirin-in-multiple-cancers-based-on-bioinformatic-analyses
#15
Diangeng Li, Peng Wang, Yi Yu, Bing Huang, Xuelin Zhang, Chou Xu, Xian Zhao, Zhiwei Yin, Zheng He, Meiling Jin, Changting Liu
Background: Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding its mechanism in different biological systems. Methods: The Drugbank and STITCH databases were used to find direct protein targets (DPTs) of aspirin. The Mentha database was used to analyze protein-protein interactions (PPIs) to find DPT-associated genes...
2018: PeerJ
https://www.readbyqxmd.com/read/30271504/the-significance-of-liquid-biopsy-in-pancreatic-cancer
#16
REVIEW
Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer. The 5-year survival rate for PDAC remains low because it is always diagnosed at an advanced stage and it is resistant to therapy. A biomarker, which could detect asymptomatic premalignant or early malignant tumors and predict the response to treatment, will benefit patients with PDAC. However, traditional biopsy has its limitations. There is an urgent need for a tumor biomarker that could easily and repeatedly sample and monitor, in real time, the progress of tumor development...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30267683/two-likely-auto-tetraploidization-events-shaped-kiwifruit-genome-and-contributed-to-establishment-of-the-actinidiaceae-family
#17
Jin-Peng Wang, Ji-Gao Yu, Jing Li, Peng-Chuan Sun, Li Wang, Jia-Qing Yuan, Fan-Bo Meng, Sang-Rong Sun, Yu-Xian Li, Tian-Yu Lei, Yu-Xin Pan, Wei-Na Ge, Zhen-Yi Wang, Lan Zhang, Xiao-Ming Song, Chao Liu, Xue-Qian Duan, Shao-Qi Shen, Yang-Qin Xie, Yue Hou, Jin Zhang, Jian-Yu Wang, Xiyin Wang
The genome of kiwifruit (Actinidia chinensis) was sequenced previously, the first in the Actinidiaceae family. It was shown to have been affected by polyploidization events, the nature of which has been elusive. Here, we performed a reanalysis of the genome and found clear evidence of 2 tetraploidization events, with one occurring ∼50-57 million years ago (Mya) and the other ∼18-20 Mya. Two subgenomes produced by each event have been under balanced fractionation. Moreover, genes were revealed to express in a balanced way between duplicated copies of chromosomes...
September 28, 2018: iScience
https://www.readbyqxmd.com/read/30265911/perceived-stress-and-depression-amongst-older-stroke-patients-sense-of-coherence-as-a-mediator
#18
Li-Na Guo, Yan-Jin Liu, Jacqueline McCallum, Ulrika Söderhamn, Xian-Fei Ding, Su-Yuan Yv, Yi-Ru Zhu, Yv-Ru Guo
OBJECTIVE: This study aimed to explore the relationship between perceived stress, sense of coherence, and depression among older stroke patients. METHODS: A demographic questionnaire, the Perceived Stress Scale (PSS), the Sense of Coherence Scale (SOC) and the Center for Epidemiologic Studies Depression Scale (CES-D) were distributed to 3000 older stroke patients from Neurology wards in six large general hospitals, and 2907 individuals completed the survey. Data analysis consisted of correlation, multiple linear regression, and structural equation modeling...
August 25, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/30241478/tem8-functions-as-a-receptor-for-upa-and-mediates-upa-stimulated-egfr-phosphorylation
#19
Lian-Cheng Zhang, Yong Shao, Li-Hua Gao, Jin Liu, Yong-Yi Xi, Yin Xu, Chutse Wu, Wei Chen, Hui-Peng Chen, You-Liang Wang, Hai-Feng Duan, Xian-Wen Hu
BACKGROUND: TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unknown. RESULTS: Here we identified uPA as an interacting partner of TEM8. Binding of uPA stimulated the phosphorylation of TEM8 and augmented phosphorylation of EGFR and ERK1/2. Finally, TEM8-Fc, a recombinant fusion protein comprising the extracellular domain of human TEM8 linked to the Fc portion of human IgG1, efficiently abrogated the interaction between uPA and TEM8, blocked uPA-induced migration of HepG2 cells in vitro and inhibited the growth and metastasis of human MCF-7 xenografts in vivo...
September 21, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/30240912/the-effect-of-hengduan-mountains-region-hmr-uplift-to-environmental-changes-in-the-hmr-and-its-eastern-adjacent-area-tracing-the-evolutionary-history-of-allium-section-sikkimensia-amaryllidaceae
#20
Chuan Xie, Deng-Feng Xie, Yan Zhong, Xian-Lin Guo, Qing Liu, Song-Dong Zhou, Xing-Jin He
Exploring the effects of orographic events and climatic shifts on geographic distribution of organism in the Hengduan Mountains Region (HMR) and its eastern adjacent area is crucial to the understanding of the environmental changes to organismal evolution. To gain further insight into these processes, we reconstruct evolutionary history of ten species in Allium section Sikkimensia, distributed across regions abovementioned. Using chloroplast and nuclear sequence variation of 79 populations of these ten Allium species with known morphological preferences, we elucidate the phylogenetic relationship, divergence time, ancestral area and genetic structures...
September 18, 2018: Molecular Phylogenetics and Evolution
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