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https://www.readbyqxmd.com/read/30114562/the-effect-of-surface-poly-ethylene-glycol-length-on-in-vivo-drug-delivery-behaviors-of-polymeric-nanoparticles
#1
Ji-Long Wang, Xiao-Jiao Du, Jin-Xian Yang, Song Shen, Hong-Jun Li, Ying-Li Luo, Shoaib Iqbal, Cong-Fei Xu, Xiao-Dong Ye, Jie Cao, Jun Wang
Engineering nanoparticles of reasonable surface poly(ethylene glycol) (PEG) length is important for designing efficient drug delivery systems. Eliminating the disturbance by other nanoproperties, such as size, PEG density, etc., is crucial for systemically investigating the impact of surface PEG length on the biological behavior of nanoparticles. In the present study, nanoparticles with different surface PEG length but similar other nanoproperties were prepared by using poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) copolymers of different molecular weights and incorporating different contents of PCL3500 homopolymer...
November 2018: Biomaterials
https://www.readbyqxmd.com/read/30024722/visible-light-photoinitiation-of-cell-adhesive-gelatin-methacryloyl-hydrogels-for-stereolithography-3d-bioprinting
#2
Zongjie Wang, Hitendra Kumar, Zhenlin Tian, Xian Jin, Jonathan F Holzman, Frederic Menard, Keekyoung Kim
We present the first cell-attachable and visible-light-crosslinkable bioinks based on gelatin methacryloyl (GelMA) with eosin Y (EY) photoinitiation for stereolithography three-dimensional (3D) bioprinting. To develop a visible-light-crosslinkable hydrogel, we systematically studied five combinations of GelMA and EY photoinitiator with various concentrations. Their mechanical properties, microstructures, and cell viability and confluency after encapsulation were investigated rigorously to elucidate the effects of the EY and GelMA macromer concentrations on the characteristics of the hydrogel...
August 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29999514/a-fluorescence-enhanced-chemosensor-based-on-multifarene-2-2-and-its-recognition-of-metal-cations
#3
Yin-Hui Huang, Xian-Yi Jin, Yong-Yi Zhao, Hang Cong, Zhu Tao
A selective and sensitive fluorescent chemosensor based on an anthracene-functionalized triazole-linked multifarene[2,2] was successfully synthesized and investigated with regard to the recognition of metal ions using fluorescence spectroscopy, 1H NMR titration, and IR spectroscopy. The proposed sensor exhibited desirable properties for potential fluorescence enhanced chemosensor applications, including selective affinity and low Zn2+ and Cd2+ detection limits compared with other metal ions. Quantum chemical calculations described the synthesized chemosensor's static structure and its coordination to Zn2+ and Cd2+...
July 25, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29974708/-spatiotemporal-dynamics-and-driving-forces-of-soil-bacterial-communities-on-the-dam-of-shibahe-copper-mine-tailings-in-shanxi-china
#4
Cui Li, Ju Hui Jing, Jin Xian Liu, Bao Feng Chai
The maintaining mechanism of community diversity is the core of community ecology. The mine tailing is a good field for studying on the underlying mechanism of community diversity, as a kind of original bare land with heavy metal pollution, where the physicochemical characteristics of soil change with the restoration periods. We examined the driving forces for bacterial community diversity based on the investigation of edaphic factors, plant community, and bacterial communities in Shibahe copper mine tailing, Shanxi...
June 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29965007/-driving-factors-of-the-dynamics-of-microbial-community-in-a-dam-of-copper-mine-tailings
#5
Cui Li, Ju-Hui Jing, Jin-Xian Liu, Bao-Feng Chai
The relative importance of the deterministic versus stochastic processes underlying community dynamics has long been a central theme in community ecology, and is intensively debated in the field. Microbial communities play key roles in nutrient cycling and the flow of energy in ecosystems. The research on the structural dynamics of microbial community will provide data and theoretical support for understanding the assembly mechanisms of community, and for predicting the dynamics of microbial community under environmental stress...
April 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/29956972/experimental-machine-learning-of-quantum-states
#6
Jun Gao, Lu-Feng Qiao, Zhi-Qiang Jiao, Yue-Chi Ma, Cheng-Qiu Hu, Ruo-Jing Ren, Ai-Lin Yang, Hao Tang, Man-Hong Yung, Xian-Min Jin
Quantum information technologies provide promising applications in communication and computation, while machine learning has become a powerful technique for extracting meaningful structures in "big data." A crossover between quantum information and machine learning represents a new interdisciplinary area stimulating progress in both fields. Traditionally, a quantum state is characterized by quantum-state tomography, which is a resource-consuming process when scaled up. Here we experimentally demonstrate a machine-learning approach to construct a quantum-state classifier for identifying the separability of quantum states...
June 15, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29945959/fbxo22-possesses-both-pro-tumorigenic-and-anti-metastatic-roles-in-breast-cancer-progression
#7
Rui Sun, Hong-Yan Xie, Jin-Xian Qian, Yan-Ni Huang, Fan Yang, Fang-Lin Zhang, Zhi-Ming Shao, Da-Qiang Li
The molecular underpinnings behind malignant progression of breast cancer from a localized lesion to an invasive and ultimately metastatic disease are incompletely understood. Here we report that F-box only protein 22 (FBXO22) plays a dual role in mammary tumorigenesis and metastasis. FBXO22 was upregulated in primary breast tumors and promoted cell proliferation and colony formation in vitro and xenograft tumorigenicity in vivo. Surprisingly, FBXO22 suppressed epithelial-mesenchymal transition (EMT), cell motility, and invasiveness in vitro and metastatic lung colonization in vivo...
June 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29767453/optimizing-antimicrobial-peptide-dendrimers-in-chemical-space
#8
Thissa N Siriwardena, Alice Capecchi, Bee-Ha Gan, Xian Jin, Runze He, Dengwen Wei, Lan Ma, Thilo Köhler, Christian van Delden, Sacha Javor, Jean-Louis Reymond
We used nearest-neighbor searches in chemical space to improve the activity of the antimicrobial peptide dendrimer (AMPD) G3KL and identified dendrimer T7, which has an expanded activity range against Gram-negative pathogenic bacteria including Klebsiellae pneumoniae, increased serum stability, and promising activity in an in vivo infection model against a multidrug-resistant strain of Acinetobacter baumannii. Imaging, spectroscopic studies, and a structural model from molecular dynamics simulations suggest that T7 acts through membrane disruption...
July 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29765986/advanced-glycation-end-products-enhance-murine-monocyte-proliferation-in-bone-marrow-and-prime-them-into-an-inflammatory-phenotype-through-mapk-signaling
#9
Xian Jin, Liang Liu, Yaping Zhang, Yin Xiang, Guizhi Yin, Yi Lu, Ludong Shi, Jian Dong, Chengxing Shen
Objective: Increased monocytes, particularly the inflammatory subset, are associated with accelerated atherosclerosis in diabetes through thus far incompletely defined mechanisms. The present study tested the hypothesis that advanced glycation end products (AGEs) promote bone marrow monocytes to proliferate and drive them into an inflammatory phenotype. Methods and Results: In vivo, AGEs (25 mg/kg i.p. for 7 days) increased proportions of CD115+ monocytes and the inflammatory subset, the CD115+ Ly6Chigh cells, in murine bone marrow (flow cytometry analysis (FCM)), and enhanced gene expression of proinflammatory cytokines (IL-1 β and TNF- α ) but only slightly upregulated mRNA expression of anti-inflammatory cytokine (IL-10) (real-time PCR) in monocytes...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29756040/experimental-two-dimensional-quantum-walk-on-a-photonic-chip
#10
Hao Tang, Xiao-Feng Lin, Zhen Feng, Jing-Yuan Chen, Jun Gao, Ke Sun, Chao-Yue Wang, Peng-Cheng Lai, Xiao-Yun Xu, Yao Wang, Lu-Feng Qiao, Ai-Lin Yang, Xian-Min Jin
Quantum walks, in virtue of the coherent superposition and quantum interference, have exponential superiority over their classical counterpart in applications of quantum searching and quantum simulation. The quantum-enhanced power is highly related to the state space of quantum walks, which can be expanded by enlarging the photon number and/or the dimensions of the evolution network, but the former is considerably challenging due to probabilistic generation of single photons and multiplicative loss. We demonstrate a two-dimensional continuous-time quantum walk by using the external geometry of photonic waveguide arrays, rather than the inner degree of freedoms of photons...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29726227/-environmental-selection-and-dispersal-limitation-drive-the-assemblage-of-bacterial-community-in-temperate-forest-soils
#11
Zhuan Zhuan Ma, Sha Sha Qiao, Miao Wen Cao, Yong Na Zhou, Jin Xian Liu, Tong Jia, Cui Li, Bao Feng Chai
Environmental selection and dispersal limitation are two basic processes underlying community assembly. The relative importance of those two processes differs across scales, community identities, and community types. The processes responsible for structuring microbial communities in soil of temperate subalpine forest are poorly understood. Here, we investigated the relationship between soil bacterial community structure and environmental factors, and quantified the relative role of edaphic factors, vegetation, and spatial variables in shaping the structure of six soil bacterial communities (LpMC1, LpMC2, PwMC, PmMC, PtMC, and BMC) in five forest types including Larix principis-rupprechtii, Picea wilsonii, Picea meyeri, Pinus tabulaeformis, and Betula platyphylla in Pangquangou Nature Reserve by using PCR-DGGE technology...
April 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29717727/an-antimicrobial-bicyclic-peptide-from-chemical-space-against-multidrug-resistant-gram-negative-bacteria
#12
Ivan Di Bonaventura, Stéphane Baeriswyl, Alice Capecchi, Bee-Ha Gan, Xian Jin, Thissa N Siriwardena, Runze He, Thilo Köhler, Arianna Pompilio, Giovanni Di Bonaventura, Christian van Delden, Sacha Javor, Jean-Louis Reymond
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
May 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29706995/tanshinone-iia-sodium-sulfonate-attenuates-lps-induced-intestinal-injury-in-mice
#13
Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang
Background: Tanshinone IIA sodium sulfonate (TSS) is known to possess anti-inflammatory effects and has exhibited protective effects in various inflammatory conditions; however, its role in lipopolysaccharide- (LPS-) induced intestinal injury is still unknown. Objective: The present study is designed to explore the role and possible mechanism of TSS in LPS-induced intestinal injury. Methods: Male C57BL/6J mice, challenged with intraperitoneal LPS injection, were treated with or without TSS 0...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29609454/pt-like-hydrogen-evolution-electrocatalysis-on-pani-cop-hybrid-nanowires-by-weakening-the-shackles-of-hydrogen-ions-on-the-surfaces-of-catalysts
#14
Jin-Xian Feng, Si-Yao Tong, Ye-Xiang Tong, Gao-Ren Li
The search for high active, stable, and cost-efficient hydrogen evolution reaction (HER) electrocatalysts for water electrolysis has attracted great interest. The coordinated water molecules in the hydronium ions will obviously reduce the positive charge density of H+ and hamper the ability of H+ to receive electrons from the cathode, leading to large overpotential of HER on nonprecious metal catalysts. Here we realize Pt-like hydrogen evolution electrocatalysis on polyaniline (PANI) nanodots (NDs)-decorated CoP hybrid nanowires (HNWs) supported on carbon fibers (CFs) (PANI/CoP HNWs-CFs) as PANI can effectively capture H+ from hydronium ions to form protonated amine groups that have higher positive charge density than those of hydronium ions and can be electro-reduced easily...
April 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29515871/an-optimized-approach-for-local-de-novo-assembly-of-overlapping-paired-end-rad-reads-from-multiple-individuals
#15
Yu-Long Li, Dong-Xiu Xue, Bai-Dong Zhang, Jin-Xian Liu
Restriction site-associated DNA (RAD) sequencing is revolutionizing studies in ecological, evolutionary and conservation genomics. However, the assembly of paired-end RAD reads with random-sheared ends is still challenging, especially for non-model species with high genetic variance. Here, we present an efficient optimized approach with a pipeline software, RADassembler, which makes full use of paired-end RAD reads with random-sheared ends from multiple individuals to assemble RAD contigs. RADassembler integrates the algorithms for choosing the optimal number of mismatches within and across individuals at the clustering stage, and then uses a two-step assembly approach at the assembly stage...
February 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29450667/a-risk-prediction-model-to-allow-personalized-screening-for-cervical-cancer
#16
Michael B Rothberg, Bo Hu, Laura Lipold, Sarah Schramm, Xian Wen Jin, Andrea Sikon, Glen B Taksler
IMPORTANCE: Cervical cancer screening guidelines are in evolution. Current guidelines do not differentiate recommendations based on individual patient risk. OBJECTIVE: To derive and validate a tool for predicting individualized probability of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) at a single time point, based on demographic factors and medical history. DESIGN: The study design consisted of an observational cohort with hierarchical generalized linear regression modeling...
March 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29445190/the-chemokine-receptor-ccr10-promotes-inflammation-driven-hepatocarcinogenesis-via-pi3k-akt-pathway-activation
#17
Qiong Wu, Jin-Xian Chen, Yu Chen, Li-Li Cai, Xiao-Zhong Wang, Wu-Hua Guo, Jian-Feng Zheng
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflammation-driven hepatocarcinogenesis. Via a targeted gene expression microarray screening alterations in GPCR family gene expression, we found CCR10 to be significantly upregulated in hepatocytes isolated from inflammation-driven human HCC tumors and matching paracancerous tissues...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29418055/activating-coooh-porous-nanosheet-arrays-by-partial-iron-substitution-for-efficient-oxygen-evolution-reaction
#18
Sheng-Hua Ye, Zi-Xiao Shi, Jin-Xian Feng, Ye-Xiang Tong, Gao-Ren Li
Iron-substituted CoOOH porous nanosheet arrays grown on carbon fiber cloth (denoted as Fex Co1-x OOH PNSAs/CFC, 0≤x≤0.33) with 3D hierarchical structures are synthesized by in situ anodic oxidation of α-Co(OH)2 NSAs/CFC in solution of 0.01 m (NH4 )2 Fe(SO4 )2 . X-ray absorption fine spectra (XAFS) demonstrate that CoO6 octahedral structure in CoOOH can be partially substituted by FeO6 octahedrons during the transformation from α-Co(OH)2 to Fex Co1-x OOH, and this is confirmed for the first time in this study...
March 1, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29405607/a-novel-well-resolved-direct-laser-bioprinting-system-for-rapid-cell-encapsulation-and-microwell-fabrication
#19
Zongjie Wang, Xian Jin, Zhenlin Tian, Frederic Menard, Jonathan F Holzman, Keekyoung Kim
A direct laser bioprinting (DLBP) system is introduced in this work. The DLBP system applies visible-laser-induced photo-crosslinking at a wavelength of 405 nm using the photoinitiator VA-086. It is shown that such a system can fabricate vertical structures with fine features (less than 50 µm) and high cell viability (greater than 95%). Experimental characterizations and theoretical simulations are presented, and good agreement is seen between the experiments and theory. The DLBP system is applied to the fabrication of (1) cell-laden hydrogel microgrids, (2) hydrogel microwells, as well as a test of (3) cell encapsulation, and (4) cell seeding...
May 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29393463/bmp4-knockdown-of-ncscs-leads-to-aganglionosis-in-the-middle-embryonic-stage
#20
Hong-Bo Li, Xian-Qing Jin, Xin Jin, Zheng-Hua Guo, Xiong-Hui Ding, Quan Wang, Rui-Zhuo Liu
Transplacental bone morphogenetic protein (BMP)4 RNA interference (RNAi) is a technique used to knockdown genes in embryos. BMP4 are essential for the development of nervous system in the differentiation of neural crest stem cells (NCSCs). The failure of differentiation and migration of NCSCs may lead to aganglionosis. In the present study, pregnant mice were divided into three groups: Ringer's group, pSES group and RNAi‑BMP4 group. In order to silence the BMP4 gene in the first generation (F1), 11.5 day pregnant mice were injected with the small interfering RNA BMP4 plasmid, pSES or Ringer's solution via the tail vein...
April 2018: Molecular Medicine Reports
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