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https://www.readbyqxmd.com/read/30536376/artemisinin-inhibits-breast-cancer-induced-osteolysis-by-inhibiting-osteoclast-formation-and-breast-cancer-cell-proliferation
#1
Jia Li, Wenyu Feng, Huiping Lu, Yan Wei, Shiting Ma, Linfeng Wei, Qian Liu, Jinmin Zhao, Qingjun Wei, Jun Yao
In addition to being used to treat malaria, artemisinin (Art) can be used as an anti-inflammatory and antitumor agent. In this study, we evaluated the effects of Art on osteoclast formation and activation and on the development of breast cancer cells in bone. To evaluate the effect of Art on osteoclast differentiation in vitro, we treated bone marrow-derived macrophages (BMMs) with various concentrations of Art and evaluated the expression of genes and proteins involved in osteoclast formation. We also performed cell counting kit-8 assays to evaluate the toxicity of Art in BMMs and MDA-MB-231 cells...
December 7, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30268503/structural-basis-for-specific-calcium-binding-by-the-polycystic-kidney-disease-domain-of-vibrio-anguillarum-protease-epp
#2
Peihai Li, Kun Zang, Yingjie Li, Changshui Liu, Qingjun Ma
Extracellular proteases are often produced as pre-pro-enzyme and then undergo multiple processing steps to mature into the active form. The protease Epp, a virulent factor of Vibrio anguillarum, belongs to this family. Its maturation might be regulated by Ca2+ via its polycystic kidney disease (PKD) domain, but the molecular mechanism is unknown. Herein, we report the crystal structure of the first PKD domain from V. anguillarum Epp (Epp-PKD1) and its specific Ca2+ -binding capacity. Epp-PKD1 exists as a monomer, consisting of seven β-strands which form two β-sheets stacking with each other...
October 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30252204/determination-and-pharmacokinetic-study-of-azd-3759-in-rat-plasma-by-ultra-performance-liquid-chromatography-with-triple-quadrupole-mass-spectrometer
#3
Qingjun Wu, Ailian Hua, Yaoguang Sun, Chao Ma, Wenxin Tian, Chuan Huang, Hanbo Yu, Peng Jiao, Shuanghu Wang, Hongfeng Tong, Weiwen Qiu
BACKGROUND: AZD-3759 is a new, potent, oral, active central nervous system-penetrant EGFR inhibitor. Despite promising clinical activity among patients pretreated and never treated with EGFR-tyrosine kinase inhibitors, no time saving pharmacokinetic study method has been reported in an animal model. METHODS: Protein was precipitated with acetonitrile and then used for sample pre-processing. A CORTECS BEH C18 column was used to separate the analytes at 40°C. Acetonitrile and water (containing 0...
November 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/30251710/development-and-application-of-a-no-clog-surgical-suction-tip-using-3d-printing-technology
#4
Jianji Wang, Long Yang, Minxian Ma, Guangdi Li, Shunen Xu, Qingjun Li, Zhe Xu, Jun Liu, Chuan Ye
BACKGROUND Clogging of the suction tip frequently occurs during orthopedic surgery. We developed a novel anti-clog suction tip using 3D printing technology to improve orthopedic surgery efficiency. MATERIAL AND METHODS We studied the root causes of obstructions in suction tips currently employed in orthopedic surgery during actual surgical cases. CAD software and 3D printer was used to design, modify, and print the novel suction tip. The frequency of clogging, the frequency of replacement of the suction tip, the time lost in replacing suction tips or connecting tubes, surgical duration, intraoperative surgical blood loss, and the satisfaction scores for the suction tips as rated by the surgeons were compared between the novel suction tip and the conventional suction tip...
September 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29717995/the-putative-siderophore-interacting-protein-from-vibrio-anguillarum-protein-production-analysis-crystallization-and-x-ray-crystallographic-studies
#5
Yu Han, Kun Zang, Changshui Liu, Yingjie Li, Qingjun Ma
Siderophore-interacting proteins (SIPs) play an important role in iron acquisition in many bacteria. SIPs release iron from the internalized ferric siderophore complex by reducing ferric iron to ferrous iron, but how the iron is reduced is not well understood. Here, a sip gene was identified in the genome of Vibrio anguillarum 775. To further understand the catalytic mechanism of the protein, the SIP was overexpressed in Escherichia coli Rosetta (DE3) cells, purified and crystallized for X-ray diffraction analysis...
May 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29576430/erectile-dysfunction-and-associated-risk-factors-in-chinese-males-of-infertile-couples
#6
Bin Yang, Peng Xu, Yichao Shi, Jixiu Xu, Lianwen Zheng, Haisong Li, Lianghong Ma, Shenmin Yang, Yong Zhao, Yan Zhang, Qiang Du, Qingjun Chu, Bin Chen, Yan Tan, Xiangru Li, Chaobin Li, Fa Sun, Yongtong Zhu, Hongjun Li
BACKGROUND: Knowledge on the occurrence of erectile dysfunction (ED) and timely ovulatory intercourse failure (TOIF) in Chinese men of infertile couples is limited. AIM: To obtain representative estimates of ED and TOIF in Chinese men of infertile couples and to analyze potential risk factors associated with ED. METHODS: 4,299 Chinese men of infertile couples with an average age of 32.85 ± 5.98 years were surveyed using the 5-item International Index of Erectile Function (IIEF-5) questionnaire for their ED occurrence...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29480366/inflammatory-cytokine-tnf-%C3%AE-promotes-corneal-endothelium-apoptosis-via-upregulating-tipe2-transcription-during-corneal-graft-rejection
#7
Qun Wang, Chao Wei, Li Ma, Xin Wang, Lin Li, Qingjun Zhou, Weiyun Shi
PURPOSE: Endothelial dysfunction accounts for 50% of total corneal transplantation failures, suggesting that corneal endothelial damage is the leading cause of graft failure. Tumor necrosis factor-α (TNF-α) is known to contribute to the negative regulation of corneal transplantation, but how it does so remains unclear. Here, we report a regulatory loop involving TNF-α, TNF-α-induced protein 8 like 2 (TNFAIP8L2 or TIPE2), and apoptosis during corneal graft rejection. METHODS: We established mice models of penetrating keratoplasty to verify whether the quantification of TNF-α in allogeneic corneas is enhanced through ELISA assay and immunofluorescence staining...
April 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29371148/structural-and-enzymatic-analysis-of-the-cytochrome-b-5-reductase-domain-of-ulva-prolifera-nitrate-reductase
#8
Cai You, Changshui Liu, Yingjie Li, Peng Jiang, Qingjun Ma
Rapid accumulations of unattached green macroalgae, referred to as blooms, constitute ecological disasters and occur in many coastal regions. Ulva are a major cause of blooms, owing to their high nitrogen utilization capacity, which requires nitrate reductase (NR) activity; however, molecular characterization of Ulva NR remains lacking. Herein we determined the crystal structure and performed an enzymatic analysis of the cytochrome b5 reductase domain of Ulva prolifera NR (UpCbRNR). The structural analysis revealed an N-terminal FAD-binding domain primarily consisting of six antiparallel β strands, a C-terminal NADH-binding domain forming a Rossmann fold, and a three β-stranded linker region connecting these two domains...
May 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29187596/the-dutpase-of-white-spot-syndrome-virus-assembles-its-active-sites-in-a-noncanonical-manner
#9
Kun Zang, Fuhua Li, Qingjun Ma
dUTPases are essential enzymes for maintaining genome integrity and have recently been shown to play moonlighting roles when containing extra sequences. Interestingly, the trimeric dUTPase of white spot syndrome virus (wDUT) harbors a sequence insert at the position preceding the C-terminal catalytic motif V (pre-V insert), rarely seen in other dUTPases. However, whether this extra sequence endows wDUT with additional properties is unknown. Herein, we present the crystal structures of wDUT in both ligand-free and ligand-bound forms...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29141144/engineering-interface-with-one-dimensional-co-3-o-4-nanostructure-in-catalytic-membrane-electrode-toward-an-advanced-electrocatalyst-for-alcohol-oxidation
#10
Zhen Yin, Yumei Zheng, Hong Wang, Jianxin Li, Qingjun Zhu, Ye Wang, Na Ma, Gang Hu, Benqiao He, Axel Knop-Gericke, Robert Schlögl, Ding Ma
Electrochemical oxidation has attracted vast interest as a promising alternative to traditional chemical processes in fine chemical synthesis owing to its fast and sustainable features. An electrocatalytic membrane reactor (ECMR) with a three-dimensional (3D) electrode has been successfully designed for the selective oxidation of alcohols with high current efficiency to the corresponding acids or ketones. The anode electrode was fabricated by the in situ loading of one-dimensional (1D) Co3 O4 nanowires (NWs) on the conductive porous Ti membrane (Co3 O4 NWs/Ti) via the combination of a facile hydrothermal synthesis and subsequent thermal treatment...
December 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/29075476/phylogeographic-and-phylogenetic-analysis-for-tripterygium-species-delimitation
#11
Baowei Ma, Tianyuan Hu, Pei Li, Qingjun Yuan, Zhaoshou Lin, Yuhe Tu, Jia Li, Xianan Zhang, Xiaoyi Wu, Xiujuan Wang, Luqi Huang, Wei Gao
Tripterygium wilfordii (Celastraceae) is a traditional Chinese medicine; and the dried root and rhizome constitute the main officinal parts. Tripterygium wilfordii has been identified as a potential candidate for the treatment of systemic lupus erythematosus, rheumatoid arthritis, nephritis, asthma, leprosy, and cancer. The phylogenetic relationships within the Tripterygium genus are ambiguous; thus, our aim is to clarify the relationships within this genus using phylogeographic and phylogenetic analyses. Here, we first sequenced three plastid DNA regions (i...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28791260/iron-acquisition-strategies-of-vibrio-anguillarum
#12
REVIEW
Yingjie Li, Qingjun Ma
The hemorrhagic septicemic disease vibriosis caused by Vibrio anguillarum shows noticeable similarities to invasive septicemia in humans, and in this case, the V. anguillarum -host system has the potential to serve as a model for understanding native eukaryotic host-pathogen interactions. Iron acquisition, as a fierce battle occurring between pathogenic V. anguillarum and the fish host, is a pivotal step for virulence. In this article, advances in defining the roles of iron uptake pathways in growth and virulence of V...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28647364/crystal-structures-of-the-isochorismatase-domains-from-vibrio-anguillarum
#13
Jiansen Du, Tian Deng, Qingjun Ma
Antibiotic resistance is becoming a global threat and overuse of antibiotics in aquaculture disease control worsens the situation. To reduce the risk of drug resistance developed in aquaculture, safer biocontrol programs are needed. Antivirulence therapy, with less chance for developing drug resistance, is a promising approach. To facilitate antivirulence inhibitor design against Vibrio anguillarum, a serious aquaculture pathogen, we present crystal structures for isochorismatase domains of AngB and VabB, which are required to synthesize siderophore, a critical virulence factor...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28299840/antimicrobial-activity-and-stability-of-protonectin-with-d-amino-acid-substitutions
#14
Shuai Qiu, Ranran Zhu, Yanyan Zhao, Xiaoping An, Fengjing Jia, Jinxiu Peng, Zelin Ma, Yuanyuan Zhu, Jiayi Wang, Jinhuan Su, Qingjun Wang, Hailin Wang, Yuan Li, Kairong Wang, Wenjin Yan, Rui Wang
The misuse and overuse of antibiotics result in the emergence of resistant bacteria and fungi, which make an urgent need of the new antimicrobial agents. Nowadays, antimicrobial peptides have attracted great attention of researchers. However, the low physiological stability in biological system limits the application of naturally occurring antimicrobial peptides as novel therapeutics. In the present study, we synthesized derivatives of protonectin by substituting all the amino acid residues or the cationic lysine residue with the corresponding D-amino acids...
May 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28184397/carbon-induced-selective-regulation-of-cobalt-based-fischer-tropsch-catalysts-by-ethylene-treatment
#15
Peng Zhai, Pei-Pei Chen, Jinglin Xie, Jin-Xun Liu, Huabo Zhao, Lili Lin, Bo Zhao, Hai-Yan Su, Qingjun Zhu, Wei-Xue Li, Ding Ma
Various carbonaceous species were controllably deposited on Co/Al2 O3 catalysts using ethylene as carbon source during the activation process for Fischer-Tropsch synthesis (FTS). Atomic, polymeric and graphitic carbon were distinguished by Raman spectroscopy, thermoanalysis and temperature programmed hydrogenation. Significant changes occurred in both the catalytic activity and selectivity toward hydrocarbon products after ethylene treatment. The activity decreased along with an increase in CH4 selectivity, at the expense of a remarkable decrease of heavy hydrocarbon production, resulting in enhanced selectivity for the gasoline fraction...
April 28, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28148787/the-severe-acute-respiratory-syndrome-coronavirus-nucleocapsid-inhibits-type-i-interferon-production-by-interfering-with-trim25-mediated-rig-i-ubiquitination
#16
Yong Hu, Wei Li, Ting Gao, Yan Cui, Yanwen Jin, Ping Li, Qingjun Ma, Xuan Liu, Cheng Cao
Severe acute respiratory syndrome (SARS) is a respiratory disease, caused by a coronavirus (SARS-CoV), that is characterized by atypical pneumonia. The nucleocapsid protein (N protein) of SARS-CoV plays an important role in inhibition of type I interferon (IFN) production via an unknown mechanism. In this study, the SARS-CoV N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation...
April 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28111947/ultrasensitive-near-infrared-photodetectors-based-on-a-graphene-mote-2-graphene-vertical-van-der-waals-heterostructure
#17
Kun Zhang, Xin Fang, Yilun Wang, Yi Wan, Qingjun Song, Wenhao Zhai, Yanping Li, Guangzhao Ran, Yu Ye, Lun Dai
Graphene and other layered materials, such as transition metal dichalcogenides, have rapidly established themselves as exceptional building blocks for optoelectronic applications because of their unique properties and atomically thin nature. The ability to stack them into van der Waals (vdWs) heterostructures with new functionality has opened a new platform for fundamental research and device applications. Nevertheless, near-infrared (NIR) photodetectors based on layered semiconductors are rarely realized. In this work, we fabricate a graphene-MoTe2 -graphene vertical vdWs heterostructure on a SiO2 /p+ -Si substrate by a facile and reliable site-controllable transfer method and apply it for photodetection from the visible to NIR wavelength range...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078904/malonyl-coa-pathway-a-promising-route-for-3-hydroxypropionate-biosynthesis
#18
Changshui Liu, Yamei Ding, Mo Xian, Min Liu, Huizhou Liu, Qingjun Ma, Guang Zhao
3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and β-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality...
November 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/27667024/interferon%C3%A2-%C3%AE-alters-the-microrna-profile-of-umbilical-cord%C3%A2-derived-mesenchymal-stem-cells
#19
Ying Chi, Junjie Cui, Youwei Wang, Wenjing Du, Fang Chen, Zongjin Li, Fengxia Ma, Baoquan Song, Fangyun Xu, Qingjun Zhao, Zhibo Han, Zhongchao Han
Numerous studies have demonstrated that interferon-γ (IFN-γ) is an important inflammatory cytokine, which may activate the immunomodulatory abilities of mesenchymal stem cells (MSCs), and may influence certain other functions of these cells. MicroRNAs are small non‑coding RNAs that regulate the majority of the biological functions of cells and are important in a variety of biological processes. However, few studies have been performed to investigate whether IFN‑γ affects the microRNA profile of MSCs...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27414256/comparison-of-chelates-for-enhancing-ricinus-communis-l-phytoremediation-of-cd-and-pb-contaminated-soil
#20
COMPARATIVE STUDY
Hanzhi Zhang, Qingjun Guo, Junxing Yang, Jie Ma, Gang Chen, Tongbin Chen, Guangxu Zhu, Jian Wang, Guangxin Zhang, Xin Wang, Chunyan Shao
We studied chelate effects on castor bean (Ricinus communis L.) growth. These effects included Cd and Pb accumulation in plant tissues and the chemical behavior of Cd and Pb in the plant rhizosphere and non-rhizosphere. Tests were conducted in a glasshouse using the rhizobag method. Two castor bean cultivars (Zibo-3 and Zibo-9) were grown in soil contaminated with 3.53mg/kg Cd and 274mg/kg Pb. The soil was treated with citric acid (CA), ethylenediamine disuccinic acid (EDDS) or ethylenediamine tetraacetic acid (EDTA) (5mmol/kg)...
November 2016: Ecotoxicology and Environmental Safety
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