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Daizong Ji, Zixiang Liu, Lei Liu, Sze Shin Low, Yanli Lu, Xiongjie Yu, Long Zhu, Candong Li, Qingjun Liu
Ascorbic acid, dopamine, and uric acid are important electroactive biomolecules for health monitoring and they coexist in serum or urine. Their quantitative determination by electrochemistry could provide the accurate reference for diseases diagnosis and treatment. However, the traditional electrochemical workstations are too large for on-field inspection. Hence, the design of handheld electrochemical system for the detection of biomolecules is significant for point-of-care testing (POCT). In this paper, a smartphone-based integrated voltammetry system using modified electrode was developed for simultaneous detection of biomolecules...
August 2, 2018: Biosensors & Bioelectronics
Binbin Zhang, Weichen Xu, Qingjun Zhu, Yantao Li, Baorong Hou
The potential marine corrosion-resistant and anti-biofouling applications of superhydrophobic materials arouse tremendous attention of researchers and engineers. Herein, we report an ultrafast (∼120 s) and eco-friendly one step electrodeposition strategy to construct fluorine-free superhydrophobic aluminum surface with outstanding water repellency and ultrahigh corrosion resistance to inhibit marine corrosion. As characterized through Field-emission scanning electron microscopy (FE-SEM), Atomic force microscopy (AFM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS), the as-constructed non-fluorinated superhydrophobic surface is composed of manganese palmitate complex featuring with a typical dual-scale hierarchical papillae structures and low surface energy...
July 31, 2018: Journal of Colloid and Interface Science
Mingli Qu, Xiaoping Zhang, Xiaoli Hu, Muchen Dong, Xiaojing Pan, Jiang Bian, Qingjun Zhou
Corneal scarring is characterized by the improper deposition of extracellular matrix components and myofibroblast differentiation from keratocytes. The bromodomain-containing protein 4 (BRD4) inhibitor JQ1 has been shown to attenuate pathological fibrosis. The present study aimed to explore the potential therapeutic effect of JQ1 on mechanical injury-induced mouse corneal scarring and TGFβ-induced human corneal myofibroblast differentiation and the related mechanism. The corneal scarring and myofibroblast differentiation were evaluated with clinical observation and fibrosis-related gene expression analysis...
2018: Cell Death Discovery
Hua Du, Wuhui Chen, Qingjun Zhu, Songlin Liu, Jianbin Zhou
Accurate measurement of cadmium content in rice is of utmost importance to determine if the inspected rice product is safe to people. X-ray fluorescence analysis is frequently used for multi-element analysis because it has characteristics of fast, accurate and nondestructive. However, due to the low content of cadmium in rice, its corresponding characteristics energy peak is relatively weak and is sensitive to the background information in the X-ray energy spectrum. Thus, it is very tough to obtain the accurate values of cadmium content by utilizing traditional X-ray fluorescence analysis...
July 26, 2018: Applied Radiation and Isotopes
Jianji Wang, Long Yang, Qingjun Li, Zhanyu Wu, Yu Sun, Qiang Zou, Xuanze Li, Zhe Xu, Chuan Ye
BACKGROUND: Knee osteoarthritis (KOA) is one of the most common chronic diseases in the elderly and is the primary cause of the loss of motor function and disability in this population. Exercise therapy is a core, basic and matureand treatment method of treating patients with KOA. Exercise therapy is "strongly recommended" or "recommended" in the diagnosis and treatment guidelines of osteoarthritis in many countries, and most scholars advocate exercise therapy as the preferred rehabilitation method for KOA patients...
July 27, 2018: BMC Musculoskeletal Disorders
Yuefan Song, Qiukuan Wang, Qingjun Wang, Yunhai He, Dandan Ren, Shu Liu, Long Wu
Brown alga-derived fucoidan has been proven to have a variety of bioactivities. To explore the antitumor effect of fucoidan, Kjellmaniella crassifolia (farmed in Dalian, China)was enzymatically digested to obtain the crude extract (F), which was further separated into three fractions (F1, F2 and F3). The monosaccharide composition and structural characteristics of the isolated fractions were determined using high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy...
July 21, 2018: International Journal of Biological Macromolecules
Qingjun Kong, Xuefeng Yin, Jia Yu, Xueyan Ren
Resveratrol, as one of the stilbenoids, is present in abundance in wine grapes and has been shown to selectively quench 1 O2 . DNA is oxidized by 1 O2 causing irreparable functional damage, and of the nucleic acids, guanine is the most susceptible. An agarose gel electrophoresis assay demonstrated that DNA was damaged by 1 O2 with less than 5 min of UVA irradiation, and also that 5 mM resveratrol dissolved in MeOH could relieve the observed oxidation stress. Ultra-high performance liquid chromatography coupled with mass spectrometry was performed to reveal the mechanism...
September 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jieyao Deng, Qingjun Yuan, Hiroshi Mamitsuka, Shanfeng Zhu
Identifying drug-target interactions is crucial for the success of drug discovery. Approaches based on machine learning for this problem can be divided into two types: feature-based and similarity-based methods. By utilizing the "Learning to rank" framework, we propose a new method, DrugE-Rank, to combine these two different types of methods for improving the prediction performance of new candidate drugs and targets. DrugE-Rank is available at ...
2018: Methods in Molecular Biology
Xiao Tian, Tongsong Wang, Songmei Zhang, Qian Wang, Xiaoli Hu, Cheng Ge, Lixin Xie, Qingjun Zhou
Purpose: The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice. Methods: Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils, macrophages and CD4+ T-cell infiltration, virus contents, and expressions of VEGF, PEDF, and proinflammatory factors were evaluated during acute period...
June 1, 2018: Investigative Ophthalmology & Visual Science
Huihong Wang, Ying Chen, Danfeng Gu, Yuan Qian, Fang Shao, Yihui Shen, Qingjun You
No abstract text is available yet for this article.
July 18, 2018: Minerva Medica
Qingjun Wang, Yong Guo, Jing Zhang, Lijing Shi, Haoyong Ning, Xiliang Zhang, Yuanyuan Lu
PURPOSE: The aim of the study was to evaluate the role of high b-value (2000 sec/mm2) diffusion-weighted imaging (DWI) by using Readout Segmentation of Long Variable Echo-trains (RESOLVE) in differentiating papillary thyroid carcinomas (PTCs) and papillary thyroid microcarcinomas (PTMCs) from benign thyroid nodules. MATERIALS AND METHODS: Consecutive patients with thyroid nodules scheduled for surgery underwent high b-value DWI with 3 b-values: 0, 800 and 2000 sec/mm2...
2018: PloS One
Zhe Li, Tie Liu, Peng Yin, Yu Wang, Shengen Liao, Shuo Zhang, Qingjun Su, Yong Hai
PURPOSE: The purpose of this study was to investigate the clinical effects of percutaneous kyphoplasty (PKP) on osteoporotic vertebral compression fractures (OVCFs) with or without intravertebral cleft (IVC). METHODS: From 2010 to 2016, 309 OVCFs patients (43 males, 266 females) treated with PKP were included in our study. All patients were divided into no intravertebral cleft (NIVC) group and intravertebral cleft (IVC) group according to pre-operative magnetic resonance imaging...
July 16, 2018: International Orthopaedics
Xiaobin Shi, Gong Chen, Huipeng Pan, Wen Xie, Qingjun Wu, Shaoli Wang, Yong Liu, Xuguo Zhou, Youjun Zhang
The sweet potato whitefly, Bemisia tabaci , is one of the most invasive insect pests worldwide. The two most destructive whitefly cryptic species are MEAM1/B and MED/Q. Given that MED/Q has replaced MEAM1/B in China and the invasion of MED/Q has coincided with the outbreak of tomato yellow leaf curl virus (TYLCV), we hypothesize that pre-infestation with viruliferous B. tabaci will affect the subsequent host preferences. To test this hypothesis, we (1) conducted bioassays to compare the host preference of viruliferous and non-viruliferous MEAM1/B and MED/Q, respectively, on plants pre-infested with viruliferous and non-viruliferous MEAM1/B and MED/Q; (2) profiled plant volatiles using GC-MS; and (3) functionally characterized chemical cues could potentially modulate B...
2018: Frontiers in Microbiology
Yanni Jia, Wenjing Li, Haoyun Duan, Zongyi Li, Qingjun Zhou, Weiyun Shi
Corneal endothelium is a single layer of hexagonal cells that maintains the corneal transparency and thickness through its barrier and pump function. For the treatment of corneal endothelial dysfunction, the transplantation of tissue-engineered corneal endothelium and direct injection of cultured corneal endothelial cells were developed because of the severe shortage of donor cornea worldwide. However, the technique difficulty or safety risk still remained. Here we report a novel mini-sheet injection for the cultured corneal endothelial cell transplantation and compare with the effects of single cells injection in rabbit model...
July 11, 2018: Tissue Engineering. Part C, Methods
Qingjun Guan, Yuehua Hu, Honghu Tang, Wei Sun, Zhiyong Gao
Huge amount of flue gas desulphurization (FGD) gypsum not only occupies the farmland but also causes severe pollution to the surrounding environment. The most effective way to achieve a high-value utilization of FGD gypsum is to prepare short columnar α-calcium sulfate hemihydrate (α-HH) since short columnar crystals show better mechanical strength than needle-like ones. Here, malic acid, a prolific, inexpensive and environment-friendly modifier was explored for the first time to effectively tune the crystal morphology of α-HH prepared from FGD gypsum in glycerol-water-NaCl solutions...
June 26, 2018: Journal of Colloid and Interface Science
Huan Lu, Zhiyong Suo, Zhenfang Li, Jinwei Xie, Jiwei Zhao, Qingjun Zhang
For Interferometry Synthetic Aperture Radar (InSAR), the normal baseline is one of the main factors that affects the accuracy of the ground elevation. For Gaofen-3 (GF-3) InSAR processing, the poor accuracy of the real-time orbit determination results in a large baseline error, leads to a modulation error in azimuth and a slope error in the range for timely Digital Elevation Model (DEM) generation. In order to address this problem, a novel baseline estimation approach based on Shuttle Radar Topography Mission (SRTM) DEM is proposed in this paper...
July 4, 2018: Sensors
Lingang Cui, Qingjun Meng, Jianguo Wen, Zechen Yan, Zhan Gao, Yudong Tian, Pengchao Xu, Pengchao Lian, Haizhou Yu
This study aimed to investigate the exact regulatory mechanisms of GRIM-19 in renal carcinoma. Tumor tissue samples from patients with renal carcinoma (n = 30, there were 7 cases of stage I, 8 cases of stage II, 8 cases of stage III, 7 cases of stage IV) and control subjects were selected from adjacent normal tissue (n = 10). Real-time quantitative PCR (qRT-PCR) and Western blotting was used to assess the level of GRIM-19, STAT3 and its downstream molecules. CD31 was detected by immunohistochemistry...
June 29, 2018: Journal of Biochemistry
Wei Xu, Jiwei Zheng, Shijie Bie, Liuyu Kang, Qingjun Mao, Weiwei Liu, Jinxin Guo, Juan Lu, Rui Xia
Aberrant activation of Wnt signaling is implicated in gliomagenesis. Propofol, the most commonly used intravenous anesthetic agent in clinics, exhibits potent antitumor activity in a variety of cancer cells through different mechanisms. However, the role of propofol on Wnt signaling and glioma cell growth remains to be fully elucidated. In the present study, propofol was identified as a potent inhibitor of Wnt signaling. In 293T cells transfected with Wnt1 or Wnt3 expression plasmids or treated with Wnt3A-conditioned medium, propofol significantly inhibited the transcriptional activity of the SuperTopFlash reporter and the expression of Wnt target genes...
July 2018: Oncology Letters
Yuwei Shan, Yingguo Li, Di Huang, Qingjun Tong, Wang Yao, Wei-Tao Liu, Shiwei Wu
Crystal symmetry plays a central role in governing a wide range of fundamental physical phenomena. One example is nonlinear optical second harmonic generation (SHG), which requires inversion symmetry breaking. We report a unique stacking-induced SHG in graphene trilayers, whose individual monolayer sheet is centrosymmetric. Depending on layer stacking sequence, we observe a strong optical SHG in a Bernal ABA-stacked non-centrosymmetric trilayer, while it vanishes in a rhombohedral ABC-stacked one, which preserves inversion symmetry...
June 2018: Science Advances
Xin Jiang, Xiaoli Niu, Qingjun Guo, Yanhong Dong, Jing Xu, Nan Yin, Qianqian Qi, Yanqiu Jia, Liwei Gao, Qihui He, Peiyuan Lv
Vascular dementia (VD) is a heterogeneous group of brain disorders in which cognitive impairment is attributed to cerebrovascular pathologies. Autophagy, a self-cannibalization mechanism, has been demonstrated to be involved in VD progression. Molecular hydrogen is known for its powerful anti-oxidative, anti-apoptotic, and anti-inflammatory activities, and it is also involved in autophagy. However, the effects of hydrogen on VD remain unclear. The current study found that hydrogen-rich water (HRW) significantly alleviated spatial learning and memory impairments...
June 7, 2018: Behavioural Brain Research
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