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Lingling Yang, Songmei Zhang, Haoyun Duan, Muchen Dong, Xiaoli Hu, Zhaohua Zhang, Yao Wang, Xiaoping Zhang, Weiyun Shi, Qingjun Zhou
Chronic inflammation and severe dry eye are two important adverse factors for the successful transplant of cultured limbal stem cells. The aim of this study was to investigate the effects of inflammation and hyperosmotic stress (a key pathological factor in dry eye) on corneal epithelial stem cells (CESCs) and corneal epithelial wound healing. We observed that the CESCs exhibited significant morphological changes when treated with either interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), or hyperosmotic stress...
October 9, 2018: Stem Cells Translational Medicine
Daizong Ji, Ning Xu, Zixiang Liu, Zhouyuanjing Shi, Sze Shin Low, Jingjing Liu, Chen Cheng, Jingwen Zhu, Tingkai Zhang, Haoxuan Xu, Xiongjie Yu, Qingjun Liu
Parkinson's disease caused by lack of dopamine in brain is a common neurodegenerative disorder. The traditional treatment is to replenish levodopa since it could pass through blood brain barrier and form dopamine. However, its accumulation can cause patients' movement disorders and uncontrollable emotion. Therefore, it is critical to control the levodopa dosage accuracy to improve the curative effect in clinical. In this study, a smartphone-based electrochemical detection system was developed for rapid monitoring of levodopa...
September 24, 2018: Biosensors & Bioelectronics
Qingjun Tong, Fei Liu, Jiang Xiao, Wang Yao
We explore the skyrmion formation and control possibilities in 2D magnets from the ubiquitous moiré pattern in vdW heterostructures. Using the example of a ferromagnetic monolayer on an antiferromagnetic substrate, we demonstrate a new origin of skyrmions in the 2D magnets, from the lateral modulation of interlayer magnetic coupling by the locally different atomic registries in moiré. The moiré skyrmions are doubly degenerate with opposite topological charge, and trapped at an ordered array of sites with the moiré periodicity that can be dramatically tuned by strain and interlayer translation...
October 4, 2018: Nano Letters
Xiancan Zhu, Qingjun Cao, Luying Sun, Xiaoqin Yang, Wenying Yang, Hua Zhang
Stomata play a critical role in the regulation of gas exchange between the interior of the leaf and the exterior environment and are affected by environmental and endogenous stimuli. This study aimed to evaluate the effect of the arbuscular mycorrhizal (AM) fungus, Rhizophagus irregularis , on the stomatal behavior of wheat ( Triticum aestivum L.) plants under combination with elevated CO2 and NaCl stress. Wheat seedlings were exposed to ambient (400 ppm) or elevated (700 ppm) CO2 concentrations and 0, 1, and 2 g kg-1 dry soil NaCl treatments for 10 weeks...
2018: Frontiers in Plant Science
Peihai Li, Kun Zang, Yingjie Li, Changshui Liu, Qingjun Ma
Extracellular proteases are often produced as pre-pro-enzyme and then undergo multiple processing steps to mature into the active form. The protease Epp, a virulent factor of Vibrio anguillarum, belongs to this family. Its maturation might be regulated by Ca2+ via its polycystic kidney disease (PKD) domain, but the molecular mechanism is unknown. Herein, we report the crystal structure of the first PKD domain from V. anguillarum Epp (Epp-PKD1) and its specific Ca2+ -binding capacity. Epp-PKD1 exists as a monomer, consisting of seven β-strands which form two β-sheets stacking with each other...
October 28, 2018: Biochemical and Biophysical Research Communications
Chen Yang, Yun Guo, Tong-Sheng Huang, Jia Zhao, Xi-Jie Huang, Hao-Xuan Tang, Ning An, Qingjun Pan, Yong-Zhi Xu, Hua-Feng Liu
Cisplatin is a well-known chemotherapeutic drug applied for the treatment of numerous human cancers. However, the use of cisplatin in clinic is limited by certain serious side effects, such as nephrotoxicity. Unfortunately, there is currently no effective therapeutic approach to prevent cisplatin-induced AKI. Increasing evidence suggests that apoptosis of tubular epithelial cells and renal inflammation mainly determine the progression and outcome of cisplatin-induced AKI. Asiatic acid (AA) has been reported have the functions of anti-inflammation and anti-apoptosis, etc...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Qingjun Wu, Ailian Hua, Yaoguang Sun, Chao Ma, Wenxin Tian, Chuan Huang, Hanbo Yu, Peng Jiao, Shuanghu Wang, Hongfeng Tong, Weiwen Qiu
BACKGROUND: AZD-3759 is a new, potent, oral, active central nervous system-penetrant EGFR inhibitor. Despite promising clinical activity among patients pretreated and never treated with EGFR-tyrosine kinase inhibitors, no time saving pharmacokinetic study method has been reported in an animal model. METHODS: Protein was precipitated with acetonitrile and then used for sample pre-processing. A CORTECS BEH C18 column was used to separate the analytes at 40°C. Acetonitrile and water (containing 0...
September 5, 2018: Thoracic Cancer
Jianji Wang, Long Yang, Minxian Ma, Guangdi Li, Shunen Xu, Qingjun Li, Zhe Xu, Jun Liu, Chuan Ye
BACKGROUND Clogging of the suction tip frequently occurs during orthopedic surgery. We developed a novel anti-clog suction tip using 3D printing technology to improve orthopedic surgery efficiency. MATERIAL AND METHODS We studied the root causes of obstructions in suction tips currently employed in orthopedic surgery during actual surgical cases. CAD software and 3D printer was used to design, modify, and print the novel suction tip. The frequency of clogging, the frequency of replacement of the suction tip, the time lost in replacing suction tips or connecting tubes, surgical duration, intraoperative surgical blood loss, and the satisfaction scores for the suction tips as rated by the surgeons were compared between the novel suction tip and the conventional suction tip...
September 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Shuang Li, Danhua Zhang, Jinglong Liu, Chen Cheng, Long Zhu, Candong Li, Yanli Lu, Sze Shin Low, Bin Su, Qingjun Liu
Silica nanopores have electron channels and ion channels interpenetrating each other, which prompt the use of this structure for creating efficient electronic devices. In this study, silica nanopores membrane modified screen printed electrodes were applied in a smartphone-based electrochemiluminescence system for nitroaromatic explosives detection. Universal serial bus-on the go (USB-OTG) and camera on smartphone were used as the electrical stimulation and luminescence capture, respectively. ⎕Multimode methods including (red-green-blue) RGB, (hue-saturation-brightness) HSB, and Gray were proposed for luminescence analysis...
September 15, 2018: Biosensors & Bioelectronics
Qingjun Jin, Gang Yang
We obtain, for the first time, the two-loop amplitudes for Higgs plus three gluons in Higgs effective field theory including dimension-seven operators. This provides the S-matrix elements for the top mass corrections for Higgs plus a jet production at LHC. The computation is based on the on-shell unitarity method combined with integration by parts reduction. We work in conventional dimensional regularization and obtain analytic expressions renormalized in the modified minimal subtraction scheme. The two-loop anomalous dimensions present operator mixing behavior...
September 7, 2018: Physical Review Letters
Huanqin Han, Shujun Wang, Yanting Liang, Jieping Lin, Lei Shi, Lin Ye, Shiting Song, Minjun He, Shihao Li, Futong Chen, Qingjun Pan, Hua-Feng Liu
Aims/Introduction: Steroid resistance and frequent relapse are problems in the treatment of minimal change disease (MCD). However, epidemiological factors that influence steroid-resistant and relapse of MCD are rarely reported. This study evaluated potential factors that influence the onset and relapse of MCD and the epidemiological features of southern Chinese patients with adult-onset MCD. Patients and Methods: Patients with adult-onset MCD were included from the Affiliated Hospital of Guangdong Medical University, which is located in the southernmost part of China's mainland, between 2015 and 2016...
2018: BioMed Research International
Hainan Chen, Yijian Liu, Qingjun Gui, Xiao Zhu, Lin Zeng, Jun Meng, Jina Qing, Ling Gao, Ampadu O Jackson, Juling Feng, Yi Li, Jin He, Kai Yin
Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending (LAD). Ghrelin or saline was intraperitoneally injected two times per day for 8 weeks after ligation. The weight of heart (mg) and the weight ratio of heart to body (mg/g) as well as the fibrotic area were increased, while serum level of ghrelin was decreased after AMI...
September 12, 2018: Peptides
Lingang Cui, Qingjun Meng, Jianguo Wen, Zhan Gao, Zechen Yan, Yudong Tian, Pengchao Xu, Xianfei He, Haizhou Yu, Pengchao Lian
This study investigated the effect of muscle-derived stem cells (MDSCs) and adipose tissue-derived stem cells (ADSCs) in the treatment of stress urinary incontinence (SUI) and their differences in a rat model. MDSCs and ADSC were isolated from rats (n = 10), examined for their properties, and labeled with enhanced green fluorescent protein (EGFP) and β-galactosidase (β-gal) gene. Rats received bladder-neck and transurethral sphincter injection of EGFP-labeled MDSCs and β-gal gene-labeled ADSC and injection of D-Hanks as a control (n = 24 each group)...
October 2018: IUBMB Life
Dandan Xu, Yanyan He, Youjun Zhang, Wen Xie, Qingjun Wu, Shaoli Wang
The two-spotted spider mite, Tetranychus urticae Koch, is a serious agricultural pest that has developed resistance to many pesticides. A leaf dip assay was used to assess the resistance of seven field populations of T. urticae to 11 pesticides in China. The mutation frequencies of target genes related to pesticide resistance were also determined. The results showed that all seven field populations had high or extremely high resistance to abamectin and had low or moderate resistance to newly developed pesticides including bifenazate, cyenopyrafen, chlorfenapyr, B-azolemiteacrylic, and spinetoram...
September 2018: Pesticide Biochemistry and Physiology
Jianhua Kang, Xiaoqin Gou, Yuehua Hu, Wei Sun, Runqing Liu, Zhiyong Gao, Qingjun Guan
This study introduces the use of a waste by-product from wet limestone flue gas desulfurization as a potential material for fluoride removal. Systematic laboratory-scale experiments were tested to identify the fluoride removal performance and determine the underlying mechanism. Flue gas desulfurization (FGD) gypsum removes 93.31% of fluoride from 109 mg/L to 7.3 mg/L. Fluoride can be efficiently removed at the optimum pH range of 5-11. Kinetics analysis indicates that the theoretical fluoride capacity at 1 g/L FGD gypsum is 96...
February 1, 2019: Science of the Total Environment
Jia Yu, Jianrui Qi, Lingling Zhang, Xing Yu, Qingjun Kong, Xueyan Ren
Stilbenoids, particularly resveratrol and its oligomer, are abundantly present in grapes, and their antioxidant activities have been widely reported. A quick and simple method based on UHPLC-ESI-QTOF-MS2 was established for the fragmentation pathways analysis of trans-ε-Viniferin, cis-ε-Viniferin, trans-δ-Viniferin and (-)-Hopeaphenol. MS/MS experiments on the [M-H]- ions provided abundant structural information, especially regarding the relative abundance of the key product ion at m/z 347. The product ion was used to further identify structures in isomers of resveratrol dimers and its analogues...
October 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
QingJun Kong, Xing Yu, DanDan Song, XueYan Ren
AIMS: Aspergillus aculeatus (A. aculeatus), a pathogen of peaches, can cause soft rot and lead to economic losses in agricultural production. However, studies on the prevention of soft rot caused by A. aculeatus have rarely been reported. Tricyclazole (TCZ) is a fungicide that has been widely used in disease prevention of various crops but the inhibitory mechanism of TCZ on A. aculeatus is unknown. Our aims were to determine the effects of TCZ on A. aculeatus. METHODS AND RESULTS: In our study, TCZ inhibited the growth of fungal colonies when applied at 0...
August 21, 2018: Journal of Applied Microbiology
Qingjun Zhang, Yun Chen, Ke Liu
Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence and mortality. miR-185, a microRNA with appriximately 22-28 nucleotides, was reported to be involved in many cancers. The potential mechanism of miR-185 on HCC through cell division cycle 42 (CDC42) was investigated. RT-qPCR was used to measure the RNA level of miR-185 and CDC42 in HCC tissues and cells. The dual luciferase reporter assay was used to verify whether CDC42 was a target gene for miR-185. Transwell assay was employed to detect the ability of migration and invasion to change miR-185...
September 2018: Oncology Letters
Qingjun Guo, Xi Yin, Meng Qiao, Yujiao Jia, Dandan Chen, Juan Shao, Tyler W Lebaron, Yuan Gao, Haishui Shi, Bin Jia
Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administration on valproic acid (VPA)-induced autistic-like behavioral deficits, and the associated underlying mechanism in adolescent mice offspring...
2018: Frontiers in Behavioral Neuroscience
Shouliang Qi, Qingjun Gao, Jing Shen, Yueyang Teng, Xuan Xie, Yueji Sun, Jianlin Wu
The human brain is a complex system composed by several large scale intrinsic networks with distinct functions. The low frequency oscillation (LFO) signal of blood oxygen level dependent (BOLD), measured through resting-state fMRI, reflects the spontaneous neural activity of these networks. We propose to characterize these networks by applying the multiple frequency bands analysis (MFBA) to the LFO time courses (TCs) resulted from the group independent component analysis (ICA). Specifically, seven networks, including the default model network (DMN), dorsal attention network (DAN), control executive network (CEN), salience network, sensorimotor network, visual network and limbic network, are identified...
2018: Frontiers in Computational Neuroscience
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