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https://www.readbyqxmd.com/read/30481766/long-non-coding-rna-xloc_006753-promotes-the-development-of-multidrug-resistance-in-gastric-cancer-cells-through-the-pi3k-akt-mtor-signaling-pathway
#1
Lisi Zeng, Quanxing Liao, Zhaowei Zou, Yuefeng Wen, Jingshu Wang, Chang Liu, Qingjun He, Nuoqing Weng, Judeng Zeng, Hongsheng Tang, Runya Fang, Ziying Lei, Zhen Tang, Xianzi Yang, Shuzhong Cui
BACKGROUND/AIMS: The development of multidrug resistance (MDR), which results in disease recurrence and metastasis, is a crucial obstacle to successful chemotherapy for patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been found to play various roles in cancer. This study aimed to investigate the effect of XLOC_006753 on the development of MDR in GC cells. METHODS: The expression levels of XLOC_006753 in GC patients and MDR GC cell lines (SGC-7901/5-FU and SGC-7901/DDP cell line) were assessed by qRT-PCR...
November 27, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30469516/fucoidan-extracted-from-the-new-zealand-undaria-pinnatifida-physicochemical-comparison-against-five-other-fucoidans-unique-low-molecular-weight-fraction-bioactivity-in-breast-cancer-cell-lines
#2
Jun Lu, Keyu Kally Shi, Shuping Chen, Junqiao Wang, Amira Hassouna, Loretta Nicole White, Fabrice Merien, Mingyong Xie, Qingjun Kong, Jinyao Li, Tianlei Ying, William Lindsey White, Shaoping Nie
Fucoidan, the complex fucose-containing sulphated polysaccharide varies considerably in structure, composition, and bioactivity, depending on the source, species, seasonality, and extraction method. In this study, we examined five fucoidans extracted from the same seaweed species Undaria pinnatifida but from different geological locations, and compared them to the laboratory-grade fucoidan from Sigma (S). The five products differed in molecular composition. The amount of over 2 kDa low molecular weight fraction (LMWF) of the New Zealand crude fucoidan (S1) was larger than that of S, and this fraction was unique, compared to the other four fucoidans...
November 22, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30458420/discrimination-of-rare-earth-element-geochemistry-and-co-occurrence-in-sediment-from-poyang-lake-the-largest-freshwater-lake-in-china
#3
Lingqing Wang, Xiaoxiao Han, Tao Liang, Qingjun Guo, Jing Li, Lijun Dai, Shiming Ding
Geochemical distribution of trace elements in sediments could reflect the impact of anthropogenic activities on environmental changes in aquatic ecosystems. In this study, rare earth elements (REEs) were used as geochemical tracers to study the environmental processes in a complex and dynamic aquatic environment. Both surface and core sediment samples were collected from Poyang Lake, the largest freshwater lake located in the middle-low region of the Yangtze River. Sediment samples were analyzed for their respective REE spatial distributions, fractionation, and co-occurrence patterns...
November 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/30453677/investigation-of-different-molecular-weight-fucoidan-fractions-derived-from-new-zealand-undaria-pinnatifida-in-combination-with-groa-therapy-in-prostate-cancer-cell-lines
#4
Xu Yang, Sheng Wang, Sari Schokoroy Trangle, Yan Li, William Lindsey White, Jinyao Li, Tianlei Ying, Qingjun Kong, Yu Zhao, Jun Lu
Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand Undaria pinnatifida , and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species U...
November 18, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30445324/contamination-patterns-in-river-water-from-rural-beijing-a-hydrochemical-and-multiple-stable-isotope-study
#5
Marc Peters, Qingjun Guo, Harald Strauss, Rongfei Wei, Siliang Li, Fujun Yue
The pollution of urban river has reached a critical level. In the present study, the hydrochemical composition of local surface water collected during two seasons from the rural area around urban Beijing, China, was examined. Concentrations of selected cations and anions reveal the temporal and spatial distribution of anthropogenic and natural pollution. Multiple stable isotopes (δ15 Nnitrate , δ18 Onitrate , δ34 Ssulfate , δ18 Osulfate , Δ33 Ssulfate ) analyses were applied for detecting of specific hydrochemical processes and identifying the major sources of contamination...
November 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30405771/mir-145-5p-inhibits-the-proliferation-and-migration-of-bladder-cancer-cells-by-targeting-tagln2
#6
Haijian Zhang, Meijuan Jiang, Qingjun Liu, Zhixing Han, Yuqian Zhao, Shiqi Ji
MicroRNA-145-5p (miR-145-5p) is found to be involved in tumor development and progression. However, there are few studies on the effects of miR-145-5p on bladder cancer (BC). The role of miR-145-5p in BC was predicted by analysis of cell proliferation and migration in this study. The miR-145-5p and transgelin-2 (TAGLN2) expressions were evaluated via reverse transcription-quantitative PCR (RT-qPCR) or western blot analysis. The MTT and Transwell assay assessed cell proliferation and migration. TAGLN2 targeted to miR-145-5p was determined using luciferase assays...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30401637/diet-induced-hepatic-steatosis-activates-ras-to-promote-hepatocarcinogenesis-via-cpt1%C3%AE
#7
An Xu, Bibo Wang, Jing Fu, Wenhao Qin, Ting Yu, Zhishi Yang, Qingjun Lu, Jingyi Chen, Yao Chen, Hongyang Wang
Aberrant activation of the RAS cascade ubiquitously occurs in human hepatocellular carcinomas (HCC), regardless of rare mutations of RAS. However, the association between the Ras cascade and hepatic steatosis during hepatocarcinogenesis remains under-investigated. Here, the variation in the constitutive activity of Ras signaling and HCC incidence was found in a nonalcoholic fatty liver disease (NAFLD)-HCC mouse model, and Ras activity was induced by hepatic steatosis. Even in hepatocyte-specific expression of KrasG12D (Alb-Cre/KrasG12D , Krashep ) mice, mutagenic activation of Ras signaling was still significantly enhanced by NAFLD, with downregulation of negative regulators...
October 26, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30373442/clinical-features-of-and-risk-factors-for-hydrocephalus-in-childhood-bacterial-meningitis
#8
Liang Huo, Yuying Fan, Chunying Jiang, Jian Gao, Meng Yin, Hua Wang, Fenghua Yang, Qingjun Cao
OBJECTIVE: To explore the clinical characteristics of and analyze the risk factors for hydrocephalus in children with bacterial meningitis. METHODS: Retrospective study of a sample of children with bacterial meningitis seen on the pediatric service of Shengjing Hospital of China Medical University between January 1, 2010, and December 31, 2016. RESULTS: Overall, 9.36% (25/267) of patients presented with hydrocephalus. Among patients with hydrocephalus, the age at onset of bacterial meningitis was usually <6 months, 15 patients had confirmed bacterial etiology, and 1 patient died...
October 29, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/30361842/constitutive-expression-of-rel1-confers-the-rice-response-to-drought-stress-and-abscisic-acid
#9
Jiayan Liang, Shaoying Guo, Bo Sun, Qing Liu, Xionghui Chen, Haifeng Peng, Zemin Zhang, Qingjun Xie
Leaf rolling is one of the most significant symptoms of drought stress in plant. Previously, we identified a dominant negative mutant, termed rolled and erect 1 (hereafter referred to rel1-D), regulating leaf rolling and erectness in rice. However, the role of REL1 in drought response is still poorly understood. Here, our results indicated that rel1-D displayed higher tolerance to drought relative to wild type, and the activity of superoxide dismutase (SOD) and drought responsive genes were significantly up-regulated in rel1-D...
October 25, 2018: Rice
https://www.readbyqxmd.com/read/30350003/curcumin-loaded-chitosan-bovine-serum-albumin-nanoparticles-potentially-enhanced-a%C3%AE-42-phagocytosis-and-modulated-macrophage-polarization-in-alzheimer-s-disease
#10
Rui Yang, Yan Zheng, Qingjun Wang, Liang Zhao
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly population. In the treatment of AD, some obstacles, including drug penetration difficulty through the blood-brain barrier (BBB), inadequate clearance of the Aβ peptide, and the massive release of inflammatory factors, must be urgently overcome. To solve these problems, we developed special and novel nanoparticles (NPs) made of chitosan (CS) and bovine serum albumin (BSA) to enhance the penetration of drugs through the BBB...
October 22, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/30302939/different-effects-of-pro-inflammatory-factors-and-hyperosmotic-stress-on-corneal-epithelial-stem-progenitor-cells-and-wound-healing-in-mice
#11
Lingling Yang, Songmei Zhang, Haoyun Duan, Muchen Dong, Xiaoli Hu, Zhaohua Zhang, Yao Wang, Xiaoping Zhang, Weiyun Shi, Qingjun Zhou
Chronic inflammation and severe dry eye are two important adverse factors for the successful transplant of cultured limbal stem cells. The aim of this study was to investigate the effects of inflammation and hyperosmotic stress (a key pathological factor in dry eye) on corneal epithelial stem cells (CESCs) and corneal epithelial wound healing. We observed that the CESCs exhibited significant morphological changes when treated with either interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), or hyperosmotic stress...
October 9, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/30297172/smartphone-based-differential-pulse-amperometry-system-for-real-time-monitoring-of-levodopa-with-carbon-nanotubes-and-gold-nanoparticles-modified-screen-printing-electrodes
#12
Daizong Ji, Ning Xu, Zixiang Liu, Zhouyuanjing Shi, Sze Shin Low, Jingjing Liu, Chen Cheng, Jingwen Zhu, Tingkai Zhang, Haoxuan Xu, Xiongjie Yu, Qingjun Liu
Parkinson's disease caused by lack of dopamine in brain is a common neurodegenerative disorder. The traditional treatment is to replenish levodopa since it could pass through blood brain barrier and form dopamine. However, its accumulation can cause patients' movement disorders and uncontrollable emotion. Therefore, it is critical to control the levodopa dosage accuracy to improve the curative effect in clinical. In this study, a smartphone-based electrochemical detection system was developed for rapid monitoring of levodopa...
September 24, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30285450/skyrmions-in-the-moir%C3%A3-of-van-der-waals-2d-magnets
#13
Qingjun Tong, Fei Liu, Jiang Xiao, Wang Yao
We explore the skyrmion formation and control possibilities in two-dimensional (2D) magnets from the ubiquitous moiré pattern in vdW heterostructures. Using the example of a ferromagnetic monolayer on an antiferromagnetic substrate, we demonstrate a new origin of skyrmions in the 2D magnets from the lateral modulation of interlayer magnetic coupling by the locally different atomic registries in moiré. The moiré skyrmions are doubly degenerate with opposite topological charge and trapped at an ordered array of sites with the moiré periodicity that can be dramatically tuned by strain and interlayer translation...
November 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/30283478/stomatal-conductance-and-morphology-of-arbuscular-mycorrhizal-wheat-plants-response-to-elevated-co-2-and-nacl-stress
#14
Xiancan Zhu, Qingjun Cao, Luying Sun, Xiaoqin Yang, Wenying Yang, Hua Zhang
Stomata play a critical role in the regulation of gas exchange between the interior of the leaf and the exterior environment and are affected by environmental and endogenous stimuli. This study aimed to evaluate the effect of the arbuscular mycorrhizal (AM) fungus, Rhizophagus irregularis , on the stomatal behavior of wheat ( Triticum aestivum L.) plants under combination with elevated CO2 and NaCl stress. Wheat seedlings were exposed to ambient (400 ppm) or elevated (700 ppm) CO2 concentrations and 0, 1, and 2 g kg-1 dry soil NaCl treatments for 10 weeks...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30268503/structural-basis-for-specific-calcium-binding-by-the-polycystic-kidney-disease-domain-of-vibrio-anguillarum-protease-epp
#15
Peihai Li, Kun Zang, Yingjie Li, Changshui Liu, Qingjun Ma
Extracellular proteases are often produced as pre-pro-enzyme and then undergo multiple processing steps to mature into the active form. The protease Epp, a virulent factor of Vibrio anguillarum, belongs to this family. Its maturation might be regulated by Ca2+ via its polycystic kidney disease (PKD) domain, but the molecular mechanism is unknown. Herein, we report the crystal structure of the first PKD domain from V. anguillarum Epp (Epp-PKD1) and its specific Ca2+ -binding capacity. Epp-PKD1 exists as a monomer, consisting of seven β-strands which form two β-sheets stacking with each other...
October 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30257350/asiatic-acid-protects-against-cisplatin-induced-acute-kidney-injury-via-anti-apoptosis-and-anti-inflammation
#16
Chen Yang, Yun Guo, Tong-Sheng Huang, Jia Zhao, Xi-Jie Huang, Hao-Xuan Tang, Ning An, Qingjun Pan, Yong-Zhi Xu, Hua-Feng Liu
Cisplatin is a well-known chemotherapeutic drug applied for the treatment of numerous human cancers. However, the use of cisplatin in clinic is limited by certain serious side effects, such as nephrotoxicity. Unfortunately, there is currently no effective therapeutic approach to prevent cisplatin-induced AKI. Increasing evidence suggests that apoptosis of tubular epithelial cells and renal inflammation mainly determine the progression and outcome of cisplatin-induced AKI. Asiatic acid (AA) has been reported have the functions of anti-inflammation and anti-apoptosis, etc...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30252204/determination-and-pharmacokinetic-study-of-azd-3759-in-rat-plasma-by-ultra-performance-liquid-chromatography-with-triple-quadrupole-mass-spectrometer
#17
Qingjun Wu, Ailian Hua, Yaoguang Sun, Chao Ma, Wenxin Tian, Chuan Huang, Hanbo Yu, Peng Jiao, Shuanghu Wang, Hongfeng Tong, Weiwen Qiu
BACKGROUND: AZD-3759 is a new, potent, oral, active central nervous system-penetrant EGFR inhibitor. Despite promising clinical activity among patients pretreated and never treated with EGFR-tyrosine kinase inhibitors, no time saving pharmacokinetic study method has been reported in an animal model. METHODS: Protein was precipitated with acetonitrile and then used for sample pre-processing. A CORTECS BEH C18 column was used to separate the analytes at 40°C. Acetonitrile and water (containing 0...
November 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/30251710/development-and-application-of-a-no-clog-surgical-suction-tip-using-3d-printing-technology
#18
Jianji Wang, Long Yang, Minxian Ma, Guangdi Li, Shunen Xu, Qingjun Li, Zhe Xu, Jun Liu, Chuan Ye
BACKGROUND Clogging of the suction tip frequently occurs during orthopedic surgery. We developed a novel anti-clog suction tip using 3D printing technology to improve orthopedic surgery efficiency. MATERIAL AND METHODS We studied the root causes of obstructions in suction tips currently employed in orthopedic surgery during actual surgical cases. CAD software and 3D printer was used to design, modify, and print the novel suction tip. The frequency of clogging, the frequency of replacement of the suction tip, the time lost in replacing suction tips or connecting tubes, surgical duration, intraoperative surgical blood loss, and the satisfaction scores for the suction tips as rated by the surgeons were compared between the novel suction tip and the conventional suction tip...
September 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30245166/electrochemiluminescence-on-smartphone-with-silica-nanopores-membrane-modified-electrodes-for-nitroaromatic-explosives-detection
#19
Shuang Li, Danhua Zhang, Jinglong Liu, Chen Cheng, Long Zhu, Candong Li, Yanli Lu, Sze Shin Low, Bin Su, Qingjun Liu
Silica nanopores have electron channels and ion channels interpenetrating each other, which prompt the use of this structure for creating efficient electronic devices. In this study, silica nanopores membrane modified screen printed electrodes were applied in a smartphone-based electrochemiluminescence system for nitroaromatic explosives detection. Universal serial bus-on the go (USB-OTG) and camera on smartphone were used as the electrical stimulation and luminescence capture, respectively. ⎕Multimode methods including (red-green-blue) RGB, (hue-saturation-brightness) HSB, and Gray were proposed for luminescence analysis...
September 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30240273/analytic-two-loop-higgs-amplitudes-in-effective-field-theory-and-the-maximal-transcendentality-principle
#20
Qingjun Jin, Gang Yang
We obtain, for the first time, the two-loop amplitudes for Higgs plus three gluons in Higgs effective field theory including dimension-seven operators. This provides the S-matrix elements for the top mass corrections for Higgs plus a jet production at LHC. The computation is based on the on-shell unitarity method combined with integration by parts reduction. We work in conventional dimensional regularization and obtain analytic expressions renormalized in the modified minimal subtraction scheme. The two-loop anomalous dimensions present operator mixing behavior...
September 7, 2018: Physical Review Letters
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