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vessel spasm

Yan-Qiang Zhou, Yin-Tao Zhao, Xiao-Yan Zhao, Cui Liang, Ya-Wei Xu, Ling Li, Yuan Liu, Hai-Bo Yang
Finding the novel drug from the effective components of traditional Chinese herbal medicine is a hotspot of the modern pharmacological research. Hyperoside (HYP) belongs to flavonoid glycosides, and it has various properties, such as anti-inflammation, anti-spasm, anti-diuretic, antitussive, lowering blood pressure, and lowering cholesterol effects as well as protective effects for the cardiac and cerebral blood vessels. The purpose of this study was to investigate the effects of HYP on inflammatory and apoptotic responses in vascular endothelial cells stimulated by lipopolysaccharide (LPS) and further to identify the possible mechanisms underlying these effects...
April 2018: Current medical science
Nicholas Sellke, Alex Kuczmarski, Isabella Lawandy, Victoria L Cole, Afshin Ehsan, Arun K Singh, Yuhong Liu, Frank W Sellke, Jun Feng
OBJECTIVE: Cardioplegic arrest (CP) and cardiopulmonary bypass (CPB) are associated with vasomotor dysfunction of coronary arterioles in patients with diabetes (DM) undergoing cardiac surgery. We hypothesized that DM may up-regulate vasopressin receptor expression and alter the contractile response of coronary arterioles to vasopressin in the setting of CP/CPB. METHODS: Right atrial tissue samples of patients with DM and without (ND) (n = 8 in each group) undergoing cardiac surgery were harvested before and after CP/CPB...
June 8, 2018: Journal of Thoracic and Cardiovascular Surgery
Rebecca Knackstedt, James Gatherwright, Raffi Gurunluoglu
INTRODUCTION: There is a hesitancy to utilize vasopressors in microsurgical reconstruction due to fear of vessel spasm and subsequent flap compromise. Although there are large literature reviews analyzing vasopressor usage in head and neck reconstruction, this has not been extrapolated to all regions of the body. The goal of this study was to perform a meta-analysis examining vasopressor usage and risk of complications in microsurgical reconstruction for all recipient sites. MATERIALS AND METHODS: A meta-analysis was conducted for articles discussing the utilization of vasopressors in microsurgical reconstruction...
July 29, 2018: Microsurgery
Christopher R Honey, Murray D Morrison, Manraj K S Heran, Baljinder S Dhaliwal
Inducible laryngeal obstruction has been described under at least 40 different monikers, including vocal cord dysfunction, paroxysmal vocal fold motion, and irritable larynx. The etiology of this condition is believed to be laryngeal hyperactivity in response to psychological issues or acid reflux. Most patients are treated with some combination of proton pump inhibitors, speech therapy, and psychotherapy. However, a small cohort of patients remains refractory to all medical interventions. The authors describe a novel condition, hemi-laryngopharyngeal spasm (HELPS), which can cause severe episodic stridor leading to unconsciousness in association with cough...
July 20, 2018: Journal of Neurosurgery
Aryadi Arsyad, Elke Sokoya, Geoffrey P Dobson
New pharmacotherapies are required to improve vessel graft protection and prevent vasoconstriction and spasm in CABG surgery. Previously we have studied adenosine (A) and lidocaine (L) relaxation in rat aortic rings, and reported a possible crosstalk between L relaxation and adenosine A2a receptor inhibition. The aim of the present study was to examine the effect of AL combination compared to A and L alone on relaxation in intact and denuded rat aortic rings and in guinea-pig pressurized mesenteric arterial segments...
2018: American Journal of Translational Research
Hua Zhao, Jin Zhu, Xin Zhang, Yin-da Tang, Ping Zhou, Xu-Hui Wang, Shiting Li
BACKGROUND: Microvascular decompression (MVD) has become widely accepted as first-line therapy for hemifacial spasm. However, not all patients are candidates for the procedure, and some surgeons ignore arterioles that represent the actual underlying cause of the condition. The aim of this study was to address the role of involved arterioles in management of MVD in patients with hemifacial spasm. METHODS: Data were collected from 765 consecutive patients who underwent MVD from January 2009 to August 2010 in our hospital...
July 11, 2018: World Neurosurgery
Jun-Hyok Oh, Seunghwan Song, Changhoon Kim, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha, Taek Jong Hong
BACKGROUND: This study aimed to evaluate the effect of adenosine on epicardial coronary artery diameter during ergonovine provocation testing. METHODS: A total of 158 patients who underwent an ergonovine provocation test with intracoronary adenosine injection between 2011 and 2014 were selected. Patients were divided into four groups based on the severity of percent diameter stenosis following intracoronary ergonovine administration: Group 1, induced spasm < 50%; Group 2, 50-89%; Group 3, 90-99%; and Group 4, total occlusion...
July 16, 2018: Cardiology Journal
Lun-Xin Liu, Yan-Ming Ren, Peng-Wei Ren, Mei-Mei Yang, Jiang-Zhou You, Liang-Xue Zhou, Heng Zhang
OBJECTIVE: The aim of this study was to identify potential prognostic factors of hemifacial spasm (HFS) after microvascular decompression (MVD), to establish the appropriate way to tackle with post-procedure symptoms and complications ( PPSC), and to find the incidence and duration of PPSC. METHODS: Two hundred and forty-eight patients with HFS were monitored between December 2009 and December 2014. The mean follow-up duration was 24 months (6-67 months). We divided patients based on their PPSC status, and investigated following factors: age, sex, spasm side, facial nerve block before MVD (botulinum toxin treatment), acupuncture before MVD, duration of HFS, hypertension, diabetes, hepatitis B virus (HBV) infection status, herpes simplex virus infection status, smoking status and alcohol use, offending vessels, Chiari malformation, electrophysiological monitoring results, and postoperative HFS...
July 5, 2018: World Neurosurgery
Toru Satoh, Takanobu Yagi, Keisuke Onoda, Masahiro Kameda, Tatsuya Sasaki, Tomotsugu Ichikawa, Isao Date
OBJECTIVE Offending vessels at the site of neurovascular contact (NVC) in patients with trigeminal neuralgia (TN) and hemifacial spasm (HFS) may have specific hemodynamic features. The purpose of this study was to investigate the wall shear stress (WSS) of offending vessels at NVCs by conducting a computational fluid dynamics (CFD) analysis. METHODS The authors retrospectively analyzed the cases of 20 patients (10 with TN and 10 with HFS) evaluated by 3D CT angiography and used the imaging findings for analysis of the hemodynamic parameters...
July 6, 2018: Journal of Neurosurgery
Jiang Liu, Peng Liu, Ying Zuo, Xiaoli Xu, Hongju Liu, Rose Du, Yanbing Yu, Yue Yuan
OBJECTIVE: Although classical hemifacial spasm (HFS) has been attributed to an atraumatic pulsatile vascular compression around the root exit zone (REZ) of the facial nerve, rare tumor-related HFS associated with meningiomas, epidermoid tumors, lipomas, and schwannomas in the cerebellopontine angle have been reported. The exact mechanism and the necessity of microvascular decompression for tumor-induced HFS is not clear, especially for vestibular schwannomas. METHODS: We retrospectively analyzed 10 patients with vestibular schwannomas out of 5218 cases of hemifacial spasm between 2004 and 2014...
August 2018: World Neurosurgery
M Sindou, P Mercier
Primary hemifacial spasm with few exceptions is due to the vascular compression of the facial nerve that can be evidenced with high resolution MRI. Microvascular decompression is the only curative treatment for this pathology. According to literature review detailed in chapter "conflicting vessels", the compression is located at the facial Root Exit Zone (REZ) in 95% of the cases, and in 5% distally at the cisternal or the intrameatal portion of the root as the sole conflict or in addition to one at brainstem/REZ...
May 2018: Neuro-Chirurgie
Kazuma Tashiro, Hiroyoshi Mori, Hiromoto Sone, Yousuke Takei, Masahiro Sasai, Atsuo Maeda, Tokutada Sato, Hiroshi Suzuki
No abstract text is available yet for this article.
May 9, 2018: Coronary Artery Disease
J Magnan
Microvascular decompression has become the sole method for a curative treatment of primary hemifacial spasm. Finding the responsible conflicting artery is not always easy as its location can be deeply situated within the cerebellopontine/medullary fissure at the facial root exit zone. Sole or additional offending vessel(s) may be at the meatus of the internal auditory canal (5% of the cases). Identifying the compressive vessel(s) and performing decompression is in most cases possible without cerebellar retraction by classical microsurgical techniques...
May 2018: Neuro-Chirurgie
M Hermier
Almost all primary hemifacial spasms are associated with one or more neurovascular conflicts, most often at the root exit zone in the immediate vicinity of the brainstem. Imaging has first to exclude a secondary hemifacial spasm and secondly to search for and characterize the responsible neurovascular conflict(s). Magnetic resonance imaging should include high-resolution anatomical hyper T2-weighted sequences and magnetic resonance angiography by using 1.5 or even better 3 Tesla magnets. The most frequent vascular compressions are from the anterior-inferior cerebellar artery, the posterior-inferior cerebellar artery and the vertebrobasilar artery; venous conflicts are very rare...
May 2018: Neuro-Chirurgie
Bernardo C Mendes, Gustavo S Oderich, Tiziano Tallarita, Karina S Kanamori, Manju Kalra, Randall R DeMartino, Fahad Shuja, Jill K Johnstone
OBJECTIVE: The objective of the study was to report the feasibility and results of superior mesenteric artery (SMA) stenting using embolic protection devices (EPDs) to treat acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). METHODS: A retrospective review was conducted of consecutive patients who underwent SMA stenting with EPDs from 2007 to 2016. EPDs were used selectively in patients with occlusions, severe calcification, or acute thrombus...
April 20, 2018: Journal of Vascular Surgery
P Mercier, M Sindou
Since several decades, it has been established that so-called primary hemifacial spasm is linked to neuro-vascular conflicts in the facial nerve, especially its root exit zone (REZ). Based on our review of the detailed publications of literature (2489 patients), together with our own series (340 patients), the responsible vessels found at surgery were: the posterior inferior cerebellar artery in 47.2%, the anterior inferior cerebellar artery in 45.9%, the vertebro-basilar artery in 17.5%, another (smaller) artery in 11...
May 2018: Neuro-Chirurgie
J-P Lefaucheur
Primary hemifacial spasm (pHFS) is due to a benign compression of the facial motor nerve by an offending vessel, leading to increased nerve excitability. Facial nerve hyperexcitability presents two different aspects. First, there is a spontaneous and ectopic generation of action potentials on the incriminated nerve and then this ectopic impulse can propagate and spread "laterally" from one facial nerve branch to another. This results in spontaneous and synkinetic spasms affecting one hemiface. Although the increase in excitability certainly concerns the nucleus of the facial motor nerve in the brainstem, it seems unlikely that the primary origin of this hyperexcitability and the associated phenomenon of lateral spreading strictly originate at the nuclear level...
May 2018: Neuro-Chirurgie
J-P Lefaucheur, N Ben Daamer, S Sangla, C Le Guerinel
The diagnosis of primary hemifacial spasm (pHFS), due to a benign compression of the facial motor nerve by a vessel, within or close to its root exit zone, is often made with delay. Misdiagnosis includes psychogenic spasm, tics, facial myokymia or blepharospasm, but in fact post-facial palsy synkinesis (post-paralytic HFS) is the closest clinical condition, because it is limited to the territory of the facial nerve of a single hemiface. The differential diagnosis between these two entities, whose pathophysiological mechanisms are very different, can be made by electroneuromyographic (ENMG) examination...
May 2018: Neuro-Chirurgie
James L West, Jasmeet Singh, Stacey Q Wolfe, Kyle M Fargen
A 33-year-old man presented with aneurysmal subarachnoid hemorrhage from a ruptured, blister-type sidewall internal carotid artery (ICA) aneurysm. Balloon-assisted coiling was performed with residual neck. He subsequently developed severe vasospasm requiring intra-arterial therapies on multiple occasions, during which it was noted that despite widespread vasospasm, a focal segment of the ICA at the site of the aneurysm showed no significant spasm, suggesting underlying vessel abnormality. He was discharged without deficit and scheduled for flow diversion given concern over this potentially pathologic segment of vessel...
March 21, 2018: Journal of Neurointerventional Surgery
Amartya Kundu, Aditya Vaze, Partha Sardar, Ahmed Nagy, Wilbert S Aronow, Naomi F Botkin
PURPOSE OF REVIEW: Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias and cardiac arrest, even in patients with no history of prior cardiac disease. This review describes the epidemiology, pathogenesis, clinical spectrum, and management of variant angina, as well as outcomes in patients who present with aborted sudden cardiac death (ASCD)...
March 8, 2018: Current Cardiology Reports
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