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https://www.readbyqxmd.com/read/30515731/the-other-side-of-the-coin-in-renal-replacement-therapies-the-burden-on-caregivers
#1
Simge Bardak, Serap Demir, Eda Aslan, Kenan Turgutalp, Havva Didem Celikcan, Murside Esra Dolarslan, Cennet Kılıcarslan, Filiz Karasu, Ayse Jini Gunes, Cemal Kurt, Ahmet Kıykım
PURPOSE: Living with end-stage renal disease may be burdensome, not only for patients, but also for caregivers. In this study, we aim to compare caregiver burden, psychological symptoms in caregivers of peritoneal dialysis (PD), hemodialysis (HD), and transplantation (TX), and find out associated factors. METHODS: A total of 43 PD, 42 HD, 42 TX patients and a total of 127 caregivers that were actively involved with the care of their patients' dialysis were enrolled...
December 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30439604/celastrol-antagonizes-high-glucose-evoked-podocyte-injury-inflammation-and-insulin-resistance-by-restoring-the-ho-1-mediated-autophagy-pathway
#2
Xiaojiang Zhan, Caixia Yan, Yanbing Chen, Xin Wei, Jun Xiao, Lijuan Deng, Yuting Yang, Panlin Qiu, Qinkai Chen
Diabetic nephropathy (DN) contributes to end-stage renal disease and kidney dysfunction with a proverbial feature of podocyte injury. Inflammation and insulin resistance is recently implicated in the pathogenesis of diabetic kidney injury. Celastrol exerts critical roles in inflammatory diseases and injury progression. However, its function and mechanism in DN remains elusive. Here, celastrol dose-dependently restored podocyte viability under high glucose (HG) conditions, but with little cytotoxicity in podocyte...
December 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30396686/psychosocial-distress-and-health-service-utilization-in-patients-undergoing-hemodialysis-a-prospective-study
#3
Salam El-Majzoub, Istvan Mucsi, Madeline Li, Ghizlane Moussaoui, Mark L Lipman, Karl J Looper, Marta Novak, Soham Rej
BACKGROUND: End-stage renal disease is associated with significant morbidity, high-symptom burden, and health care use. Studies have not yet assessed psychosocial distress and health care utilization in this population. OBJECTIVE: This study examines psychosocial distress and its association with hospitalization and emergency room (ER) visits in patients on maintenance hemodialysis (HD). METHODS: The Distress Assessment and Response Tool (DART) was administered to 80 adults on HD in a single treatment center...
October 10, 2018: Psychosomatics
https://www.readbyqxmd.com/read/30352485/benefits-challenges-and-opportunities-using-home-hemodialysis-with-a-focus-on-mississippi-a-rural-southern-state
#4
Sohail Abdul Salim, Lajos Zsom, Wisit Cheungpasitporn, Tibor Fülöp
The prevalence of end-stage renal disease continues to increase in the United States with commensurate need for renal replacement therapies. Hemodialysis continues to be the predominant modality, though less than 2% of these patients will receive hemodialysis in their own home. While home modalities utilizing peritoneal dialysis have been growing, home hemodialysis (HHD) remains underutilized despite studies showing regression in left ventricular mass, improved quality of life, reduced depressive symptoms, and decreased postdialysis recovery time...
October 23, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/30350267/the-effect-of-renal-transplantation-on-left-ventricular-function-electrocardiography-and-mechanical-synchrony-by-gated-myocardial-perfusion-imaging
#5
William Crosland, Himanshu Aggarwal, Ayman Farag, Shikha Mehta, Roslyn B Mannon, Jaekyeong Heo, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Depressed left ventricular ejection fraction (LVEF), LV mechanical dyssynchrony (LVMD), and prolonged QTc interval predict poor outcomes in end-stage renal disease (ESRD). Renal transplantation improves mortality in ESRD patients but the effects of transplantation on these indices remain undefined. METHODS: We identified patients with myocardial perfusion imaging (MPI) before and after renal transplantation. A control group consisted of ESRD patients who underwent 2 MPIs but did not receive a transplant...
October 22, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30304618/identification-of-potential-mediators-between-depression-and-fluid-adherence-in-older-adults-undergoing-hemodialysis-treatment
#6
Tiffany R Washington, Debra J Hain, Sheryl Zimmerman, Iris Carlton-LaNey
Controlled fluid intake is an important aspect of living with end stage renal disease (ESRD), and is complicated by depression, the most common mental health issue affecting individuals with ESRD. Factors that mitigate the deleterious effects of depression are underexplored. This study sought to identify potential mediators between depression and fluid adherence in 107 individuals with ESRD aged 50 years and older by comparing four logistic regression models. Age was associated with an increase in fluid adherence (adjusted odds ratio [AOR]=1...
May 2018: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/30281126/chronic-inflammation-in-end-stage-renal-disease-and-dialysis
#7
Gabriela Cobo, Bengt Lindholm, Peter Stenvinkel
Under normal conditions, inflammation is a protective and physiological response to various harmful stimuli. However, in several chronic debilitating disorders, such as chronic kidney disease, inflammation becomes maladaptive, uncontrolled and persistent. Systemic persistent inflammation has, for almost 20 years, been recognized as a major contributor to the uraemic phenotype (such as cardiovascular disease, protein energy wasting, depression, osteoporosis and frailty), and a predictor of cardiovascular and total mortality...
October 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30220369/prevalence-of-depression-and-anxiety-in-end-stage-renal-disease-a-survey-of-patients-undergoing-hemodialysis
#8
Victoria Semaan, Samar Noureddine, Laila Farhood
BACKGROUND: Dialysis is a lifelong treatment required by end stage renal disease patients who are not able to undergo renal transplantation. Dialysis impacts the patients' quality of life drastically, increasing the risk of mortality. Depression and anxiety are commonly reported among dialysis patients, but their prevalence and correlates vary by sociocultural context. OBJECTIVE: The aim of this study is to examine the prevalence of anxiety and depression and associated factors among patients receiving hemodialysis at a major tertiary referral medical center in Lebanon that receives patients from all over the country...
October 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/30190046/the-effect-of-brief-self-management-intervention-for-hemodialysis-patients-hed-smart-on-trajectories-of-depressive-and-anxious-symptoms
#9
Konstadina Griva, Kevin F Y Lam, Mooppil Nandakumar, Jo-An H Ng, Hayley McBain, Stanton P Newman
OBJECTIVE: Depression is often comorbid with End-Stage Renal Disease, and associated with poor adherence and clinical outcomes but course of symptoms is variable. This study sought to describe the long-term trajectories of anxiety and depression in hemodialysis patients, to identify predictors of these trajectories over 12 months and to evaluate the effectiveness of the HEmoDialysis Self-Management Randomized Trial (HED SMART) against usual care on symptoms of anxiety and depression...
October 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30056891/evaluation-of-quality-of-life-and-severity-of-depression-anxiety-and-stress-in-patients-after-kidney-transplantation
#10
Ł Czyżewski, P Frelik, J Wyzgał, Ł Szarpak
INTRODUCTION: End-stage renal disease (ESRD) has a significant impact on a patient's quality of life (QoL). The optimal treatment for ESRD is kidney transplantation (KTx), which aims to extend and improve QoL. The aim of the study was to assess a QoL in KTx recipients. METHODS: Our study included 118 post-KTx patients. The research tool employed for assessment was a questionnaire consisting of standardized instruments: the 36-item Short Form (SF-36); the Kidney Disease Quality of Life (KDQOL) instrument; and the Depression, Anxiety, and Stress (DASS) scale...
July 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29963567/the-effect-of-mindfulness-program-on-general-health-of-patients-undergoing-hemodialysis
#11
Maryam Moosavi Nejad, Nahid Shahgholian, Rahele Samouei
INTRODUCTION: Patients undergoing hemodialysis have a low level of health and mindfulness technique in mind-body medicine is used to help patients with chronic illness. Therefore, this clinical trial was conducted to determine the effect of the mindfulness program on the general health of patients undergoing treatment with hemodialysis. METHODS: Sixty hemodialysis patients were selected through the convenient method and randomly divided into experimental and control groups...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29961018/development-and-feasibility-of-a-guided-and-tailored-internet-based-cognitive-behavioural-intervention-for-kidney-donors-and-kidney-donor-candidates
#12
Lieke Wirken, Henriët van Middendorp, Christina W Hooghof, Tamara E Bremer, Sabine P F Hopman, Karlijn A M I van der Pant, Andries J Hoitsma, Luuk B Hilbrands, Andrea W M Evers
OBJECTIVES: Living donor kidney transplantation is currently the preferred treatment for patients with end-stage renal disease. A subgroup of the kidney donor population experiences adjustment problems during or after the donation procedure (eg, anxiety or fatigue). There is a need for evidence-based interventions that decrease donation-related difficulties before or after donation. In the current study, a guided and tailored internet-based cognitive-behavioural therapy (ICBT) intervention for donors and donor candidates was developed and the feasibility and perceived effectiveness were evaluated...
June 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29929599/end-stage-renal-disease-chronic-itch-and-its-management
#13
REVIEW
Radomir Reszke, Jacek C Szepietowski
End-stage renal disease chronic itch is a frequent symptom that bothers patients with advanced stages of chronic kidney disease. The pathogenesis of the chronic itch symptom is complex and not yet fully understood and includes many metabolic, immunologic, and neurogenic factors. A significant burden of the disease results in decreased quality of life with sleep impairment, depressive symptoms, and increased mortality of affected individuals. No treatment of choice is available; topical therapy (emollients), phototherapy (UV-B), and systemic therapy (antiepileptics, opioid agonists, and antagonists) provide significant relief in varying percentages of patients...
July 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29869149/altered-amygdala-related-structural-covariance-and-resting-state-functional-connectivity-in-end-stage-renal-disease-patients
#14
Anmao Li, Junya Mu, Mingxia Huang, Zengjun Zhang, Jixin Liu, Ming Zhang
Depression and cognitive control deficits were frequently reported in concurrent end-stage renal disease (ESRD) patients. Neuroimaging studies indicated depression could be a risk factor for cognitive control deficits, and amygdala-related circuitry may play a critical role in this abnormal interaction. To investigate the potential relationship between depressive symptoms and cognitive control reduction in ESRD patients, T1-weighted and resting fMRI images were obtained in 29 ESRD patients and 29 healthy controls...
October 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29773842/systemic-vascular-risk-factors-for-multiple-retinal-nerve-fiber-layer-defects
#15
Kyoung In Jung, Seon Joo Kim, Chan Kee Park
Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogenesis of various RNFL defect patterns. Data from subjects with multiple RNFL defects (28 patients) and glaucoma patients without multiple RNFL defects (194 patients) were analyzed. The term "multiple RNFL defects" refers to three or more isolated defects separated by a comparatively normal area...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661345/dass21-a-useful-tool-in-the-psychological-profile-evaluation-of-dialysis-patients
#16
Wen Jiun Liu, Ramli Musa, Thian Fook Chew, Christopher Thiam Seong Lim, Zaki Morad, Mohamad Adam Bin Bujang
BACKGROUND: The effect of dialysis treatment is complex, with both clinical and socio-psychological effects. In this study, we aimed to assess the psychological status of this growing population of end-stage renal disease. METHODS: Using the Short Form of Depression, Anxiety and Stress Scale (DASS21) questionnaire, we aimed (1) to measure the psychological states of hemodialysis (HD) or peritoneal dialysis (PD) subjects from 15 sites, (2) to compare DASS21 scores between HD and PD, and (3) to identify the associated demographic and medical factors of better psychological states...
April 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29629280/effectiveness-of-group-cognitive-behavioral-therapy-with-mindfulness-in-end-stage-renal-disease-hemodialysis-patients
#17
Bo Kyung Sohn, Yun Kyu Oh, Jung-Seok Choi, Jiyoun Song, Ahyoung Lim, Jung Pyo Lee, Jung Nam An, Hee-Jeong Choi, Jae Yeon Hwang, Hee-Yeon Jung, Jun-Young Lee, Chun Soo Lim
Background: Many patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) experience depression. Depression influences patient quality of life (QOL), dialysis compliance, and medical comorbidity. We developed and applied a group cognitive behavioral therapy (CBT) program including mindfulness meditation for ESRD patients undergoing HD, and measured changes in QOL, mood, anxiety, perceived stress, and biochemical markers. Methods: We conducted group CBT over a 12-week period with seven ESRD patients undergoing HD and suffering from depression...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29607636/the-quality-of-life-of-hemodialysis-patients-is-affected-not-only-by-medical-but-also-psychosocial-factors-a-canonical-correlation-study
#18
Kyungmin Kim, Gun Woo Kang, Jungmin Woo
BACKGROUND: The quality of life (QoL) of patients with end-stage renal disease (ESRD) is very poor, plausibly due to both psychosocial and medical factors. This study aimed to determine the relationship among psychosocial factors, medical factors, and QoL in patients with ESRD undergoing hemodialysis (HD). METHODS: In total, 55 male and 47 female patients were evaluated (mean age, 57.1 ± 12.0 years). The QoL was evaluated using the Korean version of World Health Organization Quality of Life Scale-Abbreviated Version...
April 2, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29593798/depressive-symptoms-but-not-chronic-pain-have-an-impact-on-the-survival-of-patients-undergoing-maintenance-hemodialysis
#19
Mariusz Kusztal, Ewa Trafidło, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Maciej Karczewski, Waclaw Weyde, Magdalena Krajewska, Joanna Rymaszewska, Marian Klinger
Introduction: More than 1/3 of patients with end-stage renal disease who are in a chronic dialysis program suffer from chronic pain and depression/anxiety. The aim of the study was to determine the impacts of symptoms of depression/anxiety, chronic pain and quality of life (QoL) on 6-year patient survival. Material and methods: Observational study of end-stage renal disease patients on maintenance hemodialysis ( n = 205) who met the inclusion criteria. Patients from three dialysis centers in Lower Silesia were asked to complete a battery of validated questionnaires: the Hospital Anxiety and Depression Scale (HADS), the 36-item Short Form Health Survey Questionnaire, the Verbal Rating Scale (VRS) and the Visual Analog Scale (VAS)...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29578403/patient-reported-outcomes-pros-argue-against-the-limited-use-of-peritoneal-dialysis-in-end-stage-renal-disease
#20
Carola W H de Fijter, Anouk T N van Diepen, Fariba Amiri, Friedo W Dekker, Ray T Krediet
AIM: Approximately 40% of dialysis patients are durably treated with peritoneal dialysis (PD) in our teaching hospital. Patients' perspectives were studied by patient-reported outcome measurements (PROMs) to find possible explanations for why the generally-reported decline in the use of PD hardly occurred in our facility. MATERIALS AND METHODS: All 75 prevalent adult dialysis patients hemodialysis (HD) duration 27, PD 16 months) were included. All had received predialysis care and education for > 6 month...
August 2018: Clinical Nephrology
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