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https://www.readbyqxmd.com/read/28830107/epidms-data-management-and-analytics-for-decision-making-from-epidemic-spread-simulation-ensembles
#1
Sicong Liu, Silvestro Poccia, K Selçuk Candan, Gerardo Chowell, Maria Luisa Sapino
Background: Carefully calibrated large-scale computational models of epidemic spread represent a powerful tool to support the decision-making process during epidemic emergencies. Epidemic models are being increasingly used for generating forecasts of the spatial-temporal progression of epidemics at different spatial scales and for assessing the likely impact of different intervention strategies. However, the management and analysis of simulation ensembles stemming from large-scale computational models pose challenges, particularly when dealing with multiple interdependent parameters, spanning multiple layers and geospatial frames, affected by complex dynamic processes operating at different resolutions...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28830030/multivariate-trajectories-across-multiple-domains-of-health-related-quality-of-life-in-children-with-new-onset-epilepsy
#2
Tolulope T Sajobi, Meng Wang, Mark A Ferro, Anita Brobbey, Shane Goodwin, Kathy N Speechley, Samuel Wiebe
The diagnosis of epilepsy in children is known to impact the trajectory of their health-related quality of life (HRQOL) over time. However, there is limited knowledge about variations in longitudinal trajectories across multiple domains of HRQOL. This study aims to characterize the heterogeneity in HRQOL trajectories across multiple HRQOL domains and to evaluate predictors of differences among the identified trajectory groups in children with new-onset epilepsy. Data were obtained from the Health Related Quality of Life in Children with Epilepsy Study (HERQULES), a prospective multi-center study of 373 children newly diagnosed with new-onset epilepsy who were followed up over 2years...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830027/factors-influencing-use-of-family-planning-in-women-living-in-crisis-affected-areas-of-sub-saharan-africa-a-review-of-the-literature
#3
REVIEW
Kelly Ackerson, Ruth Zielinski
BACKGROUND: far too many women continue to die from pregnancy and childbirth related causes. While rates have decreased in the past two decades, some areas of the world such as sub-Saharan Africa continue to have very high maternal mortality rates. One intervention that has been demonstrated to decrease maternal mortality is use of family planning and modern contraception, yet rates of use in sub-Saharan countries with the highest rates of maternal death remain very low. AIM: to review available research and summarize the factors that inhibit or promote family planning and contraceptive use among refugee women and women from surrounding areas living in Sub-Saharan Africa...
August 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28829924/the-10-conditions-that-increased-vermont-s-readiness-to-implement-statewide-health-system-transformation
#4
David Grembowski, Miriam Marcus-Smith
Following an arduous, 6-year policy-making process, Vermont is the first state implementing a unified, statewide all-payer integrated delivery system with value-based payment, along with aligned medical and social service reforms, for almost all residents and providers in a state. Commercial, Medicare, and Medicaid value-based payment for most Vermonters will be administered through a new statewide accountable care organization in 2018-2022. The purpose of this article is to describe the 10 conditions that increased Vermont's readiness to implement statewide system transformation...
August 22, 2017: Population Health Management
https://www.readbyqxmd.com/read/28829912/biomolecular-steric-hindrance-effects-are-enhanced-on-nanostructured-microelectrodes
#5
Sahar Sadat Mahshid, Alexis Vallée-Bélisle, Shana O Kelley
The availability of rapid approaches for quantitative detection of biomarkers would drastically impact global health by enabling decentralized disease diagnosis anywhere that patient care is administered. A promising new approach, the electrochemical steric hindrance hybridization assay (eSHHA) has been introduced for quantitative detection of large proteins (e.g. antibodies) with a low nano-molar detection limit within 10 minutes. Here, we report the use of a nanostructured microelectrode (NME) platform for eSHHA that improves the performance of this approach by increasing the efficiency and kinetics of DNA hybridization...
August 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28829828/choosing-the-right-rehabilitation-setting-after-herniated-disc-surgery-motives-motivations-and-expectations-from-the-patients-perspective
#6
Margrit Löbner, Janine Stein, Melanie Luppa, Alexander Konnopka, Hans Jörg Meisel, Lutz Günther, Jürgen Meixensberger, Katarina Stengler, Matthias C Angermeyer, Hans-Helmut König, Steffi G Riedel-Heller
OBJECTIVES: This study aims to investigate (1) motives, motivations and expectations regarding the choice for a specific rehabilitation setting after herniated disc surgery and (2) how rehabilitation-related motivations and expectations are associated with rehabilitation outcome (ability to work, health-related quality of life and satisfaction with rehabilitation) three months after disc surgery. METHODS: The longitudinal cohort study refers to 452 disc surgery patients participating in a subsequent rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28829812/use-of-traditional-eye-medicine-and-self-medication-in-rural-india-a-population-based-study
#7
Noopur Gupta, Praveen Vashist, Radhika Tandon, Sanjeev K Gupta, Mani Kalaivani, S N Dwivedi
OBJECTIVE: To determine the type and nature of traditional eye medicine (TEM), their sources and use and practices related to self-medication for ophthalmic diseases in a rural Indian population. METHODS: A population-based, cross-sectional study was conducted in 25 randomly selected clusters of Rural Gurgaon, Haryana, India as part of CORE (Cornea Opacity Rural Epidemiological) study. In addition to comprehensive ophthalmic examination, health-seeking behavior and use of self-medication and TEM was assessed in the adult population using a semi-structured questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28829693/effect-of-palliative-care-on-aggressiveness-of-end-of-life-care-among-patients-with-advanced-cancer
#8
Daniel P Triplett, Wendi G LeBrett, Alex K Bryant, Andrew R Bruggeman, Rayna K Matsuno, Lindsay Hwang, Isabel J Boero, Eric J Roeland, Heidi N Yeung, James D Murphy
PURPOSE: Palliative care's role in oncology has expanded, but its effect on aggressiveness of care at the end of life has not been characterized at the population level. METHODS: This matched retrospective cohort study examined the effect of an encounter with palliative care on health-care use at the end of life among 6,580 Medicare beneficiaries with advanced prostate, breast, lung, or colorectal cancer. We compared health-care use before and after palliative care consultation to a matched nonpalliative care cohort...
August 22, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28829626/transitioning-from-methadone-to-buprenorphine-maintenance-in-management-of-opioid-use-disorder-during-pregnancy
#9
Shakevia Johnson, Peter R Martin
BACKGROUND: Opioid use disorder during pregnancy is a growing health concern. Methadone maintenance is the treatment of choice but emerging data indicate buprenorphine is a viable alternative. Due to costs and limited accessibility of methadone, pregnant women may require transition from methadone to buprenorphine for maintenance treatment. OBJECTIVES: To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy...
August 22, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28829534/how-medicaid-expansion-affected-out-of-pocket-health-care-spending-for-low-income-families
#10
Sherry Glied, Ougni Chakraborti, Therese Russo
ISSUE. Prior research shows that low-income residents of states that expanded Medicaid under the Affordable Care Act are less likely to experience financial barriers to health care access, but the impact on out-of-pocket spending has not yet been measured. GOAL. Assess how the Medicaid expansion affected out-of-pocket health care spending for low-income families compared to those in states that did not expand and consider whether effects differed in states that expanded under conventional Medicaid rules vs...
August 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28829408/empowering-mayo-clinic-individualized-medicine-with-genomic-data-warehousing
#11
REVIEW
Iain Horton, Yaxiong Lin, Gay Reed, Mathieu Wiepert, Steven Hart
Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient's genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse...
August 22, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28829284/the-psychenet-public-health-intervention-for-anorexia-nervosa-a-pre-post-evaluation-study-in-a-female-patient-sample
#12
Antje Gumz, Angelika Weigel, Karl Wegscheider, Georg Romer, Bernd Löwe
Aim This non-randomized pre-post-intervention study investigated the effect of a systemic public health intervention on the length of time between anorexia nervosa symptom onset and contact with the health care system as well as the initiation of treatment. BACKGROUND: Although systemic public health interventions have successfully been implemented in physical and mental health fields, their effect on the early treatment of patients with anorexia nervosa remains unclear. METHODS: In total, 59 anorexia nervosa patients (mean age=21...
August 22, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28829240/women-s-perceptions-of-reasons-for-maternal-deaths-implications-for-policies-and-programs-for-preventing-maternal-deaths-in-low-income-countries
#13
Friday Okonofua, Lorretta Ntoimo, Rosemary Nkem Ogu
We investigated perceptions of the causes of maternal mortality by women attending referral hospitals in Nigeria. Focus group discussions were conducted with various categories of women. Our results showed that women were aware of the medical causes of mortality, although a few listed divine reasons. Delays in reaching hospitals or after women arrive in hospitals featured prominently as lead causes mentioned by women. Listening to women as end-users is an important approach to identify points of remediation in the provision of maternal health care...
August 22, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28829159/early-onset-bipolar-disorder-characteristics-and-outcomes-in-the-clinic
#14
Daniel F Connor, Julian D Ford, Geraldine S Pearson, Victoria L Scranton, Asha Dusad
OBJECTIVE: To assess patient characteristics and clinician-rated outcomes for children diagnosed with early-onset bipolar disorder in comparison to a depressive disorders cohort from a single clinic site. To assess predictors of bipolar treatment response. METHODS: Medical records from 714 consecutive pediatric patients evaluated and treated at an academic tertiary child and adolescent psychiatry clinic between 2006 and 2012 were reviewed. Charts of bipolar children (n = 49) and children with depressive disorders (n = 58) meeting study inclusion/exclusion criteria were compared on variables assessing clinical characteristics, treatments, and outcomes...
August 22, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28829158/a-positive-perspective-of-knowledge-attitude-and-practices-for-health-promoting-behaviors-of-adolescents-with-congenital-heart-disease
#15
Hui-Ru Huang, Chi-Wen Chen, Chin-Mi Chen, Hsiao-Ling Yang, Wen-Jen Su, Jou-Kou Wang, Pei-Kwei Tsai
BACKGROUND: Health-promoting behaviors could serve as a major strategy to optimize long-term outcomes for adolescents with congenital heart disease. The associations assessed from a positive perspective of knowledge, attitudes, and practice model would potentially cultivate health-promoting behaviors during adolescence. AIM: The purpose of this study was to examine the relationships between disease knowledge, resilience, family functioning, and health-promoting behaviors in adolescents with congenital heart disease...
August 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28829002/supporting-wellbeing-in-motor-neurone-disease-for-patients-carers-social-networks-and-health-professionals-a-scoping-review-and-synthesis
#16
Melanie Harris, Geoff Thomas, Mary Thomas, Paul Cafarella, Allegra Stocks, Julia Greig, R Doug McEvoy
OBJECTIVE: Disease management in motor neurone disease (MND) is focused on preserving quality of life. However, the emphasis has so far been on physical symptoms and functioning and not psychosocial wellbeing. MND affects the wellbeing of carers, of family and social network members, and of healthcare providers, as well as of the patients. We therefore aimed to assess and synthesize the knowledge about maximizing MND-related psychosocial wellbeing across all these groups. METHOD: We used a systematic search and selection process to assess the scope of the literature along with a narrative synthesis of recent high-quality reviews...
August 22, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28828981/the-primary-mechanism-of-cellular-internalization-for-a-short-cellpenetrating-peptide-as-a-nano-scale-delivery-system
#17
Betty R Liu, Yue-Wern Huang, Mallikarjuna Korivi, Shih-Yen Lo, Robert S Aronstam, Han-Jung Lee
BACKGROUND: Development of effective drug delivery systems (DDS) is a critical issue in health care and medicine. Advances in molecular biology and nanotechnology have allowed the introduction of nanomaterial-based drug delivery systems. Cell-penetrating peptides (CPPs) can form the basis of drug delivery systems by virtue of their ability to support the transport of cargoes into the cell. Potential cargoes include proteins, DNA, RNA, liposomes, and nanomaterials. These cargoes generally retain their bioactivities upon entering cells...
August 22, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28828960/survey-of-intestinal-parasitism-in-dogs-in-the-phoenix-metropolitan-area
#18
Heather N Cornell, Peter R O'Neal, Valerie M Wong, Donald L Noah
OBJECTIVE To determine the prevalence of selected intestinal parasites in pet dogs and recently apprehended free-roaming (AFR) shelter dogs in the Phoenix metropolitan area and compare those prevalences between the 2 groups. DESIGN Cross-sectional study. SAMPLE Convenience samples of fecal specimens from owned pet dogs from the Phoenix metropolitan area (n = 175) and free-roaming dogs apprehended and admitted to Maricopa County Animal Care and Control and Arizona Humane Society facilities from November 2014 through March 2015 (188)...
September 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28828933/impact-of-timely-treatment-intensification-on-glycemic-goal-achievement-in-patients-with-type-2-diabetes-failing-metformin-monotherapy
#19
Rohan Mahabaleshwarkar, Megan Templin, Frank Gohs, Holly Mulder, Andrea DeSantis, Flavia Ejzykowicz, Swapnil Rajpathak, Nick Wilkins
Purpose The purpose of the study was to examine the association between timely treatment intensification (TTI) and glycemic goal achievement in patients with type 2 diabetes (T2D) failing metformin monotherapy (MM). Methods This study was set at a large integrated health care system in the United States. The study cohort included T2D patients aged 18 to 85 years who were on MM between January 2009 and September 2013 and had an uncontrolled glycated hemoglobin (A1C) reading (≥8%) after at least 3 months of MM (corresponding date was index date)...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28828909/voice-outcomes-of-adults-diagnosed-with-pediatric-vocal-fold-nodules-and-impact-of-speech-therapy
#20
Brian H Song, Maqdooda Merchant, Luke Schloegel
Objective To evaluate the voice outcomes of adults diagnosed with vocal fold nodules (VFNs) as children and to assess the impact of speech therapy on long-term voice outcomes. Study Design Prospective cohort study. Setting Large health care system. Subjects and Methods Subjects diagnosed with VFNs as children between the years 1996 and 2008 were identified within a medical record database of a large health care system. Included subjects were 3 to 12 years old at the time of diagnosis, had a documented laryngeal examination within 90 days of diagnosis, and were ≥18 years as of December 31, 2014...
August 1, 2017: Otolaryngology—Head and Neck Surgery
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