Tianyu Lou, Hao Wu, Menghan Feng, Lirong Liu, Xiaoqin Yang, Mingxia Pan, Zuying Wei, Yinhuan Zhang, Lixia Shi, Biqiong Qu, Haolan Yang, Shiyu Cong, Kui Chen, Jie Liu, Yueting Li, Zhixin Jia, Hongbin Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCX) is a traditional herbal compound composed of Gastrodia elata Bl. and Ligusticum chuanxiong Hort, which could significantly enhance blood circulation and neuroprotection, showing promise in treating Vascular Cognitive Impairment (VCI). AIM OF STUDY: This study aims to elucidate the potential of DCX in treating VCI and its underlying mechanism. MATERIALS AND METHODS: Firstly, the cognitive behavior level, blood flow changes, and brain pathology changes were evaluated through techniques such as the Morris water maze, step-down, laser speckle, coagulation analysis, and pathological staining to appraise the DCX efficacy...
February 5, 2024: Journal of Ethnopharmacology