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https://www.readbyqxmd.com/read/30119927/gastric-antral-vascular-ectasia-in-portal-hypertensive-children-endoscopic-band-ligation-versus-argon-plasma-coagulation
#1
Carolyne Ghobrial, Mohamed Rabea, Nabil Mohsen, Ayman Eskander
BACKGROUND/PURPOSE: Gastric antral vascular ectasia (GAVE) can cause recurrent bleeding and chronic anemia in children with portal hypertension (PHT). We aimed to evaluate the efficacy of EBL in comparison to argon plasma coagulation (APC) in children with PHT, bleeding from GAVE. METHODS: This prospective comparative study included 40 children with PHT who presented with nonvariceal GIT bleeding from GAVE. Patients were divided into 2 groups, each including 20 cases: one group was managed with APC and the other with EBL...
July 27, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30117275/retrospective-evaluation-of-a-decision-support-algorithm-mipogg-for-genetic-referrals-for-children-with-neuroblastic-tumors
#2
Catherine Goudie, Noelle Cullinan, Anita Villani, Natalie Mathews, Kalene van Engelen, David Malkin, Meredith S Irwin, William D Foulkes
BACKGROUND: Neuroblastoma is the most common pediatric extracranial solid tumor. Germline pathogenic variants in ALK and PHOX2B, as well as other cancer predisposition genes, are increasingly implicated in the pathogenesis of neuroblastic tumors. A challenge for clinicians is the identification of children with neuroblastoma who require genetics evaluation for underlying cancer predisposition syndromes (CPS). PROCEDURE: We developed a decisional algorithm (MIPOGG) to identify which patients with neuroblastic tumors have an increased likelihood of an underlying CPS...
August 16, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30115830/approaches-to-assess-vitamin-a-status-in-settings-of-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#3
Leila M Larson, Junjie Guo, Anne M Williams, Melissa F Young, Sanober Ismaily, O Yaw Addo, David Thurnham, Sherry A Tanumihardjo, Parminder S Suchdev, Christine A Northrop-Clewes
The accurate estimation of vitamin A deficiency (VAD) is critical to informing programmatic and policy decisions that could have important public health implications. However, serum retinol and retinol binding protein (RBP) concentrations, two biomarkers often used to estimate VAD, are temporarily altered during the acute phase response, potentially overestimating the prevalence of VAD in populations with high levels of inflammation. In 22 nationally-representative surveys, we examined (1) the association between C-reactive protein (CRP) or α1-acid glycoprotein (AGP) and retinol or RBP, and (2) how different adjustment approaches for correcting for inflammation compare with one another...
August 16, 2018: Nutrients
https://www.readbyqxmd.com/read/30110085/enamel-defects-and-tooth-eruption-disturbances-in-children-with-sickle-cell-anemia
#4
Caroline Maria Igrejas Lopes, Marília Cabral Cavalcanti, Ana Cláudia Alves E Luna, Kátia Maria Gonçalves Marques, Maria José Rodrigues, Valdenice Aparecida DE Menezes
Sickle cell anemia, a genetic disease caused by a mutation in the beta-globin gene, can present oral manifestations such as delayed tooth eruption and hypomineralized enamel and dentin. The aim of the present study was to evaluate the prevalence and severity of developmental defects of enamel (DDE) and delayed tooth eruption in children with sickle cell anemia. The sample comprised 56 male and female children with sickle cell anemia aged 6 to 12 years and treated at the Hematology and Hemotherapy Center of Pernambuco, Brazil...
August 13, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/30103797/soil-transmitted-helminth-infections-anemia-and-undernutrition-among-schoolchildren-in-yirgacheffee-south-ethiopia
#5
Eshetu Molla, Hassen Mamo
OBJECTIVE: Current data on soil-transmitted helminth infections, anemia and malnutrition that are largely neglected is vital to the control and management of them in a specific setting. This study was, therefore, aimed at determining the status of the three health concerns in one of the high-risk groups, schoolchildren, in South Ethiopia. RESULTS: Among the 443 sampled schoolchildren, 54% were infected with soil-transmitted helminths (STHs) and 15.4% of them had anaemia, while the prevalence rate of undernutrition was 28...
August 13, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30103424/potential-point-of-care-microfluidic-devices-to-diagnose-iron-deficiency-anemia
#6
REVIEW
Boon Kar Yap, Siti Nur'Arifah M Soair, Noor Azrina Talik, Wai Feng Lim, Lai Mei I
Over the past 20 years, rapid technological advancement in the field of microfluidics has produced a wide array of microfluidic point-of-care (POC) diagnostic devices for the healthcare industry. However, potential microfluidic applications in the field of nutrition, specifically to diagnose iron deficiency anemia (IDA) detection, remain scarce. Iron deficiency anemia is the most common form of anemia, which affects billions of people globally, especially the elderly, women, and children. This review comprehensively analyzes the current diagnosis technologies that address anemia-related IDA-POC microfluidic devices in the future...
August 10, 2018: Sensors
https://www.readbyqxmd.com/read/30099593/lupus-anticoagulant-hypoprothrombinemia-syndrome-associated-with-systemic-lupus-erythematosus-in-children-report-of-two-cases-and-systematic-review-of-the-literature
#7
REVIEW
Rakesh Kumar Pilania, Deepti Suri, Ankur Kumar Jindal, Narender Kumar, Avinash Sharma, Praveen Sharma, Sandesh Guleria, Amit Rawat, Jasmina Ahluwalia, Surjit Singh
We report two children with systemic lupus erythematosus (SLE) having severe bleeding manifestations and lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) along with a review of published cases of childhood SLE and LAHPS. We report clinical and laboratory profile of two children diagnosed with childhood SLE and LAHPS. We also conducted literature search to identify similar published cases and a review was performed. An 8-year-old girl had presented with fever, arthralgia, alopecia, anasarca and bleeding from multiple sites...
August 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30095365/increased-vitamin-b-12-levels-in-children-with-zinc-deficiency
#8
Ayse Betul Ergul, Cem Turanoglu, Cigdem Karakukcu, Elif Guler Kazanci, Yasemin Altuner Torun
Additional nutritional deficiencies may accompany zinc deficiency. We determined the vitamin B12 levels in patients with zinc (Zn) deficiency. This retrospective study enrolled 256 patients age 6 months to 16 years (176 females and 80 males) in whom Zn levels in hair samples were measured concurrently with serum vitamin B12 and ferritin levels. For all patients, we retrospectively assessed the hair Zn levels, serum ferritin and vitamin B12 levels, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution levels...
August 10, 2018: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/30095285/assessment-of-risk-factors-for-iron-deficiency-anemia-in-infants-and-young-children-a-case-control-study
#9
Audrone Muleviciene, Natalija Sestel, Sigita Stankeviciene, Daiva Sniukaite-Adner, Roma Bartkeviciute, Jelena Rascon, Augustina Jankauskiene
INTRODUCTION: Iron deficiency anemia (IDA) is common in children aged 0-35 months in Lithuania. Nevertheless, there are no studies investigating IDA in this age group. We aimed to identify the major risk factors for disease development focusing on medical history and dietary habits. METHODS: A prospective case-control study was conducted in a university hospital. The enrolled cohort was divided into three groups: IDA infants (IDA-In; n = 36, aged 3-11 months), IDA children (IDA-Ch; n = 23, aged 12-32 months), and healthy controls (HCs; n = 32, aged 6-34 months)...
August 10, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/30093766/iron-deficiency-anemia-in-children-with-cyanotic-congenital-heart-disease-and-effect-on-cyanotic-spells
#10
Sweta Mukherjee, Mukti Sharma, Amit Devgan, S K Jatana
Background: Iron deficiency anemia (IDA) in cyanotic congenital heart disease (CCHD) and its association with cyanotic spells has been documented in literature. However, Indian data especially in the pediatric age group is scarce. This study was conducted to find out the prevalence of IDA in this population. Methods: An observational study was conducted in a tertiary care hospital. Children with CCHD in the age group of birth-12 years were included in the study...
July 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/30092032/correction-nutritional-iron-deficiency-anemia-magnitude-and-its-predictors-among-school-age-children-southwest-ethiopia-a-community-based-cross-sectional-study
#11
Amare Desalegn Wolide, Andualem Mossie, Lealem Gedefaw
[This corrects the article DOI: 10.1371/journal.pone.0114059.].
2018: PloS One
https://www.readbyqxmd.com/read/30090748/prevalence-diagnosis-and-management-of-iron-deficiency-and-iron-deficiency-anemia-among-syrian-children-in-a-major-outpatient-center-in-damascus-syria
#12
Issam N Albaroudi, Majed Khodder, Tareq Al Saadi, Tarek Turk, Lama A Youssef
Background: Given the public health significance of anemia, the long-term sequelae of iron deficiency anemia (IDA) on children, the expected effect of war on the trends of anemia in Syrian society, and the lack of assessment on the national burden of anemia and/or iron deficiency (ID) data, there is a vital need to investigate all-cause anemia, ID, and IDA in Syria during the crisis. Objective: To investigate the prevalence of ID and IDA in Syrian children, the effectiveness of oral iron supplements in the management of ID, and the diagnostic effectiveness of conventional iron markers...
July 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/30088588/anemia-and-associated-factors-in-women-at-reproductive-age-in-a-brazilian-northeastern-municipality
#13
Adriana Guimarães Negromonte Bezerra, Vanessa Sá Leal, Pedro Israel Cabral de Lira, Juliana Souza Oliveira, Emilia Chagas Costa, Risia Cristina Egito de Menezes, Florisbela Arruda Câmara de Siqueira E Campos, Maria Izabel Siqueira de Andrade
OBJECTIVE: To identify the prevalence of iron-deficiency anemia and associated factors in women at reproductive age in the city of Vitoria de Santo Antão, Pernambuco. METHODS: Cross-sectional study with a representative sample of 322 women aged between 15 and 49 years. Anemia was diagnosed by measuring hemoglobin below 12 g/dL. The independent variables were: demographic and socioeconomic conditions (age, race/color, education, literacy, presence of children aged < 5 years in the household, regime of residence occupation, ownership of assets, and per capita income), housing conditions (number of people in the household, number of bedrooms, and basic sanitation), food and nutrition security and women's health conditions (menarche, number of pregnancies, history of miscarriages, body mass index, and ferritin)...
2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/30088135/long-term-pediatric-hematological-morbidity-of-the-early-term-newborn
#14
Gil Gutvirtz, Tamar Wainstock, Eyal Sheiner, Daniella Landau, Alon Slutzky, Asnat Walfisch
Children born at early term (37 0/7 to 38 6/7 weeks' gestation) are at an increased risk for long-term respiratory, cardiovascular, neurological, and developmental morbidities as compared with children born at full term (39 0/7 to 40 6/7 weeks' gestation). In this population-based cohort analysis, we sought to evaluate the long-term hematological morbidity of early-term born children. The cohort consisted of 223,242 term singleton deliveries. Hospitalizations of the offspring up to 18 years of age involving hematological morbidity were evaluated, including hereditary and acquired anemias, immunodeficiency disorders, coagulation disorders, white blood cell disorders, cytopenias, polycythemia, and myelodysplastic syndrome...
August 7, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30086152/prevalence-of-anemia-among-lebanese-hospitalized-children-risk-and-protective-factors
#15
Ali Salami, Hisham F Bahmad, Ghassan Ghssein, Lamis Salloum, Hadi Fakih
BACKGROUND: Anemia is a global health problem associated with short- and long-term consequences especially in children. The incidence of anemia along with the factors associated with its increased or decreased risk is not yet well studied in Lebanon. Our study aims at determining the demographics of this health burden and identifying some of the important factors linked to it among the pediatric population. METHODS: A 4-months cross-sectional study was performed between August and November 2017 including 295 children aged 1 month to 12 years, who were hospitalized in a tertiary care hospital located in South Lebanon...
2018: PloS One
https://www.readbyqxmd.com/read/30080752/eltrombopag-for-delayed-platelet-recovery-and-secondary-thrombocytopenia-following-allogeneic-stem-cell-transplantation-in-children
#16
Sidan Li, Runhui Wu, Bin Wang, Lingling Fu, Guanghua Zhu, Xuan Zhou, Jie Ma, Liqiang Zhang, Maoquan Qin
The delay in platelet recovery after hematopoietic stem cell transplantation (HSCT) is closely related to the overall survival rate of transplanted children. The use of platelet-producing agents such as eltrombopag and romiplostim has made great progress in treating diseases such as immune thrombocytopenia and aplastic anemia. However, the use of such drugs in patients with thrombocytopenia after transplantation, especially in children, is rare. This study aimed to report eltrombopag treatment for 3 children with primary platelet engraftment failure and secondary thrombocytopenia after allogeneic HSCT...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30066818/late-diagnosis-of-congenital-syphilis-a-recurring-reality-in-women-and-children-health-care-in-brazil
#17
Ana Laura Mendes Becker Andrade, Pedro Vitor Veiga Silva Magalhães, Marília Magalhães Moraes, Antônia Teresinha Tresoldi, Ricardo Mendes Pereira
OBJECTIVE: To describe a case of congenital syphilis with a late diagnosis and identify missed opportunities at diverse phases/levels of healthcare, which led to late diagnosis. CASE DESCRIPTION: Boy, 34 days of life, referred from a basic healthcare unit to a tertiary hospital due to enlarged abdominal volume and progressive jaundice for 2 weeks, fecal hypocholia, hepatosplenomegaly, anemia, low platelet count and elevated liver enzymes. At physical examination, the infant presented with erythematous-exfoliative lesions on the palms and soles, macular rash in the inguinal region, ascitis, palpable liver 5 cm below the right costal margin and a palpable spleen 3 cm from the left costal margin...
July 26, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/30063902/predicting-anti-kell-mediated-hemolytic-disease-of-the-fetus-and-newborn-diagnostic-accuracy-of-laboratory-management
#18
Yolentha M Slootweg, Irene T Lindenburg, Joke M Koelewijn, Inge L van Kamp, Dick Oepkes, Masja de Haas
BACKGROUND: There is controversy on critical cut-off values of laboratory testing to select pregnancies at increased risk for anti-Kell (K) mediated HDFN (hemolytic disease of the fetus and newborn). Without early detection and treatment, Anti-K mediated HDFN may result in progressive fetal anemia, fetal hydrops, asphyxia and perinatal death. OBJECTIVE: We aimed to determine the value of repeated anti-K titer determination and biological activity measurement using the antibody-dependent cellular cytotoxicity (ADCC) test determination in the management of pregnancies at risk for anti-K mediated HDFN...
July 28, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30061962/severe-malaria-and-death-risk-factors-among-children-under-5-years-at-jason-sendwe-hospital-in-democratic-republic-of-congo
#19
Augustin Mulangu Mutombo, Olivier Mukuku, Kristel Nzeba Tshibanda, Edouard Kawawa Swana, Eric Mukomena, Dieudonné Tshikwej Ngwej, Oscar Numbi Luboya, Jean-Baptiste Kakoma, Stanislas Okitotsho Wembonyama, Jean-Pierre Van Geertruyden, Pascal Lutumba
Introduction: Malaria is still a major public health concern in the Democratic Republic of Congo. Its morbidity and mortality challenge the actual strategies of the fight agains malaria. This study was aimed to describe the epidemiology, the clinical caracteristics and the risk factors of death associated to severe malaria in the pediatric population under 5 years at Sendwe Hospital of Lubumbashi. Methods: This analytical retrospective study was conducted in Lubumbashi, in the province of Haut-Katanga...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30061156/silent-infarcts-in-sickle-cell-anemia-occur-in-the-borderzone-region-and-are-associated-with-low-cerebral-blood-flow
#20
Andria L Ford, Dustin K Ragan, Slim Fellah, Michael M Binkley, Melanie E Fields, Kristin P Guilliams, Hongyu An, Lori C Jordan, Robert C McKinstry, Jin-Moo Lee, Michael R DeBaun
Silent cerebral infarcts (SCI) are associated with cognitive impairment in sickle cell anemia (SCA). SCI risk factors include low hemoglobin and elevated systolic blood pressure; however, mechanisms underlying their development are unclear. Using the largest, prospective study evaluating SCIs in pediatric SCA, we identified brain regions with increased SCI density. We tested the hypothesis that infarct density is greatest within regions where cerebral blood flow is lowest, further restricting cerebral oxygen delivery in the setting of chronic anemia...
July 30, 2018: Blood
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