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https://www.readbyqxmd.com/read/30516507/characteristics-of-diarrheal-disease-complicated-with-hemolytic-uremic-syndrome-among-children-in-georgia-2009-2016
#1
O Chokoshvili, N Vepkhvadze, T Davitaia, L Tevzadze, T Tsertsvadze
Shiga toxin-producing Escherichia coli (STEC) causes illness ranging from mild diarrhea to bloody diarrhea, to the hemolytic uremic syndrome (HUS), which manifests with a triad of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. Surveillance of HUS and bloody diarrhea is not performed in Georgia. The primary objective of our study was to determine the annual incidence of diarrheal diseases. The secondary objective was to assess epidemiological characteristics, etiology and risk factors of diarrhea and HUS in Georgia among children under 15...
October 2018: Georgian Medical News
https://www.readbyqxmd.com/read/30514223/a-study-of-clinical-hematological-and-biochemical-profiles-of-patients-with-dengue-viral-infections-in-northwest-ethiopia-implications-for-patient-management
#2
Getachew Ferede, Moges Tiruneh, Ebba Abate, Yitayih Wondimeneh, Endalamaw Gadisa, Rawleigh Howe, Abraham Aseffa, Belay Tessema
BACKGROUND: Dengue is one of the most common arboviral diseases with increased outbreaks annually in tropical and subtropical areas. In Ethiopia, there are no data regarding clinical, hematological and biochemical parameters which are very important in the clinical management of dengue patients. Hence this study was carried out to provide the first baseline data of clinical, hematological and biochemical profiles of patients infected with dengue virus. METHODS: A cross-sectional study was carried out among febrile patients in northwest Ethiopia from March 2016 to May 2017...
December 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30511538/hereditary-spherocytosis-retrospective-evaluation-of-65-children
#3
Ali Güngör, Neşe Yaralı, Ali Fettah, İkbal Ok-Bozkaya, Namık Özbek, Abdurrahman Kara
Güngör A, Yaralı N, Fettah A, Ok-Bozkaya İ, Özbek N, Kara A. Hereditary spherocytosis: Retrospective evaluation of 65 children. Turk J Pediatr 2018; 60: 264-269. Hereditary spherocytosis (HS) is a common cause of congenital hemolytic anemia in Caucasians and it could be diagnosed at any age. The aim of this study is to examine the demographic characteristics, clinical features and laboratory findings of children with HS and their complications observed during follow up. Sixty-five patients, with hereditary spherocytosis between January 2008 and September 2013, were enrolled into this retrospective study...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30510945/meckel-s-diverticulum-diagnosis-by-video-capsule-endoscopy-a-case-report-and-review-of-literature
#4
Diego García-Compeán, Alan R Jiménez-Rodríguez, Ángel N Del Cueto-Aguilera, Gilberto Herrera-Quiñones, José A González-González, Héctor J Maldonado-Garza
BACKGROUND: Meckel's diverticulum (MD) occurs predominantly in children and adolescents. It is rarely diagnosed in adults. Preoperative diagnosis is difficult due to low sensitivity of the radiological imaging studies. The role of video capsule endoscopy (VCE) in the diagnosis of MD is unknown, and the endoscopic patterns are not defined. We will describe four of our cases of MD evaluated with VCE and make a review of the literature focusing on the endoscopic characteristics. CASE SUMMARY: We present four cases of MD confirmed by surgery...
November 26, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30510813/rare-benign-large-lymphoid-colonic-polyp
#5
Yousef Alshamali, Ahmad Al Taleb, Talal Al-Taweel
Benign lymphoid polyps are uncommon lesions of the small bowel and the colon to a lesser degree that are mostly found in children. There are only few reported cases in adults in which the lesions were predominantly polypoid and described as lymphonodular hyperplasia. We present a case of a large benign lymphoid polyp in the transverse colon of a 64-year-old lady who was referred to our care for a history of alteration in her bowel habit and anemia. Colonoscopy showed a 3 cm (Paris 1p) friable polyp which was excised and retrieved...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/30510258/low-plasma-haptoglobin-is-a-risk-factor-for-life-threatening-childhood-severe-malarial-anemia-and-not-an-exclusive-consequence-of-hemolysis
#6
Samuel Eneọjọ Abah, Florence Burté, Sandrine Marquet, Biobele J Brown, Francis Akinkunmi, Gbeminiyi Oyinloye, Nathaniel K Afolabi, Samuel Omokhodion, Ikeoluwa Lagunju, Wuraola A Shokunbi, Mats Wahlgren, Hélia Dessein, Laurent Argiro, Alain J Dessein, Boris Noyvert, Lilian Hunt, Greg Elgar, Olugbemiro Sodeinde, Anthony A Holder, Delmiro Fernandez-Reyes
Severe Malarial Anemia (SMA), a life-threatening childhood Plasmodium falciparum malaria syndrome requiring urgent blood transfusion, exhibits inflammatory and hemolytic pathology. Differentiating between hypo-haptoglobinemia due to hemolysis or that of genetic origin is key to understand SMA pathogenesis. We hypothesized that while malaria-induced hypo-haptoglobinemia should reverse at recovery, that of genetic etiology should not. We carried-out a case-control study of children living under hyper-endemic holoendemic malaria burden in the sub-Saharan metropolis of Ibadan, Nigeria...
December 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30504347/alternative-donor-transplants-for-severe-aplastic-anemia
#7
REVIEW
Andrea Bacigalupo
Allogeneic hematopoietic stem-cell transplantation remains the only curative treatment for patients with acquired severe aplastic anemia (SAA). When a matched sibling is not available, one can search for a matched unrelated donor or a cord blood unit (CB) in the international registries or, more recently, for an HLA haploidentical (HAPLO) family member. International guidelines call for a course of antithymocyte globulin (ATG) and cyclosporine before a patient with SAA receives a transplant from a donor other than an HLA identical sibling, but whether this is necessary for patients age <20 years is less clear...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504201/building-capacity-to-reduce-stroke-in-children-with-sickle-cell-anemia-in-the-dominican-republic-the-sacred-trial
#8
Luisanna M Sánchez, Rosa M Nieves, Teresa Latham, Susan Stuber, Judy R Luden, Gabriela S Urcuyo, Melissa E Berges, Carla Florencio, Carla Gonzalez, Paola Del Villar, Adam Lane, William Schultz, Neelum Jeste, Rafael Mena, Russell E Ware
No abstract text is available yet for this article.
November 30, 2018: Blood Advances
https://www.readbyqxmd.com/read/30504193/incorporating-low-cost-spirometry-testing-of-pulmonary-function-into-comprehensive-care-for-children-with-sickle-cell-anemia-in-northwestern-nigeria-a-multicountry-collaboration-for-achieving-a-sustainable-initiative
#9
R Aliyu Zubair, L G Dogara, M Arigliani, C Zuiani, A Dache Sunday, R C Audu, Z Sani, H Dadan-Garba, B P D Inusa
No abstract text is available yet for this article.
November 30, 2018: Blood Advances
https://www.readbyqxmd.com/read/30501706/-clinical-charcteristics-and-prognostic-analysis-of-28-cases-of-pediatric-myelodysplastic-syndrome
#10
Jian Wang, Shao-Fen Lin, Qi-Hui Chen, Kun-Yin Qiu, Hong-Gui Xu, Ke Huang, Yang Li, Jian-Pei Fang, Zhou Dun-Hua Zhou
OBJECTIVE: To analyze the clinical features and prognosis of 28 children with myelodysplastic syndrome (MDS) and to screen the high risk factors affecting the prognosis so as to provide the new ideas for standard of clinical diagnosis and therapy. METHODS: The clinical data of 28 children with newly diagnosed MDS treated in our hospital from March 1994 to July 2016 were analyzed retrospectively, the features of disease onset and the results of laboratory examination were summarized, all MDS children were followed up, the prognosis and the high risk factors affecting the prognosis were evaluated...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30501550/hydroxyurea-for-children-with-sickle-cell-anemia-in-sub-saharan-africa
#11
Léon Tshilolo, George Tomlinson, Thomas N Williams, Brígida Santos, Peter Olupot-Olupot, Adam Lane, Banu Aygun, Susan E Stuber, Teresa S Latham, Patrick T McGann, Russell E Ware
BACKGROUND: Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safety, and benefits of hydroxyurea in low-resource settings. METHODS: We enrolled children 1 to 10 years of age with sickle cell anemia in four sub-Saharan countries. Children received hydroxyurea at a dose of 15 to 20 mg per kilogram of body weight per day for 6 months, followed by dose escalation...
December 1, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30499592/preoperative-anemia-increases-the-risk-of-red-blood-cell-transfusion-and-prolonged-hospital-length-of-stay-in-children-undergoing-spine-arthrodesis-surgery
#12
Montserrat Fontanals, James D O'Leary, Christian Zaarour, Teresa Skelton, David Faraoni
BACKGROUND: Preoperative anemia is an important modifiable risk factor for red blood cell (RBC) transfusion in a variety of surgical populations. The primary objective of this study was to examine the association between preoperative anemia and i) transfusion of RBCs within 72 hours of surgery and ii) postoperative clinical outcomes in children undergoing spine arthrodesis surgery. STUDY DESIGN AND METHODS: We assembled a retrospective cohort of children included in the American College of Surgeons National Quality Improvement Program Pediatric database who underwent spine arthrodesis surgery from 2012 to 2016...
November 30, 2018: Transfusion
https://www.readbyqxmd.com/read/30488511/supplementation-of-micronutrients-in-children-and-food-fortification-initiatives-in-sri-lanka-benefits-versus-risks
#13
Renuka Jayatissa, Dulitha N Fernando
In recent decades, Sri Lanka has made substantial progress in reducing the burden of micronutrient deficiencies in children by the provision of vitamin A megadose and micronutrient supplementation programs for children of 6-23 months, along with universal iodization of salt. Consumption of voluntarily fortified foods by children was also considerably increased. The objective of our study here was to review such interventions, which are beneficial in childhood, and to assess the risk of toxicity due to excessive intakes of iron, vitamin A, and iodine...
November 28, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/30487142/screening-for-iron-deficiency-in-early-childhood-using-serum-ferritin-in-the-primary-care-setting
#14
Hannah Oatley, Cornelia M Borkhoff, Shiyi Chen, Colin Macarthur, Navindra Persaud, Catherine S Birken, Jonathon L Maguire, Patricia C Parkin
OBJECTIVES: The American Academy of Pediatrics recommends universal screening for anemia using hemoglobin at 12 months. However, hemoglobin lacks diagnostic accuracy for iron deficiency, and the optimal age for screening has not been determined. Our objective was to assess a screening strategy for iron deficiency using serum ferritin. METHODS: We conducted a cross-sectional study of children 1 to 3 years old attending a health supervision visit. We examined the relationship between child age and serum ferritin, age and hemoglobin, hemoglobin and serum ferritin, and the prevalence of elevated C-reactive protein (CRP)...
November 28, 2018: Pediatrics
https://www.readbyqxmd.com/read/30485038/crohn-s-disease-diagnosis-and-management
#15
Brian Veauthier, Jaime R Hornecker
Crohn's disease is a chronic inflammatory condition that affects the gastrointestinal tract. It can cause lesions from mouth to anus and may result in extraintestinal complications. The prevalence of Crohn's disease is increasing in adults and children. Genetic predispositions to Crohn's disease have been identified, and specific environmental factors have been associated with its development. Common presenting symptoms include diarrhea, abdominal pain, rectal bleeding, fever, weight loss, and fatigue. Physical examination should identify unstable patients requiring immediate care, include an anorectal examination, and look for extraintestinal complications...
December 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30477586/perception-of-childhood-anaemia-among-mothers-in-kumasi-a-quantitative-approach
#16
Reindolf Anokye, Enoch Acheampong, Anthony Kwaku Edusei, Wisdom Kwadwo Mprah, Justice Ofori-Amoah, Vida Maame Kissiwaa Amoah, Vincent Ekow Arkorful
BACKGROUND: Anaemia is the world's second cause of disability and it affects over half of pre-school children in developing countries and at least 30-40% in industrial countries. In poorer malaria-endemic countries, anemia is one of the commonest preventable causes of death in children under 5 years. This study sought to determine the perceived causes, signs and symptoms as well prevention of childhood anaemia among mothers of children under 5 years in Kumasi, Ghana. METHODS: A descriptive hospital-based cross-sectional study design with a sample of 228 patients attending the University Hospital, KNUST was used...
November 26, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30469412/a-randomized-placebo-controlled-pilot-clinical-trial-to-evaluate-the-effect-of-supplementation-with-prebiotic-synergy-1-on-iron-homeostasis-in-children-and-adolescents-with-celiac-disease-treated-with-a-gluten-free-diet
#17
Klaudia Feruś, Natalia Drabińska, Urszula Krupa-Kozak, Elżbieta Jarocka-Cyrta
Iron deficiency anemia (IDA) occurs in 15⁻46% of patients with celiac disease (CD), and in some cases, it may be its only manifestation. Studies in animal models have shown that prebiotics, including inulin, may help to increase intestinal absorption of iron. The aim of this study was to evaluate the effect of a prebiotic, oligofructose-enriched inulin (Synergy 1), on iron homeostasis in non-anemic children and adolescents with celiac disease (CD) in association with a gluten-free diet (GFD). Thirty-four CD patients (4⁻18 years old) were randomized into two groups receiving Synergy 1 (10 g/day) or a placebo (maltodextrin) for three months...
November 21, 2018: Nutrients
https://www.readbyqxmd.com/read/30464670/prevalence-morphological-characterization-and-associated-factors-of-anemia-among-children-below-5-years-of-age-attending-st-mary-s-hospital-lacor-gulu-district-northern-uganda
#18
Apollo Ocan, Caesar Oyet, Fred Webbo, Bashir Mwambi, Ivan Mugisha Taremwa
Aim/objective: The aim of this study was to determine the prevalence, severity, morphological characterization, and the associated factors of anemia among children under the age of 5 years at St. Mary's Hospital Lacor, Gulu District, Northern Uganda. Materials and methods: A structured questionnaire was administered to each participant's parent/caregiver to collect data on sociodemographic factors, feeding pattern, and history of chronic illness. Hemoglobin (Hb) estimation was performed using a HemoCue 201+ analyzer...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/30463771/evaluation-of-anemia-and-nutritional-status-on-children-undergoing-resection-of-primary-liver-tumors
#19
Katherine D Culbreath, Alejandro V Garcia, Ira L Leeds, Mitchell R Ladd, Todd Crawford, Emily Boss, Daniel S Rhee
INTRODUCTION: Complete tumor resection of primary malignant liver tumors offers the best chance of survival. However, many of these children may experience anemia and failure to thrive. This study analyzes the association of preoperative anemia and nutritional support with outcomes in children undergoing major resection of primary malignant liver tumors. METHODS: Using the National Surgical Quality Improvement Program Pediatric database from 2012 to 2015, children undergoing major liver resections for primary malignant hepatic tumors were selected...
December 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30459954/a-ten-year-review-of-the-sickle-cell-program-in-muhimbili-national-hospital-tanzania
#20
Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W Snow, Charles R Newton, David Roberts, Muhsin Aboud, Swee Lay Thein, Sharon E Cox, Lucio Luzzatto, Bruno P Mmbando
Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Methods: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done...
2018: BMC Hematology
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