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https://www.readbyqxmd.com/read/30530134/brivaracetam-in-adults-with-drug-resistant-epilepsy-and-psychiatric-comorbidities
#1
Evangelia Theochari, Hannah Cock, Dora Lozsadi, Clare Galtrey, Jan Arevalo, Marco Mula
This is a case series of 25 patients with drug-resistant epilepsy and psychiatric comorbidities who started on brivaracetam (BRV) at St George's University Hospitals and Frimley Health in London. Median BRV dose was 150 mg for a median follow-up period of 8 months. Twenty had focal epilepsy, four had generalized epilepsies, and one had unclassified epilepsy; 76% had mood disorders (either depression or bipolar disorder), 12% intellectual disabilities with autism spectrum disorder and challenging behavior, and 12% psychoses...
December 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30524703/medication-nonadherence-in-bipolar-disorder-a-narrative-review
#2
REVIEW
Ibrahim Jawad, Stuart Watson, Peter M Haddad, Peter S Talbot, R Hamish McAllister-Williams
A number of effective maintenance medication options exist for bipolar disorder (BD) and these are regarded as the foundation of long-term treatment in BD. However, nonadherence to medication is common in BD. For example, a large data base study in the United States of America (USA) showed that approximately half of patients with BD were nonadherent with lithium and maintenance medications over a 12 month period. Such nonadherence carries a high risk of relapse due to the recurrent nature of the illness and the fact that abrupt cessation of treatment, particularly lithium, may cause rebound depression and mania...
December 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/30500484/prevalence-of-psychiatric-disorders-in-thai-patients-with-epilepsy
#3
Sanchai Kuladee, Thanavadee Prachason, Porntip Srisopit, Dussanee Trakulchang, Apisit Boongird, Pattarabhorn Wisajan, Sudawan Jullagate
BACKGROUND: Many studies have shown that the prevalence of psychiatric disorders in patients with epilepsy (PWE) appears higher than that in general population. However, most epidemiological studies regarding psychiatric comorbidities among PWE were conducted in Western countries. This work aimed to determine the prevalence of psychiatric disorders in Thai PWE, including potential variables that could be associated with psychiatric disorders. METHODS: A cross-sectional study was conducted at Ramathibodi Hospital...
November 27, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30483161/patterns-of-management-of-patients-with-dual-disorder-psychosis-in-italy-a-survey-of-psychiatrists-and-other-physicians-focusing-on-clinical-practice
#4
Massimo Clerici, Andrea de Bartolomeis, Sergio De Filippis, Giuseppe Ducci, Icro Maremmani, Giovanni Martinotti, Fabrizio Schifano
Patients with severe psychotic disorders such as schizophrenia, schizoaffective, and bipolar disorders frequently suffer from concomitant substance use disorders (SUDs)-Dual Disorder (DD) patients. In order to better understand current practices for management of patients with psychotic episodes and concomitant SUD in Italy, we carried out a survey of psychiatrists on current routine practice among prescribers. These aspects can help to identify at-risk patients, improve current prescribing practices, and favor early intervention...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30480855/the-morbidity-of-subthreshold-pediatric-bipolar-disorder-a-systematic-literature-review-and-meta-analysis
#5
REVIEW
Carrie A H Vaudreuil, Stephen V Faraone, Maura Di Salvo, Janet R Wozniak, Rebecca A Wolenski, Nicholas W Carrellas, Joseph Biederman
OBJECTIVE: Evaluate the morbidity of subthreshold pediatric bipolar (BP) disorder. METHODS: We performed a systematic literature search in November 2017 and included studies examining the morbidity of pediatric subthreshold BP. Extracted outcomes included functional impairment, severity of mood symptoms, psychiatric comorbidities, suicidal ideation and behaviors, and mental health treatment. We used meta-analysis to compute the pooled standardized mean difference (SMD) for continuous measures and the pooled risk ratio (RR) for binary measures between two paired groups: subthreshold pediatric BP vs...
November 27, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/30474297/risk-of-obstructive-sleep-apnea-in-patients-with-bipolar-disorder-a-nationwide-population-based-cohort-study-in-taiwan
#6
En-Ting Chang, Shih-Fen Chen, Jen-Huai Chiang, Ling-Yi Wang, Chung-Y Hsu, Yu-Chih Shen
AIM: Previous studies have found a high prevalence of risk factors for obstructive sleep apnea (OSA) in patients with bipolar disorder (BD). The study aims to determine whether BD patients are associated with an increased risk of incident OSA. METHODS: Using the National Health Insurance Research Database (NHIRD) of Taiwan, 3,650 BD patients and 18,250 non-BD controls matched by gender and age were enrolled between 2000-2010 and followed until the end of 2013. Patients who developed OSA confirmed by a polysomnographic examination during the follow-up period were identified...
November 25, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30471979/characteristics-and-outcomes-of-young-people-with-substance-induced-psychotic-disorder
#7
Jessica O'Connell, Monica Sunwoo, Patrick McGorry, Brian O'Donoghue
BACKGROUND: Substance induced psychotic disorders (SIPD) have been historically considered as associated with better clinical and functional outcomes than other psychotic diagnoses. As a result, treatments for those with SIPD are often considerably less intensive, yet this is not based on evidence. The present study aimed to examine whether differences exist between those with SIPD and other first episode psychosis (FEP) diagnoses in regards to demographic and clinical factors, and to determine the symptomatic, clinical and functional outcomes in those with SIPD...
November 21, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/30471214/early-life-trauma-predicts-affective-phenomenology-and-the-effects-are-partly-mediated-by-staging-coupled-with-lowered-lipid-associated-antioxidant-defences
#8
Michael Maes, Ana Congio, Juliana Brum Moraes, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, Heber Odebrecht Vargas, Gerwyn Morris, Basant K Puri, Ana Paula Michelin, Sandra Odebrecht Vargas Nunes
Background Early life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences. Methods This study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). ELT was assessed using the Child Trauma Questionnaire...
November 20, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/30456519/earlier-versus-later-augmentation-with-an-antipsychotic-medication-in-patients-with-major-depressive-disorder-demonstrating-inadequate-efficacy-in-response-to-antidepressants-a-retrospective-analysis-of-us-claims-data
#9
Irina Yermilov, Mallik Greene, Eunice Chang, Ann Hartry, Tingjian Yan, Michael S Broder
INTRODUCTION: There is little evidence regarding the most effective timing of augmentation of antidepressants (AD) with antipsychotics (AP) in patients with major depressive disorder (MDD) who inadequately respond to first-line AD (inadequate responders). The study's objective was to understand the association between timing of augmentation of AD with AP and overall healthcare costs in inadequate responders. METHODS: Using the Truven Health MarketScan® Medicaid, Commercial, and Medicare Supplemental databases (7/1/09-12/31/16), we identified adult inadequate responders if they had one of the following indicating incomplete response to initial AD: psychiatric hospitalization or emergency department (ED) visit, initiating psychotherapy, or switching to or adding on a different AD...
November 19, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30439852/dysphoria-as-a-psychiatric-syndrome-a-preliminary-study-for-a-new-transnosographic-dimensional-approach
#10
Patrizia Moretti, Massimo C Bachetti, Tiziana Sciarma, Alfonso Tortorella
BACKGROUND: We currently define dysphoria as a complex and disorganized emotional state with proteiform phenomenology, characterized by a multitude of symptoms. Among them prevail irritability, discontent, interpersonal resentment and surrender. Dysphoria, in line with the most recent Interpersonal Dysphoria Model, could represent a "psychopathological organizer" of the Borderline Personality Disorder. We would like to extend this theoretical concept to other psychiatric disorders in order to consider dysphoria as a possible psychopathological nucleus, a syndrome on its own...
November 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/30430941/common-environmental-factors-may-underpin-the-comorbidity-between-generalized-anxiety-disorder-and-mood-disorders-via-activated-nitro-oxidative-pathways
#11
Chutima Roomruangwong, Denitsa S Simeonova, Drozdstoy S Stoyanov, George Anderson, Andre Carvalho, Michael Maes
Generalized anxiety disorder (GAD) commonly co-occurs with mood disorders, especially major depressive disorder (MDD) and bipolar disorder (BD), which are accompanied by activated neuro-immune and neuro-oxidative pathways. The aim of this narrative review is to review the phenomenological similarities and dissimilarities and the shared pathways between GAD and mood disorders. We searched PubMed, Scopus, and Google Scholar for articles published in English from 1980 to present. GAD and mood disorders, either MDD or BD, show some phenomenological overlaps and a high degree of comorbidity, especially between GAD and MDD...
November 14, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30419527/predominant-polarity-classification-and-associated-clinical-variables-in-bipolar-disorder-a-machine-learning-approach
#12
Gabriel Okawa Belizario, Renato Gomes Borges Junior, Rogerio Salvini, Beny Lafer, Rodrigo da Silva Dias
BACKGROUND: Bipolar disorder (BD) is a severe psychiatric disorder characterized by periodic episodes of manic and depressive symptomatology. Predominant polarity (PP) appears to be an important specifier of BD. The present study employed machine learning (ML) algorithms to accurately determine a patient´s PP without the inclusion of number and polarity of past episodes, while exploring associations between PP and demographic and clinical variables. METHODS: From a cohort of 148 BD patients, demographic and clinical variables were collected using a customized questionnaire and the SCID-CV...
November 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30416410/antidepressant-prescription-patterns-in-bipolar-disorder-a-nationwide-register-based-study-in-korea
#13
Woon Yoon, Seung-Hyun Shon, Youjin Hong, Yeon Ho Joo, Jung Sun Lee
Background: The role of antidepressants (ADs) in bipolar disorder is long-standing controversial issue in psychiatry. Many clinicians have used ADs as a treatment for bipolar depression, and the selection of therapeutic agents is very diverse and inconsistent. This study aimed to examine recent AD prescription patterns for patients with bipolar disorder in Korea, using the nationwide, population-based data. Methods: This study utilized the Korean nationwide, whole population-based registry data of the year 2010, 2011, and 2013...
November 12, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30403274/-prevalence-of-bipolar-spectrum-disorders-in-migraine-patients
#14
Barış Önen Ünsalver, Alper Evrensel, Mehmet Kerem Doksat
OBJECTIVES: Comorbidity of migraine and mood disorders has long been recognized. Most of the studies have focused on the relationship between migraine and major depression with only few studies suggesting a special association between migraine and bipolar spectrum disorders. We aimed to evaluate the prevalence of bipolar disorder in migraine patients in a specialized headache outpatient clinic. METHODS: The sample consisted of 78 consecutive patients with migraine headache presenting to the specialized headache outpatient clinic in a Medical Faculty...
October 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/30402985/the-role-impairment-associated-with-mental-disorder-risk-profiles-in-the-who-world-mental-health-international-college-student-initiative
#15
Jordi Alonso, Gemma Vilagut, Philippe Mortier, Randy P Auerbach, Ronny Bruffaerts, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Edel Ennis, Raul A Gutiérrez-García, Jennifer Greif Green, Penelope Hasking, Sue Lee, Jason Bantjes, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Alan M Zaslavsky, Ronald C Kessler
OBJECTIVE: The objective of this study is to assess the contribution of mental comorbidity to role impairment among college students. METHODS: Web-based self-report surveys from 14,348 first-year college students (Response Rate [RR] = 45.5%): 19 universities, eight countries of the World Mental Health International College Student Initiative. We assessed impairment (Sheehan Disability Scales and number of days out of role [DOR] in the past 30 days) and seven 12-month DSM-IV disorders...
November 6, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/30399503/rise-and-shine-a-treatment-experiment-testing-a-morning-routine-to-decrease-subjective-sleep-inertia-in-insomnia-and-bipolar-disorder
#16
Katherine A Kaplan, David C Talavera, Allison G Harvey
Sleep inertia involves decreased performance or disorientation upon waking that lasts several hours and impairs functioning. Though sleep inertia is common in insomnia and may interfere with treatment, Cognitive Behavioral Therapy for Insomnia (CBTI) does not routinely include a component to address sleep inertia. The present study evaluates such a component, the RISE-UP routine, in CBTI for insomnia comorbid with bipolar disorder. We hypothesized that the RISE-UP routine would increase physical activity in the morning and reduce the duration and severity of self-reported sleep inertia...
October 27, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/30397567/treatment-of-anxiety-disorders-in-patients-with-comorbid-bipolar-disorder
#17
Carol A Ott
Anxiety disorders are the most prevalent comorbid diagnoses in patients with bipolar disorder (BD). A comorbid anxiety diagnosis can significantly impact the severity of bipolar symptoms, increase the risk of suicidality, and decrease psychosocial functioning and quality of life. The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force published recommendations for treatment in 2012 suggesting that specific anticonvulsant mood stabilizers and second-generation antipsychotics are the medications of choice to treat these comorbidities...
November 2018: The mental health clinician
https://www.readbyqxmd.com/read/30383553/the-association-between-gabapentin-and-suicidality-in-bipolar-patients
#18
Wendy M Leith, William E Lambert, James K Boehnlein, Michael D Freeman
The aims of this study were to assess the association between gabapentin and suicidality in patients diagnosed with bipolar disorder (BD) and to determine whether the risk is greater relative to patients prescribed lithium. This retrospective observational study utilizes US population-based claims data assembled by PharMetrics Inc., comprising 47 918 patients diagnosed with BD. Patients were included if they were at least 18 years old and initiated a new monotherapy prescription of either gabapentin (n=2421) or lithium (n=3101)...
October 31, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30376205/obesity-mixed-and-bipolar-features-in-major-depression-should-we-identify-the-usual-suspects-or-also-look-for-covert-mediators
#19
Bruno Etain, Frank Bellivier
No abstract text is available yet for this article.
October 30, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/30365917/characterization-of-psychiatrically-hospitalized-college-students
#20
Laura Braider, Candice La Lima, Nicholas Crimarco, Beth Hollander, Azure Reid-Russell, John Kane, Blaine Greenwald
OBJECTIVE: To characterize contemporary college students requiring psychiatric hospitalization. PARTICIPANTS AND METHODS: Sociodemographic and diagnostic information was gathered retrospectively and analyzed from the electronic medical records (EMRs) of the consecutive inpatient hospitalizations of 905 college students admitted to a psychiatric inpatient unit. RESULTS: Significantly more females compared to males experienced the following: more hospitalizations, more family and financial stressors, more depression, and less psychotic and bipolar disorder...
October 26, 2018: Journal of American College Health: J of ACH
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