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"bipolar disorder","comorbidity"

Ji Hyun Baek, Kyooseob Ha, Yongkang Kim, Young-Ah Cho, So Yung Yang, Yujin Choi, Sung-Lee Jang, Taesung Park, Tae Hyon Ha, Kyung Sue Hong
BACKGROUND: Given its diverse disease courses and symptom presentations, multiple phenotype dimensions with different biological underpinnings are expected with bipolar disorders (BPs). In this study, we aimed to identify lifetime BP psychopathology dimensions. We also explored the differing associations with bipolar I (BP-I) and bipolar II (BP-II) disorders. METHODS: We included a total of 307 subjects with BPs in the analysis. For the factor analysis, we chose six variables related to clinical courses, 29 indicators covering lifetime symptoms of mood episodes, and 6 specific comorbid conditions...
October 17, 2018: Psychological Medicine
Daniel S Tylee, Jiayin Sun, Jonathan L Hess, Muhammad A Tahir, Esha Sharma, Rainer Malik, Bradford B Worrall, Andrew J Levine, Jeremy J Martinson, Sergey Nejentsev, Doug Speed, Annegret Fischer, Eric Mick, Brian R Walker, Andrew Crawford, Struan F A Grant, Constantin Polychronakos, Jonathan P Bradfield, Patrick M A Sleiman, Hakon Hakonarson, Eva Ellinghaus, James T Elder, Lam C Tsoi, Richard C Trembath, Jonathan N Barker, Andre Franke, Abbas Dehghan, Stephen V Faraone, Stephen J Glatt
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics methods...
October 16, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Abhinav Nahar, Harish Thippeswamy, Mukku Shiva Shanker Reddy, M Thomas Kishore, Santosh K Chaturvedi
BACKGROUND: The literature on co-morbid psychiatric illnesses in adults with high-functioning autism (HFA) spectrum disorder is sparse. PURPOSE: To examine the nature of psychiatric comorbidity and treatment response in adults with HFA spectrum disorder. MATERIALS AND METHODS: Case records of subjects (age ≥17 years) who presented over a period of 16 years with primary psychiatric symptoms and further detected to have an HFA spectrum disorder, were analyzed...
September 26, 2018: Asian Journal of Psychiatry
Rachel L Kember, Liping Hou, Xiao Ji, Lars H Andersen, Arpita Ghorai, Lisa N Estrella, Laura Almasy, Francis J McMahon, Christopher Brown, Maja Bućan
Bipolar disorder (BD) is a mental disorder characterized by alternating periods of depression and mania. Individuals with BD have higher levels of early mortality than the general population, and a substantial proportion of this is due to increased risk for comorbid diseases. To identify the molecular events that underlie BD and related medical comorbidities, we generated imputed whole-genome sequence data using a population-specific reference panel for an extended multigenerational Old Order Amish pedigree (n = 394), segregating BD and related disorders...
October 12, 2018: Translational Psychiatry
Laura Musetti, Antonio Tundo, Alessandra Benedetti, Gabriele Massimetti, Erika Cambiali, Irene Pergentini, Claudia Del Grande, Liliana Dell'Osso
OBJECTIVE: This study aims to describe the prescription patterns of the mood stabilizers most commonly used for the treatment of bipolar I and II disorders (lithium, valproate, and carbamazepine) and to analyze the treatment outcomes. METHODS: Two hundred and thirty-four outpatients with bipolar disorders receiving prophylactic treatment with lithium, valproate, carbamazepine, or their combination were followed up for at least 18 months in two Italian psychiatric centers specialized in mood disorders...
October 12, 2018: Human Psychopharmacology
Scott H Waltman, David Shearer, Bret A Moore
PURPOSE OF REVIEW: Post-traumatic nightmares (PTN) are a common and enduring problem for individuals with post-traumatic stress disorder (PTSD) and other clinical presentations. PTN cause significant distress, are associated with large costs, and are an independent risk factor for suicide. Pharmacological and non-pharmacological treatment options for PTN exist. A previous review in this journal demonstrated that Prazosin, an alpha blocker, was a preferred pharmacological treatment for PTN and imagery rescripting therapy (IRT) was a preferred non-pharmacological treatment...
October 11, 2018: Current Psychiatry Reports
Christian Lange-Asschenfeldt
BACKGROUND: Chronic schizophrenia, depression, and bipolar disorders, among other chronic psychiatric disorders with onset at youth or early adulthood are often referred to as severe mental illness (SMI). Aging with SMI is associated with various psychosocial, physiological, and medical problems with potential impact on psychiatric pharmacotherapy. OBJECTIVES: Determination and discussion of problems and special features of the psychopharmacological treatment of older persons with SMI and presentation of treatment recommendations for the distinct diagnoses...
October 9, 2018: Zeitschrift Für Gerontologie und Geriatrie
Naren P Rao, Sweta Sheth, Shivarama Varambally
No abstract text is available yet for this article.
September 2018: Indian Journal of Psychological Medicine
Jens Benninghoff, Peter Brieger
Diagnostic and therapeutic measures in patients with bipolar disorders are significantly different depending on the age of those affected. Given the demographic changes and the fact that approximately one quarter of patients with bipolar disease are in old age, it is important for geriatricians to be aware of the specific aspects of bipolar disease. This review article presents the diagnostics of bipolar disorders in old people. Interactions with somatic comorbidities, which may lead to the occurrence of secondary mania, just to mention one of the characteristics of old age, are elaborated...
September 28, 2018: Zeitschrift Für Gerontologie und Geriatrie
Qi Chen, Catharina A Hartman, Jan Haavik, Jaanus Harro, Kari Klungsøyr, Tor-Arne Hegvik, Rob Wanders, Cæcilie Ottosen, Søren Dalsgaard, Stephen V Faraone, Henrik Larsson
Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with other psychiatric conditions in adults. Yet, less is known about its relationship with common metabolic disorders and how sex and ageing affect the overall comorbidity patterns of adult ADHD. We aimed to examine associations of adult ADHD with several common psychiatric and metabolic conditions. Through the linkage of multiple Swedish national registers, 5,551,807 adults aged 18 to 64 years and living in Sweden on December 31, 2013 were identified and assessed for clinical diagnoses of adult ADHD, substance use disorder (SUD), depression, bipolar disorder, anxiety, type 2 diabetes mellitus (T2DM), and hypertension...
2018: PloS One
Ilaria Cuomo, Daria Piacentino, Georgios D Kotzalidis, Luana Lionetto, Sergio De Filippis
AIM: Bipolar disorder (BD) is often treated with anticonvulsants. Lacosamide has not been tested in BD. We assessed its effects in a hospital setting in patients with BD without epilepsy. METHOD: We treated with lacosamide 50-300 mg/day 102 consecutive hospitalised patients with acute BD. We compared this sample with a retrospective sample treated with other antiepileptics (OAEs). We rated patients after 3, 7, 15, and 30 days of treatment with the Brief Psychiatric Rating Scale (BPRS), Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Clinical Global Impressions-severity (CGIs), and Global Assessment of Functioning (GAF)...
September 24, 2018: Psychiatry and Clinical Neurosciences
Ching-Wen Chu, Wu-Chien Chien, Chi-Hsiang Chung, Pei-Chun Chao, Hsin-An Chang, Yu-Chen Kao, Yu-Ching Chou, Nian-Sheng Tzeng
Background: Electroconvulsive therapy (ECT) is an effective treatment for schizophrenia, bipolar disorder, and major depressive disorder, and a temporary memory loss may occur after ECT. However, the association between ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, and the risk of dementia is yet to be examined. Objective: This study aimed to clarify as to whether ECT is associated with the risk of dementia after ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, using Taiwan's National Health Insurance Research Database (NHIRD)...
2018: Frontiers in Psychiatry
Anne Duffy, Naomi Heffer, Sarah M Goodday, Arielle Weir, Scott Patten, Gin S Malhi, Andrea Cipriani
OBJECTIVES: To assess the efficacy and tolerability of lithium for the treatment of acute mania in children and adolescent diagnosed with bipolar disorder. METHODS: A systematic literature search up to August 2017 was conducted for clinical trials that included lithium in males and females up to 18 years of age with a diagnosis of bipolar disorder and experiencing a manic or mixed episode according to standardized diagnostic criteria. The protocol was registered in PROSPERO (CRD42017055675)...
September 16, 2018: Bipolar Disorders
Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt, Per Ivar Finseth
BACKGROUND: About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition (BD due to TBI). We investigated whether these patients have similar clinical characteristics as previously described in BD due to TBI (i.e. more aggression and irritability and an increased hypomania/mania:depression ratio) and other distinct clinical characteristics...
September 10, 2018: International Journal of Bipolar Disorders
Michael S Broder, Mallik Greene, Eunice Chang, Ann Hartry, Maëlys Touya, Jennifer Munday, Tingjian Yan
PURPOSE: Schizophrenia (SCZ) and bipolar disorder (BD) are typically viewed as nonconcurrent psychiatric disorders, yet patients may experience mood and SCZ symptoms simultaneously. Several studies have shown overlap between SCZ and BD symptoms and susceptibility genes. This study explored the following: (1) patterns of administrative claims; (2) demographic characteristics and comorbidities; (3) health care resource use; and (4) health care costs in patients with diagnoses of SCZ, type I BD (BD-I), and both in a real-world setting...
September 4, 2018: Clinical Therapeutics
Rosalinda V Ignacio, Paul G Barnett, Hyungjin Myra Kim, Mark C Geraci, Carol A Essenmacher, Stephanie V Hall, Adam Chow, Paul N Pfeiffer, Scott E Sherman, Kipling M Bohnert, Kara Zivin, Sonia A Duffy
Introduction: There is evidence suggesting that certain subgroups of people who use tobacco do not receive tobacco pharmacology as consistently as others. Methods: This retrospective, cohort study examined the trend in the use of cessation pharmacotherapy from 2004 to 2013 using Veterans Health Administration (VHA) administrative data. Among Veterans who used tobacco in the fiscal year (FY) 2011 and had not received pharmacotherapy in the prior year, multivariable Cox regression was used to assess the independent associations between patient clinical and demographic characteristics and pharmacotherapy initiation in the 6-months follow-up period...
September 4, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Alex Gisunterman, Yoav Cohn, Abraham Weizman
The year 2013 saw the publication of a new edition of the Diagnostic and Statistical Manual of Mental Disorders, the DSM-5. In this edition a new diagnosis - Disruptive Mood Dysregulation Disorder (DMDD) - was added. It defines children suffering from irritable and angry moods with frequent severe temper outbursts. The diagnosis is included in the chapter on mood disorders and relates only to children. This diagnosis was suggested in order to prevent over-diagnosis of bipolar disorder and over-use of antipsychotics and mood stabilizers in children...
August 2018: Harefuah
L Plans, C Barrot, E Nieto, J Rios, T G Schulze, S Papiol, M Mitjans, E Vieta, A Benabarre
BACKGROUND: Completed suicide is a major cause of death in bipolar disorder (BD) patients. OBJECTIVE: The aim of this paper is to provide an overall review of the existing literature of completed suicide in BD patients, including clinical and genetic data DATA SOURCES: We performed a systematic review of English and non-English articles published on MEDLINE/PubMed, PsycInfo and Cochrane database (1970-2017). Additional studies were identified by contacting clinical experts, searching bibliographies, major textbooks and website of World Health Organization...
January 1, 2019: Journal of Affective Disorders
Li Han, Leyuan Wang, Sha Tang, Lin Yuan, Shuangyan Wu, Xizi Du, Yang Xiang, Xiangping Qu, Huijun Liu, Huaiqing Luo, Xiaoqun Qin, Chi Liu
BACKGROUND: Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidity is almost unknown. Integrin β4 (ITGB4) is downregulated on the airway epithelial of asthma patients, which might play a critical role in the parthenogenesis of airway inflammation. So this study aimed to examine the role of ITGB4 deficiency in mediating airway inflammation and further leading to the BD-like behaviors...
August 31, 2018: Journal of Neuroinflammation
Ying-Chou Wang, Ying Hao Yu, Meng-Li Tsai, Andrew Chih Wei Huang
In a clinical setting, anxiety disorder is highly correlated with bipolar I disorder in humans. However, the comorbidity of anxiety behavior and bipolar disorder still remains unclear in an animal model. This study utilized an ouabain-induced animal mode to examine anxiety and mania in an open field test. In the present study, 5 µl of artificial cerebrospinal fluid (aCSF) or ouabain (10-5 , 10-4 , and 10-3  M) were administered into the left ventricle. The animals' motor functions and anxiety behaviors were measured for 15 min...
October 2018: Psychiatry Research
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