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"bipolar disorder","comorbidity"

Li-Chi Chen, Mu-Hong Chen, Tung-Ping Su, Shih-Jen Tsai, Ya-Mei Bai, Cheng-Ta Li, Albert C Yang, Wen-Han Chang, Tzeng-Ji Chen
INTRODUCTION: Previous studies have suggested that both bipolar disorder and atopy are associated with an increased risk of stroke. However, the role of atopic diseases/diathesis in the risk of stroke among patients with bipolar disorder remains unclear. METHODS: Using Taiwan's National Health Insurance Research Database, we selected 55,593 patients with bipolar disorder between 2002 and 2008, divided them into patients with atopic diseases/diathesis (n = 21,050) and patients without atopic diseases/diathesis (n = 34,543), and observed them until the end of 2011...
2018: PloS One
Bettina S Fehr, William F Katz, Erin A Van Enkevort, Imran S Khawaja
Objective: To examine the correlations between obstructive sleep apnea (OSA) and psychiatric disorders such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), or bipolar disorder (BD) and whether comorbid psychiatric diagnosis increases the risk of OSA. Methods: This retrospective chart review study included all patients (N = 413) seen within a randomly selected 4-month period (August 2014 to November 2014) in a Veterans Administration outpatient psychiatry clinic...
August 9, 2018: Primary Care Companion to CNS Disorders
Ebele Compean, Mark Hamner
Trauma exposure leads to various psychiatric disorders including depression, anxiety, bipolar disorders, personality disorders, psychotic disorders, and trauma related disorders, especially posttraumatic stress disorder (PTSD). There are some overlapping symptoms of both PTSD and psychosis that make diagnosis challenging. Despite this overlap, the evidence of PTSD with comorbid psychosis as a distinct entity lies in the research showing biologic, genetic and treatment management differences between psychotic PTSD, non-psychotic PTSD, psychotic disorders and healthy controls...
August 6, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Hannah J Jones, Jon Heron, Gemma Hammerton, Jan Stochl, Peter B Jones, Mary Cannon, George Davey Smith, Peter Holmans, Glyn Lewis, David E J Linden, Michael C O'Donovan, Michael J Owen, James Walters, Stanley Zammit
Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modelling comorbidity across psychopathology. We examine how genetic risk for schizophrenia relates to adolescent psychosis-related and internalizing psychopathology using a latent modelling approach, and compare this to genetic risk for other psychiatric disorders, to gain a more comprehensive understanding of the developmental pathways at this age...
August 8, 2018: Translational Psychiatry
Zeynep Yilmaz, Matthew Halvorsen, Julien Bryois, Dongmei Yu, Laura M Thornton, Stephanie Zerwas, Nadia Micali, Rainald Moessner, Christie L Burton, Gwyneth Zai, Lauren Erdman, Martien J Kas, Paul D Arnold, Lea K Davis, James A Knowles, Gerome Breen, Jeremiah M Scharf, Gerald Nestadt, Carol A Mathews, Cynthia M Bulik, Manuel Mattheisen, James J Crowley
Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3495 AN cases, 2688 OCD cases, and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (rg  = 0.49 ± 0.13, p = 9.07 × 10-7 ) and a sizable SNP heritability (SNP h2  = 0.21 ± 0.02) for the cross-disorder phenotype. Although no individual loci reached genome-wide significance, the cross-disorder phenotype showed strong positive genetic correlations with other psychiatric phenotypes (e...
August 7, 2018: Molecular Psychiatry
Verinder Sharma, Minakshi Doobay
IntroductionLamotrigine is a commonly used drug in the treatment of bipolar disorder. Although there are reports of its effectiveness in the management of bipolar disorder and comorbid obsessive-compulsive disorder (OCD), lamotrigine has also been associated with obsessionality in patients with bipolar disorder. METHODS: Charts of 8 patients with bipolar disorder who had de novo onset of obsessions and compulsions after the use of lamotrigine were reviewed. The Naranjo scale was used to assess the likelihood of patients developing OCD due to lamotrigine use...
August 8, 2018: CNS Spectrums
David A Lovas, Zev Schuman-Olivier
BACKGROUND: Persisting high levels of relapse, morbidity and mortality in bipolar disorder (BD) in spite of first-line, evidence-based psychopharmacology has spurred development and research on adjunctive psychotherapies. Mindfulness-based cognitive therapy (MBCT) is an emerging psychotherapy that has shown benefit in related and comorbid conditions such as major depressive, anxiety, and substance disorders. Furthermore, neurocognitive studies of MBCT suggest that it may have effects on some of the theorized pathophysiological processes in BD...
July 6, 2018: Journal of Affective Disorders
Christine L McKibbin, Aaron Lee, Dale Glaser, Stephanie Kanuch, Kristin Cassidy, Charles Thomas, Douglas Gunzler, Richard McCormick, Neal V Dawson, Martha Sajatovic
Objective Adults with serious mental illness are at increased risk for diabetes mellitus and diabetes-related complications. This article classifies subgroups among people with serious mental illness and comorbid diabetes with respect to functional status and examines differences among those groups. Methods This analysis used a baseline sample of 157 adults with serious mental illness and diabetes mellitus enrolled in a National Institute of Health-funded research study. Latent profile analysis was used to distinguish health status profiles and investigate how these subgroups differed across assessment domains...
August 4, 2018: International Journal of Psychiatry in Medicine
R B Bassey, S N Chapman, M Pessu, A Jayam-Trouth, M C Gondré-Lewis
Background: Human immunodeficiency virus (HIV) infection remains a serious immunological disease with new infections in the U.S. disproportionately reported in minority populations. For many years, the District of Columbia (DC) has reported the highest HIV infection rate in the nation. Drug abuse and addiction is also prevalent in DC and has traditionally been linked to HIV/AIDS because of the likelihood for opportunistic infections. Despite this data, the relationship between HIV status, drugs of abuse, and the incidence of neurological disorders are scarcely reported for minority populations...
2018: Journal of Neurology and Neuroscience
C Hansson, E Joas, E Pålsson, K Hawton, B Runeson, M Landén
OBJECTIVE: Bipolar disorder carries a high risk of suicide. Identification of risk factors is important. The aim of this study was to study risk factors for suicide in a large cohort of men and women with bipolar disorder. METHOD: A prospective cohort study using clinical data from the Swedish National Quality Register for Bipolar Affective Disorder (BipoläR). The outcome variable was suicide captured in the Cause of Death Register between 2004 and 2014. Hazard ratios (HR) were calculated using Cox proportional hazards models...
August 3, 2018: Acta Psychiatrica Scandinavica
Alberto Aedo, Andrea Murru, Raúl Sanchez, Iria Grande, Eduard Vieta, Juan Undurraga
BACKGROUND: Rapid cycling (RC) bipolar disorder (BD) is associated with more disability and worse global functioning than non-rapid cycling BD (NRC) and is understudied. This study aims to investigate clinical characteristics associated to RC in a Latin-American sample and secondarily, to generate a clinical model to test the likelihood of RC in BD. METHODS: 250 BD patients were enrolled between 2007 and 2015. All patients met DSM-IV criteria for BD type I, II or NOS...
July 23, 2018: Journal of Affective Disorders
W David Lohr, Liza Creel, Yana Feygin, Michelle Stevenson, Michael J Smith, John Myers, Charles Woods, Gil Liu, Deborah Winders Davis
BACKGROUND: The rates of mental health diagnoses in children have increased. Children in poverty have the highest rates. The use of psychotropic medication for children has been increasing, which is concerning because of the unknown long-term effects and the increased burden on the health care system. The state of Kentucky ranks among the highest in the United States for children with mental health problems, children living in poverty, and children receiving psychotropic medication. OBJECTIVE: To examine recent trends and determinants of interclass psychotropic polypharmacy (PP) use for children and youth receiving Medicaid to inform intervention development...
August 2018: Journal of Managed Care & Specialty Pharmacy
Leorides Severo Duarte-Guerra, Bruno Mendonça Coêlho, Marco Aurélio Santo, Francisco Lotufo-Neto, Yuan-Pang Wang
BACKGROUND: Psychiatric disorders tend to distribute unevenly in women and men with severe obesity. The current research aimed to identify homogeneous clusters of concurrent psychiatric disorders among patients seeking bariatric surgery, by gender. METHODS: We recruited a consecutive sample of 393 candidates with obesity (311 women and 82 men) in a university-based bariatric center. Trained clinicians assessed psychiatric disorders through the Structured Clinical Interview for DSM-IV (SCID)...
July 17, 2018: Journal of Affective Disorders
Ainsley M Sutherland, Judith Nicholls, James Bao, Hance Clarke
There is significant overlap in the pharmacological management of pain and psychological disorders. Appropriate treatment of patients' comorbid psychological disorders, including sleep disturbances often leads to an improvement in reported pain intensity. The three first line agents for neuropathic pain include tricyclic antidepressants and serotonin norepinephrine reuptake inhibitors which are medications originally developed as antidepressants. The other first line medication for chronic neuropathic pain are anticonvulsant medications initially brought to the market-place for the treatment of epilepsy and are also now being used for the treatment of anxiety disorders and substance withdrawal symptoms...
July 25, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Martina Platzer, Frederike T Fellendorf, Susanne A Bengesser, Armin Birner, Nina Dalkner, Carlo Hamm, Riccarda Hartleb, Robert Queissner, René Pilz, Alexandra Rieger, Alexander Maget, Harald Mangge, Sieglinde Zelzer, Bernd Reininghaus, Hans-Peter Kapfhammer, Eva Z Reininghaus
OBJECTIVES: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits. METHODS: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed...
July 26, 2018: World Journal of Biological Psychiatry
Alexandra K Gold, Amy T Peters, Michael W Otto, Louisa G Sylvia, Pedro Vieira da Silva Magalhaes, Michael Berk, Darin D Dougherty, David J Miklowitz, Ellen Frank, Andrew A Nierenberg, Thilo Deckersbach
OBJECTIVE: Up to 60% of patients with bipolar disorder develop a substance use disorder during their lifetime. The purpose of this paper was to assess the impact of substance use disorders on depression recovery among bipolar patients randomly assigned to different psychotropic medications and psychosocial interventions. We hypothesized that patients with a comorbid substance use disorder would benefit less from psychotherapy regardless of treatment intensity/length compared to patients without a comorbid substance use disorder...
July 26, 2018: Australian and New Zealand Journal of Psychiatry
Surbhi Gupta, Andrea Caskey, Neelkamal Soares, Marilyn Augustyn
Sam is a 6-year-old boy with a diagnosis of autism spectrum disorder (ASD) who recently relocated and has an appointment with you, his new pediatric clinician, to establish care. He was previously followed by a psychiatrist for 2 years for additional diagnoses of insomnia, bipolar disorder, anxiety, attention deficit hyperactivity disorder, and intellectual disability. He has tried and (apparently) failed multiple psychotropic trials including stimulants, nonstimulants, mood stabilizers, atypical antipsychotics, and nonbenzodiazepine hypnotics...
July 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Juliet Beni Edgcomb, Bonnie Zima
OBJECTIVE: To perform a systematic review and meta-analysis of studies investigating predictors of medication adherence in children and adolescents with severe mental illness (SMI). METHOD: A systematic literature search was conducted in PubMed/MEDLINE, Web of Science, and PsycINFO from 1980 through October 1st, 2017, for original peer-reviewed articles that investigated predictors of adherence to psychopharmacologic treatment among children (≤18-years-old) with a primary psychotic disorder, bipolar disorder, depression, recent suicide attempt, or psychiatric hospitalization...
July 24, 2018: Journal of Child and Adolescent Psychopharmacology
Antonette Scavone, Vanessa Timmins, Jordan Collins, Brenda Swampillai, Trehani M Fonseka, Dwight Newton, Melanie Naiberg, Rachel Mitchell, Athena Ko, Joshua Shapiro, Katelyn Collinger, Carolyn Boulos, Benjamin I Goldstein
Objectives: Despite increasing evidence of excessive substance use disorder (SUD) prevalence among adolescents with bipolar disorder (BP), little is known about this topic among Canadian adolescents with BP. We therefore sought to examine the clinical characteristics and dimensional measures of psychopathology associated with comorbid SUD among Canadian BP adolescents. Method: Participants were 100 adolescents, ages 13-19 years, with BP I, II, or not otherwise specified (NOS)...
August 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
Gianna Sepede, Marco Lorusso, Maria Chiara Spano, Piero Di Nanno, Giuseppe Di Iorio, Massimo Di Giannantonio
OBJECTIVES: Bipolar disorder (BD) patients with a comorbid substance use disorder (SUD) are notoriously difficult to treat. Atypical antipsychotics (AAPs) are widely prescribed in BD, but their efficacy in patients with comorbid SUD is still debated. The aim of the present article is to systematically review the literature findings on the efficacy and safety of AAPs in BD patients with comorbid SUD. METHODS: We searched PubMed to identify original studies focused on the treatment of dual diagnosed BD with AAPs...
July 21, 2018: Clinical Neuropharmacology
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