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3D print*

D Gareth Jones
New technological developments have frequently had major consequences for anatomy education, and have raised ethical queries for anatomy educators. The advent of three-dimensional (3D) printing of human material is showing considerable promise as an educational tool that fits alongside cadaveric dissection, plastination, computer simulation, and anatomical models and images. At first glance its ethical implications appear minimal, and yet the more extensive ethical implications around clinical bioprinting suggest that a cautious approach to 3D printing in the dissecting room is in order...
December 15, 2018: Anatomical Sciences Education
Kanwal M Farooqi, Cathleen Cooper, Anjali Chelliah, Omar Saeed, Paul J Chai, Sachin R Jambawalikar, Hod Lipson, Emile A Bacha, Andrew J Einstein, Ulrich P Jorde
Advanced imaging modalities provide essential anatomic and spatial information in patients with complex heart disease. Two-dimensional imaging can be limited in the extent to which true 3-dimensional (3D) relationships are represented. The application of 3D printing technology has increased the creation of physical models that overcomes the limitations of a 2D screen. Many groups have reported the use of 3D printing for preprocedural planning in patients with different causes of heart failure. This paper reviews the innovative applications of this technique to provide patient-specific models to improve patient care...
December 10, 2018: JACC. Heart Failure
José A Robles Linares-Alvelais, J Obedt Figueroa-Cavazos, C Chuck-Hernandez, Hector R Siller, Ciro A Rodríguez, J Israel Martínez-López
In this work, we assess the effects of sterilization in materials manufactured using additive manufacturing by employing a sterilization technique used in the food industry. To estimate the feasibility of the hydrostatic high-pressure (HHP) sterilization of biomedical devices, we have evaluated the mechanical properties of specimens produced by commercial 3D printers. Evaluations of the potential advantages and drawbacks of Fused Deposition Modeling (FDM), Digital Light Processing (DLP) technology, and Stereolithography (SLA) were considered for this study due to their widespread availability...
December 13, 2018: Materials
Bruno C Borro, Adam Bohr, Saskia Bucciarelli, Johan P Boetker, Camilla Foged, Jukka Rantanen, Martin Malmsten
In an effort to contribute to research in scalable production systems for polymeric delivery systems loaded with antimicrobial peptides (AMPs), we here investigate effects of hydrodynamic flow conditions on microfluidic particle generation. For this purpose, rapid prototyping using 3D printing was applied to prepare micromixers with three different geometric designs, which were used to prepare Ca2+ -cross-linked alginate microgels loaded with the AMP polymyxin B in a continuous process. Based on fluid dynamic simulations, the hydrodynamic flow patterns in the micromixers were designed to be either (i) turbulent with chaotic disruption, (ii) laminar with convective mixing, or (iii) convective with microvortex formation...
December 4, 2018: Journal of Colloid and Interface Science
Orlando Marin, Maria Alesker, Shani Guttman, Gregory Gershinsky, Eitan Edri, Hagay Shpaisman, Rodrigo E Guerra, David Zitoun, Moshe Deutsch, Eli Sloutskin
HYPOTHESIS: Temperature-controlled self-faceting of liquid droplets has been recently discovered in surfactant-stabilized alkane-in-water emulsions. We hypothesize that similar self-faceting may occur in emulsion droplets of UV-polymerizable linear hydrocarbons. We further hypothesize that the faceted droplet shapes can be fixed by UV-initiated polymerization, thus providing a new route towards the production of solid polyhedra. EXPERIMENTS: Temperature-induced shape variations were studied by optical microscopy in micron-size emulsion droplets of UV-polymerizable alkyl acrylate...
December 2, 2018: Journal of Colloid and Interface Science
Ju Hyuk Lee, Hyun Nam Kim, Hyung San Lim, Sung Oh Cho
PURPOSE: Vaginal applicators for a novel miniature X-ray tube were developed using three-dimensional (3D) printing to be used in brachytherapy of endometrial cancers. METHODS: Cylindrical vaginal applicators with various diameters, lengths, and infill percentages (IFPs) were fabricated using a 3D printer. X-ray dose distributions and depth-dose profiles were calculated using a Monte Carlo simulation. The performances of the applicators were evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the miniature X-ray tube equipped with the applicators...
December 13, 2018: Medical Physics
Anton Enders, Ina G Siller, Katharina Urmann, Michael R Hoffmann, Janina Bahnemann
One of the basic operations in microfluidic systems for biological and chemical applications is the rapid mixing of different fluids. However, flow profiles in microfluidic systems are laminar, which means molecular diffusion is the only mixing effect. Therefore, mixing structures are crucial to enable more efficient mixing in shorter times. Since traditional microfabrication methods remain laborious and expensive, 3D printing has emerged as a potential alternative for the fabrication of microfluidic devices...
December 10, 2018: Small
Joshua Loessberg-Zahl, Andries D van der Meer, Albert van den Berg, Jan C T Eijkel
Laminar flow patterning is an iconic microfluidic technology used to deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology using Darcy flow within a three-dimensional (3D) hydrogel. Our test device is a simple 3-inlet microfluidic channel, totally filled with collagen, a cured biological hydrogel, where the concentration profiles of solutes are manipulated via the inlet pressures. This method allows solutes to be delivered with 50 micron accuracy within the gel, as we evidence by controlling concentration profiles of 40 kDa and 1 kDa fluorescent polysaccharide dyes...
December 14, 2018: Lab on a Chip
M Bartikian, A Ferreira, A Gonçalves-Ferreira, L L Neto
PURPOSE: In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home. METHODS: We selected regular and well-shaped bones of the head upon which we based the 3D models...
December 13, 2018: Surgical and Radiologic Anatomy: SRA
Zhen-Hua Feng, Xiao-Bin Li, Kevin Phan, Zhi-Chao Hu, Kai Zhang, Jie Zhao, Wen-Fei Ni, Ai-Min Wu
Rapid development of 3D printing techniques has led to the design of navigation templates to assist with accurate insertion of pedicle screws in last decades. However, there are still without the precise step-by-step methods to design 3D navigation templates from computed tomography (CT) images. Our present article provides a detailed protocol to allow the readers or researchers to obtain the 3D navigation template easily, and assist with pedicle screw insertion in their future research and surgery. Using 3D navigation template-assisted pedicle screw fixation in spine surgery is low cost and can decrease the radiation exposure to both patients and surgeons...
September 2018: Journal of Spine Surgery (Hong Kong)
Sam L Francis, Claudia Di Bella, Gordon G Wallace, Peter F M Choong
There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has presented hope in overcoming the issues involved with current treatment strategies. Novel advances in 3D bioprinting technology have promoted more focus on efficient delivery of engineered tissue constructs. There have been promising in-vitro studies and several animal studies looking at 3D bioprinting of engineered cartilage tissue...
2018: Frontiers in Surgery
Ian Holland, Jack Logan, Jiezhong Shi, Christopher McCormick, Dongsheng Liu, Wenmiao Shu
The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field...
2018: Bio-design and manufacturing
Elisabeth L Gill, Xia Li, Mark A Birch, Yan Yan Shery Huang
It is envisaged that the creation of cellular environments at multiple length scales, that recapitulate in vivo bioactive and structural roles, may hold the key to creating functional, complex tissues in the laboratory. This review considers recent advances in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on 3D printing of hydrogels and fabrication of biomaterial fibres that could extend the feature resolution and material functionality of soft tissue constructs...
2018: Bio-design and manufacturing
Hasan Erbil Abaci, Abigail Coffman, Yanne Doucet, James Chen, Joanna Jacków, Etienne Wang, Zongyou Guo, Jung U Shin, Colin A Jahoda, Angela M Christiano
Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed molds. Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs...
December 13, 2018: Nature Communications
Gabriela Štumberger, Boštjan Vihar
We report a modification of the freeform reversible embedding of suspended hydrogels (FRESH) 3D printing method for the fabrication of freeform perfusable microfluidics inside a hydrogel matrix. Xanthan gum is deposited into a CaCl₂ infused gelatine slurry to form filaments, which are consequently rinsed to produce hollow channels. This provides a simple method for rapid prototyping of microfluidic devices based on biopolymers and potentially a new approach to the construction of vascular grafts for tissue engineering...
December 12, 2018: Materials
Miquel Domingo-Espin, J Antonio Travieso-Rodriguez, Ramon Jerez-Mesa, Jordi Lluma-Fuentes
In this paper, the fatigue response of fused filament fabrication (FFF) Acrylonitrile butadiene styrene (ABS) parts is studied. Different building parameters (layer height, nozzle diameter, infill density, and printing speed) were chosen to study their influence on the lifespan of cylindrical specimens according to a design of experiments (DOE) using the Taguchi methodology. The same DOE was applied on two different specimen sets using two different infill patterns-rectilinear and honeycomb. The results show that the infill density is the most important parameter for both of the studied patterns...
December 11, 2018: Materials
Jonas Herter, Valentin Wunderlich, Christian Janeczka, Vanessa Zamora
Whispering gallery mode (WGM) glass bottle microresonators are potential highly sensitive structures for a variety of physical and bio-chemical sensing applications. In this paper, we experimentally demonstrate the practical use of glass bottle resonators as temperature sensors. The basic parameters, such as WGM resonance wavelengths, free spectral ranges, and Q factors, have been investigated by coupling light from a tapered fiber to the bottle structure. We show the spectral characteristics of the WGMs by choosing different bottle dimensions and taper diameters...
December 7, 2018: Sensors
Marc Arnela, Oriol Guasch, Patricia Sánchez-Martín, Joan Camps, Rosa Ma Alsina-Pagès, Carme Martínez-Suquía
Omnidirectional sound sources are needed to perform a large variety of tests in acoustics. Typically, they consist of conventional speaker drivers arranged in a dodecahedron. However, the directivity of the speaker drivers sharpens with frequency, which induces an intense decrease of the sound pressure levels at the edges of the dodechaedron. In this work, the problem is mitigated by building an Omnidirectional Parametric Loudspeaker (OPL), which contains hundreds of small ultrasound transducers set on a sphere...
December 7, 2018: Sensors
Bin Liu, Zhenyu Wang, Guozhong Lin, Jia Zhang
RATIONALE: Currently, interventional injection of albumin glue and nerve sleeve plasty by cyst excision is the main treatment for sacral cysts. However, albumin glue can only be used in patients with partial cystic neck stenosis, and surgical treatment may result in postoperative complications such as numbness and cyst recurrence. Here, a modified radiculoplasty is presented, in which the lamina is restored with the nerve root wrapped with 3-dimensional (3D)-printed artificial dura mater...
December 2018: Medicine (Baltimore)
Anton du Plessis, Chris Broeckhoven
Albert Einstein once said "look deep into nature, and then you will understand everything better". Looking deep into nature has in the last few years become much more achievable through the use of high-resolution X-ray micro-computed tomography (microCT). The non-destructive nature of microCT, combined with three-dimensional visualization and analysis, allows for the most complete internal and external "view" of natural materials and structures at both macro- and micro-scale. This capability brings with it the possibility to learn from nature at an unprecedented level of detail in full three dimensions, allowing us to improve our current understanding of structures, learn from them and apply them to solve engineering problems...
December 10, 2018: Acta Biomaterialia
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