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Shaban A Khaled, Morgan R Alexander, Derek J Irvine, Ricky D Wildman, Martin J Wallace, Sonja Sharpe, Jae Yoo, Clive J Roberts
An extrusion-based 3D printer was used to fabricate paracetamol tablets with different geometries (mesh, ring and solid) from a single paste-based formulation formed from standard pharmaceutical ingredients. The tablets demonstrate that tunable drug release profiles can be achieved from this single formulation even with high drug loading (> 80% w/w). The tablets were evaluated for drug release using a USP dissolution testing type I apparatus. The tablets showed well-defined release profiles (from immediate to sustained release) controlled by their different geometries...
August 10, 2018: AAPS PharmSciTech
Kuo-Hao Huang, Yen-Hong Lin, Ming-You Shie, Chun-Pin Lin
BACKGROUND/PURPOSE: The mesoporous calcium silicate (MesoCS) 3D-printed scaffold show excellent bioactivity and can enhance the bone-like apatite formation. The purpose of this study aims to consider the effects of the different loading methods on the novel grafting materials which composed of bone morphogenetic protein-2 (BMP-2) loaded MesoCS scaffold by employing 3D-printing technique. METHODS: The MesoCS scaffold were fabricated by fused deposition modeling. In this study, there are two methods of loading BMP-2: (1) the pre-loading (PL) method by mixing MesoCS and BMP-2 as a raw material for a 3D-printer, and (2) the direct-loading (DL) method by soaking the 3D-printed MesoCS scaffold in a BMP-2 solution...
August 7, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Ranjith Kumar Kankala, Feng-Jun Lu, Chen-Guang Liu, Shan-Shan Zhang, Ai-Zheng Chen, Shi-Bin Wang
In recent times, cartilage defects have been the most common athletic injuries, often leading to dreadful consequences such as osteoarthritis, pain, joint deformities, and other symptoms. It is also evident that damage to articular cartilage is often difficult to recover or self-heal because of poor vascular, nervous, and lymphatic supplies. Moreover, cartilage cells have poor regeneration ability and high maturity. Inspired by these facts and the rapid advances in the field of tissue engineering (TE), we fabricated highly porous three-dimensional (3D) scaffold architectures based on cell-responsive polymeric inks, i...
August 9, 2018: Materials
Prashanth Ravi, Jamie Wright, Panos S Shiakolas, Tré R Welch
Bioresorbable materials have been frequently used to three-dimensional (3D) print biomedical structures. In this study, we developed a technique to 3D print poly(glycerol sebacate fumarate) gadodiamide (Rylar)-poly(ethylene glycol) diacrylate (PEGDA) samples and investigated their mechanical and thermal properties as a function of (PS) and ultraviolet intensity (UVI). The Young's modulus (E), ultimate tensile strength (UTS), failure strain (ɛF ), and glass transition temperature (Tg ) showed strong correlation with PS and UVI...
August 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jing Zhang, Yang Chen, Jing Xu, Jingjing Wang, Chengzhang Li, Liyan Wang
The purposes of this study were to construct a novel tissue engineered bone composed of 3D-printed bioactive glass block/chitosan nanoparticles (BD/CSn) composites loaded with Nel-like Type I molecular-1 DNA (pDNA-NELL1) and/or bone marrow mesenchymal stem cells (BMSCs), and study their osteogenic activities by repairing bone defects in rhesus monkeys. CSn with NELL1 gene plasmid and rhesus monkey BMSCs were composited with a BD scaffold to prepare the tissue-engineered bone. Four adult female rhesus monkeys with 10- to 12-years old and 5-7 kg in weight were used in animal experiments...
August 2018: Regenerative Biomaterials
Marta Revilla-León, Adriana Besné-Torre, Jose Luis Sánchez-Rubio, Javier J Fábrega, Mutlu Özcan
The development of technologies including intraoral scanners, dental software for digital restoration design, and additive manufacturing has improved the digital workflow of restorative treatment. The present article describes a digital workflow with intraoral scanning, computer-aided design (CAD) software, and subtractive and additive manufacturing procedures for a patient receiving lithium disilicate laminate veneers.
August 7, 2018: Journal of Prosthetic Dentistry
Huijun Li, Yu Jun Tan, Lin Li
A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and κ-carrageenan, which are the cationic and anionic hydrogels respectively, are used. It is found that the interfacial bonding strength between these two oppositely charged hydrogels is significantly higher than that of a bilayered gelatin or a bilayered κ-carrageenan...
October 15, 2018: Carbohydrate Polymers
Hasan Motaghi, Sima Ziyaee, Masoud Ayatollahi Mehrgardi, Abolghasem Abbasi Kajani, Abdol-Khalegh Bordbar
In the present manuscript, a closed bipolar electrode system integrated with electrochemiluminescence (ECL) detection has been introduced for sensitive diagnosis of human breast cancer cells (MCF-7). For sensitive and selective detection, the anodic pole of the bipolar electrode was modified with the AS1411 aptamer, a specific aptamer for the nucleolin, and treated by the secondary aptamer modified gold nanoparticles. The electrochemiluminescence of luminol was followed in the presence of hydrogen peroxide on the anode pole of bipolar electrode (BPE) as an analytical signal...
July 31, 2018: Biosensors & Bioelectronics
Kan Chen, Di Xiao, Bassam Abotaleb, Haozhe Chen, Yunfeng Li, Songsong Zhu
PURPOSE: This study evaluated the accuracy of virtual surgical planning and 3-dimensional (3D) printed templates to guide osteotomy and distraction osteogenesis (DO) in the treatment of temporomandibular joint (TMJ) ankylosis and secondary mandibular deformity. PATIENTS AND METHODS: Seven consecutive patients diagnosed with TMJ ankylosis and mandibular deformities were included. A composite skull model was obtained with data from spiral computed tomography (CT) and laser scanning of the dental arch...
August 6, 2018: Journal of Oral and Maxillofacial Surgery
Sang Jin Lee, Hyo-Jung Lee, Sung-Yeol Kim, Ji Min Seok, Jun Hee Lee, Wan Doo Kim, Il Keun Kwon, Shin-Young Park, Su A Park
In this study, we designed scaffolds coated with gold nanoparticles (GNPs) grown on a polydopamine (PDA) coating of a three-dimensional (3D) printed polycaprolactone (PCL) scaffold. Our results demonstrated that the scaffolds developed here may represent an innovative paradigm in bone tissue engineering by inducing osteogenesis as a means of remodeling and healing bone defects.
August 9, 2018: Nanoscale
Yun Luo, Shangsi Chen, Yufei Shi, Jun Ma
In this study, strontium substituted hydroxyapatite (Sr-HAP) was synthesized using collagen type I and citrate as bi-templates and the obtained nanoparticles with high similarity to natural bone minerals were made into composite scaffolds with inter-connected porous structure using a three-dimensional (3D) printing technique. A calcium-deficient structure of HAP phase was caused by doping Sr which was verified by FT-IR, XRD, SEM and TEM. The Sr/(Sr+Ca) molar ratio in Sr-HAP nanoparticles was 5.8% estimated by EDX...
August 9, 2018: Biomedical Materials
Henry H Hwang, Wei Zhu, Grace Victorine, Natalie Lawrence, Shaochen Chen
3D-printing is a powerful additive manufacturing tool, one that enables fabrication of biomedical devices and systems that would otherwise be challenging to create with more traditional methods such as machining or molding. Many different classes of 3D-printing technologies exist, most notably extrusion-based and light-based 3D-printers, which are popular in consumer markets, with advantages and limitations for each modality. The focus here is primarily on showcasing the ability of these 3D-printing platforms to create different types of functional biomedical microdevices-their advantages and limitations are covered with respect to other classes of 3D-printing, as well as the past, recent, and future efforts to advance the functional microdevice domain...
February 13, 2018: Small methods
Michal Bartnikowski, Ho-Jin Moon, Sašo Ivanovski
The immunomodulatory effects of lithium have been reported across a range of models and contexts. Lithium appears to have a positive effect on osteogenesis in vivo, while in vitro outcomes throughout the literature are varied. Tissue engineering approaches have rarely targeted local lithium delivery within a regenerative setting. We hypothesized that part of the positive effects of lithium in vivo may be due to an immunomodulatory effect manifesting in a local environment. To achieve a sustained lithium release from scaffold constructs, we blended lithium carbonate, a soluble salt of lithium, with the biomaterial polymer polycaprolactone (PCL)...
August 9, 2018: Biomedical Materials
Dekel Shilo, Omri Emodi, Ori Blanc, Dani Noy, Adi Rachmiel
Three-dimensional (3D) printing is based on additive technology in which layers of materials are gradually placed to create 3D objects. The world of 3D printing is a rapidly evolving field in the medical industry as well as in most sectors of our lives. In this report we present current technological possibilities for 3D printing in the surgical field. There are different 3D printing modalities and much confusion among clinicians regarding the differences between them. Three-dimensional printing technologies can be classified based on the basic material used: solid, liquid, and powder...
July 30, 2018: Rambam Maimonides Medical Journal
Ning Li, Tie Yang, Peng Yu, Junling Chang, Liao Zhao, Xingang Zhao, Imad H Elhajj, Ning Xi, Lianqing Liu
Stroke has become the leading cause of disability and the second-leading cause of mortality worldwide. Dyskinesia complications are the major reason of these high death and disability rates. As a tool for rapid motion function recovery in stroke patients, exoskeleton robots can reduce complications and thereby decrease stroke mortality rates. However, existing exoskeleton robots interfere with the wearer's natural motion and damage joints and muscles due to poor human-machine coupling. In this paper, a novel ergonomic soft bionic exoskeleton robot with 7 degrees of freedom was proposed to address these problems based on the principles of functional anatomy and sports biomechanics...
August 8, 2018: Bioinspiration & Biomimetics
Austin J Taylor, Rudy Montayre, Zhuo Zhao, Ka Wai Kwok, Zion Tsz Ho Tse
PURPOSE: Soft robots are highly flexible and adaptable instruments that have proven extremely useful, especially in the surgical environment where compliance allows for improved maneuverability throughout the body. Endoscopic devices are a primary example of an instrument that physicians use to navigate to difficult-to-reach areas inside the body. This paper presents a modular soft robotic pneumatic actuator as a proof of concept for a compliant endoscopic device. METHODS: The actuator is 3D printed using an FDM printer...
August 7, 2018: International Journal of Computer Assisted Radiology and Surgery
Florian D Grill, Lucas M Ritschl, Franz X Bauer, Andrea Rau, Dominik Gau, Maximilian Roth, Markus Eblenkamp, Klaus-Dietrich Wolff, Denys J Loeffelbein
Computer-aided design and computer-aided manufacturing (CAD/CAM) technology has been implemented in the treatment of cleft lip and palates (CLP) by several research groups. This pilot study presents a technique that combines intraoral molding with a semi-automated plate generation and 3D-printing. The clinical results of two intraoral molding approaches are compared. This is the first clinical investigation of semi-automated intraoral molding. Our study included newborns with unilateral CLP. Plaster models were digitalized and measured by two independent observers...
August 7, 2018: Scientific Reports
Hiroki Ogura, Venkatesh Naidu Nerella, Viktor Mechtcherine
Incorporating reinforcement into the practice of digital concrete construction, often called 3D-concrete-printing, is a prerequisite for wide-ranging, structural applications of this new technology. Strain-Hardening Cement-based Composites (SHCC) offer one possible solution to this challenge. In this work, printable SHCC were developed and tested. The composites could be extruded through a nozzle of a 3D-printer so that continuous filaments could be deposited, one upon the other, to build lab-scaled wall specimens without noticeable deformation of the bottom layers...
August 7, 2018: Materials
Deyber Arley Vargas Medina, Álvaro José Santos-Neto, Víctor Cerdà, Fernando Maya
In this work, the dispersive liquid-liquid microextraction technique based on the solidification of the organic phase (DLLME-SFO) has been automated for the first time. DLLME-SFO is automated by hyphenating a sequential injection analysis (SIA) system with a custom-made robotic phase separator. Automated in-syringe DLLME is followed by phase separation in a 3D printed device integrating a Peltier cell set, mounted on a multi-axis robotic arm. The combined action of the flow system and the robotic arm is controlled by a single software package, enabling the solidification/melting and collection of the organic phase for further analyte quantification...
November 1, 2018: Talanta
Shende Pravin, Agrawal Sudhir
3D printing is an additive manufacturing technique capable of producing various 3D drug products, medical devices, tissues and organs from digital designs. The first FDA approved 3D drug product, Spritam®, has encouraged and attracted many researchers in this field with research undergoing to develop various customized dosage forms. This review aims to introduce 3D printing, its history, advantages, challenges and various techniques used in fabrication of drug products. This review also assesses the advantages and importance of customized dosage forms obtained from 3D printing...
August 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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