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https://www.readbyqxmd.com/read/30315810/exploration-and-preparation-of-a-dose-flexible-regulation-system-for-levetiracetam-tablets-via-novel-semisolid-extrusion-sse-3d-printing
#1
Mengsuo Cui, Yuenan Li, Shu Wang, Yuanyuan Chai, Jintong Lou, Fen Chen, Qijun Li, Weisan Pan, Pingtian Ding
Levetiracetam therapy is often associated with high levels of individual variation in the recommended dose required to achieve preferential treatment. Thus, a reliable and dynamic regulation system to accurately tailor dose is necessary. The main objective of this work was to explore and prepare a dose-flexible control system suitable for rapid release tablets equipped with high drug loading and a cylindrical model design. Semisolid extrusion 3D printing was utilized to fabricate a series of tablets of increased volume...
October 10, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30314390/3d-printing-of-pla-clay-nanocomposites-influence-of-printing-temperature-on-printed-samples-properties
#2
Bartolomeo Coppola, Nicola Cappetti, Luciano Di Maio, Paola Scarfato, Loredana Incarnato
In this study, the possibility of using a layered silicate-reinforced polylactic acid (PLA) in additive manufacturing applications was investigated. In particular, the aim of this work was to study the influence of printing temperature in the 3D printing process of PLA/clay nanocomposites. For this reason, two PLA grades (4032D and 2003D, D-isomer content 1.5 and 4, respectively) were melt-compounded by a twin screw extruder with a layered silicate (Cloisite 30B) at 4 wt %. Then, PLA and PLA/clay feedstock filaments (diameter 1...
October 11, 2018: Materials
https://www.readbyqxmd.com/read/30314331/mechanical-analysis-of-ceramic-polymer-composite-with-mesh-type-lightweight-design-using-binder-jet-3d-printing
#3
Dong-Hyun Kim, Jinwoo Lee, Jinju Bae, Sungbum Park, Jihwan Choi, Jeong Hun Lee, Eoksoo Kim
3D printing technology has recently been highlighted as an innovative manufacturing process. Among various 3D printing methods, binder jetting (BJ) 3D printing is particularly known as technology used to produce the complex sand mold quickly for a casting process. However, high manufacturing costs, due to its expensive materials, need to be lowered for more industrial applications of 3D printing. In this study, we investigated mechanical properties of sand molds with a lightweight structure for low material consumption and short process time...
October 11, 2018: Materials
https://www.readbyqxmd.com/read/30312722/effect-of-dosing-cup-size-on-the-aerosol-performance-of-high-dose-carrier-based-formulations-in-a-novel-dry-powder-inhaler
#4
Stewart Yeung, Daniela Traini, Alan Tweedie, David Lewis, Tanya Church, Paul M Young
This study investigated how varying the dosing cup size of a novel reservoir dry powder inhaler (DPI) affects the detachment of a micronised active pharmaceutical ingredient from larger carrier particles, and the aerosol performance of a DPI carrier formulation. Three different sized dosing cups were designed; 3D printed with cup volumes of 16.26 mm3 , 55.99 mm3 and 133.04 mm3 , and tested with five different carrier type formulations with Beclomethasone Dipropionate - (BDP) concentrations between 1% and 30% (w/w)...
October 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30311453/anisotropically-aligned-cell-laden-nanofibrous-bundle-fabricated-via-cell-electrospinning-to-regenerate-skeletal-muscle-tissue
#5
Miji Yeo, Geun Hyung Kim
For muscle regeneration, a uniaxially arranged micropattern is important to mimic the structure of the natural extracellular matrix. Recently, cell electrospinning (CE) has been tested to fabricate cell-laden fibrous structures by embedding cells directly into micro/nanofibers. Although homogenous cell distribution and a reasonable cell viability of the cell-laden fibrous structure fabricated using the CE process are achieved, unique topographical cues formed by an aligned fibrous structure have not been applied...
October 11, 2018: Small
https://www.readbyqxmd.com/read/30311272/continuous-surface-polymerization-via-fe-ii-mediated-redox-reaction-for-thick-hydrogel-coatings-on-versatile-substrates
#6
Shuanhong Ma, Changyou Yan, Meirong Cai, Jun Yang, Xiaolong Wang, Feng Zhou, Weimin Liu
The development of versatile generalized strategies for easy surface modification is of immense scientific interest. Herein, a novel mechanism to form functional hydrogel coatings on a wide variety of substrate materials including polymers, polymeric resins, ceramics, and intermetallic compounds, enabling easy change of the surface wettability and lubrication property, is reported. In situ polymerization and hydrogel coating formation is initiated by free radicals generated through the redox reaction between Fe2+ and S2 O8 2- at the solid-liquid interface, which shows controllable growth kinetics...
October 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30310843/application-of-three-dimensional-printing-technology-in-orbital-floor-fracture-reconstruction
#7
Sherby Suet Ying Pang, Christian Fang, Jimmy Yu Wai Chan
Importance: Orbital floor fracture is common among patients suffering from facial trauma. Open reduction and reconstruction of the orbital floor with Medpor is the treatment of choice in our centre to correct diplopia and enophthalmos. Objective: Application of locally available 3D printing service in perioperative planning of orbital floor reconstruction with porous polyethylene. Design: We present two patients who suffered from orbital floor fracture complicated by diplopia...
October 2018: Trauma case reports
https://www.readbyqxmd.com/read/30310164/multi-compartment-scaffold-fabricated-via-3d-printing-as-in-vitro-co-culture-osteogenic-model
#8
Elvira De Giglio, Maria A Bonifacio, Ana M Ferreira, Stefania Cometa, Zhi Yuan Ti, Antonella Stanzione, Kenny Dalgarno, Piergiorgio Gentile
The development of in vitro 3D models to get insights into the mechanisms of bone regeneration could accelerate the translation of experimental findings to the clinic, reducing costs and duration of experiments. This work explores the design and manufacturing of multi-compartments structures in poly(ε-caprolactone) (PCL) 3D-printed by Fused Filament Fabrication technique. The construct was designed with interconnected stalls to host stem cells and endothelial cells. Cells were encapsulated within an optimised gellan gum (GG)-based hydrogel matrix, crosslinked using strontium (Sr2+ ) ions to exploit its bioactivity and finally, assembled within compartments with different sizes...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30309704/development-and-evaluation-of-semi-destructive-ultrasound-assisted-extraction-method-followed-by-gas-chromatography-coupled-to-mass-spectrometry-enabling-discrimination-of-red-lipstick-samples
#9
Marta Gładysz, Małgorzata Król, Patryk Własiuk, Michał Piwowar, Grzegorz Zadora, Paweł Kościelniak
In this study, the effective and robust semi-destructive ultrasound assisted extraction (UAE) method followed by gas chromatography coupled to mass spectrometry (GC-MS) method used for analysis of red lipsticks samples was developed, optimized and evaluated. 43 red lipsticks of a very similar hue representing of 21 different manufacturers were investigated. The red lipsticks (approximately 0.05 mg) were applied on a disc (of ø 2 mm) placed on specially designed stand printed with a 3D printer. In order to optimize the main factors affecting extraction process, Doehlert experimental design with response surface methodology was applied...
October 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30306494/3d-printing-in-spine-surgery
#10
Hong Cai, Zhongjun Liu, Feng Wei, Miao Yu, Nanfang Xu, Zihe Li
In the past 5 years, the application of 3D printing technology in the field of spine surgery had obtained enormous and substantial progress. Among which, vertebral skeleton model (including lesion model) printing has been widely used in clinical application due to its relatively simple technology and low cost. It shows practical value and becomes popular as the reference of clinical education, auxiliary diagnosis, communication between doctor and patient, and the planning of surgical approaches as well as the reference of more accurate operation in surgery...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30305139/consistent-and-reproducible-cultures-of-large-scale-3d-mammary-epithelial-structures-using-an-accessible-bioprinting-platform
#11
John A Reid, Peter M Mollica, Robert D Bruno, Patrick C Sachs
BACKGROUND: Standard three-dimensional (3D) in vitro culture techniques, such as those used for mammary epithelial cells, rely on random distribution of cells within hydrogels. Although these systems offer advantages over traditional 2D models, limitations persist owing to the lack of control over cellular placement within the hydrogel. This results in experimental inconsistencies and random organoid morphology. Robust, high-throughput experimentation requires greater standardization of 3D epithelial culture techniques...
October 10, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30301348/biomimetic-mineralization-of-3d-printed-alginate-tempo-oxidized-cellulose-nanofibril-scaffolds-for-bone-tissue-engineering
#12
Ragab Esmail Abou-Zeid, Ramzi Khiari, Davide Beneventi, Alain Dufresne
3D printed scaffolds were prepared by partial crosslinking of TEMPO-oxidized cellulose nanofibril/alginate hydrogel using calcium ions for printing the hydrogel while maintaining its shape, fidelity and preventing collapse of the filaments. The prepared scaffolds were fully crosslinked using calcium ions immediately after printing to provide the rigidity of the hydrogel and give it long-term stability. The composition of the prepared pastes was optimized based on the characterization of the hydrogel and 3D printing experiments...
October 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30300967/3d-printed-polycaprolactone-scaffold-mixed-with-%C3%AE-tricalcium-phosphate-as-a-bone-regenerative-material-in-rabbit-calvarial-defects
#13
Hyung-Chul Pae, Joo-Hyun Kang, Jae-Kook Cha, Jung-Seok Lee, Jeong-Won Paik, Ui-Won Jung, Byung-Hoon Kim, Seong-Ho Choi
Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) addition in PCL scaffold. In this work, four circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% β-TCP (PCL/β-TCP), and (4) PCL/β-TCP plus collagen membrane (PCL/β-TCP + M)...
October 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30300964/a-review-on-the-use-of-computational-methods-to-characterize-design-and-optimize-tissue-engineering-scaffolds-with-a-potential-in-3d-printing-fabrication
#14
REVIEW
Shuo Zhang, Sanjairaj Vijayavenkataraman, Wen Feng Lu, Jerry Y H Fuh
The design and fabrication of tissue engineering scaffolds is a highly complex process. In order to provide a proper architecture for cells to grow, proliferate, and differentiate to form tissues, scaffolds have to be made with suitable properties. However, the limited structural designs and conventional fabrication techniques severely cripple the improvement of scaffold properties. To overcome these limitations, many researchers have recently adopted computational methods combined with 3D printing techniques as a new approach for scaffold design and fabrication...
October 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30300914/reproducibility-accuracy-and-effect-of-autoclave-sterilization-on-a-thermoplastic-three-dimensional-model-printed-by-a-desktop-fused-deposition-modelling-three-dimensional-printer
#15
Jean-François Boursier, Alexandre Fournet, Jean Bassanino, Mathieu Manassero, Anne-Sophie Bedu, Dimitri Leperlier
OBJECTIVES:  The main purpose of this study was to determine the reproducibility and accuracy of a three-dimensional (3D) bone model printed on a desktop 3D-printer based on fused deposition modelling (FDM) technology with polylactic acid (PLA) and the effect of autoclave sterilization on the printed models. METHODS:  Computed tomographic images of the tibia were obtained from 10 feline cadavers, used to create a bone surface-rendering file and sent to the 3D printing software...
October 9, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/30300696/snakegourd-root-astragalus-polysaccharide-hydrogel-preparation-and-application-in-3d-printing
#16
Jinxin Yan, Yu Wang, Xuan Zhang, Xiaoliang Zhao, Jianzhong Ma, Xiuying Pu, Yonggang Wang, Fen Ran, Yanling Wang, Feifan Leng, Weijie Zhang
Hydrogels have good water retention, biocompatibility and biodegradability, so they are well used in the medical industry. Here, we have active polysaccharide exacted from Chinese traditional medicine and carboxymethyl chitosan cross-linked to form hydrogel and characterized them by Scanning electron microscopy, FTIR analysis, swelling, degradation, release and cytotoxicity tests. We printed the composite hydrogel into patches with three different shapes by Hot-Melt extruded 3D printer and studied the effects of different shapes on the release of drug...
October 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30300278/comparison-of-3-pediatric-pelvic-osteotomies-for-acetabular-dysplasia-using-patient-specific-3d-printed-models
#17
Jason P Caffrey, Megan E Jeffords, Christine L Farnsworth, James D Bomar, Vidyadhar V Upasani
BACKGROUND: Children with developmental dysplasia of the hip may require a pelvic osteotomy to treat acetabular dysplasia. Three osteotomies are commonly performed in these patients (Pemberton, Dega, and San Diego), though comparative studies of each are limited. The purpose of this study was to compare changes in acetabular morphology (acetabular version, volume, and octant coverage angles) created by these 3 osteotomies using matched patient-specific 3D-printed pelvic models. METHODS: Fourteen patients with developmental dysplasia of the hip and preoperative computed tomography (CT) imaging were retrospectively included...
October 8, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/30296827/coating-3d-printed-polycaprolactone-scaffolds-with-nanocellulose-promotes-growth-and-differentiation-of-mesenchymal-stem-cells
#18
Ahmad Rashad, Samih Mohamed-Ahmed, Miina Ojansivu, Kaia Berstad, Mohammed Ahmed Yassin, Tove Kivijärvi, Ellinor Bævre Heggset, Kristin Syverud, Kamal Mustafa
3D printed polycaprolactone (PCL) has potential as a scaffold for bone tissue engineering, but the hydrophobic surface may hinder optimal cell responses. The surface properties can be improved by coating the scaffold with cellulose nanofibrils material (CNF), a multiscale hydrophilic biocompatible biomaterial derived from wood. In this study, human bone marrow-derived mesenchymal stem cells were cultured on tissue culture plates (TCP) and 3D printed PCL scaffolds coated with CNF. Cellular responses to the surfaces (viability, attachment, proliferation and osteogenic differentiation) were documented...
October 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30296596/stiffness-memory-of-indirectly-3d-printed-elastomer-nanohybrid-regulates-chondrogenesis-and-osteogenesis-of-human-mesenchymal-stem-cells
#19
Linxiao Wu, Adrián Magaz, Tao Wang, Chaozong Liu, Arnold Darbyshire, Marilena Loizidou, Mark Emberton, Martin Birchall, Wenhui Song
The cellular microenvironment is dynamic, remodeling tissues lifelong. The biomechanical properties of the extracellular matrix (ECM) influence the function and differentiation of stem cells. While conventional artificial matrices or scaffolds for tissue engineering are primarily static models presenting well-defined stiffness, they lack the responsive changes required in dynamic physiological settings. Engineering scaffolds with varying elastic moduli is possible, but often lead to stiffening and chemical crosslinking of the molecular structure with limited control over the scaffold architecture...
December 2018: Biomaterials
https://www.readbyqxmd.com/read/30296344/a-preliminary-investigation-into-the-accuracy-of-3d-modeling-and-3d-printing-in-forensic-anthropology-evidence-reconstruction
#20
Rachael M Carew, Ruth M Morgan, Carolyn Rando
There is currently no published empirical evidence-base demonstrating 3D printing to be an accurate and reliable tool in forensic anthropology, despite 3D printed replicas being exhibited as demonstrative evidence in court. In this study, human bones (n = 3) scanned using computed tomography were reconstructed as virtual 3D models (n = 6), and 3D printed using six commercially available printers, with osteometric data recorded at each stage. Virtual models and 3D prints were on average accurate to the source bones, with mean differences from -0...
October 8, 2018: Journal of Forensic Sciences
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