Dongsun Park, Yun-Hui Yang, Dae Kwon Bae, Sun Hee Lee, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Seong Won Lee, Gon Hyung Kim, Jin Tae Hong, Kyung-Chul Choi, Hong Jun Lee, Seung U Kim, Yun-Bae Kim
Aging is characterized by progressive loss of cognitive and memory functions as well as decrease in physical activities. In the present study, a human neural stem cell line (F3 NSC) over-expressing choline acetyltransferase (F3.ChAT), an enzyme responsible for acetylcholine synthesis, was generated and transplanted in the brain of 18-month-old male ICR mice. Four weeks post-transplantation, neurobehavioral functions, expression of ChAT enzyme, production of acetylcholine and neurotrophic factors, and expression of cholinergic nervous system markers in transplanted animals were investigated...
November 2013: Neurobiology of Aging