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Sclerose en plaques

Jiwon Oh, Marie-Sarah Gagné-Brosseau, Melanie Guenette, Catherine Larochelle, François Lemieux, Suresh Menon, Sarah A Morrow, Laurence Poliquin-Lasnier, Chantal Roy-Hewitson, Carolina Rush, Anne-Marie Trudelle, Paul S Giacomini
The objective of this study was to develop a shared-care model to enable primary-care physicians to participate more fully in meeting the complex, multidisciplinary healthcare needs of patients with multiple sclerosis (MS). DESIGN: The design consisted of development of consensus recommendations and a shared-care algorithm. PARTICIPANTS: A working group of 11 Canadian neurologists involved in the management of patients with MS were included in this study. MAIN MESSAGE: The clinical management of patients with multiple sclerosis is increasing in complexity as new disease-modifying therapies (DMTs) become available, and ongoing safety monitoring is required...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Salem Hannoun, Damien Heidelberg, Roula Hourani, Thi Thuy Trang Nguyen, Jean-Christophe Brisset, Sylvie Grand, Stéphane Kremer, Fabrice Bonneville, Charles R G Guttmann, Vincent Dousset, François Cotton
BACKGROUND AND PURPOSE: The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS). MATERIAL AND METHODS: 164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD...
May 2018: European Journal of Radiology
Melissa Colbeck
BACKGROUND: Quality of life for persons living with multiple sclerosis (MS) is significantly lower than population norms. Fatigue, both physical and cognitive, is one of the most prevalent and debilitating symptoms of MS that decrease quality of life. Cognitive fatigue presents similarly to sensory overresponsiveness, but the connection has not been explored. PURPOSE: This study aims to describe how sensory-processing preferences and cognitive fatigue relate to variances in quality of life for people with MS...
April 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
B Trumbic, H Zéphir, J-C Ouallet, E Le Page, D Laplaud, C Bensa, J de Sèze
BACKGROUND: Launched in the US in 2012, Choosing Wisely® is a campaign promoted by the American Board of Internal Medicine (ABIM) Foundation with the goal of improving healthcare effectiveness by avoiding wasteful or unnecessary medical tests, treatments and procedures. It uses concise recommendations produced by national medical societies to start discussions between physicians and patients on the relevance of these services as part of a shared decision-making process. The Multiple Sclerosis Focus Group (Groupe de Reflexion Autour de la Sclérose en Plaques; GRESEP) undertook a pilot study to assess the relevance and feasibility of this approach in the management of multiple sclerosis (MS) in France...
January 2018: Revue Neurologique
Alexis Montcuquet, Nicolas Collongues, Caroline Papeix, Helene Zephir, Bertrand Audoin, David Laplaud, Bertrand Bourre, Bruno Brochet, Jean-Philippe Camdessanche, Pierre Labauge, Thibault Moreau, David Brassat, Bruno Stankoff, Jerome de Seze, Sandra Vukusic, Romain Marignier
OBJECTIVE: To evaluate the effectiveness and tolerance of mycophenolate mofetil (MMF) as a first-line treatment in neuromyelitis optica spectrum disorder (NMOSD). METHODS: In all, 67 NMOSD patients treated by MMF as first-line therapy, from the NOMADMUS cohort were included. A total of 65 fulfilled 2015 NMOSD criteria, and 5 were myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) positive. Effectiveness was evaluated on percentage of patients continuing MMF, percentage of patients free of relapse, pre- and post-treatment change in the annualized relapse rate (ARR), and Expanded Disability Status Scale (EDSS)...
September 2017: Multiple Sclerosis: Clinical and Laboratory Research
F Cotton, S Kremer, S Hannoun, S Vukusic, V Dousset
Multiple sclerosis (MS) is most generally considered as a severe disease with high physical and mental risks of disability. Since the end of the 1990s, several high cost long-term disease-modifying treatments provided some clinical efficiency. However, patient's follow-up was needed for the detection and the assessment of their side-effects. The "Observatoire français de la sclérose en plaques" (OFSEP) project aims to improve the clinical, biological and imaging systematic longitudinal follow-up of patients...
June 2015: Journal of Neuroradiology. Journal de Neuroradiologie
O Walusinski
Philanthropy aimed at helping medical research has been around for a long time. In the 19th century, cash awards were distributed by the French Academy of Medicine according to criteria determined by each generous donor. It was thus that Mrs. Bernard de Civrieux endowed the Academy each year with the task of supporting one or more laureates whose work furthered understanding of "nervous diseases". In 1903, Raymond Cestan (1872-1933) and Claudien Philippe (1866-1903) were selected for their dissertation on "cerebral disturbances" during multiple sclerosis with clinical as well as anatomical-pathological effects...
April 2015: Revue Neurologique
E Bodiguel, C Bensa, D Brassat, D Laplaud, E Le Page, J-C Ouallet, H Zephir, J De Seze
The question of pregnancy in patients with multiple sclerosis is regularly raised due to the prevalence of the disease in middle age women. The multiple sclerosis think tank (Groupe de Réflexion sur la Sclérose en Plaques [GRESEP]) decided to develop recommendations on this issue, with consideration to both the impact of multiple sclerosis on pregnancy, and that of pregnancy on the disease. As with topics of previous works, the formal expert consensus method was used. The working group was composed of hospital-based and private practice neurologists...
April 2014: Revue Neurologique
Darin T Okuda, Aksel Siva, Orhun Kantarci, Matilde Inglese, Ilana Katz, Melih Tutuncu, B Mark Keegan, Stacy Donlon, Le H Hua, Angela Vidal-Jordana, Xavier Montalban, Alex Rovira, Mar Tintoré, Maria Pia Amato, Bruno Brochet, Jérôme de Seze, David Brassat, Patrick Vermersch, Nicola De Stefano, Maria Pia Sormani, Daniel Pelletier, Christine Lebrun
OBJECTIVE: To report the 5-year risk and to identify risk factors for the development of a seminal acute or progressive clinical event in a multi-national cohort of asymptomatic subjects meeting 2009 RIS Criteria. METHODS: Retrospectively identified RIS subjects from 22 databases within 5 countries were evaluated. Time to the first clinical event related to demyelination (acute or 12-month progression of neurological deficits) was compared across different groups by univariate and multivariate analyses utilizing a Cox regression model...
2014: PloS One
Mikael Cohen, Elisabeth Maillart, Ayman Tourbah, Jérôme De Sèze, Sandra Vukusic, David Brassat, Olivier Anne, Sandrine Wiertlewski, William Camu, Sylvie Courtois, Aurélie Ruet, Marc Debouverie, Emmanuelle Le Page, Olivier Casez, Olivier Heinzlef, Bruno Stankoff, Bertrand Bourre, Giovanni Castelnovo, Audrey Rico, Eric Berger, Jean-Philippe Camdessanche, Gilles Defer, Pierre Clavelou, Abdullatif Al Khedr, Hélène Zephir, Agnès Fromont, Caroline Papeix, Bruno Brochet, Jean Pelletier, Christine Lebrun
IMPORTANCE: The safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge. OBJECTIVE: To collect data from patients with MS switching from natalizumab to fingolimod. DESIGN, SETTING, AND PARTICIPANTS: The Enquête Nationale sur l'Introduction du Fingolimod en Relais au Natalizumab (ENIGM) study, a survey-based, observational multicenter cohort study among MS tertiary referral centers...
April 2014: JAMA Neurology
Elisa Gervasoni, Davide Cattaneo, Johanna Jonsdottir
People with multiple sclerosis (PwMS) tend to be less physically active than the general population. Limited physical activity increases fatigue, possibly affecting other functions such as balance. Treadmill training is a promising method to ameliorate these symptoms. The aim of this study was to assess the effect of treadmill training on fatigue and balance. Thirty PwMS were recruited; the mean age was 47.6 (SD 9.2). The median EDSS score was 5.5 (range 3-6.5). Individuals were randomized into a control group receiving 12 sessions of conventional therapy and an experimental group receiving conventional therapy including 15 min of treadmill training...
March 2014: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
C Bensa, E Bodiguel, D Brassat, D Laplaud, L Magy, J-C Ouallet, H Zephir, J De Seze, F Blanc
The aim of the Multiple Sclerosis Think Tank (Groupe de réflexion sur la sclérose en plaques [GRESEP]) is to prescribe recommendations following a systematic literature search and using a Rand Corporation and California University (RAND/UCLA) appropriateness derived method, in response to practical questions that are raised in the management of patients with multiple sclerosis (MS). The topics of this working program were chosen because they were not addressed in the French recommendations and because of the few data in the literature that enabled practices to be based on validated data...
November 2012: Revue Neurologique
H Zéphir, E Bodiguel, C Bensa, F Blanc, D Laplaud, L Magy, J-C Ouallet, J De Seze, D Brassat
The aim of the Multiple Sclerosis Think Tank (Groupe de Réflexion sur la Sclérose en Plaques: GRESEP), composed of hospital neurologists involved in the management of patients with multiple sclerosis, is to provide recommendations in response to clinical questions that are raised when managing these patients. After work done on the themes on useful serum testing with suspected multiple sclerosis, as well as the detection and management of cognitive disorders early in the course of the disease, the subject of the present work is the early definition and early treatment of the disease...
April 2012: Revue Neurologique
C Lebrun, E Le Page, O Kantarci, A Siva, D Pelletier, D T Okuda
BACKGROUND: In multiple sclerosis (MS), the relapse rate declines during pregnancy and increases during the first three months post-partum before returning to the pre-pregnancy rate. It is unknown whether pregnancy impacts the risk of clinical conversion in those within the presymptomatic period. OBJECTIVES: We investigate the impact of pregnancy on developing a clinical event in women diagnosed with radiologically isolated syndrome (RIS). METHODS: All women with RIS underwent clinical and radiological assessments as part of an observational, prospective, longitudinal study...
September 2012: Multiple Sclerosis: Clinical and Laboratory Research
A Pappalardo, F Patti, A Reggio, A Guglielmino, S Mangiameli
Already in 1860, the great neurologist Charcot described the symptom spasticity in patients affected by "sclerose en plaque". Spasticity is one of the most common symptoms of multiple sclerosis MS). The consequences of spasticity are very disadvantages because it hinders the functional mobility and overburden disability. Moreover, in the later stages of MS spasticity may be complicated by seating problems, pressure sores, fibrous contractures and poor perineal hygiene. In this article, the therapeutical management of MS spasticity, in all its components (pharmacological, rehabilitative, surgical) is reviewed...
April 2004: La Clinica Terapeutica
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