Delphine Lamoral-Theys, Nathalie Wauthoz, Petra Heffeter, Véronique Mathieu, Utte Jungwirth, Florence Lefranc, Jean Nève, Jacques Dubois, François Dufrasne, Karim Amighi, Walter Berger, Philippe Gailly, Robert Kiss
Cancer cells exhibit de-regulation of multiple cellular signalling pathways and treatments of various types of cancers with polyphenols are promising. We recently reported the synthesis of a series of 33 novel divanillic and trivanillic polyphenols that displayed anticancer activity, at least in vitro, through inhibiting various kinases. This study revealed that minor chemical modifications of a trivanillate scaffold could convert cytotoxic compounds into cytostatic ones. Compound 13c, a tri-chloro derivative of trivanillic ester, displayed marked inhibitory activities against FGF-, VEGF-, EGF- and Src-related kinases, all of which are implicated not only in angiogenesis but also in the biological aggressiveness of various cancer types...
July 2012: Journal of Cellular and Molecular Medicine