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Impulsive control

Maya Barake, Anne Klibanski, Nicholas A Tritos
Dopamine agonists (DAs) represent a cornerstone in the management of patients with hyperprolactinemia and have an important role in the treatment of neurologic disorders, including Parkinson’s disease and restless legs syndrome. A growing body of evidence has identified impulse control disorders (ICDs) as possible adverse effects of DA therapy. A variety of ICDs may occur in patients treated with DA, including compulsive shopping, pathologic gambling, stealing, hypersexuality and punding (repetitive performance of tasks, such as collecting, sorting, disassembling and assembling objects)...
September 24, 2018: European Journal of Endocrinology
Alexandru Hanganu, Oury Monchi
PURPOSE OF REVIEW: Parkinson's disease was studied for a long time from the prism of a motor impairment. Recent advances have outlined the importance of cognitive and neuropsychiatric symptoms (NPS) in the PD equation. This review concentrates on the present possibilities of using neuroimaging techniques in order to quantify the cognitive performance and NPS in PD patients. RECENT FINDINGS: Mild cognitive impairment as well as many NPS have been acknowledged as important criteria for assessing the quality of life in patients with Parkinson's disease and have been shown as potential factors in predicting further evolution of PD from a clinical perspective...
October 15, 2018: Current Neurology and Neuroscience Reports
Juan Marín-Lahoz, Javier Pagonabarraga, Saul Martinez-Horta, Ramón Fernandez de Bobadilla, Berta Pascual-Sedano, Jesús Pérez-Pérez, Alexandre Gironell, Jaime Kulisevsky
Introduction: Impulse control disorders (ICDs) are a common complication of Parkinson's disease (PD) receiving dopamine agonist (DAA) Impulsivity is considered an underlying mechanism but evidence of this relationship is scarce. To explore the relationship between impulsivity and the presence and severity of ICD in PD. Methods: Prospective cross-sectional study of consecutive PD outpatients. Patients with dementia or previously known ICDs were excluded. Two measures of impulsivity were assessed: Barratt Impulsiveness Scale (BIS-11) for impulsiveness trait (main exposure) and commission errors in the Continuous Performance Test (CE) for motor inhibition...
2018: Frontiers in Psychiatry
Elisabeth Kaiser, Qinghai Tian, Michael Wagner, Monika Barth, Wenying Xian, Laura Schroeder, Sandra Ruppenthal, Lars Kaestner, Ulrich Boehm, Philipp Wartenberg, Huiyan Lu, Sara M McMillin, Derek B Bone, Jürgen Wess, Peter Lipp
Aims: Signaling via Gq-coupled receptors is of profound importance in many cardiac diseases such as hypertrophy and arrhythmia. Nevertheless, owing to their widespread expression and the inability to selectively stimulate such receptors in vivo, their relevance for cardiac function is not well understood. We here use DREADD technology to understand the role of Gq-coupled signaling in vivo in cardiac function. Methods and Results: We generated a novel transgenic mouse line that expresses a Gq-coupled DREADD (Dq) in striated muscle under the control of the MCK promotor...
October 13, 2018: Cardiovascular Research
Ji-Woo Seok, Jin-Hun Sohn
Accumulating evidence suggests a relationship between problematic hypersexual behavior (PHB) and diminished executive control. Clinical studies have demonstrated that individuals with PHB exhibit high levels of impulsivity; however, relatively little is known regarding the neural mechanisms underlying impaired executive control in PHB. This study investigated the neural correlates of executive control in individuals with PHB and healthy controls using event-related functional magnetic resonance imaging (fMRI)...
2018: Frontiers in Psychiatry
Katherine R Naish, Lana Vedelago, James MacKillop, Michael Amlung
BACKGROUND: There is growing interest in non-invasive brain stimulation techniques as treatments for addictive disorders. While multiple reviews have examined the effects of neuromodulation on craving and consumption, there has been no review of how neuromodulation affects cognitive functioning in addiction. This systematic review examined studies of the cognitive effects of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) in individuals exhibiting addictive behavior...
October 3, 2018: Drug and Alcohol Dependence
Christine Ghadery, Mikaeel Valli, Alexander Mihaescu, Rebecca Strafella, Irene Navalpotro, Jinhee Kim, Antonio P Strafella
Parkinson's disease (PD) is commonly associated with motor symptoms, however cognitive and neurobehavioral complications are increasingly recognized and contribute to long-term disability. Dopamine replacement therapy is effective for motor symptoms, but can also lead to motor side-effects and addictive behavior such as impulse control disorders. Molecular imaging is advancing our knowledge of the mechanisms involved in the development of behavioral addictions. This chapter will discuss potential risk factors and associations with the development of addictive behavior in PD including the role of dopaminergic medication and genetic predisposition...
2018: International Review of Neurobiology
Stephane Thobois, Christine Brefel-Courbon, Didier Le Bars, Véronique Sgambato-Faure
Opioid receptors are localized throughout peripheral and central nervous system and interact with endogenous opioid peptides and drugs including heroin, synthetic opioids, and pain relievers (codeine, morphine). If several opioid PET tracers exist for preclinical studies, only a few have been used in human. Some tracers are selective for one subtype of opioid receptors (e.g., [11 C]CAF (carfentanil) for μ receptor) while others are not ([11 C]DPN (diprenorphine)). As shown by imaging studies, the opioid system is involved in pain processing, but also in addiction, neuropsychiatric manifestations (harm avoidance, sadness, novelty seeking behavior), feeding and food disorders and, finally, movement disorders and levodopa-induced dyskinesias...
2018: International Review of Neurobiology
Elena Salmoirago-Blotcher, Susan Druker, Florence Meleo-Meyer, Christine Frisard, Sybil Crawford, Lori Pbert
BACKGROUND: Since impulsivity is associated with unhealthy behaviors in adolescents, interventions targeting impulsivity could positively affect such behaviors. Whether integrating mindfulness training (MT) into standard school-based health education could improve impulsivity is unknown. PURPOSE: To obtain preliminary estimates of effect of MT integrated in standard high school health education on impulsivity. METHODS: Two high schools in Massachusetts were randomized to school-based health education plus MT (HE-MT) or to health education plus attention control (HE-AC)...
August 22, 2018: Explore: the Journal of Science and Healing
Daniel Cordovani, Twain Russell, Wallace Wee, Andrew Suen, Richard M Cooper
BACKGROUND: In patients with predictive features associated with easy direct laryngoscopy, videolaryngoscoy with the GlideScope has been shown to require less force when compared with Macintosh direct laryngoscopy. OBJECTIVE: The aim of this study was to compare forces applied with Glidescope vs. Macintosh laryngoscopes in patients with predictive features associated with difficult direct laryngoscopy. DESIGN: A prospective randomised study...
October 10, 2018: European Journal of Anaesthesiology
Shunsuke Kobayashi, Kohei Asano, Nozomu Matsuda, Yoshikazu Ugawa
Clinicians are increasingly recognizing impulse control disorders (ICDs) as a complication of dopaminergic treatment in Parkinson's disease (PD). Considering the pivotal role of dopamine in reward information processing, ICDs may originate from dysregulation of reward-oriented behavior, and the behavioral changes may be reflected in shifts of psychological risk preference during decision-making. We used a behavioral economics paradigm to evaluate quantitatively the risk preferences of PD patients in levodopa on and off states...
October 10, 2018: Cognitive, Affective & Behavioral Neuroscience
Jennifer Wernicke, Mei Li, Peng Sha, Min Zhou, Cornelia Sindermann, Benjamin Becker, Keith M Kendrick, Christian Montag
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is characterized by inattention, hyperactivity, and impulsivity but also by negative emotionality. The aim of the present study was to investigate whether subclinical ADHD tendencies are associated with negative emotionality in healthy adult samples. The present study is of special interest since it investigated negative emotionality with a questionnaire anchored in Neuroscience Theory-the Affective Neuroscience Personality Scales (ANPS)...
October 10, 2018: Attention Deficit and Hyperactivity Disorders
Sekaran Saravanan, Niketa Sareen, Ejlal Abu-El-Rub, Hend Ashour, Glen Lester Sequiera, Hania I Ammar, Venkatraman Gopinath, Ashraf Ali Shamaa, Safinaz Salah Eldin Sayed, Meenal Moudgil, Jamuna Vadivelu, Sanjiv Dhingra
Abnormal conduction and improper electrical impulse propagation are common in heart after myocardial infarction (MI). The scar tissue is non-conductive therefore the electrical communication between adjacent cardiomyocytes is disrupted. In the current study, we synthesized and characterized a conductive biodegradable scaffold by incorporating graphene oxide gold nanosheets (GO-Au) into a clinically approved natural polymer chitosan (CS). Inclusion of GO-Au nanosheets in CS scaffold displayed two fold increase in electrical conductivity...
October 10, 2018: Scientific Reports
Anthony C Ruocco, Alexander R Daros, Jie Chang, Achala H Rodrigo, Jaeger Lam, Justine Ledochowski, Shelley F McMain
BACKGROUND: Borderline personality disorder (BPD) is characterized by a heterogeneous clinical phenotype that emerges from interactions among genetic, biological, neurodevelopmental, and psychosocial factors. In the present family study, we evaluated the familial aggregation of key clinical, personality, and neurodevelopmental phenotypes in probands with BPD (n = 103), first-degree biological relatives (n = 74; 43% without a history of psychiatric disorder), and non-psychiatric controls (n = 99)...
October 10, 2018: Psychological Medicine
Nataliya Titova, Oleg Levin, Elena Katunina, K Ray Chaudhuri
'Levodopa Phobia' is under-recognised in Parkinson's disease but can cause profound detrimental clinical complications if left to continue. Several types can be encountered in clinical practice and can be driven by a misplaced fear of levodopa-induced dyskinesias, other gastrointestinal side effects and also the theoretical notion that levodopa may be toxic to dopaminergic neurons in the brain. The condition can be underpinned by a sense of strong influence from the physicians or carers who are unwilling to prescribe or consider levodopa, and also high levels of anxiety or even impulsive compulsive traits in patients who have been influenced by available literature or social media-based information...
2018: NPJ Parkinson's Disease
Holly McCready, Milky Kohno, Michael Kolessar, Laura Dennis, Daniel Kriz, Hannah Luber, Renee Anderson, Michael Chang, Anna Sasaki, Kenneth Flora, Arthur Vandenbark, Suzanne H Mitchell, Jennifer M Loftis, William F Hoffman, Marilyn Huckans
Hepatitis C virus-infected (HCV+) adults evidence increased rates of psychiatric and cognitive difficulties. This is the first study to use functional magnetic resonance imaging (fMRI) to examine brain activation in untreated HCV+ adults. To determine whether, relative to non-infected controls (CTLs), HCV+ adults exhibit differences in brain activation during a delay discounting task (DDT), a measure of one's tendency to choose smaller immediate rewards over larger delayed rewards-one aspect of impulsivity...
October 8, 2018: Journal of Neurovirology
Trinity K Shaver, Jenny E Ozga, Binxing Zhu, B A, Karen G Anderson, Kris M Martens, Cole Vonder Haar
Traumatic brain injury (TBI) affects 2.8 million people annually in the United States, with significant populations suffering from ongoing cognitive dysfunction. Impairments in decision-making can have major implications for patients and their caregivers, often enduring for years to decades, yet are rarely explored in experimental TBI. In the current study, the Rodent Gambling Task (RGT), an Iowa Gambling Task analog, was used to assess risk-based decision-making and motor impulsivity after TBI. During testing, rats chose between options associated with different probabilities of reinforcement (sucrose) or punishment (timeout)...
October 5, 2018: Brain Research
Danitsa Marcos Rodrigues, Gisele Gus Manfro, Robert Daniel Levitan, Meir Steiner, Michael Joseph Meaney, Patrícia Pelufo Silveira
Poor fetal growth is associated with long-term behavioral, metabolic and psychiatric alterations, including impulsivity, insulin resistance, and mood disorders. However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control...
October 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Lucien Rochat, Pierre Maurage, Alexandre Heeren, Joël Billieux
Decision-making impairments play a pivotal role in the emergence and maintenance of addictive disorders. However, a sound conceptualization of decision making as an umbrella construct, encompassing its cognitive, affective, motivational, and physiological subcomponents, is still lacking. This prevents an efficient evaluation of the heterogeneity of decision-making impairments and the development of tailored treatment. This paper thus unfolds the various processes involved in decision making by adopting a critical approach of prominent dual- or triadic-process models, which postulate that decision making is influenced by the interplay of impulsive-automatic, reflective-controlled, and interoceptive processes...
October 6, 2018: Neuropsychology Review
Lucas Simieli, Fabio Augusto Barbieri, Diego Orcioli-Silva, Ellen Lirani-Silva, Victor Spiandor Beretta, Paulo Cezar Rocha Dos Santos, Lilian Teresa Bucken Gobbi
Our aim was investigating variability in spatiotemporal parameters and kinetics of obstacle avoidance steps of different height obstacles in people with Parkinson's disease (PD) and healthy older people. Twenty-eight participants have included (15 PD - stage disease: 2.1 ± 0.4 pts) and 13 healthy older people (control group). Each subject performed 10 trials of the following tasks: low obstacle, intermediate obstacle and high obstacle. The presentation order was randomized by block for each condition and participant...
October 5, 2018: Scientific Reports
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