keyword
https://read.qxmd.com/read/38532362/a-transcriptome-wide-identification-of-atp-binding-cassette-abc-transporters-revealed-participation-of-abcb-subfamily-in-abiotic-stress-management-of-glycyrrhiza-glabra-l
#1
JOURNAL ARTICLE
Ritu Devi, Pooja Goyal, Bhawna Verma, Shahnawaz Hussain, Fariha Chowdhary, Palak Arora, Suphla Gupta
Transcriptome-wide survey divulged a total of 181 ABC transporters in G. glabra which were phylogenetically classified into six subfamilies. Protein-Protein interactions revealed nine putative GgABCBs (-B6, -B14, -B15, -B25, -B26, -B31, -B40, -B42 &-B44) corresponding to five AtABCs orthologs (-B1, -B4, -B11, -B19, &-B21). Significant transcript accumulation of ABCB6 (31.8 folds), -B14 (147.5 folds), -B15 (17 folds), -B25 (19.7 folds), -B26 (18.31 folds), -B31 (61.89 folds), -B40 (1273 folds) and -B42 (51 folds) was observed under the influence of auxin...
March 27, 2024: BMC Genomics
https://read.qxmd.com/read/38438769/histological-analysis-of-antral-follicle-density-in-ovarian-cortex-tissue-attached-to-stripped-endometriomas
#2
JOURNAL ARTICLE
Rozemarijn de Koning, Mathijs D Blikkendaal, Susana M Chuva de Sousa Lopes, Lotte E van der Meeren, Hui Cheng, Frank Willem Jansen, Eileen E L O Lashley
PURPOSE: When resecting endometriomas with the stripping technique, in the majority of cases, a thin line of adjacent ovarian cortex is attached to the endometrioma. In this study, we performed histological analysis to determine (antral) follicle density in the ovarian cortex tissue attached to stripped endometriomas and assessed patient- and surgical characteristics that could affect this. METHODS: Histological slides of previously removed endometriomas were assessed...
March 5, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38165285/selective-dehydrogenation-of-ammonia-borane-to-polycondensated-bn-rings-catalysed-by-ruthenium-olefin-complexes
#3
JOURNAL ARTICLE
Daniel Himmelbauer, Fabian Müller, Clara Schweinzer, Fernando Casas, Bruno Pribanic, Grégoire Le Corre, Debora Thöny, Monica Trincado, Hansjörg Grützmacher
Dehydrogenation of ammonia borane to well-defined products is an important but challenging reaction. A dinuclear ruthenium complex with a Ru-Ru bond bearing a diazadiene (dad) unit and olefins as non-innocent ligands catalyzes the highly selective formation of conjugated polycondensed borazine oligomers (B x N x H y ), predominantly B21 N21 H18 , the BN analogue of superbenzene.
January 2, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38084737/clinical-and-economic-impact-of-ventricular-assist-device-infections-a-real-world-claims-analysis
#4
JOURNAL ARTICLE
Anton Y Peleg, Erika D Feller, Marcus Müller, Sebastian Schulte-Eistrup, David McGiffin, Daniel Zimpfer, Reece Holbrook, Jamie Margetta, Swathi Seshadri, Nahush A Mokadam
BACKGROUND: VAD therapy has revolutionized the treatment of end-stage heart failure, but infections remain an important complication. The objective of this study was to characterize the clinical and economic impacts of VAD-specific infections. METHODS: A retrospective analysis of a United States claims database identified members 18 years with a claim for a VAD implant procedure, at least 6 months of pre-implant baseline data, and 12 months of follow-up between June 1, 2016 and December 31, 2019...
December 12, 2023: Journal of Medical Economics
https://read.qxmd.com/read/38003819/serosurvey-of-immunity-to-monkeypox-mpox-virus-antigens-in-people-living-with-hiv-in-south-florida
#5
JOURNAL ARTICLE
Jonah Kupritz, Savita Pahwa, Suresh Pallikkuth
Mpox is an infectious disease caused by the monkeypox virus (MPXV) belonging to the Orthopoxvirus (OPXV) genus, which includes smallpox and vaccinia virus (VACV). A global mpox outbreak which began in May 2022 has infected more than 88,000 people. VACV-based vaccines provide protection against mpox disease but complicate the use of serological assays for disease surveillance. We tested the reactivity of serum IgG from Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN)-vaccinated ( n = 12) and convalescent mpox-infected ( n = 5) individuals and uninfected, non-vaccinated controls ( n = 32) to MPXV/VACV proteins A27, A29, A30, A35, B16, B21, C19, D6, E8, H3, I1, and L1...
November 15, 2023: Pathogens
https://read.qxmd.com/read/38003740/plant-disease-suppressive-and-growth-promoting-activities-of-endophytic-and-rhizobacterial-isolates-associated-with-citrullus-colocynthis
#6
JOURNAL ARTICLE
Badriya Khalfan Al-Shuaibi, Elham Ahmed Kazerooni, Shah Hussain, Rethinasamy Velazhahan, Abdullah Mohammed Al-Sadi
This study was conducted to investigate the antagonistic potential of endophytic and rhizospheric bacterial isolates obtained from Citrullus colocynthis in suppressing Fusarium solani and Pythium aphanidermatum and promoting the growth of cucumber. Molecular identification of bacterial strains associated with C. colocynthis confirmed that these strains belong to the Achromobacter , Pantoea , Pseudomonas , Rhizobium , Sphingobacterium , Bacillus , Sinorhizobium , Staphylococcus , Cupriavidus , and Exiguobacterium genera...
October 24, 2023: Pathogens
https://read.qxmd.com/read/37959834/discovery-of-novel-biphenyl-carboxylic-acid-derivatives-as-potent-urat1-inhibitors
#7
JOURNAL ARTICLE
Xianxin Hou, Yongcheng Wang, Yajun Yang, Zhiyan Xiao
Urate transporter 1 (URAT1) is a clinically validated target for the treatment of hyperuricemia and gout. Due to the absence of protein structures, the molecular design of new URAT1 inhibitors generally resorts to ligand-based approaches. Two series of biphenyl carboxylic acids were designed based on the structures of URAT1 inhibitors Epaminurad and Telmisartan via a strategy of pharmacophore fusion. Fifty-one novel compounds were synthesized and most of them showed obvious inhibition against human URAT1. A1 and B21 were identified as the most potent URAT1 inhibitors in series A and B, respectively...
November 3, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37733789/discovery-of-novel-diamides-scaffold-containing-monofluoro-acrylamides-activating-the-insect-ryanodine-receptor
#8
JOURNAL ARTICLE
Guantian Yang, Yutong Wang, Cong Zhou, Yuxin Li, Yucheng Gu, Zhong Li, Zhiping Xu, Jiagao Cheng, Xiaoyong Xu
The research and development of organofluorine chemistry has flourished; in particular, monofluoroalkene has aroused considerable interest from medicinal and organic chemists. It is a significant attempt to introduce monofluoroalkene into agrochemicals. In this study, monofluoroalkene was introduced into diamide molecules and inserted between the aliphatic amide and benzene ring, and 44 compounds have been successfully synthesized. The bioassay results showed that compounds with monofluoro-acrylamide moiety ( Z -isomers) had excellent larvicidal activity against lepidopteran pests at 5 mg·L-1 ...
September 21, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37675466/hyperprogressive-disease-during-pd-1-blockade-in-patients-with-advanced-pancreatic-cancer
#9
JOURNAL ARTICLE
Shiyun Chen, Lu Han, Shiyuan Guo, Zhaoli Tan, Guanghai Dai
The occurrence of markedly accelerated tumor growth during immunotherapy is considered a new mode of progression called hyperprogressive disease (HPD) and its impact on pancreatic cancer (PC) patients receiving immunotherapy is unknown. In this study, we described and explored the incidence, prognosis and predictors of HPD in patients with advanced PC treated with programmed cell death-1 (PD-1) inhibitors. We retrospectively analyzed clinicopathological data from 104 patients with advanced pancreatic cancer who were treated with PD-1 inhibitors at our institution during 2015-2020 and identified 10 (9...
August 1, 2023: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/37332783/three-polyborates-with-high-symmetry-b-12-o-24-units-featuring-different-dimensions-of-anion-groups
#10
JOURNAL ARTICLE
Yu Dang, Jingdong Yan, Xueling Hou, Hongsheng Shi
Three polyborates, namely, LiNa11 B28 O48 , Li1.45 Na7.55 B21 O36 , and Li2 Na4 Ca7 Sr2 B13 O27 F9 , were synthesized via the high-temperature solution method. All of them feature high-symmetry [B12 O24 ] units, yet their anion groups exhibit distinct dimensions. LiNa11 B28 O48 features a three-dimensional anionic structure of 3 [B28 O48 ]∞ framework, which is composed of three units: [B12 O24 ], [B15 O30 ], and [BO3 ]. Li1.45 Na7.55 B21 O36 possesses a one-dimensional anionic structure of 1 [B21 O36 ]∞ chain consisting of [B12 O24 ] and [B9 O18 ] units...
June 13, 2023: ACS Omega
https://read.qxmd.com/read/37321811/change-in-cardiorespiratory-parameters-following-surgical-correction-of-pectus-excavatum-protocol-for-the-historical-prospective-heartsoar-cohort
#11
JOURNAL ARTICLE
Carey Meredith Suehs, Nicolas Molinari, A Bourdin, Laurence Solovei
INTRODUCTION: How cardiorespiratory function changes following the surgical correction of pectus excavatum (PE) often gives mixed results, with meta-analyses demonstrating no benefit in terms of pulmonary function but improvement in cardiac function. Functional responses may depend on type of surgery, follow-up time and/or the patient's presurgical functional status, and debate persists on the purely aesthetic nature of such surgery. The aim of this protocol is to analyse data describing lung function and incremental exercise testing before vs after the surgical correction of PE...
June 15, 2023: BMJ Open
https://read.qxmd.com/read/37318325/genome-sequences-of-two-plant-beneficial-chryseobacterium-strains-isolated-from-agricultural-soils-in-the-province-of-quebec-canada
#12
JOURNAL ARTICLE
Adrien Biessy, Marie Ciotola, Mélanie Cadieux, Daphné Albert, Martin Filion
Two Chryseobacterium strains, B21-013 and B21-037, were isolated from agricultural soils located in the province of Quebec, Canada, as part of a screening for plant-beneficial bacteria able to suppress Xanthomonas hortorum pv. vitians and other lettuce bacterial pathogens. Here, we report the genome sequences of these two organisms.
June 15, 2023: Microbiology Resource Announcements
https://read.qxmd.com/read/36726278/hpai-resistant-ri-chickens-exhibit-elevated-antiviral-immune-related-gene-expression
#13
JOURNAL ARTICLE
Thi Hao Vu, Jubi Heo, Yeojin Hong, Suyeon Kang, Ha Thi Thanh Tran, Hoang Vu Dang, Anh Duc Truong, Yeong Ho Hong
BACKGROUND: Highly pathogenic avian influenza viruses (HPAIVs) is an extremely contagious and high mortality rates in chickens resulting in substantial economic impact on the poultry sector. Therefore, it is necessary to elucidate the pathogenic mechanism of HPAIV for infection control. OBJECTIVE: Gene set enrichment analysis (GSEA) can effectively avoid the limitations of subjective screening for differential gene expression. Therefore, we performed GSEA to compare HPAI-infected resistant and susceptible Ri chicken lines...
January 2023: Journal of Veterinary Science
https://read.qxmd.com/read/36569899/b21-dna-vaccine-expressing-ag85b-rv2029c-and-rv1738-confers-a-robust-therapeutic-effect-against-latent-mycobacterium-tuberculosis-infection
#14
JOURNAL ARTICLE
Shufeng Weng, Jinyi Zhang, Huixia Ma, Jingyu Zhou, Liqiu Jia, Yanmin Wan, Peng Cui, Qiaoling Ruan, Lingyun Shao, Jing Wu, Honghai Wang, Wenhong Zhang, Ying Xu
Latent tuberculosis infection (LTBI) treatment is known to accelerate the decline in TB incidence, especially in high-risk populations. Mycobacterium tuberculosis ( M. tb ) expression profiles differ at different growth periods, and vaccines protective and therapeutic effects may increase when they include antigenic compositions from different periods. To develop a post-exposure vaccine that targets LTBI, we constructed four therapeutic DNA vaccines ( A39 , B37 , B31 , and B21 ) using different combinations of antigens from the proliferation phase (Ag85A, Ag85B), PE/PPE family (Rv3425), and latent phase (Rv2029c, Rv1813c, Rv1738)...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36189228/marek-s-disease-virus-specific-t-cells-proliferate-express-antiviral-cytokines-but-have-impaired-degranulation-response
#15
JOURNAL ARTICLE
Nitish Boodhoo, Shahriar Behboudi
The major histocompatibility complex (MHC) haplotype is one of the major determinants of genetic resistance and susceptibility of chickens to Marek's disease (MD) which is caused by an oncogenic herpesvirus; Marek's disease virus (MDV). To determine differential functional abilities of T cells associated with resistance and susceptibility to MD, we identified immunodominant CD4+TCRvβ1 T cell epitopes within the pp38 antigen of MDV in B19 and B21 MHC haplotype chickens using an ex vivo ELISPOT assay for chicken IFN-gamma...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36115640/enhancing-the-expression-of-multi-antigen-chimeric-tgags-bst-protein-from-toxoplasma-gondii-in-escherichia-coli-bl-21-star-during-batch-cultivation
#16
JOURNAL ARTICLE
Stephanie Caroline Bivar Matias, Beatriz de Azevedo, José Daladiê Barreto da Costa Filho, Marina Moura Lima, Andrews Douglas Moura, Daniella Regina Arantes Martins, Francisco Canindé de Sousa Júnior, Everaldo Silvino Dos Santos
Toxoplasmosis, despite advances in science and technology, is a disease that requires attention since there is no vaccine capable of immunizing humans and animals against all isolated types of Toxoplasma gondii. Thus, the use of chimeric proteins, which can contain multiple antigens, is a very promising alternative for the process of obtaining a vaccine and diagnostic test for toxoplasmosis due to the great diversity of antigens presented by T. gondii. In this context, the present study evaluates batch culture strategies in the production of the multi-antigenic chimeric protein TgAGS/BsT from Toxoplasma gondii...
September 14, 2022: Protein Expression and Purification
https://read.qxmd.com/read/36111897/pembrolizumab-as-a-single-agent-for-patients-with-msi-h-advanced-endometrial-carcinoma
#17
JOURNAL ARTICLE
Margherita Turinetto, Valentina Lombardo, Carmela Pisano, Lucia Musacchio, Sandro Pignata
INTRODUCTION: Endometrial cancer can be characterized by high instability of microsatellites (MSI-H), a biomarker indicative of sensibility to immune checkpoint inhibitors (ICIs). The results of the KEYNOTE-158 trial led to the approval of pembrolizumab - a monoclonal, humanized IgG4 kappa anti-PD-1 antibody able to prevent T-cell PD-1/tumor cell PD-L1/2 interaction, thus restoring T-cell mediated anti-tumor immunity - in MSI-H endometrial cancer relapsing after at least one line of chemotherapy (CT)...
September 16, 2022: Expert Review of Anticancer Therapy
https://read.qxmd.com/read/35908887/inhibitory-effect-of-dextran-derivatives-on-multidrug-resistance-related-efflux-transporters-in-vitro
#18
JOURNAL ARTICLE
Kaori Morimoto, Makoto Ishii, Yoshikazu Sugimoto, Takuo Ogihara, Mikio Tomita
Dextran is a promising candidate as a nanocarrier of chemotherapeutic drugs due to its biocompatibility, biodegradability, and ability to accumulate in tumors. Furthermore, dextran derivatives interact with P-glycoprotein (P-gp), so we hypothesized that they may be available as tumor-specific drug delivery systems with the ability to reverse multidrug resistance. Here, to test this idea, we investigated whether dextran and its derivatives inhibit breast cancer resistance protein (BCRP), multidrug resistance associated protein 1 (MRP1), and P-gp in vitro...
2022: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/35908886/picropodophyllin-inhibits-the-proliferation-of-human-prostate-cancer-du145-and-lncap-cells-via-ros-production-and-pi3k-akt-pathway-inhibition
#19
JOURNAL ARTICLE
Xuejie Zhu, Xiaojie Chen, Guoli Wang, Dan Lei, Xiaoyu Chen, Kehao Lin, Minjing Li, Haiyan Lin, Defang Li, Qiusheng Zheng
The reactive oxygen species (ROS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway play critical roles in the pathogenesis of prostate cancer by modulating cell proliferation. Picropodophyllin (PPP), an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R), exerts significant antitumor effects via the PI3K/AKT signaling pathway. However, the effects of PPP on prostate cancer via ROS production and the PI3K/AKT signaling pathway remain elusive. Herein, we focused on examining the antitumor effects of PPP on DU145 and LNCaP human prostate cancer cells to determine the possible molecular mechanism...
2022: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/35786603/study-on-catalpol-content-in-rehmannia-glutinosa-root-an-important-ingredient-in-kampo-prescriptions
#20
JOURNAL ARTICLE
Yuting Huang, Hirokazu Ando, Mai Tsujino, Kazuki Yoshihara, Li Zhang, Yohei Sasaki
Rehmannia glutinosa is an important medicinal plant in Asia, and its roots are used as an ingredient in herbal medicine. However, the roots exhibit different medicinal effects depending on the processing conditions. Since the catalpol content differs greatly during the process, the catalpol content is an essential index for quality evaluation. R. glutinosa roots have various weights, diameters, and lengths, and there are differences between individuals and within an individual immediately after harvest. We found that, catalpol content in the roots tended to increase as root diameter increased...
2022: Biological & Pharmaceutical Bulletin
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