Guowei Gu, Lin Tian, Sarah K Herzog, Yassine Rechoum, Luca Gelsomino, Meng Gao, Lili Du, Jin-Ah Kim, Derek Dustin, Hin Ching Lo, Amanda R Beyer, David G Edwards, Thomas Gonzalez, Anna Tsimelzon, Helen J Huang, Natalie M Fernandez, Sandra L Grimm, Susan G Hilsenbeck, Dan Liu, Jun Xu, Alyssa Alaniz, Shunqiang Li, Gordon B Mills, Filip Janku, Ralf Kittler, Xiang H-F Zhang, Cristian Coarfa, Charles E Foulds, W Fraser Symmans, Sebastiano Andò, Suzanne A W Fuqua
Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vitro. When small subpopulations of Y537S ESR1 mutant cells were injected along with WT parental cells, tumor growth was enhanced with mutant cells becoming the predominant population in distant metastases...
February 2021: Oncogene