Tonglei Wu, Ruitao Ma, Xiaoyi Pan, Fengjie Wang, Zhiqiang Zhang, Qiumei Shi, Xiaofeng Shan, Guisheng Gao
INTRODCTION: Aeromonas veronii is a significant pathogen to various aquatic life. Infections in fish can lead to high mortality rates, causing substantial economic losses in aquaculture. Vaccination is proposed as a substitute for antibiotics in aquaculture to decrease disease-related mortality and morbidity. Our study previously constructed a hisJ -deleted strain of A. veronii , which provided protective effect to Loach . METHODS: To further assess the vaccine's applicability, this study evaluated its genetic stability and safety, and the immune protective effects in Carassius auratus through four distinct administration routes: intraperitoneal injection, intramuscular injection, oral administration, and immersion, to determine the efficacy of these administration routes...
2024: Frontiers in Veterinary Science