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https://www.readbyqxmd.com/read/30334607/maintenance-chemotherapy-to-reduce-the-risk-of-a-metachronous-wilms-tumor-in-children-with-bilateral-nephroblastomatosis
#1
Michael V Ortiz, Shannon Fernandez-Ledon, Kavitha Ramaswamy, Christopher J Forlenza, Neerav N Shukla, Rachel Kobos, Todd E Heaton, Michael P LaQuaglia, Peter G Steinherz
From 2009 to 2018, 10 consecutive patients with Wilms tumors and bilateral nephroblastomatosis, who had completed standard therapy, were provided a maintenance chemotherapy regimen consisting of vincristine and dactinomycin every 3 months for 12 months in order to prevent an early metachronous Wilms tumor. One patient (10%) with Beckwith-Wiedemann syndrome developed a new tumor, without anaplasia. There were no significant toxicities reported during maintenance. All patients are currently alive with no evidence of disease...
October 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30333772/procedural-memory-working-memory-and-declarative-memory-skills-are-each-associated-with-dimensional-integration-in-sound-category-learning
#2
Carolyn Quam, Alisa Wang, W Todd Maddox, Kimberly Golisch, Andrew Lotto
This paper investigates relationships between procedural-memory, declarative-memory, and working-memory skills and adult native English speakers' novel sound-category learning. Participants completed a sound-categorization task that required integrating two dimensions: one native (vowel quality), one non-native (pitch). Similar information-integration category structures in the visual and auditory domains have been shown to be best learned implicitly (e.g., Maddox et al., 2006). Thus, we predicted that individuals with greater procedural-memory capacity would better learn sound categories, because procedural memory appears to support implicit learning of new information and integration of dimensions...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30333745/experimentally-validated-pharmacoinformatics-approach-to-predict-herg-inhibition-potential-of-new-chemical-entities
#3
Saba Munawar, Monique J Windley, Edwin G Tse, Matthew H Todd, Adam P Hill, Jamie I Vandenberg, Ishrat Jabeen
The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+ ) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes (TdPs). Therefore, we presented a pharmacoinformatics strategy using combined ligand and structure based models for the prediction of hERG inhibition potential (IC50 ) of new chemical entities (NCEs) during early stages of drug design and development. Integrated GRid-INdependent Descriptor (GRIND) models, and lipophilic efficiency (LipE), ligand efficiency (LE) guided template selection for the structure based pharmacophore models have been used for virtual screening and subsequent hERG activity (pIC50 ) prediction of identified hits...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30333318/combining-sting-based-neoantigen-targeted-vaccine-with-checkpoint-modulators-enhances-antitumor-immunity-in-murine-pancreatic-cancer
#4
Heather L Kinkead, Alexander Hopkins, Eric Lutz, Annie A Wu, Mark Yarchoan, Kayla Cruz, Skylar Woolman, Teena Vithayathil, Laura H Glickman, Chudi O Ndubaku, Sarah M McWhirter, Thomas W Dubensky, Todd D Armstrong, Elizabeth M Jaffee, Neeha Zaidi
Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algorithm, NetMHC, to generate a neoantigen-targeted vaccine, PancVAX, which was administered together with the STING adjuvant ADU-V16 to mice bearing pancreatic adenocarcinoma (Panc02) cells. PancVAX activated a neoepitope-specific T cell repertoire within the tumor and caused transient tumor regression...
October 18, 2018: JCI Insight
https://www.readbyqxmd.com/read/30333317/%C3%AE-v%C3%AE-3-integrin-drives-fibroblast-contraction-and-strain-stiffening-of-soft-provisional-matrix-during-progressive-fibrosis
#5
Vincent F Fiore, Simon S Wong, Coleen Tran, Chunting Tan, Wenwei Xu, Todd Sulchek, Eric S White, James S Hagood, Thomas H Barker
Fibrosis is characterized by persistent deposition of extracellular matrix (ECM) by fibroblasts. Fibroblast mechanosensing of a stiffened ECM is hypothesized to drive the fibrotic program; however, the spatial distribution of ECM mechanics and their derangements in progressive fibrosis are poorly characterized. Importantly, fibrosis presents with significant histopathological heterogeneity at the microscale. Here, we report that fibroblastic foci (FF), the regions of active fibrogenesis in idiopathic pulmonary fibrosis (IPF), are surprisingly of similar modulus as normal lung parenchyma and are nonlinearly elastic...
October 18, 2018: JCI Insight
https://www.readbyqxmd.com/read/30333237/mixed-effects-association-of-single-cells-identifies-an-expanded-effector-cd4-t-cell-subset-in-rheumatoid-arthritis
#6
Chamith Y Fonseka, Deepak A Rao, Nikola C Teslovich, Ilya Korsunsky, Susan K Hannes, Kamil Slowikowski, Michael F Gurish, Laura T Donlin, James A Lederer, Michael E Weinblatt, Elena M Massarotti, Jonathan S Coblyn, Simon M Helfgott, Derrick J Todd, Vivian P Bykerk, Elizabeth W Karlson, Joerg Ermann, Yvonne C Lee, Michael B Brenner, Soumya Raychaudhuri
High-dimensional single-cell analyses have improved the ability to resolve complex mixtures of cells from human disease samples; however, identifying disease-associated cell types or cell states in patient samples remains challenging because of technical and interindividual variation. Here, we present mixed-effects modeling of associations of single cells (MASC), a reverse single-cell association strategy for testing whether case-control status influences the membership of single cells in any of multiple cellular subsets while accounting for technical confounders and biological variation...
October 17, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30333164/can-perfusion-ct-unmask-postictal-stroke-mimics-a-case-control-study-of-133-patients
#7
Margot G A Van Cauwenberge, Sven Dekeyzer, Omid Nikoubashman, Manuel Dafotakis, Martin Wiesmann
OBJECTIVE: To study the diagnostic value of volume perfusion CT (VPCT) in patients with transient focal neurologic deficits following and during epileptic seizures, that mimic symptoms of stroke. METHODS: A retrospective case-control study was performed on 159 patients who presented with a seizure and received an emergency VPCT within the first 3.5 hours of admission, after being misjudged to have an acute stroke. The reference test was a clinical-based, EEG-supported diagnostic algorithm for seizure...
October 17, 2018: Neurology
https://www.readbyqxmd.com/read/30332662/the-spatial-distribution-of-congener-specific-human-pcb-concentrations-in-a-pcb-polluted-region
#8
Maximilián Strémy, Zuzana Šutová, Ľubica Palkovičová Murínová, Denisa Richterová, Soňa Wimmerová, Kamil Čonka, Beata Drobná, Lucia Fábelová, Dana Jurečková, Todd A Jusko, Juraj Tihányi, Tomáš Trnovec
Serum PCB congener concentrations were measured in 602 adults living near a PCB pollution source in eastern Slovakia. We created isoconcentration maps for 21 PCB congeners by geocoding each participant's place of residence and kriging. Concentrations of PCB congeners were inversely associated with the distance of the participants' residence from the source of pollution. Congener-specific risk factors were derived, particularly for PCBs 52 and 153. We observed that the spatial distribution of serum concentrations was influenced by micro-climatic parameters and physicochemical properties of the congeners...
October 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30332322/vestibular-cerebellar-evoked-potentials-vsceps-in-humans-and-their-modulation-during-optokinetic-stimulation
#9
Neil P M Todd, Sendhil Govender, James Gordon Colebatch
We recorded evoked potentials (EPs) from over the posterior fossa and in parallel ocular vestibular evoked myogenic potentials (OVEMPs) during visuo-vestibular stimulation in a sample of 7 male and 11 female human subjects. In 9 of the 18 subjects we were able to record EPs reliably in the form of an early biphasic positive-negative wave with latencies about 12 and 17 ms ipsilateral to head acceleration direction (P12-N17) and a slightly later, contralateral, biphasic positive-negative wave with latencies about 19 and 23 ms (P19-N23)...
October 17, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/30329222/long-read-sequence-capture-of-the-hemoglobin-gene-clusters-across-gadid-species
#10
Siv Nam Khang Hoff, Helle T Baalsrud, Ave Tooming-Klunderud, Morten Skage, Todd Richmond, Gregor Obernosterer, Reza Shirzadi, Ole Kristian Tørresen, Kjetill S Jakobsen, Sissel Jentoft
Combining high-throughput sequencing with targeted sequence capture has become an attractive tool to study specific genomic regions of interest. Most studies have so far focused on the exome using short-read technology. These approaches are not designed to capture intergenic regions needed to reconstruct genomic organization, including regulatory regions and gene synteny. Here, we demonstrate the power of combining targeted sequence capture with long-read sequencing technology for comparative genomic analyses of the hemoglobin (Hb) gene clusters across eight species separated by up to 70 million years...
October 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/30328675/a-program-to-train-medical-physicists-for-direct-patient-care-responsibilities
#11
Derek W Brown, Todd Atwood, Kevin Moore, Robert MacAulay, James Murphy, Arno Mundt, Todd Pawlicki
OBJECTIVES: To develop a training program designed to meet the specific needs of medical physicists as they transition into a clinical role with direct patient care responsibilities. MATERIALS AND METHODS: The training program was designed in collaboration with the faculty at the UC San Diego School of Medicine and incorporates training techniques that have been shown to be effective in improving communication skills. The program emphasizes experiential, practice-based learning over didactic presentations...
October 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/30328483/optimizing-methods-to-quantify-intramuscular-fat-in-rotator-cuff-tears-with-normalization
#12
Paul S Micevych, Ankur Garg, Lucas T Buchler, Guido Marra, Matthew D Saltzman, Todd B Parrish, Amee L Seitz
OBJECTIVE: To determine which normalization method may best account for confounding individual factors, such as age or BMI, when quantifying fat infiltration on MRI in patients with rotator cuff tears, the effects of normalization using three different muscles (teres major; triceps brachii; teres minor) were compared. METHODS: Thirty-seven consecutive patients diagnosed with rotator cuff pathology were included. MRI fat-water sequences were used to quantify rotator cuff intramuscular fat (%fat)...
October 17, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/30328155/mother-daughter-interpersonal-processes-underlying-the-association-between-child-maltreatment-and-adolescent-suicide-ideation
#13
Elizabeth D Handley, Tangeria R Adams, Jody Todd Manly, Dante Cicchetti, Sheree L Toth
OBJECTIVE: The aim of the present study was to investigate whether mother-daughter relationship quality and mother-daughter conflict represent mechanisms underlying the association between child maltreatment and adolescent passive or active suicide ideation. METHOD: The sample included 164 socioeconomically disadvantaged depressed adolescent girls and their mothers (adolescents: mean age = 14.00 years; 66.3% African-American, 21.3% white, 14.0% Latina). Structural equation modeling was used to test three simultaneous and distinct mediating pathways linking child maltreatment to adolescent suicide ideation: (1) mother-daughter relationship quality, (2) mother-daughter conflict, and 3) adolescent depressive symptoms...
October 17, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/30327914/occult-contralateral-inguinal-hernias-what-is-their-true-incidence-and-should-they-be-repaired
#14
Joey A Jarrard, Michael R Arroyo, B Todd Moore
BACKGROUND: The true incidence of occult contralateral inguinal hernia is unknown; however, when found, there exists controversy as to whether or not they should be repaired. The aim of our study is to identify the incidence of contralateral incidental inguinal hernias in our surgical population, compare our results to previous studies timelining occult hernia identification to repair need, and generate debate as to whether incidental contralateral hernias should be repaired at the index operation...
October 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30326233/successful-conservative-management-of-a-large-splenic-abscess-secondary-to-infective-endocarditis
#15
Saleh A Alnasser, Cezarina Mindru, Ourania Preventza, Todd Rosengart, Lorraine Cornwell
The spleen is the most common abdominal site for systemic septic emboli that often complicate infective endocarditis. Management of an embolic splenic abscess usually involves surgical splenectomy or image-guided drainage, but the natural history of splenic abscess without drainage is unknown. We describe the successful conservative treatment of a large complex splenic abscess with antibiotics alone in a patient with aortic valve infective endocarditis who required emergent valve replacement surgery. Previous complex abdominal wall surgery with the presence of a synthetic mesh made abdominal surgical intervention unfavorable...
October 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30325887/design-and-implementation-of-an-enhanced-recovery-after-surgery-eras-program-for-minimally-invasive-lumbar-decompression-spine-surgery-initial-experience
#16
Ellen M Soffin, Avani S Vaishnav, Douglas Wetmore, Lauren Barber, Patrick Hill, Catherine Himo Gang, James D Beckman, Todd J Albert, Sheeraz A Qureshi
STUDY DESIGN: A retrospective cohort study of prospectively-collected data. OBJECTIVE: To describe the development of and early experience with an evidence-based ERAS pathway for lumbar decompression. SUMMARY OF BACKGROUND DATA: Enhanced recovery after surgery (ERAS) protocols have been consistently associated with improved patient experience and outcomes, and reduced cost and length of hospital stay (LoS). Despite successes in other orthopedic subspecialties, ERAS has yet to be established in spine surgery...
October 15, 2018: Spine
https://www.readbyqxmd.com/read/30325761/an-evaluation-of-the-iolmaster-700
#17
Mark A Bullimore, Stephen Slade, Paul Yoo, Todd Otani
OBJECTIVES: To evaluate the repeatability and reproducibility of the Carl Zeiss Meditec IOLMaster 700, which uses swept-source optical coherence tomography technology, along with its agreement with the IOLMaster 500 and Lenstar LS 900. METHODS: In a clinical practice, complete measurements were taken on one eye of 100 subjects: 51 with cataracts and 49 with clear lenses. Three sets of measurements were taken by 3 operators with three different IOLMaster 700 units, and one operator took 3 measurements with the IOLMaster 500 and the Lenstar...
October 15, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/30325267/precision-hiv-care-responding-to-old-questions-and-meeting-new-challenges
#18
Todd Hulgan, Chandravanu Dash, David W Haas, Elizabeth J Phillips
No abstract text is available yet for this article.
October 16, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/30324569/impact-of-simulation-based-training-on-perceived-provider-confidence-in-acute-multidisciplinary-pediatric-trauma-resuscitation
#19
Cory M McLaughlin, Minna M Wieck, Erica N Barin, Alyssa Rake, Rita V Burke, Heather B Roesly, L Caulette Young, Todd P Chang, Elizabeth A Cleek, Inge Morton, Catherine J Goodhue, Randall S Burd, Henri R Ford, Jeffrey S Upperman, Aaron R Jensen
PURPOSE: Simulation-based training has the potential to improve team-based care. We hypothesized that implementation of an in situ multidisciplinary simulation-based training program would improve provider confidence in team-based management of severely injured pediatric trauma patients. METHODS: An in situ multidisciplinary pediatric trauma simulation-based training program with structured debriefing was implemented at a free-standing children's hospital. Trauma providers were anonymously surveyed 1 month before (pre-), 1 month after (post-), and 2 years after implementation...
October 15, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/30323222/crispr-knockout-screening-identifies-combinatorial-drug-targets-in-pancreatic-cancer-and-models-cellular-drug-response
#20
Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J Adair, Stephen Shang, Alex D Michaels, Matthew G Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B Stelow, P Todd Stukenberg, J Thomas Parsons, Todd W Bauer, Mazhar Adli
Predicting the response and identifying additional targets that will improve the efficacy of chemotherapy is a major goal in cancer research. Through large-scale in vivo and in vitro CRISPR knockout screens in pancreatic ductal adenocarcinoma cells, we identified genes whose genetic deletion or pharmacologic inhibition synergistically increase the cytotoxicity of MEK signaling inhibitors. Furthermore, we show that CRISPR viability scores combined with basal gene expression levels could model global cellular responses to the drug treatment...
October 15, 2018: Nature Communications
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