L Sciacca, V Vella, L Frittitta, A Tumminia, L Manzella, S Squatrito, A Belfiore, R Vigneri
AIMS: Hyperinsulinemia is a recognized risk factor for cancer and plays a major role for the increased cancer incidence in diabetic patients. Whether insulin analogs, and particularly long-acting analogs, worsen the pro-cancer effect of excess insulin is still controversial. DATA SYNTHESIS: In this paper we summarize the biological bases for the potential detrimental effect of long-acting analogs on cancer cells and review the in vitro and in vivo evidence on this issue...
February 24, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD