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apoptosis irradiation

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https://www.readbyqxmd.com/read/30107854/inhibition-of-mtorc1-signaling-protects-kidney-from-irradiation-induced-toxicity-via-accelerating-recovery-of-renal-stem-like-cells
#1
Lijian Shao, Wuping Yang, Rui Xu, Shuqin Zhu, Yanqiu Huang, Huan Li, Xincheng Wu, Mengzhen Yue, Xiaoliang Xiong, Xiaowen Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu, Huihong Zeng
BACKGROUND: Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, the role of mTOR complex 1 (mTORC1) signaling was investigated in irradiation-induced renal injuries. METHODS: Mice were exposed to 8.0-Gy X-ray of total body irradiation and subsequently treated with rapamycin. Changes of renal morphology were assessed by hematoxylin and eosin staining...
August 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30106602/nuclear-localized-raf1-isoform-alters-dna-dependent-protein-kinase-activity-and-the-dna-damage-response
#2
Benjamin R Nixon, Sara C Sebag, Michael S Glennon, Eric J Hall, Emily S Kounlavong, Michael L Freeman, Jason R Becker
Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have identified a novel splice isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf1-tr). We found that Raf1-tr has increased nuclear localization compared with full-length Raf1, and this finding was secondary to reduced binding of Raf1-tr to the cytoplasmic chaperone FK506 binding protein 5. We show that Raf1-tr has increased binding to DNA-dependent protein kinase (DNA-PK), which inhibits DNA-PK function and causes amplification of irradiation- and bleomycin-induced DNA damage...
August 14, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30106279/ros-responsive-nanoparticles-based-on-peglated-prodrug-for-targeted-treatment-of-oral-tongue-squamous-cell-carcinoma-by-combining-photodynamic-therapy-and-chemotherapy
#3
Shurui Shi, Lianyun Zhang, Mengqi Zhu, Guoyun Wan, Changyi Li, Juan Zhang, Yue Wang, Yinsong Wang
In this study, a reactive oxygen species (ROS)-responsive nanoparticle system was designed for combining photodynamic therapy (PDT) and chemotherapy for oral tongue squamous cell carcinoma (OTSCC)-targeted treatment. A PEGlated prodrug (RPTD) of doxorubicin (DOX) via thioketal linkage and cRGD peptide modification was synthesized and then used to prepare nanoparticles for encapsulating photosensitizer hematoporphyrin (HP). Thus obtained HP-loaded RPTD (RPTD/HP) nanoparticles had regular spherical shape and small size approximately 180 nm...
August 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30106056/selenocysteine-antagonizes-oxygen-glucose-deprivation-induced-damage-to-hippocampal-neurons
#4
Xian-Jun Wang, Mei-Hong Wang, Xiao-Ting Fu, Ya-Jun Hou, Wang Chen, Da-Chen Tian, Su-Yun Bai, Xiao-Yan Fu
Designing and/or searching for novel antioxidants against oxygen glucose deprivation (OGD)-induced oxidative damage represents an effective strategy for the treatment of human ischemic stroke. Selenium is an essential trace element, which is beneficial in the chemoprevention and chemotherapy of cerebral ischemic stroke. The underlying mechanisms for its therapeutic effects, however, are not well documented. Selenocysteine (SeC) is a selenium-containing amino acid with neuroprotective potential. Studies have shown that SeC can reduce irradiation-induced DNA apoptosis by reducing DNA damage...
August 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30105482/examination-of-the-cellular-mechanisms-of-leukocyte-elevation-by-10-6-%C3%AE-m-and-650-nm-laser-acupuncture-moxibustion
#5
Lanlan Liu, Ling Zhao, Ke Cheng, Haiping Deng, Menghu Guo, Jianzi Wei, Xueyong Shen
To investigate the cell cycle and cellular mechanisms of leukocyte elevation by laser acupuncture in rats with cyclophosphamide (CTX)-induced leukopenia. Sixty-six rats were randomized into six groups: normal, model control group, sham treatment group, 10.6 μm laser treatment group, 650 nm laser treatment group, and 10.6 μm-650 nm compound laser treatment group. Eleven rats were used in the normal group and 55 were models that were injected with cyclophosphamide to induce leukopenia. For the three laser treatment groups, 10...
July 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30100998/camp-mediated-autophagy-inhibits-dna-damage-induced-death-of-leukemia-cells-independent-of-p53
#6
Seham Skah, Nina Richartz, Eva Duthil, Karin M Gilljam, Christian Bindesbøll, Elin Hallan Naderi, Agnete B Eriksen, Ellen Ruud, Marta M Dirdal, Anne Simonsen, Heidi Kiil Blomhoff
Autophagy is important in regulating the balance between cell death and survival, with the tumor suppressor p53 as one of the key components in this interplay. We have previously utilized an in vitro model of the most common form of childhood cancer, B cell precursor acute lymphoblastic leukemia (BCP-ALL), to show that activation of the cAMP signaling pathway inhibits p53-mediated apoptosis in response to DNA damage in both cell lines and primary leukemic cells. The present study reveals that cAMP-mediated survival of BCP-ALL cells exposed to DNA damaging agents, involves a critical and p53-independent enhancement of autophagy...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30098520/femtosecond-laser-pulse-assisted-photoporation-for-drug-delivery-in-chronic-myelogenous-leukemia-cells
#7
Hemanth Naick Banavath, Srinivasa Rao Allam, Stella Sravanthi Valathati, Alok Sharan, Baskaran Rajasekaran
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder occurs in the pluripotent hematopoietic stem cell. Currently, first-generation tyrosine kinase inhibitor (TKI) imatinib is the mainstay for the treatment of CML. Second generation TKI's like ponatinib, dasatinib, nilotinib, and bafetinib were treated against resistant CML. However, several CML patients develop resistance towards all existing inhibitors. Curcumin (Curcuma longa) a plant-derived natural compound is an effective bioactive component against various cancers including CML...
July 31, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30097231/ionizing-radiation-induced-cellular-senescence-promotes-tissue-fibrosis-after-radiotherapy-a-review
#8
REVIEW
Hoang Quy Nguyen, Nhu Hanh To, Patricia Zadigue, Stéphane Kerbrat, Alexandre De La Taille, Sabine Le Gouvello, Yazid Belkacemi
Ionizing radiation-exposure induces a variety of cellular reactions, such as senescence and apoptosis. Senescence is a permanent arrest state of the cell division, which can be beneficial or detrimental for normal tissue via an inflammatory response and senescence-associated secretion phenotype. Damage to healthy cells and their microenvironment is considered as an important source of early and late complications with an increased risk of morbidity in patients after radiotherapy (RT). In addition, the benefit/risk ratio may depend on the radiation technique/dose used for cancer eradication and the irradiated volume of healthy tissues...
September 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/30096563/folate-conjugated-nanobubbles-selectively-target-and-kill-cancer-cells-via-ultrasound-triggered-intracellular-explosion
#9
Shuxin Shen, Ying Li, Yunbin Xiao, Zonglei Zhao, Chuanxi Zhang, Junfen Wang, Hairui Li, Feng Liu, Nvqin He, Ye Yuan, Yongkang Lu, Shengcun Guo, Yan Wang, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
With the rapid development of cancer-targeted nanotechnology, a variety of nanoparticle-based drug delivery systems have clinically been employed in cancer therapy. However, multidrug resistance significantly impacts the therapeutic efficacy. Physical non-drug therapy has emerged as a new and promising strategy. This study aimed to determine whether novel folate-nanobubbles (F-NBs), combined with therapeutic ultrasound (US), could act as a safe and effective physical targeted cancer therapy. Using folate-conjugated N-palmitoyl chitosan (F-PLCS), we developed novel F-NBs and characterised their physicochemical properties, internalization mechanism, targeting ability, therapeutic effects, and killing mechanism...
July 30, 2018: Biomaterials
https://www.readbyqxmd.com/read/30093492/micrornas-selectively-protect-hub-cells-of-the-germline-stem-cell-niche-from-apoptosis
#10
Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein, Hila Toledano
Genotoxic stress such as irradiation causes a temporary halt in tissue regeneration. The ability to regain regeneration depends on the type of cells that survived the assault. Previous studies showed that this propensity is usually held by the tissue-specific stem cells. However, stem cells cannot maintain their unique properties without the support of their surrounding niche cells. In this study, we show that exposure of Drosophila melanogaster to extremely high levels of irradiation temporarily arrests spermatogenesis and kills half of the stem cells...
August 9, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/30087707/knockdown-of-c1galt1-inhibits-radioresistance-of-human-esophageal-cancer-cells-through-modifying-%C3%AE-1-integrin-glycosylation
#11
Chuanyi Zhang, Xinzhou Deng, Li Qiu, Feng Peng, Shanshan Geng, Li Shen, Zhiguo Luo
Radiotherapy has played a limited role for the treatment of human esophageal cancer owing to the risk of tumor radioresistance. Core 1 β1, 3-galactosyltransferase (C1GalT1), which catalyzes the formation of core 1 O-glycan structures, is frequently overexpressed during tumorigenesis. However, the exact effects and mechanisms of C1GalT1 in the radioresistance of esophageal cancer remain unclear. In this study, Public databases and our data revealed that C1GalT1 expression was up-regulated in esophageal cancer tissues and was associated with poor survival...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30084935/cblb502-a-toll-like-receptor-5-agonist-offers-protection-against-radiation-induced-male-reproductive-system-damage-in-mice
#12
Hao Bai, Feifei Sun, Ganggang Yang, Lei Wang, Quanyi Zhang, Quanhai Zhang, Yiqun Zhan, Jiaojiao Chen, Miao Yu, Changyan Li, Ronghua Yin, Xiaoming Yang, Changhui Ge
CBLB502, a Toll-like receptor (TLR)5 agonist derived from Salmonella flagellin, was shown to protect mammalian hematopoietic and gastrointestinal systems from acute irradiation syndrome and to stimulate regeneration. To explore whether CBLB502 can improve testicular injuries caused by irradiation, mice were intraperitoneally injected with 0.2 mg/kg CBLB502 or vehicle control 30 min prior to applying 5.0 Gy ionizing radiation (IR). We observed these mice for the following 120 days and determined that CBLB502 pretreatment alleviated IR-induced oxidative stress, alleviated the distorted architecture of seminiferous tubules, reversed the decline of sperm quantity and quality, and helped recover male mouse fertility...
July 30, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/30083841/unexpected-dose-response-of-hacat-to-uvb-irradiation
#13
Rong-Shing Chang, Chi-Shuo Chen, Ching-Lung Huang, Chiu-Ting Chang, Yujia Cui, Wei-Ju Chung, Wun-Yi Shu, Chi-Shiun Chiang, Chun-Yu Chuang, Ian C Hsu
Application of high-dosage UVB irradiation in phototherapeutic dermatological treatments present health concerns attributed to UV-exposure. In assessing UV-induced photobiological damage, we investigated dose-dependent effects of UVB irradiation on human keratinocyte cells (HaCaT). Our study implemented survival and apoptosis assays and revealed an unexpected dose response wherein higher UVB-dosage induced higher viability. Established inhibitors, such as AKT- (LY294002), PKC- (Gö6976, and Rottlerin), ERK- (PD98059), P38 MAPK- (SB203580), and JNK- (SP600125), were assessed to investigate UV-induced apoptotic pathways...
August 6, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/30080989/silencing-of-telomere-binding-protein-adrenocortical-dysplasia-acd-homolog-enhances-radiosensitivity-in-glioblastoma-cells
#14
Francesca Polito, Maria Cucinotta, Rosaria V Abbritti, Anna Brogna, Stefano Pergolizzi, Chiara Tomasello, Flavio F Angileri, Rosa Maria Di Giorgio, Alfredo Conti, Domenico La Torre, Antonino Germanò, M'hammed Aguennouz
Adrenocortical dysplasia (ACD) is a shelterin protein involved in the maintenance of telomere length and in cancer radioresistance. This study investigated the expression profile of ACD in human gliomas and its role in radioresistance of glioma cells. The expression of ACD was analyzed in 62 different grades of glioma tissues and correlated with prognosis. A radioresistant cell line was generated from U87MG cells. For mechanistic studies, ACD was inhibited by small interfering RNA-targeting ACD and the effect on cell radioresistance, telomerase activity, cyclinD1, caspase-3, hTERT, and BIRC1 was evaluated...
July 20, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/30077650/multimodal-cancer-cell-therapy-using-au-fe-2-o-3-core-shell-nanoparticles-in-combination-with-photo-thermo-radiotherapy
#15
Vahid Hosseini, Mehri Mirrahimi, Ali Shakeri-Zadeh, Fereshteh Koosha, Behafarid Ghalandari, Shayan Maleki, Ali Komeili, S Kamran Kamrava
In this study, gold coated iron oxide nanoparticle (Au@Fe2 O3 NP) was synthesized in a core-shell structure. Photothermal and radiosensitization effects of Au@Fe2 O3 NPs were investigated on KB human mouth epidermal carcinoma cell line. Cell death and apoptosis were measured to study the effects of nanoparticles in combination with both radiotherapy (RT) and photothermal therapy (PTT). The KB cells were treated with Au@Fe2 O3 NPs (20 μg/ml; 4 h) and then received different treatment regimens of PTT and/or RT using laser (808 nm, 6 W/cm2 , 10 min) and/or 6 MV X-ray (single dose of 2 Gy)...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/30075024/radical-change-of-apoptotic-strategy-following-irradiation-during-later-period-of-embryogenesis-in-medaka-oryzias-latipes
#16
Takako Yasuda, Yuta Ishikawa, Noriko Shioya, Kazusa Itoh, Miyuki Kamahori, Kento Nagata, Yoshiro Takano, Hiroshi Mitani, Shoji Oda
Induction of apoptosis in response to various genotoxic stresses could block transmission of teratogenic mutations to progeny cells. The severity of biological effects following irradiation depends on the stage at which embryos are irradiated during embryogenesis. We reported previously that irradiation of medaka embryos 3 days post fertilization (dpf) with 10 Gy of gamma rays induced high incidence of apoptotic cells in the mid-brain, however, the embryos hatched normally and developed without apparent malformations...
2018: PloS One
https://www.readbyqxmd.com/read/30074096/protection-of-normal-cells-from-irradiation-bystander-effects-by-silica-flufenamic-acid-nanoparticles
#17
Giovanna Gomes Lara, Gracielle Ferreira Andrade, Marcelo Fernandes Cipreste, Wellington Marcos da Silva, Pedro Lana Gastelois, Dawidson Assis Gomes, Marcelo Coutinho de Miranda, Waldemar Augusto de Almeida Macedo, Maria Jose Neves, Edésia Martins Barros de Sousa
The development of a myriad of nanoparticles types has opened new possibilities for the diagnostics and treatment of many diseases, especially for cancer. However, most of the researches done so far do not focus on the protection of normal cells surrounding a tumor from irradiation bystander effects that might lead to cancer recurrence. Gap-junctions are known to be involved in this process, which leads to genomic instability of neighboring normal cells, and flufenamic acid (FFA) is included in a new group of gap-junction blockers recently discovered...
August 3, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30065996/solar-uv-damage-to-cellular-dna-from-mechanisms-to-biological-effects
#18
Leon H F Mullenders
Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose stress to cells and organisms by hindering DNA replication and transcription. In addition, solar UV also induces various types of oxidative DNA lesions and single strand DNA breaks. Relieving toxicity and maintenance of genomic integrity are of clinical importance in relation to erythema/edema and diseases such as cancer, neurodegeneration and premature ageing, respectively. Following solar UV radiation, a network of DNA damage response mechanisms triggers a signal transduction cascade to regulate various genome-protection pathways including DNA damage repair, cell cycle control, apoptosis, transcription and chromatin remodeling...
August 1, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/30065170/restraining-akt1-phosphorylation-attenuates-the-repair-of-radiation-induced-dna-double-strand-breaks-and-reduces-the-survival-of-irradiated-cancer-cells
#19
Klaudia Szymonowicz, Sebastian Oeck, Adam Krysztofiak, Jansje van der Linden, George Iliakis, Verena Jendrossek
The survival kinase protein kinase B (Akt) participates in the regulation of essential subcellular processes, e.g., proliferation, growth, survival, and apoptosis, and has a documented role in promoting resistance against genotoxic stress including radiotherapy, presumably by influencing the DNA damage response and DNA double-strand break (DSB) repair. However, its exact role in DSB repair requires further elucidation. We used a genetic approach to explore the consequences of impaired phosphorylation of Akt1 at one or both of its key phosphorylation sites, Threonine 308 (T308) or Serine 473 (S473), on DSB repair and radiosensitivity to killing...
July 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30064063/core-shell-poly-methyl-methacrylate-nanoparticles-covalently-functionalized-with-a-non-symmetric-porphyrin-for-anticancer-photodynamic-therapy
#20
Marco Ballestri, Enrico Caruso, Andrea Guerrini, Claudia Ferroni, Stefano Banfi, Marzia Gariboldi, Elena Monti, Giovanna Sotgiu, Greta Varchi
Photodynamic therapy (PDT) is an anticancer modality that exploits singlet oxygen and other reactive oxygen species, that are formed by selective irradiation of photosensitive molecules, to kill cancer cells. Most photosensitizers (PS) are hydrophobic and poorly soluble in water and several nanoplatforms have been established to achieve a more efficient delivery. Moreover, the covalent binding of the PS to nanoparticles could in principle reduce unwanted bleaching of the PS, while preserving its photodynamic activity...
July 25, 2018: Journal of Photochemistry and Photobiology. B, Biology
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