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Aging Review

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https://www.readbyqxmd.com/read/30541179/ruptured-renal-artery-aneurysm-in-a-pregnant-woman-case-report-and-literature-review
#1
Adriane Castro de Souza, Caio Henrique Yoshikatsu Ueda, Denise Hiromi Matsubara, João Raphael Zanlorensi Glir
Renal artery aneurysms (RAAs) are rare and usually asymptomatic; ∼ 90% of them are unilateral. Once diagnosed during pregnancy, they may rupture, presenting a high maternal-fetal risk. The present study reports the case of a 32-year-old pregnant woman with a 30-week gestational age and a ruptured unilateral RAA.
December 12, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/30541096/validated-screening-tools-for-the-assessment-of-cachexia-sarcopenia-and-malnutrition-a-systematic-review
#2
Janice Miller, Liz Wells, Ugochinyere Nwulu, David Currow, Miriam J Johnson, Richard J E Skipworth
Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients. Objectives: The aim was to systematically review validated screening tools for cachexia, sarcopenia, and malnutrition in adults and, if a combined tool is absent, make suggestions for the generation of a novel screening tool. Design: A systematic search was performed in Ovid Medline, EMBASE, CINAHL, and Web of Science...
December 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30541031/dna-damage-and-repair-in-the-female-germline-contributions-to-art
#3
Jacinta H Martin, R John Aitken, Elizabeth G Bromfield, Brett Nixon
BACKGROUND: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. If structural alterations result and are left unrepaired, they have the potential to cause mutations and propagate disease...
December 12, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30540924/asthma-control-in-the-quality-of-life-levels-of-asthmatic-patients-caregivers-a-systematic-review-with-meta-analysis-and-meta-regression
#4
REVIEW
Daniela Duarte Costa, Paulo Márcio Pitrez, Nathália Foltz Barroso, Cristian Roncada
OBJECTIVE: To perform a systematic review with meta-analysis and meta-regression to correlate the total scores of asthma control with the increase in the total scores of health-related quality of life levels of parents of asthmatic children. SOURCES: The search was carried out in the following databases: PubMed (MEDLINE); Embase and ScienceDirect (Elsevier); SciELO and LILACs (Bireme) in June 2017. The included studies assessed asthma control through the Asthma Control Questionnaire (ACQ), Asthma Control Test (C-ACT/ACT), and Global Initiative for Asthma (GINA) questionnaires, whereas the Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) was applied to assess the HRQoL of parents and family members...
December 9, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/30540862/-recent-advances-in-pediatric-non-hodgkin-lymphoma-report-on-a-retrospective-single-center-cohort-and-review-of-the-literature
#5
István Szegedi, Imre Gáspár, Katalin Gyurina, Zsuzsa Zele, Csongor Kiss
Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. The small number of patients hinders introduction of targeted therapies. Here we summarize principles and perspectives of pediatric NHL supported by results of a retrospective clinical survey. Twenty-five patients (21 boys, 4 girls; mean age: 11.9 years) were registered between 2009 and 2018: 11 Burkitt lymphomas, 4 diffuse large B-cell lymphomas, 5 T-cell lymphoblastic lymphomas, and 1-1 grey-zone lymphoma, anaplastic large-cell lymphoma, cutaneous T-cell lymphoma, angioimmunoblastic lymphoma, and Castleman disease...
December 12, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/30540831/clinical-outcomes-of-bortezomib-based-therapy-in-myeloma
#6
Faouzi Djebbari, Anandagopal Srinivasan, Grant Vallance, Sally Moore, Jaimal Kothari, Karthik Ramasamy
Bortezomib, a first generation proteasome inhibitor, is used in both newly diagnosed and relapsed myeloma settings. Considerable differences exist in the usage of bortezomib therapy in the clinical practice setting in comparison to clinical trial setting as well manufacturer's recommendations. These differences include route of administration (intravenous (iv) vs. subcutaneous (sc)), frequency from twice to once weekly, choice of alkylating agent used in combination with bortezomib (melphalan or cyclophosphamide), and choice of glucocorticoids (dexamethasone or prednisolone)...
2018: PloS One
https://www.readbyqxmd.com/read/30540729/-prognostic-value-of-lymph-node-ratio-lnr-in-patients-who-underwent-radical-gastrectomy
#7
Andrés Guevara Jabiles, Eloy Ruiz Figueroa, Francisco Berrospi Espinoza, Iván Chávez Passiuri, Frank Young Tabusso, Carlos Luque Vásquez, Ebert Poquioma Rojas, Raul Mantilla, Eduardo Payet Meza
The study objective was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer who underwent radical gastrectomy D2. MATERIALS AND METHODS: We reviewed retrospectively 498 medical records of patients with gastric cancer who were attended at the National Institute of Neoplastic Diseases (INEN) between 2008 and 2011and met the inclusion and exclusion criteria. They were distributed into 4 groups according to their LNR, LNR0: 0, LNR1: 0-0.13, LNR2: 0.14-0...
July 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/30540728/-gastric-polyps-experience-in-daniel-alcides-carrion-hospital-2014-2016
#8
Sebastián Prado-Núñez, Jin Marcos Yamamoto Kagami, Antoine Jeri-Yabar, Javiera Marín Leiva, Fernando Arévalo Suárez, Nilton Ríos Julca, Eduardo Monge
OBJECTIVE: The purpose of this study was to determine the prevalence of the different types of gastric polyps in the Daniel Alcides Carrión Hospital between the years of 2014 and 2016, and also define the endoscopic and histopathological characteristics of the lesions. MATERIALS AND METHODS: 7559 endoscopic reports were reviewed, in which 148 gastric polyps were found. The patients age and sex as well as the localization, number, size and macroscopic and microscopic aspects of the polyps were recorded...
July 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/30540722/vertebral-growth-around-distal-instrumented-vertebra-in-patients-with-early-onset-scoliosis-who-underwent-traditional-dual-growing-rod-treatment
#9
Tianhua Rong, Jianxiong Shen, Kenny Kwan, Jianguo Zhang, Yahan Wang, Shugang Li, Zheng Li, Chong Chen, Youxi Lin, Haining Tan
STUDY DESIGN: Retrospective radiographic study. OBJECTIVE: To investigate the growth of the vertebrae around distal instrumented vertebra (DIV) in patients with early-onset scoliosis (EOS) who underwent dual growing rod (DGR) treatment. SUMMARY OF BACKGROUND DATA: Previous studies indicated that DGR was likely to preserve or even stimulate the spinal growth. However, report pertaining to the effect of growing rod on the growth of individual vertebral body is rare...
December 11, 2018: Spine
https://www.readbyqxmd.com/read/30540720/pre-operative-assessment-of-bone-quality-in-spine-deformity-surgery-correlation-with-clinical-practice-and-published-recommendations
#10
Tomas K Kuprys, Leah M Steinmetz, Charla R Fischer, Themistocles S Protopsaltis, Peter G Passias, Jeffrey A Goldstein, John A Bendo, Thomas J Errico, Aaron J Buckland
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The goals of this study were to (1) evaluate pre-operative bone quality assessment and intervention practice over time and (2) review the current evidence for bone evaluation in spine fusion surgery. SUMMARY OF BACKGROUND DATA: Deformity spine surgery has demonstrated improved quality of life in patients however its cost has made it controversial. If pre-operative bone quality can be optimized then potentially these treatments could be more durable however, at present, no clinical practice guidelines have been published by professional spine surgical organizations...
December 11, 2018: Spine
https://www.readbyqxmd.com/read/30540697/long-term-outcomes-of-ossiculoplasty-with-and-without-an-intact-malleus
#11
Joshua Cody Page, Matthew D Cox, DeAnne King, Tristan Allsopp, John L Dornhoffer
OBJECTIVE: To compare long-term hearing outcomes following ossiculoplasty with cartilage tympanoplasty with (M) and without (M) the malleus present. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: One twenty-six patients (18-88 yr of age) undergoing ossiculoplasty with tympanoplasty or tympanomastoidectomy using cartilage tympanic membrane grafts from 1998 to 2012 with at least 5 years of documented postoperative follow-up...
January 2019: Otology & Neurotology
https://www.readbyqxmd.com/read/30540684/the-titration-and-tolerability-of-sacubitril-valsartan-for-patients-with-heart-failure-in-clinical-practice
#12
Amy X Du, Cynthia M Westerhout, Finlay A McAlister, Miriam Shanks, Gavin Y Oudit, D Ian Paterson, Mikael Hanninen, Jissy Thomas, Justin A Ezekowitz
Little is known about the dosing and tolerability of sacubitril/valsartan (LCZ696; Entresto™, Quebec, Canada) in a non-clinical trial population. This study was conducted to evaluate the use and tolerability of sacubitril/valsartan in patients followed at a multidisciplinary heart failure clinic. We performed a retrospective chart review of 126 patients with heart failure, initiated on sacubitril/valsartan, and seen at a specialty heart failure clinic between August 1, 2015 and August 1, 2017. We defined the target dose of sacubitril/valsartan as 200 mg B...
December 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/30540656/a-quartet-of-elastic-stable-intramedullary-nails-for-more-challenging-pediatric-femur-fractures
#13
Michael T Busch, Crystal A Perkins, Brian T Nickel, Daniel J Blizzard, Samuel Clifton Willimon
INTRODUCTION: The insertion of 2 elastic stable intramedullary nails (ESINs) is a common treatment for pediatric femur fractures. However, the use of this technique in length-unstable or metadiaphyseal fractures has historically been associated with higher complication rates. To improve stability, the addition of a third ESIN has been assessed biomechanically and clinically, but the addition of a fourth nail has only been evaluated biomechanically. The purpose of this study is to report our surgical technique and radiographic outcomes using a quartet of ESINs in pediatric femur fractures...
January 2019: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/30540612/observational-study-examining-the-association-of-baseline-frailty-and-postcardiac-surgery-delirium-and-cognitive-change
#14
Yohei Nomura, Mitsunori Nakano, Brian Bush, Jing Tian, Atsushi Yamaguchi, Jeremy Walston, Rani Hasan, Kenton Zehr, Kaushik Mandal, Andrew LaFlam, Karin J Neufeld, Vidyulata Kamath, Charles W Hogue, Charles H Brown
BACKGROUND: Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity and mortality has been reported to be higher for frail patients after cardiac surgery compared to nonfrail patients. However, the cognitive consequences of frailty after cardiac surgery have not been well described. In this study, we examined the hypothesis that baseline frailty would be associated with postoperative delirium and cognitive change at 1 and 12 months after cardiac surgery...
December 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30540591/reason-and-timing-for-conversion-to-sternotomy-in-robotic-assisted-coronary-artery-bypass-grafting-and-patient-outcomes
#15
Nickolas K Christidis, Stephanie A Fox, Stuart A Swinamer, Rodrigo Bagur, Kumar Sridhar, Shahar Lavi, Ivan Iglesias, Daniel Bainbridge, Philip M Jones, Christopher C Harle, Michael W A Chu, Patrick Teefy, Bob B Kiaii
OBJECTIVE: Conversion to sternotomy is a primary bailout method for robotically assisted coronary artery bypass grafting procedures. The aims of this study were to identify the primary reasons for conversion from robotically assisted coronary artery bypass grafting to sternotomy and to evaluate the in-hospital outcomes in such patients. METHODS: Prospectively collected data from February 2004 to April 2017 were reviewed for 72 patients (56 men; mean age = 63.8 years) who required conversion to sternotomy during a robotically assisted coronary artery bypass grafting procedure with planned endoscopic left internal thoracic artery harvest and anastomosis to the left anterior descending on the beating heart...
December 5, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/30540573/surgical-algorithmic-approach-to-facilitate-primary-closure-of-the-anterolateral-thigh-flap-donor-site-in-head-and-neck-reconstruction
#16
Kuo-Shu Hung, Szu-Han Chen, Wei-Chen Chen, Wan-Ling Tseng, Yao-Chou Lee
BACKGROUND: Use of the anterolateral thigh (ALT) flap has gained popularity in head and neck reconstruction. However, donor sites that cannot achieve primary closure are reported to have poorer functional and aesthetic outcomes. Therefore, we propose an algorithm to facilitate primary closure of the donor site. METHODS: Since May 2013, when an attempt at donor site direct closure failed, we have used a VY advancement flap or a propeller flap for primary closure of the donor site, using the remnant lateral thigh perforator or nearby medial thigh perforator...
December 6, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/30540346/association-of-screening-and-treatment-for-preoperative-asymptomatic-bacteriuria-with-postoperative-outcomes-among-us-veterans
#17
Jaime Gallegos Salazar, William O'Brien, Judith M Strymish, Kamal Itani, Westyn Branch-Elliman, Kalpana Gupta
Importance: Limited data suggest that screening for asymptomatic bacteriuria (ASB) prior to nonurologic procedures is not useful. However, high-quality evidence to support consensus recommendations and influence clinical practice is lacking. Objective: To characterize the association between detection and treatment of preoperative ASB and postoperative outcomes. Design, Setting, and Participants: This retrospective cohort study involved patients, predominantly male veterans, who underwent surgical procedures in 109 US facilities within the US Department of Veterans Affairs health care system from October 1, 2008, to September 30, 2013...
December 12, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/30540343/association-of-noninfectious-pneumonia-with-ustekinumab-use
#18
Allen Brinker, Carmen Cheng, Vicky Chan
Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA. Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Design, Setting, and Participants: This retrospective analysis of postmarketing (spontaneous) case reports reviewed the FDA Adverse Event Reporting System (FAERS) and the PubMed databases from September 25, 2009, through November 20, 2017...
December 12, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30540112/socioeconomic-and-nutritional-characteristics-of-children-and-adolescents-with-sickle-cell-anemia-a-systematic-review
#19
Amanda Cristina da Silva de Jesus, Tulio Konstantyner, Ianna Karolina Véras Lôbo, Josefina Aparecida Pellegrini Braga
OBJECTIVE: To describe the socioeconomic and nutritional characteristics of children and adolescents with sickle cell anemia. DATA SOURCES: The present study is a systematic literature review based on published scientific articles. The searches were carried out using the electronic database of the National Library of Medicine, National Institutes of Health- PubMed. Two searches of articles published in the last 20years and without limitation of language were carried out...
October 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/30540101/squamous-cell-carcinoma-of-the-tongue-in-patients-older-than-45-years
#20
Constantino Ledesma-Montes, Juan Carlos Hernández-Guerrero, Marco Antonio Durán-Padilla, Avissai Alcántara-Vázquez
This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Complete data from 60 cases were evaluated. They were more common in males (mean age = 63...
December 6, 2018: Brazilian Oral Research
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