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Aging And Review

Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, Julie Brown
BACKGROUND: Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. OBJECTIVES: To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies. METHODS: We searched the Cochrane Database of Systematic Reviews (5 January 2018) for reviews of treatment/management for women with GDM...
August 14, 2018: Cochrane Database of Systematic Reviews
Zuzana Sipkova, Elizabeth A Insull, Joel David, Helen E Turner, Shay Keren, Jonathan H Norris
OBJECTIVES: The current first-line treatment for management of active thyroid eye disease (TED) is high-dose intravenous corticosteroids, which have the potential for serious adverse effects. Our aim was to evaluate the effect of steroid-sparing agents (SSAs) in patients with moderate-to-severe active TED, using methotrexate as first-line. METHODS: Presented is a retrospective, four-year, single-centre, consecutive case series of patients with moderate-to-severe TED treated using the Oxford protocol...
August 13, 2018: Clinical Endocrinology
Julie Monteagudo, Catherine M Dickinson, Michelle Wakeley, Shamlal Mangray, Hale E Wills, Francois I Luks
INTRODUCTION:  Rhabdomyomatous dysplasia (RD) is a pathologic finding in CPAMs that was incorrectly attributed to their malignant potential. The increasing recognition of extrathoracic (intradiaphragmatic and intraabdominal) congenital pulmonary airway malformations (CPAMs) offers a clue to the origin of RD. We hypothesize that the presence of RD is related to the CPAM's anatomic location. MATERIALS AND METHODS:  Retrospective review was performed of all children who underwent resection of a CPAM during a 10-year period...
August 13, 2018: European Journal of Pediatric Surgery
Masahiro Kitami
PURPOSE: To examine the presence of ridge of plicae palmatae (RPP) in pediatric population and evaluate its depiction rate and appearance on magnetic resonance imaging (MRI). MATERIALS AND METHODS: Consecutive pelvic MRI examinations of female patients aged 0-19 years between January 2005 and April 2017 were retrospectively reviewed. Patients with underlying diseases affecting the uterus and whose MRI data were not available on the picture archiving and communication system were excluded...
August 8, 2018: Clinical Imaging
B Lévesque, V Huppé, M Dubé, R C Fachehoun
OBJECTIVES: The 'Mon habitat: plus qu'un simple toit' (MHPQST) survey was designed to identify public health risks and priorities for local decision makers in relation to housing. The aims of the present study were to describe the exposure of households to indoor air contaminants and to verify the relationship between these contaminants and respiratory symptoms/diseases. STUDY DESIGN: This is a cross-sectional study. METHODS: MHPQST was conducted in Baie-Saint-Paul, a French Canadian municipality (7000 inhabitants) using a protocol adapted from the 'Large Analysis and Review of European Housing and Health Status' study performed in Europe in 2002-2003...
August 10, 2018: Public Health
Nicole A Guitar, Denise M Connelly, Lindsay S Nagamatsu, Joseph B Orange, Susan W Muir-Hunter
Executive function deficit is an indicator of Alzheimer's-type dementia and manifests as disruptions of attentional control, memory, cognitive flexibility, planning, and reasoning, among other cognitive problems. Physical exercise is suggested to have a protective effect on global cognition with aging. However, whether it influences executive function in people living with Alzheimer's-type dementia specifically is unknown. The current systematic review examined the efficacy of physical exercise on executive function performance in community-dwelling older adults living with Alzheimer's-type dementia...
August 10, 2018: Ageing Research Reviews
In Soo Kim, Donghwi Park, Jin Young Ko, Ju Seok Ryu
OBJECTIVE: To evaluate whether medial knee support in seating systems aggravates hip displacement in children with cerebral palsy. DESIGN: Retrospective chart review SETTING: Rehabilitation department of tertiary university hospital PARTICIPANTS: Children with cerebral palsy using seating systems (Intervention group, n=42; mean age 6.86y) and using regular wheelchairs (Control group, n=34; mean age 8.15y). INTERVENTIONS: The intervention group was provided with a seating system with medial knee support...
August 10, 2018: Archives of Physical Medicine and Rehabilitation
Sabrina Fernandez
When I was young, I remember my parents used to play the Beatles song "Here Comes the Sun" in the morning on the old record player. My mother helped hire the first band director at my middle school, and my father played opera in the car on my way to elementary school. I dabbled with different instruments, and played trumpet (cornet actually), flute, piccolo, oboe, English horn, and Ukulele. I also sang in several choirs and still sing today. What did all this musical influence do to my developing brain? This article reviews some of the existing evidence about music and brain development, to make a case for exposing children to music at an early age and supporting school music programs...
August 1, 2018: Pediatric Annals
Jennifer J Thomas, Olivia B Wons, Kamryn T Eddy
PURPOSE OF REVIEW: Avoidant/restrictive food intake disorder (ARFID) was added to the psychiatric nomenclature in 2013, but little is known about its optimal treatment. The purpose of this article is to review the recent literature on ARFID treatment and highlight a novel cognitive-behavioral approach, currently under study. RECENT FINDINGS: The current evidence base for ARFID treatment relies primarily on case reports, case series, and retrospective chart reviews, with only a handful of randomized controlled trials in young children...
August 9, 2018: Current Opinion in Psychiatry
Maki Kawasaki, Naoko Arata, Yoshihiro Ogawa
PURPOSE OF REVIEW: Type 2 diabetes and obesity during childhood, puberty, and adulthood have become more common. This trend presents a global problem in terms of public health and health economics. Associations between intrauterine exposure to hyperglycemia, obesity, and abnormal glucose tolerance (AGT) in offspring have been reported in populations at high risk of diabetes such as Pima Indians, but these associations have not been established in other groups. In this review, we summarize the evidence on obesity and AGT in the offspring of mothers with diabetes...
August 9, 2018: Current Opinion in Obstetrics & Gynecology
Hannah Lewis, Robert Egerman, Amir Kazory, Maryam Sattari
Diabetes in pregnancy increases the risk of adverse maternal, obstetric, fetal, and neonatal outcomes. Internists can reduce these risks by optimizing glycemic control before conception and providing effective counseling on strategies to reduce the risks associated with pregnancy and diabetes. Routine screening of reproductive-age women with diabetes should include a comprehensive physical examination and laboratory tests to identify at-risk patients and begin strategic management. A review of medications for teratogenic potential is also needed...
August 2018: Cleveland Clinic Journal of Medicine
F Crawford, G Cezard, M Chappell
AIMS: Diabetes guidelines recommend screening for the risk of foot ulceration but vary substantially in the underlying evidence base. Our purpose was to derive and validate a prognostic model of independent risk factors for foot ulceration in diabetes using all available individual patient data from cohort studies conducted worldwide. METHODS: We conducted a systematic review and meta-analysis of individual patient data from 10 cohort studies of risk factors in the prediction of foot ulceration in diabetes...
August 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
K Simpson, P Chapman, A Klag
OBJECTIVES: To determine the incidence of relapse after discharge from the hospital in dogs with a diagnosis of presumed primary immune-mediated thrombocytopenia, risk factors associated with relapse and whether or not indefinite use of immunosuppressive medication influences risk of relapse. MATERIALS AND METHODS: Medical records from August 2007 through July 2016 were reviewed to identify dogs with a diagnosis of presumed primary immune-mediated thrombocytopenia...
August 13, 2018: Journal of Small Animal Practice
Anne Ducassou, Laetitia Padovani, Leonor Chaltiel, Stéphanie Bolle, Jean-Louis Habrand, Line Claude, Christian Carrie, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Stéphane Supiot, Charlotte Demoor-Goldschmidt, Valerie Bernier-Chastagner, Aymeri Huchet, Julie Leseur, Elisabeth Le Prise, Christine Kerr, Gilles Truc, Tan Dat Nguyen, Anne-Isabelle Bertozzi, Didier Frappaz, Sergio Boetto, Annick Sevely, Fatima Tensaouti, Anne Laprie
PURPOSE: The objective of this study was to analyze survival and prognostic factors for children, adolescents, and young adults treated with postoperative radiation therapy (RT) for intracranial ependymoma. METHODS AND MATERIALS: Between 2000 and 2013, 202 patients aged ≤25 years were treated in the 13 main French pediatric RT reference centers. Their medical records were reviewed for information, treatments received, and survival rates. All children had received postoperative RT- conformal, intensity modulated, or proton beam...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Stuart B Murray, Daniel S Quintana, Katharine L Loeb, Scott Griffiths, Daniel Le Grange
BACKGROUND: To determine the impact of specialized treatments, relative to comparator treatments, upon the weight and psychological symptoms of anorexia nervosa (AN) at end-of-treatment (EOT) and follow-up. METHODS: Randomized controlled trials (RCTs) between January 1980 and December 2017 that reported the effects of at least two treatments on AN were screened. Weight and psychological symptoms were analyzed separately for each study. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed, and studies were assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria and Cochrane risk of bias tool...
August 13, 2018: Psychological Medicine
Duraiswamy Basavan, Nehru Sai Suresh Chalichem, Suresh K Mohan Kumar
As the global aged population is increasing tremendously, time has come to concentrate on tail end life stage diseases. Alzheimer's disease (AD) is one such disease whose origin is an enigmatic, impacts later stage of life drastically due to irreparable damage of cognition. The characteristic feature of the disease is the accumulation of neurotoxic amyloid-beta (Aβ) and hyper phosphorylated Tau protein as fibrillary tangles. Several research reports obtained from in vitro and in vivo studies proved the efficacy of herbals in culminating neurodegenerative changes of AD by acting through various molecular pathways at various stages...
August 12, 2018: Current Drug Targets
Leigh Davis, Joshua S Murphy, Kenneth A Shaw, Kaitlin Cash, Dennis P Devito, Michael L Schmitz
BACKGROUND: Orthotic treatment for adolescent idiopathic scoliosis is a mainstay in nonoperative treatment to prevent progressive spinal deformity. OBJECTIVE: To determine the effectiveness of the Providence orthosis in the treatment of adolescent idiopathic scoliosis. STUDY DESIGN: Retrospective review. METHODS: Patients treated with a Providence orthosis for adolescent idiopathic scoliosis were reviewed. Inclusion criteria included the following: age of 10-18 years; curve magnitude of 25°-40°; Risser stage of 0-2; and, if female, <1 year post menarche at the time of brace initiation...
August 13, 2018: Prosthetics and Orthotics International
Tom Matthews, Victoria Holt, Senem Sahin, Amelia Taylor, David Griksaitis
This research investigated the prevalence of looked-after and adopted young people within a case file review of 185 young people referred to a UK gender identity development service over a 2-year period (1 April 2009 to 1 April 2011). Data were extracted from referral letters, clinical notes and clinician letters. Looked-after young people were found to represent 4.9% of referrals in this cohort, which is significantly higher than within the English general population (0.58%). Adopted young people represented 3...
August 11, 2018: Clinical Child Psychology and Psychiatry
Ming-Hui Li, Hao-Qiang Zhang, Ya-Jie Lu, Peng Gao, Hai Huang, Yong-Cheng Hu, Zhen Wang
Gorham-Stout disease (GSD) is an extremely rare bone condition of unknown etiology characterized by spontaneous and progressive resorption of bones. GSD can occur at any age and is not related to gender, genetic inheritance, or race. Any part of the skeleton can be affected and the symptoms correlate with the sites involved. The diagnosis of GSD is established based on the combination of clinical, radiologic, and histologic features after excluding other diseases. Because of its rarity, current knowledge is limited to case reports and there is no agreement on the best strategy for treatment...
August 12, 2018: Orthopaedic Surgery
Elham Hosseini, Mohsen Janghorbani
BACKGROUND: There is an ongoing discussion about the optimal diagnostic strategy for gestational diabetes mellitus (GDM). OBJECTIVE: To assess the magnitude of the association between GDM diagnosed with the one-step (International Association of Diabetes and Pregnancy Study Groups criteria) or two-step (Carpenter and Coustan criteria) approach and selected adverse pregnancy outcomes. SEARCH STRATEGY: Five electronic databases were searched up to October 2017 using Medical Subject Headings for each adverse outcome combined with the term "gestational diabetes...
August 12, 2018: International Journal of Gynaecology and Obstetrics
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