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Neutrophils to lymphocytes ratio

Stamatis Karakonstantis, Niki Gryllou, George Papazoglou, Charalampos Lydakis
INTRODUCTION: Eosinopenia has been previously investigated as a marker to differentiate infectious from non-infectious diagnoses and as a prognostic marker. Most previous studies were conducted in intensive care unit patients. Our study focuses on the value of eosinopenia in patients admitted to the Internal Medicine department. METHODS: We retrospectively analyzed 271 consecutive patients with infection and 31 patients presenting with fever or inflammatory syndrome and a non-infectious diagnosis...
November 1, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
I C Hasselbalch, H B Søndergaard, N Koch-Henriksen, A Olsson, H Ullum, F Sellebjerg, A B Oturai
Background: Subtypes of white blood cell counts are known biomarkers of systemic inflammation and a high neutrophil-to-lymphocyte ratio (NLR) has been associated with several autoimmune diseases. Few studies have investigated the NLR in multiple sclerosis (MS). Objective: To examine the association between NLR, MS and disability measured by the MS severity score (MSSS). Methods: Patients were included from the Danish Multiple Sclerosis Biobank...
October 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Quhong Song, Yisong Li, Yanan Wang, Chenchen Wei, Junfeng Liu, Ming Liu
BACKGROUND AND PURPOSE: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of hemorrhagic transformation (HT) after acute ischemic stroke (AIS). METHODS: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission...
December 4, 2018: Current Neurovascular Research
Yeona Cho, Jun Won Kim, Hong In Yoon, Chang Geol Lee, Ki Chang Keum, Ik Jae Lee
BACKGROUND: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR) in patients treated with definitive radiotherapy (RT) for head and neck cancer. METHODS: We retrospectively analyzed 621 patients who received definitive RT for nasopharyngeal, oropharyngeal, hypopharyngeal, and laryngeal cancer. An NLR cut-off value of 2.7 was identified using a receiver operating characteristic curve analysis, with overall survival (OS) as an endpoint...
December 3, 2018: Journal of Clinical Medicine
Guifang Guo, Xiuxing Chen, Wenzhuo He, Haohua Wang, Yixing Wang, Pili Hu, Yuming Rong, Lei Fan, Liangping Xia
PURPOSE: To establish three novel prognostic nomograms with inflammatory factors for advanced colorectal cancer (ACRC), right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) according to real world data. MATERIALS AND METHODS: ACRC patients receiving medicine therapy from January 1st, 2005 to September 31th, 2015 in Sun Yat-sen University Cancer Center were enrolled. Inflammatory indicators such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were analyzed for establishing nomograms predicting overall survival (OS)...
2018: PloS One
Guoming Hu, Feng Xu, Kefang Zhong, Shimin Wang, Qi Xu, Liming Huang, Pu Cheng
BACKGROUND: Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains controversial. Hence, we performed this meta-analysis to better understand the role of preoperative circulating NLR in prognosis prediction for primary BC patients undergoing RC...
December 3, 2018: World Journal of Urology
Thang Thanh Phan, Toan Trong Ho, Hue Thi Nguyen, Hang Thuy Nguyen, Thu Bich Tran, Son Truong Nguyen
Purpose: To identify and clarify the roles of inflammatory markers in prognosis for advanced non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitor (TKI). Patients and methods: One hundred and twelve adenocarcinoma, clinical stage IV, NSCLC patients with either EGFR exon 19 deletion (E19del) or EGFR exon 21 L858R substitution mutation (L858R) were selected for this study. The blood cell count at different stages of treatment was used to calculate the inflammatory markers...
2018: International Journal of General Medicine
Marina Alessandra Pereira, Marcus Fernando Kodama Pertille Ramos, Andre Roncon Dias, Sheila Friedrich Faraj, Cinthya Dos Santos Cirqueira, Evandro Sobroza de Mello, Bruno Zilberstein, Venancio Avancini Ferreira Alves, Ulysses Ribeiro
Objective: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU. Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent...
October 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Nikoletta Dimitriou, Evangelos Felekouras, Ioannis Karavokyros, Andreas Alexandrou, Emmanuel Pikoulis, John Griniatsos
BACKGROUND: The incidence of colorectal cancer (CRC) is expected to increase by 80% in year 2035. Even though advantages in treatment of CRC have being made over the last decades, the outcome remains poor. Recently, several inflammatory markers including pretreatment neutrophil to lymphocyte ratio (NLR), have being used as prognostic factors, since host inflammatory response to cancer is believed to determine disease progression. The aim of this study is to evaluate the prognostic significance of pretreatment NLR, in terms of overall survival (OS), 5-year survival, disease-free survival (DFS) and recurrence, in CRC patients who underwent curative resection...
December 3, 2018: BMC Cancer
Romain Niessen, Benoit Bihin, Maximilien Gourdin, Jean-Cyr Yombi, Olivier Cornu, Patrice Forget
BACKGROUND: Elderly patients are at high risk for postoperative complications and increased mortality after hip fracture (HF) surgery due to frailty and co-morbidities. The prediction of postoperative outcome could be used for clinical decision making. A reliable score to predict postoperative mortality after HF surgery in this sub-population remains unavailable. METHODS: A single-centre retrospective cohort study was performed in 782 patients who were operated on for HF...
December 3, 2018: BMC Anesthesiology
Jin-Sun Park, Kyoung-Woo Seo, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
The ratio between the absolute number of neutrophils and the number of lymphocytes (NLR) has recently emerged as a potential new biomarker predicting worse clinical conditions ranging from infectious disease to cardiovascular disease. Prognostic significance of NLR in patients with ST-elevation myocardial infarction (STEMI) is not established. This study aimed to investigate prognostic impact of NLR in patients with STEMI.We analyzed the data and clinical outcomes of 30-day survivors with STEMI who received successful coronary intervention from 2006 to 2010...
November 2018: Medicine (Baltimore)
Jayita Basu, Chhanda Datta, Subhankar Chowdhury, Debasmita Mandal, Nandan Kumar Mondal, Amlan Ghosh
AIMS: Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence of GDM among pregnant women visiting antenatal clinic of a tertiary-care hospital of Kolkata, India; possible mechanism of disease pathogenesis and potency of associated parameters as disease biomarkers were also explored. METHODS: 735 pregnant women were screened for GDM according to DIPSI (Diabetes in Pregnancy Study Group India) guideline and risk-factors were analyzed...
December 3, 2018: Experimental and Clinical Endocrinology & Diabetes
Takao Mochimaru, Soichiro Ueda, Yusuke Suzuki, Koichiro Asano, Koichi Fukunaga
No abstract text is available yet for this article.
November 30, 2018: Annals of Allergy, Asthma & Immunology
Stéphane Renaud, Joseph Seitlinger, David St-Pierre, Richard Garfinkle, Yaseen Al Lawati, Francesco Guerrera, Enrico Ruffini, Pierre-Emmanuel Falcoz, Gilbert Massard, Lorenzo Ferri, Jonathan Spicer
OBJECTIVES: Neutrophil to lymphocyte ratio (NLR) has been shown to be a promising biomarker in several cancers. Prognostic biomarkers are still needed to define good candidates for lung metastasectomy for colorectal cancer. We aimed to evaluate the role of NLR. METHODS: Data from 574 patients who underwent lung metastasectomy for colorectal cancer in 3 departments of thoracic surgery from 2004 to 2014 were retrospectively reviewed. Overall survival (OS) and the time to pulmonary recurrence (TTPR) were the main end points...
December 1, 2018: European Journal of Cardio-thoracic Surgery
B Losada, J A Guerra, D Malón, C Jara, L Rodriguez, S Del Barco
PURPOSE: Several studies have found an association between peripheral inflammatory cells and outcome. However, no study has explored their impact specifically in elderly patients. We have retrospectively examined pretreatment peripheral neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and neutrophil/monocyte ratio (NMR) in 113 elderly breast cancer patients and correlated our findings with disease-free survival (DFS) and overall survival (OS)...
November 30, 2018: Clinical & Translational Oncology
Amr Shaaban Hanafy, Mohamed Hesham Monir, Hany Abdel Malak, Mohamed Desoky Aiad
Background: There is a need to use noninvasive markers in refining the management of ulcerative colitis to reduce the number of unnecessary colonoscopies, which facilitates the follow-up of activity and the response to treatment. Aim: Postulation of a sensitive, specific, simple and noninvasive score to monitor disease activity in ulcerative colitis. Methods: A case-control study was conducted: 168 patients with ulcerative colitis, 40 healthy individuals, and 60 patients for validation...
November 2018: Inflammatory Intestinal Diseases
Ian Nora, Ravi Shridhar, Jamie Huston, Kenneth Meredith
Background: Accurate predictors of locally advanced and recurrence disease in patients with gastrointestinal cancer are currently lacking. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have emerged as possible markers for predicting recurrence in these patients. In this study, we sought to evaluate the utility of NLR and PLR in predicting the presence of regional nodal disease, metastasis and systemic recurrence in patients with gastrointestinal malignancies...
October 2018: Journal of Gastrointestinal Oncology
Joo Ho Lee, Changhoon Song, Sung-Bum Kang, Hye Seung Lee, Keun-Wook Lee, Jae-Sung Kim
BACKGROUND: This study evaluated the efficacy of haematological markers for predicting the pathological complete regression (pCR) during and after neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). PATIENTS AND METHODS: A total of 297 patients with LARC underwent neoadjuvant CRT followed by surgical resection. Complete blood counts (CBCs) were performed before CRT, 3 weeks after the start of CRT (intra-therapy), and 4 weeks after CRT...
December 2018: Anticancer Research
Martin Svaton, Milada Zemanova, Jana Skrickova, Lenka Jakubikova, Vitezslav Kolek, Juraj Kultan, Leona Koubkova, Alzbeta Bejckova, Frantisek Salajka, Michal Hrnciarik, Bohuslav Melichar, David Vrana, Marek Konecny, Renata Chloupkova, Milos Pesek
AIM: To investigate potential associations between clinical and standard peripheral blood biomarkers and clinical outcome in patients with non-small cell lung cancer (NSCLC) treated with nivolumab. PATIENTS AND METHODS: A total of 120 patients with advanced NSCLC treated at seven comprehensive cancer care centers were analyzed in this national retrospective study. Survival statistics were evaluated using the Kaplan-Meier method and Cox analysis. RESULTS: Among clinical parameters, histology was significantly associated with progression-free survival...
December 2018: Anticancer Research
Jian Wu, Xueyan Zhang, Hongyang Liu, Naizhou Guo, Qiuwei Pan, Yijin Wang
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection contributes to substantial proportion of acute liver injury. This study aims to evaluate the ability of red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and RDW to lymphocyte ratio (RLR) in predicating the development of liver failure following HEV infection and the prognosis. METHODS: 93 healthy controls, 152 current/recent HEV infected patients without liver failure (HEV-non-LF) and 62 HEV patients who developed liver failure (HEV-LF) were enrolled in the study...
November 28, 2018: Clinical Biochemistry
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