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Neutrophils to lymphocytes ratio

Zhang F, Tao C, Hu X, Qian J, Li X, You C, Jiang Y, Yang M
BACKGROUND: Inflammatory response plays a vital role in the pathological mechanism of intracerebral hemorrhage. It has been recently reported that neutrophil to lymphocyte ratio (NLR) could represent a novel composite inflammatory marker for predicting the prognosis of intracranial hemorrhage (ICH). However, in considering that surgical evacuation effects on the initiation of inflammatory responses. Thus, the relationship between NLR and functional outcome of ICH patients after surgical treatment is still controversial...
August 10, 2018: World Neurosurgery
Kohei Nakamura, Kentaro Nakayama, Nagisa Tatsumi, Toshiko Minamoto, Tomoka Ishibashi, Kaori Ohnishi, Hitomi Yamashita, Ruriko Ono, Hiroki Sasamori, Sultana Razia, Shanta Kamrunnahar, Masako Ishikawa, Satoru Kyo
The aim of the present study was to assess the prognostic significance of the pre-treatment neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and other clinicopathological characteristics in patients with non-surgically treated uterine cervical carcinoma. The correlations of clinicopathological characteristics with overall and progression-free survival were determined in 98 Japanese patients who received non-surgical treatment for uterine cervical carcinoma between January 1997 and July 2013...
August 2018: Molecular and Clinical Oncology
Xiaoyan Chen, Jinguo Liu, Mengchan Zhu, Bijie Hu, Fengxi Bai, Wenting Jin, Jian Zhou, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Progranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). OBJECTIVES: The study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD. METHODS: The plasma progranulin levels were measured and compared in patients with AECOPD (n = 52), patients with stable COPD (n = 56) and healthy controls (n = 36)...
August 12, 2018: Clinical Respiratory Journal
Mitsuru Tashiro, Suguru Yamada, Fuminori Sonohara, Hideki Takami, Masaya Suenaga, Masamichi Hayashi, Yukiko Niwa, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Tsutomu Fujii, Yasuhiro Kodera
BACKGROUND: The association between neoadjuvant therapy (NAT) and nutritional status in pancreatic cancer (PC) is unknown. OBJECTIVE: The aim of this study was to assess the impact of NAT on nutritional status. METHODS: Overall, 161 patients who underwent pancreatoduodenectomy for PC between August 2010 and March 2017 were enrolled and were divided into two groups: the neoadjuvant group (NAG; n = 67) and the control group (CG; n = 94)...
August 10, 2018: Annals of Surgical Oncology
Jason Yongsheng Chan, Zewen Zhang, Winston Chew, Grace Fangmin Tan, Chloe Liwen Lim, Lingyue Zhou, Wei Lin Goh, Eileen Poon, Nagavalli Somasundaram, Sathiyamoorthy Selvarajan, Kesavan Sittampalam, Francis Chin, Jonathan Teh, Mann Hong Tan, Khee Chee Soo, Melissa Teo, Mohamad Farid, Richard Quek
Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts at diagnosis and/or metastatic relapse were retrospectively examined. An optimal cutoff for NLR-high (>2.5) in predicting overall survival (OS) was determined using receiver operating curve analyses...
August 10, 2018: Scientific Reports
Giuseppe Luigi Banna, Francesco Passiglia, Francesca Colonese, Stefania Canova, Jessica Menis, Alfredo Addeo, Antonio Russo, Diego Luigi Cortinovis
The identification of reliable predictive biomarkers of efficacy or resistance to immune-oncology (I-O) agents is a major issue for translational research and clinical practice. However, along with PDL1 and molecular features other clinical, radiological and laboratory factors can be considered for the selection of those patients who would not be the best candidate for immune-checkpoint inhibitors (ICPIs). We examined these factors, emerging from the results of currently available studies in non-small cell lung cancer (NSCLC), aiming to provide a useful and manageable tool which can help Oncologists in their everyday clinical practice...
September 2018: Critical Reviews in Oncology/hematology
Catherine M Phillips, Nitin Shivappa, James R Hébert, Ivan J Perry
Accumulating evidence identifies diet and inflammation as potential mechanisms contributing to cardiometabolic risk. However, inconsistent reports regarding dietary inflammatory potential, biomarkers of cardiometabolic health and metabolic syndrome (MetS) risk exist. Our objective was to examine the relationships between a food frequency questionnaire (FFQ)-derived dietary inflammatory index (DII® ), biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis and MetS risk in a cross-sectional sample of 1992 adults...
August 8, 2018: Nutrients
Boram Park, Eun Kyung Choe, Hae Yeon Kang, Eunsoon Shin, Sangwoo Lee, Sungho Won
BACKGROUND: The neutrophil⁻lymphocyte ratio (NLR) is a valuable prognostic or predictive biomarker in various diseases, but the genetic factors that underlie the NLR have not been studied. We attempted to investigate polymorphisms related to NLR phenotype and analyze their ability to predict metabolic risks. METHODS: A genome-wide association study was performed with log-transformed NLR using an Affymetrix Axiom™ KORV1.1-96 Array. Regression models for metabolic risk status were designed using the identified significant single-nucleotide polymorphisms (SNPs)...
August 8, 2018: Journal of Clinical Medicine
Yifeng Bao, Minfeng Yang, Chunjing Jin, Shiqiang Hou, Beitian Shi, Jinlong Shi, Ning Lin
OBJECTIVE: Hematologic inflammatory markers are simple, inexpensive prognostic markers for various conditions. The prognostic significance of representative markers neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and red cell distribution width (RDW) in patients exist in a variety of tumors. The objective of this study was to evaluate prognostic value of these markers in glioma. METHODS: A retrospective chart review study was conducted for 219 glioma patients between January 2012 and January 2017...
August 6, 2018: World Neurosurgery
R A Ajadi, A A Adebiyi, E B Otesile, O B Kasali
Inflammatory markers such as erythrocyte sedimentation rates (ESR) have been evaluated in humans withosteoarthritis (OA). However, there has been no record of evaluation of ESR during OA in dogs. Changes in erythrocytesedimentation rates (ESR) and leukogram functions were evaluated following experimental knee osteoarthritis (OA).Tendogs of both sexes with (mean weight = 12.4 ± 1.8kg) were used. Experimental OA was induced in the right knee, using thegroove model and confirmed radiographically using evidence of joint space narrowing and presence of osteophytes...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Simona Lattanzi, Francesco Brigo, Eugen Trinka, Claudia Cagnetti, Mario Di Napoli, Mauro Silvestrini
Spontaneous intracerebral hemorrhage (ICH) accounts for approximately 10 to 30% of all acute cerebrovascular events, and it is the type of stroke associated with the highest rates of mortality and residual disability. The inflammatory response is early triggered by hematoma components and can enhance the damage within the hemorrhagic brain. Assessment of peripheral biomarkers of inflammation could contribute to increase knowledge about some of the mechanisms involved in the ICH-induced injury and yield information on the disease course...
August 8, 2018: Translational Stroke Research
Yuki Kohada, Tetsutaro Hayashi, Keisuke Goto, Kohei Kobatake, Hamidreza Abdi, Yukiko Honda, Kazuhiro Sentani, Shogo Inoue, Jun Teishima, Kazuo Awai, Wataru Yasui, Akio Matsubara
Background: To improve the prediction of outcomes in patients who will undergo radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), we examined the preoperative prognostic factors and established a risk classification model. Methods: A total of 148 patients who underwent RNU without history of neo-adjuvant chemotherapy between 1999 and 2016 in Hiroshima University Hospital were retrospectively reviewed. Associations between preoperative/clinicopathological factors and outcomes including cancer-specific survival (CSS) and recurrence-free survival (RFS) were assessed...
July 31, 2018: Japanese Journal of Clinical Oncology
Ersin Çintesun, Feyza Nur Incesu Çintesun, Huriye Ezveci, Fikret Akyürek, Çetin Çelik
PURPOSE: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) are known as systemic inflammatory response markers. In this study, we aimed to evaluate changes in NLR, PLR, PDW, RDW, MPV, and PCT in preeclampsia (PE) and their use in predicting its severity. MATERIALS AND METHODS: This is a retrospective case-control study. The study comprised 64 control group (healthy pregnant females), 51 females with mild PE, and 13 with severe PE...
July 2018: Journal of Laboratory Physicians
Sehra Birgül Batmaz
Background: Atopic dermatitis is a dermatological disease characterized by chronic inflammation. In recent years, systemic inflammation is also mentioned along with local inflammation for its pathogenesis. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) are nonspecific indicators of systemic inflammation, and they were shown to be associated with the disease and its prognosis in allergic or nonallergic diseases. Aims and Objectives: The aim of this study was to evaluate the values of NLR, PLR, and MPV in atopic dermatitis patients and also to investigate the associations of them with the atopic dermatitis disease severity and duration...
July 2018: Indian Journal of Dermatology
Mauricio P Pinto, Carlos Balmaceda, Maria L Bravo, Sumie Kato, Alejandra Villarroel, Gareth I Owen, Juan Carlos Roa, Mauricio A Cuello, Carolina Ibañez
BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histologic type of ovarian cancer. To date, there are no reliable biomarkers to effectively predict patient prognosis. Studies have demonstrated inflammation and tumor infiltrating lymphocytes (TILs) correlate with a bad and good prognosis, respectively. Here, we sought to evaluate systemic inflammation and TILs as early prognostic markers of survival. METHODS: Neutrophil-to-lymphocyte ratio (NLR) and serum Lactate Dehydrogenase (LDH) were used as indicators of systemic inflammation...
August 2, 2018: Gynecologic Oncology
Mihai Dorin Vartolomei, Matteo Ferro, Francesco Cantiello, Giuseppe Lucarelli, Savino Di Stasi, Rodolfo Hurle, Giorgio Guazzoni, Gian Maria Busetto, Ettore De Berardinis, Rocco Damiano, Sisto Perdona, Paolo Verze, Roberto La Rocca, Marco Borghesi, Riccardo Schiavina, Eugenio Brunocilla, Gilberto L Almeida, Pierluigi Bove, Estevao Lima, Giovanni Grimaldi, Riccardo Autorino, Nicolae Crisan, Abdal Rahman Abu Farhan, Michele Battaglia, Vincenzo Serretta, Giorgio Ivan Russo, Giuseppe Morgia, Daniela Terracciano, Gennaro Musi, Ottavio de Cobelli, Vincenzo Mirone, Shahrokh F Shariat
INTRODUCTION: The aim of this multicenter study was to investigate the prognostic role of neutrophil-to-lymphocyte ratio (NLR) and to validate the NLR cutoff of 3 in a large multi-institutional cohort of patients with primary T1 HG/G3 non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: The study period was from January 2002 through December 2012. A total of 1046 patients with primary T1 HG/G3 who had NMIBC on re-transurethral bladder resection (TURB) who received adjuvant intravesical bacillus Calmette-Guérin therapy with maintenance from 13 academic institutions were included...
July 6, 2018: Clinical Genitourinary Cancer
Hai-Jie Hu, Yan-Wen Jin, Rong-Xing Zhou, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Fei Liu, Nan-Sheng Cheng, Fu-Yu Li
BACKGROUND: We aimed to examine whether inflammation-based prognostic scores could predict tumor resectability in a cohort of hilar cholangiocarcinoma patients with preoperative hyperbilirubinemia. We also sought to investigate the prognostic factors associated with overall survival in the subgroup of patients with an R0 resection. METHODS: A total of 173 patients with potentially resectable hilar cholangiocarcinoma, as judged by radiological examinations, were included...
August 3, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Chung-Sik Oh, Jaemoon Lee, Tae-Gyoon Yoon, Eun-Hye Seo, Hyun-Jun Park, Liyun Piao, Seung-Hyun Lee, Seong-Hyop Kim
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Clusters of differentiation 39 and 73, enzymes expressed on the surface of regulatory T cells, promote cancer recurrence and metastasis by suppressing immune cells. The authors hypothesized that propofol is less immunosuppressive than volatile anesthetics. The objective of this randomized trial was to compare the changes in cluster of differentiation 39 and 73 expression on regulatory T cells between propofol- and sevoflurane-based anesthesia during breast cancer surgery...
August 3, 2018: Anesthesiology
Weiji Weng, Xu Chen, Shaohui Gong, Liemei Guo, Xiaohua Zhang
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a simple, low-cost and easily measured inflammation marker, corresponding with pathological tumor grading and clinical prognosis in various cancers. OBJECTIVES: This study aimed to investigate the relationship between preoperative NLR and glioma grading and also the correlation between NLR and glioblastoma survival. METHODS: The preoperative NLR was analyzed retrospectively in 239 gliomas of different grades, and receiver operating characteristic (ROC) curve analysis was adopted to investigate the prediction of glioma grading...
August 3, 2018: Neurological Research
Tang-Meng Guo, Bei Cheng, Li Ke, Si-Ming Guan, Ben-Ling Qi, Wen-Zhu Li, Bin Yang
Coronary artery disease (CAD) is a multifactorial disease in which inflammation plays a central role. This study aimed to investigate the association of inflammatory markers such as the neutrophil to lymphocyte ratio (NLR), the Global Registry of Acute Coronary Events (GRACE) score with in-hospital mortality of elderly patients with acute myocardial infarction (AMI) in an attempt to explore the prognostic value of these indices for elderly AMI patients. One thousand consecutive CAD patients were divided into two groups based on age 60...
April 2018: Current medical science
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