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Neutrophils to lymphocytes ratio

Guilherme Pinheiro Machado, Gustavo N Araujo, Christian K Carpes, Mateus C Lech, Stefani Mariani, Felipe H Valle, Luiz C C Bergoli, Rodrigo V Wainstein, Marco V Wainstein
BACKGROUND: Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9...
October 16, 2018: Coronary Artery Disease
Yun-Xia Zhao, Hui-Ran Zhang, Xiu-Na Yang, Yu-Hao Zhang, Shan Feng, Feng-Xue Yu, Xi-Xin Yan
Background: Fine particulate matter (PM2.5 ) exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations of PM2.5 on the pathology and airway hyperresponsiveness (AHR) of BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA) and to observe the effects of apoptosis and T-cell immunoglobulin and mucin domain 1 (TIM-1) in this process...
October 20, 2018: Chinese Medical Journal
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Ayame Kitamura, Takashi Ichikawa, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Yoshiki Okita, Junichiro Hiro, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: The systemic inflammatory response (SIR) via host-tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC). METHODS: A total of 308 patients with CRC were enrolled in this study. Preoperative psoas muscle mass index and intramuscular adipose tissue content were evaluated using preoperative computed tomographic images, and the correlation between body composition status and several SIR markers, including C-reactive protein (CRP), serum albumin level, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index (SII) was assessed using statistical methods...
October 18, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Satoru Kobayashi, Yoko Karube, Takashi Inoue, Osamu Araki, Sumiko Maeda, Yuji Matsumura, Masayuki Chida
PURPOSE: The correlation of advanced cancer with inflammation and/or nutrition factors is well known. Recently, the advanced lung cancer inflammation index (ALI) was developed as a new prognostic tool for patients with advanced lung cancer. In this study, we examined whether ALI results are correlated with prognosis of patients with early stage lung adenocarcinoma who undergo lung resection. METHODS: From January 2009 to December 2014, 544 patients underwent lung resection due to primary lung cancer at Dokkyo Medical University Hospital, of whom 166 with pathological stage IA lung adenocarcinoma were retrospectively investigated in this study...
October 17, 2018: Annals of Thoracic and Cardiovascular Surgery
Fanny Laroumanie, Arina Korneva, Matthew R Bersi, Matthew R Alexander, Liang Xiao, Xue Zhong, Justin P Van Beusecum, Yuhan Chen, Mohamed A Saleh, William G McMaster, Kyle A Gavulic, Bethany L Dale, Shilin Zhao, Yan Guo, Yu Shyr, Daniel S Perrien, Nancy J Cox, John A Curci, Jay D Humphrey, Meena S Madhur
Aortic dissection (AD) is a life-threatening vascular disease with limited treatment strategies. Here, we show that loss of the GWAS-identified SH2B3 gene, encoding lymphocyte adaptor protein LNK, markedly increases susceptibility to acute AD and rupture in response to angiotensin (Ang) II infusion. As early as day 3 following Ang II infusion, prior to the development of AD, Lnk-/- aortas display altered mechanical properties, increased elastin breaks, collagen thinning, enhanced neutrophil accumulation, and increased MMP-9 activity compared with WT mice...
October 18, 2018: JCI Insight
Haris Zahoor, Pedro C Barata, Xuefei Jia, Allison Martin, Kimberly D Allman, Laura S Wood, Timothy D Gilligan, Petros Grivas, Moshe C Ornstein, Jorge A Garcia, Brian I Rini
BACKGROUND: Nivolumab is approved for the treatment of refractory metastatic renal cell carcinoma. Patterns and predictors of progressive disease (PD) on nivolumab, and outcomes in such patients are lacking. METHODS: A retrospective analysis of patients (pts) with metastatic clear cell renal cell carcinoma (ccRCC) who received nivolumab at Cleveland Clinic (2015-2017) was performed. PD was defined per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 or clinical progression as per treating physician...
October 17, 2018: Journal for Immunotherapy of Cancer
Mehmet A Bilen, Dylan J Martini, Yuan Liu, Colleen Lewis, Hannah H Collins, Julie M Shabto, Mehmet Akce, Haydn T Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Rathi N Pillai, Conor E Steuer, Christina S Wu, David H Lawson, Ragini R Kudchadkar, Bassel F El-Rayes, Viraj A Master, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey
BACKGROUND: Optimal prognostic and predictive biomarkers for patients with advanced-stage cancer patients who received immunotherapy (IO) are lacking. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the platelet-to-lymphocyte ratio (PLR), are readily available. The authors investigated the association between these markers and clinical outcomes of patients with advanced-stage cancer who received IO. METHODS: A retrospective review was conducted of 90 patients with advanced cancer who received treatment on phase 1 clinical trials of IO-based treatment regimens...
October 17, 2018: Cancer
Alaaddin Yorulmaz, Hikmet Akbulut, Suna Adeviye Taş, Merve Tıraş, İbaa Yahya, Harun Peru
In this study, we aimed to investigate whether neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) might be helpful in the diagnosis of subclinical inflammation of familial Mediterranean fever (FMF). Clinical, laboratory, and genetic results of the patients who were followed up with the diagnosis of FMF were obtained retrospectively from the hospital files and recorded to standardized form. Age- and sex-matched healthy subjects were included as the control group...
October 16, 2018: Clinical Rheumatology
Saraswoti Khadge, Geoffrey M Thiele, John Graham Sharp, Timothy R McGuire, Lynell W Klassen, Paul N Black, Concetta C DiRusso, Leah Cook, James E Talmadge
Epidemiological studies show a reduced risk of breast cancer (BC) in women consuming high levels of long-chain (LC) omega-3 (ω-3) fatty acids (FAs) compared with women who consumed low levels. However, the regulatory and mechanistic roles of dietary ω-6 and LC-ω-3 FAs on tumor progression, metastasis and survival are poorly understood. Female BALB/c mice (10-week old) were pair-fed with a diet containing ω-3 or an isocaloric, isolipidic ω-6 diet for 16 weeks prior to the orthotopic implantation of 4T1 mammary tumor cells...
October 16, 2018: Clinical & Experimental Metastasis
Ozcan Kocaturk, Feyzullah Besli, Fatih Gungoren, Mehtap Kocaturk, Zulkif Tanriverdi
BACKGROUND: Stroke therapy options have focused on limiting the infarct volume. Neutrophil to lymphocyte ratio (NLR) can be valuable to detect the patients that required intensive treatment at early stage by predicting infarct volume. The aim of this study is to evaluate the relationship between NLR and infarct volume according to the stroke territory, and to determine the prognostic value of NLR for predicting 3-month mortality in acute ischemic stroke (AIS) patients. METHODS: A total of 107 patients with AIS were enrolled and followed up 3 months in terms of mortality...
October 17, 2018: Neurological Sciences
Marlid Cruz-Ramos, Laura Del Puerto-Nevado, Binbin Zheng, Rafael López-Bajo, Arancha Cebrian, María Rodríguez-Remirez, Laura García-García, Sonia Solanes-Casado, Jesús García-Foncillas
Aging is associated with a higher risk of cancer, >70% of cancer-related deaths occur in aged patients; however, this population is underrepresented in clinical trials, therefore, clinical information regarding this age group is rather limited. OBJECTIVES: Neutrophil-to lymphocyte ratio (NLR) and platelet-to lymphocyte ratio (PLR) have been described as biomarkers in cancer, thus, we have assessed their impact in an aged cohort of patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: 110 patients with a mean age of 72...
October 13, 2018: Journal of Geriatric Oncology
Andrea Casadei Gardini, Francesco Giuseppe Foschi, Fabio Conti, Elisabetta Petracci, Ranka Vukotic, Giorgia Marisi, Federica Buonfiglioli, Giovanni Vitale, Federico Ravaioli, Stefano Gitto, Gabriella Verucchi, Marco Lenzi, Luigi Bolondi, Giuseppe Mazzella, Stefano Brillanti, Pietro Andreone
BACKGROUND: Unexpectedly high occurrence or recurrence rate of hepatocellular carcinoma (HCC) has been observed in patients with chronic hepatitis C receiving direct-acting antivirals (DAAs) therapy. AIMS: We evaluated the predictive value of albumin-bilirubin (ALBI) score and immune-inflammation indicators to identify the risk of occurrence or recurrence of HCC in patients treated with DAAs in a real life setting. METHODS: In this retrospective cohort study, we analysed data from 514 patients with cirrhosis who were prospectively enrolled for treatment with DAAs...
September 22, 2018: Digestive and Liver Disease
Kazuhiro Araki, Yoshinori Ito, Ippei Fukada, Kokoro Kobayashi, Yoshimasa Miyagawa, Michiko Imamura, Ayako Kira, Yuichi Takatsuka, Chiyomi Egawa, Hirofumi Suwa, Shinji Ohno, Yasuo Miyoshi
BACKGROUND: Although peripheral blood-based parameters (PBBPs) are reported as prognostic indicators in patients with breast cancers, their utility has not been studied in human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer (ABC). Tumor-infiltrating lymphocytes (TILs) might be a predictive factor in patients with HER2-positive ABC treated with pertuzumab and trastuzumab (PT) plus docetaxel. We aimed to evaluate whether PBBPs could have predictive value in HER2-positive ABC treated with pertuzumab and trastuzumab (PT) combined with eribulin (ERI) or nab-paclitaxel (Nab-PTX)...
October 16, 2018: BMC Cancer
Xiao-Feng Qiao, Xin Li, Guo-Ping Wang, Yin-Huan Bai, Wei Zheng, Tong-Li Li
OBJECTIVES: Sudden sensorineural hearing loss (SNHL) is a common acute disease with an incidence of 0.5-2/10,000. This study aimed to determine whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) could be indicators for sudden sensorineural hearing loss (SNHL). METHODS: A total of 60 confirmed cases of SNHL and 60 healthy volunteers were inducted into this study. Peripheral blood NLRs and PLRs were both compared between these. These SNHL patients were divided into two groups, according to therapeutic effect: effective group and ineffective group...
October 16, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Ping Hou, Hui-Ping Xue, Xin-E Mao, Yong-Nan Li, Lin-Feng Wu, Yong-Bing Liu
The neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) are important indicators of adverse outcomes and have predictive value for many diseases; however, the relationships between frailty, and the NLR and RDW in patients with coronary heart disease (CHD) have not been determined. In this cross-sectional study, we investigated the association between frailty, and the NLR and RDW in elderly CHD patients ≥ 60 years of age. Frailty was defined according to frailty phenotype. Of 345 patients enrolled in the study, 22...
October 16, 2018: Aging
Burak Arslan, Okan Gürkan, Bugra Çetin, Öykü Aksoy Arslan, Taha Göv, Gökhan Yazıcı, Tolga Eroglu, Mustafa Asım Avcı, Enver Ozdemir
PURPOSE: The aim of our study was to investigate the impact of the ABO blood groups and blood-based biomarkers on the growth kinetics of renal angiomyolipoma (AML). METHODS: A total of 124 patients with AML who were followed-up between 2010 and 2018 were retrospectively reviewed. The patients' characteristics were recorded, including age, body mass index (BMI), blood pressure, smoking history, and ABO blood group. Baseline laboratory test results, including serum creatinine, AST, ALT, platelet, neutrophil and lymphocyte count, were used to calculate the estimated glomerular filtration rate (eGFR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and De Ritis ratio...
October 15, 2018: International Urology and Nephrology
Yu-Qi Zhou, Ding-Yun Feng, Wen-Juan Li, Hai-Ling Yang, Zhao-Ni Wang, Tian-Tuo Zhang, Zhuang-Gui Chen
Background and purpose: Hospital-acquired pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. The emergence of multidrug resistant (MDR) Pseudomonas aeruginosa (PA) is of major concern. Our aim was to evaluate the risk factors and prognosis of HAP due to MDR-PA infection. Patients and methods: In a retrospective observational study, we collected data on all episodes of HAP caused by PA (PA-HAP) occurring from January 2013 to December 2016...
2018: Therapeutics and Clinical Risk Management
Emine Aksoy, Sinem Güngör, Meltem Çoban Ağca, İpek Özmen, Dildar Duman, Nagihan Durmuş Koçak, Ülkü Aka Aktürk, Eylem Tunçay, Cüneyt Saltürk, Murat Yalçınsoy, Birsen Ocaklı, Zuhal Karakurt
OBJECTIVES: The choice of treatment according to the inflammation type in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been of recent interest. This study investigated the role of novel biomarkers, hospital outcomes, and readmission rates in the first month in patients with eosinophilic or neutrophilic AECOPD. MATERIALS AND METHODS: We conducted a retrospective observational cohort study in a Chest Teaching Hospital with hospitalized AECOPD patients...
September 13, 2018: Turkish Thoracic Journal
María S Gastón, Laura C Pereyra, Marcos Vaira
Light pollution or artificial lighting at night (ALAN) is an emerging threat to biodiversity that can disrupt physiological processes and behaviors. Because ALAN stressful effects are little studied in diurnal amphibian species, we investigated if chronic ALAN exposure affects the leukocyte profile, body condition, and blood cell sizes of a diurnal toad. We hand-captured male toads of Melanophryniscus rubriventris in Angosto de Jaire (Jujuy, Argentina). We prepared blood smears from three groups of toads: "field" (toads processed in the field immediately after capture), "natural light" (toads kept in the laboratory under captivity with natural photoperiod), and "constant light" (toads kept in the laboratory under captivity with constant photoperiod/ALAN)...
October 15, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Shuaishuai Chen, Haijian Ying, Juping Du, Xiaoli Zhu, Jianfeng Shi, Ying Zhang, Shiyong Chen, Bo Shen, Jun Li
BACKGROUND: Recently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin-dNLR (ALB-dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA. METHODS: We retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB-dNLR score was based on serum albumin level, neutrophil count, and white cell count...
October 15, 2018: Journal of Clinical Laboratory Analysis
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