keyword
https://read.qxmd.com/read/38531045/timing-of-endoscopic-retrograde-cholangiopancreatography-in-postcholecystectomy-patients-and-its-effect-on-post-ercp-complications
#1
JOURNAL ARTICLE
Fevzi Cebi, Burak Altunpak, Arif Kaya, Hande Kandemir, Mehmet Karabulut
Background: Due to the increasing use of laparoscopy for symptomatic cholelithiasis and other gallbladder disorders, as well as the ongoing issue of associated biliary tree injuries, endoscopic retrograde cholangiopancreatography (ERCP) still holds a significant position in the diagnosis and treatment of postcholecystectomy disorders. In our study, we aimed to examine the relationship between the time elapsed between cholecystectomy and ERCP with the post-ERCP complications. Methods: Ninety-six patients with a history of cholecystectomy who underwent ERCP between January 2016 and January 2021 at the General Surgery Clinic of the University of Health Sciences Bakırköy Dr...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38530728/production-of-targeted-estrone-liposomes-using-a-herringbone-micromixer
#2
JOURNAL ARTICLE
Mohamed Agam, Vinod Paul, Mohamed Abdelgawad, Ghaleb Husseini
Liposomes are spherical vesicles formed from bilayer lipid membranes that are extensively used in targeted drug delivery as nanocarriers to deliver therapeutic reagents to specific tissues and organs in the body. Recently, we have reported using estrone as an endogenous ligand on doxorubicin-encapsulating liposomes to target estrogen receptor (E.R.)-positive breast cancer cells. Estrone liposomes were synthesized using the thin-film hydration method, which is a long, arduous, and multistep process. Here, we report using a herringbone micromixer to synthesize estrone liposomes in a simple and rapid manner...
March 26, 2024: IEEE Transactions on Nanobioscience
https://read.qxmd.com/read/38530653/national-athletic-trainers-association-bridge-statement-management-of-sport-related-concussion
#3
JOURNAL ARTICLE
Steven P Broglio, Johna K Register-Mihalik, Kevin M Guskiewicz, John J Leddy, Alejandra Merriman, Tamara C Valovich McLeod
OBJECTIVE: To provide athletic trainers and team physicians with updated recommendations to the 2014 National Athletic Trainers' Association (NATA) concussion position statement regarding concussion management, specifically in the areas of education, assessment, prognostic factors, mental health, return to academics, physical activity, rest, treatment, and return to sport. BACKGROUND: Athletic trainers have benefited from the 2 previous NATA position statements on concussion management, and although the most recent NATA position statement is a decade old, knowledge gains in the medical literature warrant updating several (but not all) recommendations...
March 1, 2024: Journal of Athletic Training
https://read.qxmd.com/read/38530551/nutrition-to-enhance-metabolic-bariatric-surgery-outcomes
#4
JOURNAL ARTICLE
Kim B Knopp
BACKGROUND: Gender-specific post-surgical goals for 12-month percent body fat (%BF) based on World Health Organization (WHO) obesity thresholds and for lean mass-sparing were published as preliminary body composition (BC) guidelines to address a knowledge gap in metabolic-bariatric surgery (MBS). Other studies' %BF outcomes inconsistently fell below obesity thresholds; none described nutrition practices. To help practitioners positively influence patients' BC and weight changes, this study describes the team-supported process of conducting serial body composition analysis (sBCA) concomitantly with the evidence-based nutrition practices applied to generate the preliminary guidelines...
March 26, 2024: Obesity Surgery
https://read.qxmd.com/read/38530472/differences-in-branched-chain-amino-acid-to-tyrosine-ratio-btr-among-etiologies-of-chronic-liver-disease-progression-compared-to-healthy-adults
#5
JOURNAL ARTICLE
Masaaki Mino, Akitoshi Sano, Eiji Kakazu, Hiroko Matsubara, Keisuke Kakisaka, Takayuki Kogure, Katsunori Sekine, Yoshihiko Aoki, Masatoshi Imamura, Michitaka Matsuda, Taiji Yamazoe, Taizo Mori, Sachiyo Yoshio, Jun Inoue, Atsushi Masamune, Tatsuya Kanto
BACKGROUND: The branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is used to evaluate the progression of chronic liver disease (CLD). However, the differences across sex, age, body mass index (BMI) and etiologies are still unclear. METHODS: We retrospectively reviewed data from 2,529 CLD cases with free amino acids (FAAs) in peripheral blood from four hospitals and 16,421 general adults with FAAs data from a biobank database. In total, 1,326 patients with CLD (covering seven etiologies) and 8,086 healthy controls (HCs) were analyzed after exclusion criteria...
March 26, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38530155/post-weaning-social-isolation-modifies-neonatal-anoxia-induced-changes-in-energy-metabolism-and-growth-of-rats
#6
JOURNAL ARTICLE
Natalia Andrea Cruz-Ochoa, Lívia Clemente Motta-Teixeira, Pablo Felipe Cruz-Ochoa, Santiago Lopez-Paredes, Julieta Esperanza Ochoa-Amaya, Silvia Honda Takada, Gilberto Fernando Xavier, Maria Inês Nogueira
Neonatal oxygen deficiency in rats may disturb growth and long-term metabolic homeostasis. In order to facilitate metabolic evaluation, the subjects are usually housed individually. However, social isolation associated with individually housed conditions alters animal behavior, which may influence the experimental results. This study investigated the effects of social isolation on neonatal anoxia-induced changes in growth and energy metabolism. Male and female Wistar rats were exposed, on postnatal day 2 (P2), to either 25-min of anoxia or control treatment...
March 26, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38529938/associations-of-regional-body-fat-with-risk-of-cardiovascular-disease-and-mortality-among-individuals-with-type-2-diabetes
#7
JOURNAL ARTICLE
Zixin Qiu, Dong Hoon Lee, Qi Lu, Rui Li, Kai Zhu, Lin Li, Ruyi Li, An Pan, Edward L Giovannucci, Gang Liu
OBJECTIVES: We aimed to prospectively examine the association between regional body fat and risk of cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D), who often exhibit changes in relative fat distribution and have increased CVD risk. METHODS: The main analysis included 21,472 participants with T2D from the UK Biobank. Regional body fat was measured by bioelectric impedance assessment. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs)...
March 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38529864/-asthenic-disorders-correction-with-recognan
#8
JOURNAL ARTICLE
O A Shavlovskaya, I A Bokova
Asthenia, asthenic syndrome, asthenic condition, asthenic reaction, asthenic disorders are terms that describe the state of «impotence». Fatigue that occurs against the background of habitual physical or intellectual stress for a person, and persists after rest, is asthenia. For people of the older age group, the term senile asthenia syndrome is used. Asthenia manifests itself with increased fatigue and exhaustion, mood instability, increased irritability, sleep disorders. Asthenic conditions manifest themselves along with a decrease in physical activity, increased cognitive and mental fatigue...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529451/incidental-cytodiagnosis-of-carotid-body-tumour-on-fine-needle-aspiration-cytology
#9
Sreetama Mukherjee, Arvind Bhake
A carotid body tumor is a rare form of neoplasm that arises near the carotid artery bifurcation and it has an incidence rate of less than 0.3 per 100,000 population. The low incidence rate of such tumors is due to their origination from the paraganglion cells which is relatively uncommon as compared to other forms of tumor. Here we present an incidental and unusual cytodiagnosis of carotid body tumors. A 45-year-old male presented to the surgery outpatient department with swelling in the left-sided anterior region of the neck...
February 2024: Curēus
https://read.qxmd.com/read/38529410/physiological-anthropometric-and-athletic-performance-adaptations-from-completing-a-1-month-pre-season-period-a-two-year-longitudinal-study-in-female-collegiate-soccer-players
#10
JOURNAL ARTICLE
Andrew S Perrotta, Brent D Day, Camila J Correa, Anika J Scott, Jennifer Ramos, Elizabeth A Gnatiuk, Darren E R Warburton
INTRODUCTION: Collegiate coaches and integrative support staff often utilize pre-season as a brief and intense training period to prepare athletes technically, tactically, and physiologically, to meet the demands of competition during a soccer season. This study sought to examine the dose-response from performing on-field soccer activities during a four-week pre-season period in female collegiate soccer players, and if the magnitude in response was associated with accumulated exercise stress...
2024: Frontiers in sports and active living
https://read.qxmd.com/read/38529389/independent-association-of-general-and-central-adiposity-with-risk-of-gallstone-disease-observational-and-genetic-analyses
#11
JOURNAL ARTICLE
Min Zhang, Ye Bai, Yutong Wang, Huijie Cui, Wenqiang Zhang, Li Zhang, Peijing Yan, Mingshuang Tang, Yunjie Liu, Xia Jiang, Ben Zhang
BACKGROUND: General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD. METHODS: We first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using data from UK Biobank (N=472,050). We then explored the genetic relationship using summary statistics from the largest genome-wide association study of GSD ( ncase =43,639, ncontrol =506,798) as well as WHR, with and without adjusting for body mass index (BMI) (WHR: n =697,734; WHRadj BMI: n =694,649)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529002/superior-oblique-muscle-extramedullary-plasmacytoma-in-a-patient-with-multiple-myeloma-and-a-review-of-literature
#12
Amirreza Veisi, Kimia Daneshvar, Sadid Hooshmandi, Maryam Najafi, Peyman Mohammadi Torbati, Kiana Hassanpour
INTRODUCTION: Multiple myeloma (MM), a plasma cell malignancy, is a systemic disease affecting various body organs. Plasmacytoma of bone and extramedullary disease (EMD) are presentations of MM. EMD is usually the sign of a more aggressive form of the disease. Herein, we report a patient with refractory MM presenting with extramedullary plasmacytoma in the superior oblique (SO) muscle. CASE PRESENTATION: A 51-year-old female presented complaining of gradual protrusion of the left eye and ocular pain from 20 days prior...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38528893/extending-social-accountability-mandates-to-biomedical-research-in-canadian-faculties-of-medicine
#13
JOURNAL ARTICLE
Nadine Wiper-Bergeron, Holly L Adam, Kaylee Eady, Katherine A Moreau, Christopher Rj Kennedy, Claire E Kendall
BACKGROUND: Social accountability (SA), as defined by Boelen and Heck, is the obligation of medical schools to address the needs of communities through education, research and service activities. While SA is embedded within health profession education frameworks in medicine, they are rarely taught within graduate-level (MSc/PhD) education. METHODS: As these programs train future medical researchers, we invited first-year graduate students enrolled in a mandatory professionalism class at our institution ( n = 111) to complete a survey on their perceptions of the importance of SA in their research, training, and future careers...
February 2024: Canadian Medical Education Journal
https://read.qxmd.com/read/38528656/altered-placental-immune-cell-composition-and-gene-expression-with-isolated-fetal-spina-bifida
#14
JOURNAL ARTICLE
Marina White, Hasan Abdo, David Grynspan, Tim Van Mieghem, Kristin L Connor
PROBLEM: Fetal spina bifida (SB) is more common in pregnant people with folate deficiency or anomalies of folate metabolism. It is also known that fetuses with SB have a higher risk of low birthweight, a condition that is typically placental-mediated. We therefore hypothesized that fetal SB would associate with altered expression of key placental folate transporters and an increase in Hofbauer cells (HBCs), which are folate-dependent placental macrophages. METHOD OF STUDY: Folate receptor-α (FRα), proton coupled folate receptor (PCFT), and reduced folate carrier (RFC) protein localization and expression (immunohistochemistry) and HBC phenotypes (HBC abundance and folate receptor-β [FRβ] expression; RNA in situ hybridization) were assessed in placentae from fetuses with SB (cases; n = 12) and in term (n = 10) and gestational age (GA) - and maternal body mass index - matched (n = 12) controls without congenital anomalies...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38528577/perceived-attitudes-toward-lgbtq%C3%A2-%C3%A2-physicians-among-individuals-with-psychiatric-illness-in-the-religiously-diverse-southern-region-of-thailand-a-multihospital-based-survey
#15
JOURNAL ARTICLE
Jarurin Pitanupong, Garn Wichitnark, Pakawat Wiwattanaworaset, Laddaporn Tepsuan, Naruttha Norphun, Puangsan Yakkaphan
OBJECTIVES: This study purposed to analyze perceived attitudes toward LGBTQ + physicians and related factors among individuals with psychiatric illnesses in southern Thailand. MATERIALS AND METHODS: From May to July 2023, a cross-sectional study was conducted at four psychiatric outpatient clinics in Southern Thailand. The questionnaires utilized were: 1) a demographic information questionnaire, 2) a questionnaire regarding attitudes toward LGBTQ + physicians, 3) a questionnaire evaluating individuals' attitudes toward LGBTQ + physicians while receiving medical attention, and 4) a patient-doctor relationship questionnaire...
March 25, 2024: BMC Psychology
https://read.qxmd.com/read/38528555/formononetin-reverses-treg-th17-imbalance-in-immune-mediated-bone-marrow-failure-mice-by-regulating-the-pi3k-akt-signaling-pathway
#16
JOURNAL ARTICLE
Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang, Lingling Zhu
BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established...
March 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38528535/predicting-factors-for-acute-encephalopathy-in-febrile-seizure-children-with-sars-cov-2-omicron-variant-a-retrospective-study
#17
JOURNAL ARTICLE
Ching-Min Tang, Cheng-Yen Kuo, Chen-Wei Yen, Jainn-Jim Lin, Yu-Chia Hsieh, Shao-Hsuan Hsia, Oi-Wa Chan, En-Pei Lee, Po-Cheng Hung, Huei-Shyong Wang, Kuang-Lin Lin, Cheng-Hsun Chiu
BACKGROUND: SARS-CoV-2 posed a threat to children during the early phase of Omicron wave because many patients presented with febrile seizures. The study aimed to investigate predicting factors for acute encephalopathy of children infected by SARS-CoV-2 Omicron variant presenting with febrile seizures. METHODS: The retrospective study analyzed data from pediatric patients who visited the emergency department of Chang Gung Memorial Hospital in Taiwan between April and July 2022...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38528131/analysis-of-the-thigh-aesthetic-profiles-one-of-physical-ideal-body-proportions
#18
JOURNAL ARTICLE
Gkionoul Nteli Chatzioglou, Figen Govsa, Gokhan Gokmen, Ahmet Bicer
BACKGROUND: The contour of the thigh is increasingly being recognized as crucial component of the ideal human physique, giving rise to heightened interest in attaining the perfect thigh profile. Notwithstanding, the contemporary landscape of cosmetic surgery appears to be bereft of efficient and precise objective methodologies to evaluate the outcomes of thigh contouring treatments. The present study is aimed to investigate the aesthetic appeal of varying thigh contours, employing specialized software as an indispensable instrument for quantitative and qualitative analysis...
March 25, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38527927/a-rare-case-of-cutaneous-granular-cell-tumor-with-unusual-melan-a-expression-in-a-child
#19
Nina H Cheng, David Smith, Carla Errickson, Shaymaa Ashi
Granular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo-ovoid bodies of Milian. We describe a case of a 10-year-old female presenting with a GCT of the upper arm, remarkable for positive Melan-A expression without additional melanocytic features. The differentiation between granular cells versus melanocytic neoplasms carries significant implications for clinical management, and such diagnoses should be considered carefully in the setting of unusual immunophenotypes...
March 25, 2024: Journal of Cutaneous Pathology
https://read.qxmd.com/read/38527854/connecting-dementia-risk-loci-to-the-csf-proteome-identifies-pathophysiological-leads-for-dementia
#20
JOURNAL ARTICLE
Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Milan
Genome-wide association studies have successfully identified many genetic risk loci for dementia, but exact biological mechanisms through which genetic risk factors contribute to dementia remains unclear. Integrating CSF proteomic data with dementia risk loci could reveal intermediate molecular pathways connecting genetic variance to the development of dementia. We tested to what extent effects of known dementia risk loci can be observed in CSF levels of 665 proteins (proximity extension-based (PEA) immunoassays) in a deeply-phenotyped mixed-memory clinic cohort (n=502, mean age (sd) = 64...
March 25, 2024: Brain
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