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Urinary albumin excretion

Duc Ninh Nguyen, Thomas Thymann, Sandra K Goericke-Pesch, Shuqiang Ren, Wei Wei, Kerstin Skovgaard, Peter Damborg, Anders Brunse, Charlotte van Gorp, Boris W Kramer, Tim G Wolfs, Per T Sangild
Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic immune status and organ functions. Preterm pigs exposed to IA lipopolysaccharide (LPS) for 3 days were compared with controls at birth and postnatal day 5 after formula feeding. IA LPS induced mild chorioamnionitis but extensive intra-amniotic inflammation...
October 4, 2018: American Journal of Pathology
Muhammad Usman, Clare L Gillies, Kamlesh Khunti, Melanie J Davies
AIMS: The effect of intensive glycaemic control, blood pressure control and lipid levels control alone or as part of a multifactorial intervention has not been fully evaluated. We aimed to estimate the effects of more intensive interventions, compared with standard care, on risk factor control and cardiovascular outcomes in people with type 2 diabetes and microalbuminuria. METHODS: We searched MEDLINE, Embase and the Cochrane library without language restrictions from inception to August 10, 2018...
October 9, 2018: Diabetes Research and Clinical Practice
Lingling Xu, Xiaopu Lin, Meiping Guan, Yingshan Liu
INTRODUCTION: Early detection of diabetic peripheral neuropathy (DPN) is critical in patients with type 2 diabetes mellitus (T2DM) due to the lack of targeted therapy for DPN. We have investigated the relationship between different stages of diabetic nephropathy and DPN in an attempt to elucidate whether albuminuria can be used as an early warning signal of DPN progression. METHODS: A total of 217 T2DM patients who met the inclusion criteria were recruited from the Department of Endocrinology, Nanfang Hospital between January 2016 and June 2016...
October 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Xun Sun, Ye Xiao, Pei-Mei Li, Xiu-Yun Ma, Xiao-Jie Sun, Wen-Shan Lv, Yi-Li Wu, Peng Liu, Yan-Gang Wang
BACKGROUND: The association of serum high-density lipoprotein cholesterol (HDL-C) with microalbuminuria in type 2 diabetes mellitus (T2DM) remains controversial. Therefore, a cross-sectional study was conducted on patients with T2DM to investigate the relationship of HDL-C with microalbuminuria. METHODS: A total of 524 participants with T2DM were recruited in this cross-sectional study. The patients were divided into four groups according to serum HDL-C quartile...
October 5, 2018: Lipids in Health and Disease
Manjuri Sharma, Arunima Mahanta, Anup Kumar Barman, P J Mahanta
Background: Children with nephrotic syndrome (NS) are at risk for the development of acute kidney injury (AKI) through a variety of mechanisms.The frequency of NS hospitalizations complicated by AKI has almost doubled in the last decade. Children with AKI have longer hospital length of stay and increased need for intensive care unit admission. The main objectives of this study were to determine the incidence, clinical characteristics, risk factors and short-term outcome of AKI in children hospitalized with NS...
October 2018: Clinical Kidney Journal
Richarlisson Borges de Morais, Victor Pereira do Couto Muniz, Emerson Nunes Costa, Sebastião Rodrigues Ferreira Filho, Karen Renata Nakamura Hiraki, Luiz Borges Bispo-da-Silva, Ana Paula Coelho Balbi
Considering the importance of the renin-angiotensin system (RAS) in diabetic nephropathy (DN) and the link between mast cells (MC) and the RAS, this study evaluated the effects of RAS blockade on the MC cell population in the kidneys from rats with experimental diabetes. Wistar rats were divided into six groups: control non-diabetic (C); sham (S); diabetic (D); and D treated with enalapril (EN), losartan (LO), or aliskiren (AL). Ninety days after diabetes induction, glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were determined...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ya Luo, Kai Lu, Gang Liu, Jing Wang, Irakoze Laurent, Xiaoli Zhou
BACKGROUND AND OBJECTIVE: The effects of novel antidiabetic drugs, including sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) receptor agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors, on albuminuria in patients with type 2 diabetes mellitus (T2DM) are still controversial. Therefore, we performed a meta-analysis to evaluate the effects of novel antidiabetic drugs on albuminuria in patients with T2DM. METHODS: We conducted a random-effects meta-analysis of randomized controlled trials (RCTs) by searching the MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases up to 16 August 2018...
September 25, 2018: Clinical Drug Investigation
Daniela S C Magalhães, Jorge M P Pedro, Pedro E B Souteiro, João Sérgio Neves, Sofia Castro-Oliveira, Rita Bettencourt-Silva, Maria Manuel Costa, Ana Varela, Joana Queirós, Paula Freitas, Davide Carvalho
BACKGROUND: Obesity is an independent risk factor for chronic kidney disease (CKD). Our aims were: (1) to evaluate the impact of bariatric surgery (BS) on kidney function, (2) clarify the factors determining postoperative evolution of glomerular filtration rate (ΔGFR) and urinary albumin-to-creatinine ratio (ΔUACR), and (3) access the occurrence of oxalate-mediated renal complications. METHODS: We investigated a cohort of 1448 obese patients who underwent BS. Those with baseline-estimated GFR (eGFR0) < 30 mL/min or without information about the 2-year post-surgical eGFR (eGFR2) were excluded...
September 20, 2018: Obesity Surgery
Eugene Han, Mi-Kyung Kim, Yong-Ho Lee, Hye Soon Kim, Byung-Wan Lee
AIM: Although albuminuria and urinary N-acetyl-β-d-glucosaminidase (uNAG) are known as progression markers of diabetic kidney disease, there is limited information regarding the association between urinary nonalbumin proteinuria (NAP) and uNAG and the clinical relevance thereof in patients without albuminuria. METHODS: This cross-sectional study included samples from 244 consecutive patients with type 2 diabetes mellitus (T2D) without albuminuria. Proteinuria and albuminuria were defined according to protein-to-creatinine ratio (uPCR) and albumin-to-creatinine ratio (uACR), respectively...
September 15, 2018: Journal of Diabetes and its Complications
Jie-Ming Nie, Hai-Feng Li
Involvement of collagen IV (ColIV) and fibronectin (FN) in the occurrence and development of diabetic nephropathy (DN) and the effects of telmisartan and Salvia miltiorrhiza injection in the treatment of the patients were investigated. Two hundred and fifty-eight patients with stage IV DN were selected as the case group, and another 110 normal healthy subjects were incorporated as the control group. Involved patients were subdivided into different groups according to different treatment therapies; patients in the telmisartan group (T group) were given oral telmisartan; patients in the Salvia miltiorrhiza injection + telmisartan (S + T group) were administered with Salvia miltiorrhiza injection combined with telmisartan treatment, and there was a group of patients who received no intervention as the placebo group...
October 2018: Experimental and Therapeutic Medicine
Lucas Brandolt Farias, Daniel Lavinsky, Camila Zanella Benfica, Jacó Lavisnky, Luis Henrique Canani
BACKGROUND AND OBJECTIVE: To evaluate retinal layer changes in patients with type 2 diabetes, microalbuminuria, and no diabetic retinopathy, and to investigate its possible relationship with age, gender, diabetes duration, urinary albumin excretion (UAE), glycosylated hemoglobin, and hypertension. PATIENTS AND METHODS: A prospective, cross-sectional study was performed in 60 patients divided into three groups: diabetic patients with normal UAE, diabetic patients with microalbuminuria, and controls...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Eugenia Gkaliagkousi, Panagiota Anyfanti, Antonios Lazaridis, Areti Triantafyllou, Anastasios Vamvakis, Nikolaos Koletsos, Panagiotis Dolgyras, Stella Douma
The significance of nondipping and increased nighttime systolic blood pressure (SBP) in established hypertension is well defined. We investigated whether these factors alone or combined correlate with vascular damage in early-stage hypertension. Newly diagnosed, untreated hypertensives were classified as dippers and nondippers according to ambulatory blood pressure (BP). Twenty-four-hour urinary albumin excretion and markers of arterial stiffness (pulse wave velocity, augmentation index, central and peripheral pulse pressure, central BP) and atherosclerosis (carotid intima-media thickness) were assessed...
August 27, 2018: Journal of the American Society of Hypertension: JASH
Jani K Haukka, Niina Sandholm, Carol Forsblom, Jeffrey E Cobb, Per-Henrik Groop, Ele Ferrannini
Elevated urinary albumin excretion (microalbuminuria) is an early marker of diabetic nephropathy, but there is an unmet need for better biomarkers that capture the individuals at risk with higher accuracy and earlier than the current markers do. We performed an untargeted metabolomic study to assess baseline differences between individuals with type 1 diabetes who either developed microalbuminuria or remained normoalbuminuric. A total of 102 individuals progressed to microalbuminuria during a median follow-up of 3...
September 14, 2018: Scientific Reports
Akihiro Tsuda, Eiji Ishimura, Hideki Uedono, Akinobu Ochi, Shinya Nakatani, Tomoaki Morioka, Katsuhito Mori, Junji Uchida, Masanori Emoto, Tatsuya Nakatani, Masaaki Inaba
OBJECIVE: Little is known about the relationships between insulin resistance, intrarenal hemodynamics, and urinary albumin excretion (UAE) in humans with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). The aim of the current study was to examine intrarenal hemodynamic abnormalities, insulin resistance, and UAE in subjects with IFG or IGT. We hypothesized that intrarenal hemodynamic abnormalities would be associated with insulin resistance. RESEARCH DESIGN AND METHODS: Fifty-four kidney donors underwent 75-g oral glucose tolerance and inulin and para-aminohippuric acid clearance testing...
September 13, 2018: Diabetes Care
Wei Liu, Jiangyi Yu, Qianhua Yan, Lijuan Wang, Nan Li, Wei Xiong
The purpose of this meta-analysis was to evaluate the evidence of the clinical efficacy and safety of sitagliptin in diabetic patients with incipient nephropathy. PubMed, Ovid, Cochrane library, Chinese National Knowledge Infrastructure, and Wanfang databases were searched in September 2017 to identify randomized controlled trials (RCTs) of sitagliptin in diabetic patients with incipient nephropathy. Study selection, data extraction and study quality assessment were performed independently by two investigators, while disagreements were resolved by a third reviewer...
September 2018: Experimental and Therapeutic Medicine
Jinyu Li, Jiamin Pan, Bohan Li, Huiyu Tian, Ying Zhu, Zhihao Liao, Li Kou, Chaogang Tang, Mingwei Wang, Guoqiang Ye, Ming Wang
Objective This study was performed to explore the correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy (T2DN) by detecting changes in cognitive function and cerebral metabolism in these patients with different stages of T2DN. Methods Prospectively maintained databases were reviewed from 2006 to 2017. Blood biochemical indexes and the urinary albumin excretion rate (UAER) were measured in all participants. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA)...
September 12, 2018: Journal of International Medical Research
Humberto de Moura Barbosa, Dionísio Amaral, Jailson Nunes do Nascimento, Dijanah Cota Machado, Thiago Antônio de Sousa Araújo, Ulysses Paulino de Albuquerque, Jackson Roberto Guedes da Silva Almeida, Larissa Araújo Rolim, Norberto Peporine Lopes, Dayane Aparecida Gomes, Eduardo Carvalho Lira
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus (DM) is one of the most important medical emergencies of the 21st century. However, commercially available oral drugs with antidiabetic properties have been limited because of potential side effects, such as: hypoglycemia, weight gain, hepatic dysfunction and abdominal discomfort. As well as antidiabetic drugs, many types of medicinal herbal supplements are utilized as alternative treatments for DM and related comorbidities. Spondias tuberosa Arruda (Anacardiaceae), popularly known as "umbu", has been used in traditional medicine to treat a vast range of diseases, including DM, infections, digestive disorders, diarrhea and menstrual abnormalities...
December 5, 2018: Journal of Ethnopharmacology
Wen-Jing Yang, Yan-Ru Li, Hui Gao, Xue-Yi Wu, Xiao-Ling Wang, Xiao-Ning Wang, Lan Xiang, Dong-Mei Ren, Hong-Xiang Lou, Tao Shen
ETHNOPHARMACOLOGY RELEVANCE: Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. MATERIALS AND METHODS: Hepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264...
December 5, 2018: Journal of Ethnopharmacology
Evgenia Gurevich, Eytan Israel, Yael Segev, Daniel Landau
Background: Transient proteinuria during febrile illness is a common phenomenon. Recent studies have re-examined the pathophysiology of proteinuria and new urinary markers to characterize it, including B7-1 (CD80), which is expressed also in glomerular podocytes and influences the glomerular barrier. Aim: To investigate the pattern of proteinuria in febrile non-renal diseases, including B7-1. Methods: We prospectively analyzed urine samples of 44 febrile children and 28 afebrile controls for different protein components: albumin (glomerular marker), β2-microglobulin (tubular marker), uromodulin (Tamm Horsfall protein-THP, a renal endogenous protein) and B7-1...
2018: Frontiers in Pediatrics
Uchenna Anyanwagu, Richard Donnelly, Iskandar Idris
Background: Albuminuria is a recognized diagnostic and prognostic marker of chronic kidney disease and cardiovascular (CV) risk but the well-known relationship between increments in urinary albumin:creatinine ratio (UACR) and CV outcomes and mortality has not been fully explored in insulin-treated patients with type 2 diabetes (T2D) in routine clinical care. Methods: We investigated data for insulin users with T2D from UK general practices between 2007 and 2014...
August 28, 2018: Nephrology, Dialysis, Transplantation
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