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Urinary albumin excretion

Alena Krajcoviechova, Francois-Christophe Marois-Blanchet, Stephan Troyanov, Francois Harvey, Pierre Dumas, Johanne Tremblay, Renata Cifkova, Philip Awadalla, Francois Madore, Pavel Hamet
Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e., SLC2A9, SLC22A12, ABCG2) on the association between fractional excretion of uric acid (FEUA) and urinary albumin/creatinine ratio (uACR). Second, we examined uromodulin and sodium excretion as mediators of the association between FEUA and uACR. Methods: We performed cross-sectional analysis of 737 French Canadians from the CARTaGENE cohort, a random sample of the Quebec population aged 40-69 years (a total of 20,004 individuals)...
December 14, 2018: American Journal of Hypertension
Christophe Mariat, Pierre Delanaye, Jean-Philippe Bastard, Guillaume Résimont, Etienne Cavalier, Laurence Piéroni
Urinary proteins or urinary albumin exhibit a high intra individual variability. Therefore, urine collected during 24 hours has been recognized as a reference biological fluid for usual values determination. However, urine collection during a day is difficult and numerous studies have been performed to replace the "gold standard" with measures on random samples and results given as protein/creatinine ratio or albumin/creatinine ratio, to decrease the variability. The paper presents the populations where ratios are well correlated with protein excretion, the cut-off values recommended in clinical settings and the limits of using ratio rather than 24 h excretion...
December 1, 2018: Annales de Biologie Clinique
Chris H L Thio, Priya Vart, Lyanne M Kieneker, Harold Snieder, Ron T Gansevoort, Ute Bültmann
Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association. Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Educational level was categorized into low, medium and high (< secondary, secondary/equivalent, > secondary schooling, respectively)...
December 12, 2018: Nephrology, Dialysis, Transplantation
Ching-Wei Tsai, Han-Chun Huang, Ni Tien, Chih-Wei Chung, Hsien-Tsai Chiu, Hung-Chieh Yeh, Chin-Chi Kuo
BACKGROUND: The clinical importance of random urine creatinine concentration in CKD population remains undetermined. Earlier studies found that lower 24-h urine creatinine excretion was associated with the risk of ESRD and all-cause mortality among CKD patients. METHODS: We modeled the longitudinal trajectories of serial random urine creatinine among 4689 CKD patients enrolled in a national registry-based pre-ESRD program between 2003 and 2015 at a tertiary medical center...
December 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Hidenori Hirukawa, Shinji Kamei, Tomohiko Kimura, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
It is very important to explore how we can reduce urinary albumin excretion which is an independent risk factor for ischemic heart disease. In this study, we retrospectively evaluated the effects of RAS inhibitor therapy on diabetic nephropathy in Japanese subjects whose urinary albumin levels were within normal range. We enrolled 100 subjects with type 2 diabetes who did not take any renin-angiotensin system (RAS) inhibitor. We defined the subjects taking RAS inhibitor for more than 3 years as RAS inhibitor group...
2018: Journal of Diabetes Research
Antonio Mirijello, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Giuspina T Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
BACKGROUND: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM...
December 4, 2018: BMC Nephrology
Wen-Ling Liao, Chiz-Tzung Chang, Ching-Chu Chen, Wen-Jane Lee, Shih-Yi Lin, Hsin-Yi Liao, Chia-Ming Wu, Ya-Wen Chang, Chao-Jung Chen, Fuu-Jen Tsai
Diabetic nephropathy (DN) is a major complication in diabetic patients. Microalbuminuria testing is used to identify renal disease; however, its predictive value is questionable. We aimed to identify urinary biomarkers to early diagnosis nephropathy before identifiable alternations in kidney function or urine albumin excretion occurs. Proteomic approaches were used to identify potential urinary biomarkers and enzyme-linked immunosorbent assay was performed to verify the results. The data identified haptoglobin (HPT) and α-1-microglobulin/bikunin precursor (AMBP) as two biomarkers with the highest ability to distinguish between healthy individuals and patients with nephropathy, and between diabetic patients with and without DN...
November 26, 2018: Journal of Clinical Medicine
H K Aggarwal, Deepak Jain, Sudhir Mor, R K Yadav, Promil Jain
Introduction: Albuminuria is predictor of target organ damage and worse cardiovascular outcomes. Microalbuminuria has been found in a large number of patients with essential hypertension. Aim of our study was to evaluate the frequency of microalbuminuria in essential hypertension and to study its correlation with severity of hypertension and target organ damage. Materials and Methods: This cross-sectional study was conducted at the outpatient clinic of General Medicine department of Pt...
May 2018: Journal of the Association of Physicians of India
Changrun Guo, Yaping Dong, Hengqing Zhu, Yuxi Liu, Guoyong Xie
BACKGROUND: Diabetic nephropathy is one of the most common and serious complications of diabetes mellitus. HYPOTHESIS/PURPOSE: The present study aimed to investigate the effects of protodioscin on renal damage in high-fat diet-fed and streptozotocin-induced diabetic rats. METHODS: After 4 weeks of feeding a high-fat diet, male Sprague-Dawley rats were injected 35 mg/kg streptozotocin intraperitoneally. The diabetic rats were divided into 4 groups, and treated orally with carboxymethylcellulose sodium, metformin, or protodioscin (20 or 40 mg/kg)...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Eline H van den Berg, Eke G Gruppen, Richard W James, Stephan J L Bakker, Robin P F Dullaart
Non-alcoholic fatty liver disease (NAFLD) is featured by low HDL cholesterol, but activity of the HDL-associated anti-oxidative enzyme paraoxonase-1 (PON-1) remains unclear. To determine the association of PON-1 with suspected NAFLD, we measured serum enzyme activity in 7,622 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Fatty Liver Index (FLI)≥60, a proxy of NAFLD, was present in 2,083 participants (27.3%), and coincided with increased prevalence of type 2 diabetes mellitus (T2D), metabolic syndrome (MetS), (central) obesity, elevated triglycerides and low HDL cholesterol (all P<0...
November 19, 2018: Journal of Lipid Research
Luxitaa Goenka, R Padmanaban, Melvin George
Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon...
November 15, 2018: Current Clinical Pharmacology
Ryoko Umebayashi, Haruhito A Uchida, Yuka Okuyama, Yuki Kakio, Yoshihisa Hanayama, Kenichi Shikata, Jun Wada
PURPOSE: The purpose of present study was to evaluate the clinical efficacy of irbesartan on the anti-inflammatory and anti-oxidative stress effect in patients with hypertension compared to other ARBs. Further, we assessed the effect of the ARBs on kidney function and urinary albumin excretion. METHODS: Eighty-five outpatients with hypertension who took an ARB except irbesartan more than 3 months were assigned into 2 groups, one continued the same ARB and the other switched the ARB to irbesartan for 6 months...
November 16, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Ryohei Yamamoto, Maki Shinzawa, Yoshitaka Isaka, Etsuko Yamakoshi, Enyu Imai, Yasuo Ohashi, Akira Hishida
BACKGROUND AND OBJECTIVES: Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10-59 ml/min per 1...
December 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Minfang Zhang, Chaojun Qi, Yan Zha, Jian Chen, Ping Luo, Li Wang, Zhuxing Sun, Jianxin Wan, Changying Xing, Song Wang, Gengru Jiang, Mindan Sun, Qinkai Chen, Jianghua Chen, Detian Li, Tianjun Guan, Zhaohui Ni
OBJECTIVES: A prospective, multi-center, randomized controlled study was conducted to evaluate the efficacy and safety of a 24-week course low-dose leflunomide combined with prednisone in the induction treatment of proliferative lupus nephritis in Chinese patients. METHOD: Patients (n = 100) with biopsy-proved proliferative lupus nephritis were enrolled in this study. They were randomized into two groups and received either leflunomide or cyclophosphamide in conjunction with prednisone for 24 weeks...
November 13, 2018: Clinical Rheumatology
Habib Yaribeygi, Stephen L Atkin, Amirhossein Sahebkar
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α, and macrophage chemotactic protein-1; however, the role of IL-18 seems to be more specific than other cytokines in the inflammatory process. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate...
November 11, 2018: Journal of Cellular Physiology
Flaviu Bob, Adalbert Schiller, Romulus Timar, Daniel Lighezan, Oana Schiller, Bogdan Timar, Cristiana Georgeta Bujor, Mircea Munteanu, Florica Gadalean, Adelina Mihaescu, Iulia Grosu, Andreea Hategan, Lazar Chisavu, Agneta-Maria Pusztai, Adrian Covic
BACKGROUND: Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process. The aim of our study was to show the relationship between the levels of s-Klotho and tubular injury in patients with diabetic kidney disease (DKD), using as tubular injury marker the kidney injury molecule-1 (KIM-1). METHODS: Our study included 63 DKD patients (stages 1-5, mean eGFR 65...
November 2, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
D O Soyoye, S D Dawha, O O Ayoola, B O Ibitoye, R T Ikem, T A Adedeji
OBJECTIVES: Diabetic nephropathy is a common complication of diabetes mellitus due to microangiopathy leading to end stage renal disease. This study determined the relationship between renal resistivity index and pulsatility index with biochemical indices of renal function in patients with type 2 diabetes mellitus methods: This study involved 80 adults with type 2 diabetes mellitus. Urinary albumin excretion rate (UAER) and serum creatinine levels were measured, and the estimated glomerular filtration rate (eGFR) was calculated...
September 2018: West African Journal of Medicine
Maria Moura Santana Chaves, Matheus de Souza Mendes, Maximilian Pinho Schwermann, Raquel Queiroz, Regina Freitas Coelho, Francisco Thiago Santos Salmito, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins, Ana Cristina de Oliveira Monteiro Moreira, Alexandre Braga Libório
INTRODUCTION: Glomerulopathy is a group of diseases that affect mainly young adults between the ages of 20 and 40 years. Recently, it has been demonstrated that syndecan-1, a biomarker of endothelial glycocalyx damage, is increased in nephrotic patients with near-normal renal function and it is important to endothelial dysfunction in these patients. Angiopoietin-2 (AGPT2) is an endothelial growth factor that promotes cell derangement. Here we evaluated AGPT2 levels in patients with nephrotic syndrome, near-normal renal function and the possible interaction of AGPT2 with endothelial glycocalyx derangement...
October 31, 2018: Journal of Clinical Medicine
Qingfei Xiao, Yinghui Guan, Chenhao Li, Li Liu, Dan Zhao, Hongyue Wang
BACKGROUND: Lotensin has been shown to have a protective function in the early stage of chronic renal failure. However, its role in the intermediate and late stages of chronic renal failure remains largely unknown. The present study aimed to investigate the role and underlying mechanism of lotensin in advanced chronic kidney disease. METHODS: Female Wistar rats were randomly divided into three groups (n = 10): sham group, 5/6 nephrectomy (5/6 Nx) group, and lotensin group (oral administration of lotensin for 9 weeks following 5/6 Nx)...
November 2018: Renal Failure
Hiroaki Ichikawa, Ikuyo Narita, Masato Narita, Tomohiro Tanno, Yoshikazu Yokono, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita
Enhanced renin-angiotensin activity contributes to hypertension, albuminuria, and glomerular hypertrophy. The angiotensin (Ang)-converting enzyme (ACE) 2/Ang (1-7)/Mas axis pathway acts against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits albuminuria independently of blood pressure and elucidated the potential mechanisms.Three- to 4-month-old male mice overexpressing renin in the liver (Ren-TG) were given olmesartan (5 mg/kg/day) or hydralazine (Hyd) (3...
October 25, 2018: International Heart Journal
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