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Urinary albumin excretion

Takeshi Osonoi, Maki Gouda, Mamiko Kubo, Kenji Arakawa, Toshio Hashimoto, Masanori Abe
BACKGROUND: Albuminuria characterizes the progression of kidney injury. The effect of canagliflozin on the excretion of microalbumin was assessed for investigating its renoprotective potential in Japanese patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: Twenty Japanese patients with T2DM and microalbuminuria were enrolled and administered with 100 mg of canagliflozin once a day for 12 weeks. These subjects were admitted to the clinic at the start and end of the treatment period for 24-h urine collection...
August 10, 2018: Diabetes Technology & Therapeutics
Ana Luiza Teixeira Dos Santos, Camila Kummel Duarte, Manoella Santos, Maira Zoldan, Jussara Carnevalle Almeida, Jorge Luiz Gross, Mirela Jobim Azevedo, Alice Hinda Lichtenstein, Themis Zelmanovitz
AIM: This cross-sectional study aimed to assess the association of the fat content in the diet with Diabetic Kidney Disease (DKD) in patients with type 2 diabetes. METHODOLOGY: Patients from the Diabetes research clinic at Hospital de Clínicas de Porto Alegre (Brazil) were consecutively recruited. The inclusion criterion was the diagnosis of type 2 diabetes. The exclusion criteria were as follows: body mass index >40 kg/m2, heart failure, gastroparesis, diabetic diarrhea, dietary counseling by a registered dietitian during the previous 12 months, and inability to perform the weighed diet records (WDR)...
2018: PloS One
Hazem M El-Ashmawy, Azza M Ahmed
BACKGROUND: The aim of the study was to evaluate the relationship between serum cathelicidin level and diabetic nephropathy (DN) in patients with type 1 diabetes mellitus (T1DM). METHODS: The study group consisted of 76 patients with T1DM (47 men), aged 36 ± 7 years and with duration of T1DM 14 (7-18) years. Serum cathelicidin was measured by ELISA kit test in healthy controls (n = 20) and in 76 T1DM patients grouped as follows: G1= patients with normal urinary albumin excretion (n = 20); G2= patients with microalbumin excretion (n = 19); G 3= patients with macroalbumin excretion but normal serum creatinine level (n = 19), G4 = patients with macroalbumin excretion with increased serum creatinine (n = 18)...
August 9, 2018: Diabetes/metabolism Research and Reviews
Jiehan Chong, James Fotheringham, Charles Tomson, Timothy Ellam
Background: Current classification systems do not specify a healthy normal range for urinary albumin excretion. Occult microvascular disease induced by a Western lifestyle may mean that normal values for apparently healthy adults exceed optimal levels defined by mortality risk. Methods: Using a national population sample [the US Third National Health and Nutrition Examination Survey (NHANES III) cohort; n = 11 887], the distributions of albumin:creatinine ratio (ACR) and fractional excretion of albumin (FEalb) were studied in healthy young adults [ages 20-40 years, without cardiovascular disease (CVD) or risk factors]...
August 6, 2018: Nephrology, Dialysis, Transplantation
Pengxun Han, Hongyue Zhan, Mumin Shao, Wenjing Wang, Gaofeng Song, Xuewen Yu, Chunlei Zhang, Na Ge, Tiegang Yi, Shunmin Li, Huili Sun
AIMS: Early diabetic kidney disease (DKD) is characterized by renal hypertrophy and albuminuria. The mTOR signal pathway is closely related to DKD. This study was performed to determine the renal protection of niclosamide ethanolamine salt (NEN) which was identified as mTOR inhibitor. METHODS: Type 2 diabetes (T2D) db/db mice were used and divided into db/db and db/db+NEN groups. Lean wild type mice served as T2D-control. NEN treatment lasted for 12 weeks. The kidney morphological changes, urine indices, blood glucose and metabolic symptoms were evaluated...
August 3, 2018: Diabetes Research and Clinical Practice
Xue Gao, Hongfang Liu, Zhichao An, Qiying He
Background: Diabetic nephropathy (DN) is a microvascular complication induced by diabetes mellitus (DM), which can affect life quality and long-term prognosis of patients with DM. Angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) are currently recommended for treating DN proteinuria, but patients receiving ACEI/ARB are at risk of elevated serum creatinine or potassium levels. Based on the "yin-yang" theory of traditional Chinese medicine, the present study explored the effect of QiDiTangShen (QDTS) granules on DN and the phosphorylation balance of tyrosine and serine residues of IRS-1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yu-Hsuan Li, Wayne H-H Sheu, I-Te Lee
OBJECTIVE: Normoalbuminuric chronic kidney disease (NA-CKD) is recognised as a distinct phenotype of diabetic kidney disease, but the role of diabetic retinopathy (DR) in predicting long-term mortality among these patients remains unclear. Here, we aimed to investigate the effects of DR and CKD on mortality in type 2 diabetic patients with normoalbuminuria. DESIGN: We conducted this study as a retrospective cohort study. SETTING: We collected clinical information from the medical records of a public medical centre in central Taiwan...
July 25, 2018: BMJ Open
Hua Zhou, Min Yang, Zhenxing Jiang, Jiule Ding, Jia Di, Li Cui
BACKGROUND: Blood oxygen level-dependent (BOLD)-MRI is a novel and noninvasive tool that can assess renal oxygenation. The R2* value is a parameter of tissue deoxyhemoglobin concentration detected by BOLD-MRI. The purpose of the current study was to determine the relationships between renal R2* values and clinical parameters and to determine whether renal R2* values were associated with the risk for progression of chronic kidney disease (CKD). METHODS: Sixty patients with CKD were enrolled in this prospective observational study in China from March 2013 to August 2014...
July 26, 2018: American Journal of Nephrology
Alexandra Kovalčíková, Marianna Gyurászová, Roman Gardlík, Martin Boriš, Peter Celec, Ľubomíra Tóthová
Representative urine collection that respects the standards of animal welfare is still an issue in experimental nephrology. The commonly used metabolic cages induce stress in rodents. In mice, the volume of collected urine is sometimes insufficient for further analysis. The aim of this experiment was to analyse the effects of time of day, temperature and 2%, 5% or 10% sucrose solutions on diuresis, weight change and liquid intake of adult mice placed in metabolic cages for urine collection. Mice were placed in metabolic cages for 12 h during the day or night at standard ambient (22℃) and thermoneutral (28℃) temperatures...
July 25, 2018: Laboratory Animals
So Young Kim, Tae Dong Jeong, Woochang Lee, Sail Chun, Sung Sunwoo, Soon Bae Kim, Won Ki Min
BACKGROUND: An increase in neutrophil gelatinase-associated lipocalin (NGAL) indicates tubular injury. Diabetic nephropathy causes typical changes in the kidney, characterized by glomerulosclerosis and eventual tubular damage. We validated the usefulness of plasma NGAL (pNGAL) as a biomarker of tubular damage in patients with diabetic nephropathy. METHODS: We included 376 patients with diabetes mellitus (260 patients with chronic renal insufficiency who had not received hemodialysis and 116 hemodialyzed due to diabetic nephropathy) and 24 healthy controls...
November 2018: Annals of Laboratory Medicine
Chao-Jung Chen, Wen-Ling Liao, Chiz-Tzung Chang, Hsin-Yi Liao, Fuu-Jen Tsai
Diabetic nephropathy (DN) is one of the most common complications in diabetic patients. New noninvasive markers are still needed for the early detection of DN before identifiable alternations in kidney function or urine albumin excretion occurs. A C18 plate and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) were used to compare the urinary protein profiles of 238 subjects from the following 4 groups: patients with type 2 diabetic (T2D) with microalbuminuria, patients with DM without micro- or macroalbuminuria, patients with micro- or macroalbuminuria due to nondiabetic disease, and healthy controls...
2018: PloS One
Pingping Jiang, Lei Xiang, Zewei Chen, Hanqi Lu, Lin Zhou, Lebin Yang, Yanzhao Ji, Yanyan Liu, Xiaomin Sun, Yingfeng Deng, Xiaoli Nie, Ren Luo, Xiaoshan Zhao
OBJECTIVE: To evaluate the protective effect of catalpol against diabetic nephropathy in db/db mouse. METHODS: 8 week old C57BLKS/J db/db mice (type 2 diabetic mouse model) were divided into three groups to feed for 16 weeks on chow diet with or without catalpol supplementation. Their food intake, water consumption, body weight, and fasting glucose levels were recorded every 4 weeks. At the end of study, urine and blood samples were examined for several metabolic variables, and kidneys were harvested for structural characterization and microarray analysis...
2018: American Journal of Translational Research
Ruben Rodriguez, Andrew Lee, Keisa W Mathis, Hanna J Broome, Max Thorwald, Bridget Martinez, Daisuke Nakano, Akira Nishiyama, Michael J Ryan, Rudy M Ortiz
Pathological activation of the renin-angiotensin system and inflammation are associated with hypertension and the development of metabolic syndrome (MetS). The contributions of angiotensin receptor type 1 (AT1) activation, independent of blood pressure, and inflammation on glucose intolerance and renal damage are not well defined. Using a rat model of MetS, we hypothesized that the onset of glucose intolerance is primarily mediated by AT1 activation and inflammation independent of elevated systolic blood pressure (SBP)...
July 11, 2018: American Journal of Physiology. Renal Physiology
Vishal J Patel, Amit A Joharapurkar, Samadhan G Kshirsagar, Brijesh K Sutariya, Maulik S Patel, Hiren M Patel, Dheerendra K Pandey, Rajesh H Bahekar, Mukul R Jain
AIM: To investigate the role of glucagon-like peptide-1 (GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS: Chronic high-fat diet fed C57BL/6J mice, streptozotocin-treated high-fat diet fed C57BL/6J mice and diabetic C57BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocin-treated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist (Aib2 C24 Chimera2, 150 μg/kg, sc ) for twelve weeks, while in chronic high-fat diet fed mice, coagonist (Aib2 C24 Chimera2, 150 μg/kg, sc ) treatment was continued for forty weeks...
June 15, 2018: World Journal of Diabetes
A Sattarinezhad, J Roozbeh, B Shirazi Yeganeh, G R Omrani, M Shams
AIM: Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500mg/day) or placebo for 90 days. Losartan (12.5mg/day) was also administered to all participants...
June 8, 2018: Diabetes & Metabolism
Liang Feng, Hithanadura Asita de Silva, Imtiaz Jehan, Aliya Naheed, Anuradhani Kasturiratne, Gulshan Himani, Mohammad Abul Hasnat, Tazeen H Jafar
Background: We aimed to determine the prevalence of chronic kidney disease (CKD) and its cross-country variation among hypertensive individuals in rural Bangladesh, Pakistan and Sri Lanka. We also explored the factors associated with CKD in these populations. Method: We studied baseline data from the Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan and Sri Lanka (COBRA-BPS) trial, an ongoing cluster randomized controlled trial on 2643 hypertensive adults ≥40 years of age from 30 randomly selected rural clusters, 10 in each of the three countries...
July 5, 2018: Nephrology, Dialysis, Transplantation
Ali C M Johnson, Richard A Zager
BACKGROUND: Recent clinical data support the utility/superiority of a new AKI biomarker ("NephroCheck"), the arithmetic product of urinary TIMP × IGFBP7 concentrations. However, the pathophysiologic basis for its utility remains ill defined. METHODS: To clarify this issue, CD-1 mice were subjected to either nephrotoxic (glycerol, maleate) or ischemic AKI. Urinary TIMP2/IGFBP7 concentrations were determined at 4 and 18 hours postinjury and compared with urinary albumin levels...
August 2018: Journal of the American Society of Nephrology: JASN
Xin-Bin Wang, En-Lai Dai, Guo-Zhong Xue, Rui-Ling Ma
BACKGROUND: The present study aims to comprehensively determine the efficacy of different therapy regimens based on Tripterygium wilfordii Hook F (TwHF) for patients with primary nephrotic syndrome (PNS) using network meta-analysis method. METHODS: Seven electronic databases were searched to identify randomized controlled trials (RCTs) that compared the differences between different therapy regimens based on TwHF for patients with PNS. The risk of bias in included RCTs was evaluated according to the Cochrane Handbook version 5...
July 2018: Medicine (Baltimore)
Gaizun Hu, Osamu Ito, Rong Rong, Akihiro Sakuyama, Takahiro Miura, Daisuke Ito, Yoshiko Ogawa, Masahiro Kohzuki
Background: Clinical trials show potent renoprotective effects of pitavastatin (PTV), although the precise mechanism for these renoprotective effects is not fully clarified. The aim of this study was to examine the antihypertensive and renoprotective effects of PTV, focusing on the nitric oxide (NO) system. Methods: Male, 6-week-old, spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were randomized to receive vehicle or PTV (2 mg/kg bodyweight) for 8 weeks...
June 27, 2018: American Journal of Hypertension
Yan Xing, Shandong Ye, Yan Chen, Aihong Fan, Zhuohua Xu, Wen Jiang
Introduction:To observe the effects of metformin on urinary excretion of MIF, CD74 and podocalyxin in type 2 diabetics and to explore its possible renoprotective mechanisms. METHODS: 202 uncontrolled type 2 diabetics, who were previously prescribed sulfonylurea monotherapy(n=100) or sulfonylurea in combination with metformin (n=102) were enrolled in the study. The amount of macrophage migration inhibitory factor(MIF) and CD74 in serum, urinary MIF to creatine ratio(UMCR), urinary CD74 to creatine ratio(UCCR), urinary albumin to creatine ratio(UACR) and urinary podocalyxin to creatine ratio (UPCR) were determined...
2018: Endokrynologia Polska
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