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https://www.readbyqxmd.com/read/30328050/predictors-of-time-to-death-after-distant-recurrence-in-breast-cancer-patients
#1
Victoria Sopik, Ping Sun, Steven A Narod
BACKGROUND: After experiencing a distant recurrence, breast cancer patients have a poor prognosis; fewer than 5% survive for ten or more years. However, the time to death is highly variable, ranging from a few months to many years. The purpose of this study is to identify, in a large hospital-based series of patients with early-stage breast cancer, factors which predict survival after distant recurrence. METHODS: We studied a cohort of 2312 women diagnosed with invasive breast cancer at Women's College Hospital between 1987 and 2000 (stages I-III)...
October 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30298381/radiotherapy-in-palliation-of-thoracic-tumors-a-phase-i-ii-study-sharon-project
#2
Eleonora Farina, Gabriella Macchia, Milly Buwenge, Giambattista Siepe, Alice Zamagni, Silvia Cammelli, Savino Cilla, Tigeneh Wondemagegnhu, Aynalem A Woldemariam, A F M Kamal Uddin, Mostafà Aziz Sumon, Francesco Cellini, Francesco Deodato, Alessio G Morganti
The main clinical goal for patients with advanced or metastatic thoracic cancer is palliation of tumor-related symptoms and improvement of quality of life. The aim of this phase I-II trial was to define the maximum tolerated dose (MTD) of a short-course of palliative radiotherapy (RT) and to evaluate its efficacy in terms of palliative response. A phase I trial was planned with escalating dose increments. Total doses ranged from 16 to 20 Gy delivered (BID) in two consecutive days. Dose limiting toxicity was defined as any acute grade ≥ 3 toxicity based on the RTOG scale...
October 8, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/30289394/positive-effect-of-single-nucleotide-rad51-135g-c-polymorphism-and-low-ku70-protein-expression-on-female-rectal-cancer-patients-survival-after-preoperative-radiotherapy
#3
Anna Gasinska, Beata Biesaga, Anna Janecka Widla, Zbigniew Darasz
BACKGROUND/AIMS: This is a retrospective analysis of 103 patients having locally advanced rectal cancer who received short-course radiotherapy (SCRT). The objective of the study was to check whether a polymorphism in the RAD51 gene (135 G>C), Ku70 protein expression, and tumor microenvironment: proliferation rate measured by BrdUrdLI and Ki-67LI, hypoxia (glucose transporter-1 expression), P53 protein expression, and DNA ploidy can influence DNA repair capacity, the factors contributing to patient overall survival (OS) and the incidence of recurrences and metastases...
October 5, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/30284906/comparison-of-long-course-and-short-course-preoperative-radiotherapy-in-the-treatment-of-locally-advanced-rectal-cancer-a-systematic-review-and-meta-analysis
#4
Yongjun Yu, Yuwei Li, Chen Xu, Zhao Zhang, Xipeng Zhang
BACKGROUND: rectal cancer (RC) is one of the most prevalent malignancies worldwide and different preoperative radiotherapies may lead to different outcomes. This meta-analysis aimed to compare the effectiveness of long-course (LC) and short-course radiotherapy (SC), with or without chemotherapy, for locally advanced rectal cancer. METHODS: studies published up to March 31st 2018 were retrieved from PubMed, Medline, Cochrane and EMABSE. Randomized control or consort control trials that reported the outcomes of short or long course radiotherapy were eligible...
October 4, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/30284239/preoperative-radiotherapy-and-curative-surgery-for-the-management-of-localised-rectal-carcinoma
#5
REVIEW
Iosief Abraha, Cynthia Aristei, Isabella Palumbo, Marco Lupattelli, Stefano Trastulli, Roberto Cirocchi, Rita De Florio, Vincenzo Valentini
BACKGROUND: This is an update of the original review published in 2007.Carcinoma of the rectum is a common malignancy, especially in high income countries. Local recurrence may occur after surgery alone. Preoperative radiotherapy (PRT) has the potential to reduce the risk of local recurrence and improve outcomes in rectal cancer. OBJECTIVES: To determine the effect of preoperative radiotherapy for people with localised resectable rectal cancer compared to surgery alone...
October 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30274984/targeting-resistance-against-the-mdm2-inhibitor-rg7388-in-glioblastoma-cells-by-the-mek-inhibitor-trametinib
#6
Anne Berberich, Tobias Kessler, Carina M Thomé, Stefan Pusch, Thomas Hielscher, Felix Sahm, Iris Oezen, Lara-Marie Schmitt, Sara Ciprut, Nanina Hucke, Petra Rübmann, Manuel Fischer, Dieter Lemke, Michael O Breckwoldt, Andreas von Deimling, Martin Bendszus, Michael Platten, Wolfgang Wick
PURPOSE: Resistance is an obstacle of glioma therapy. Despite targeted interventions, tumors harbor primary resistance or become resistant over short course of treatment. This study examined the mouse double minute 2 (MDM2) inhibitor RG7388 together with radiotherapy and analyzed strategies to overcome acquired MDM2 inhibitor resistance in glioblastoma. EXPERIMENTAL DESIGN: Effects of RG7388 and radiotherapy were analyzed in p53 wild-type glioblastoma cell lines and glioma-initiating cells...
October 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30258994/bacchus-a-randomised-non-comparative-phase-ii-study-of-neoadjuvant-chemotherapy-nact-in-patients-with-locally-advanced-rectal-cancer-larc
#7
R Glynne-Jones, M R Hall, A Lopes, S Pearce, V Goh, S Bosompem, J Bridgewater, I Chau, H Wasan, B Moran, L Melcher, N P West, P Quirke, W-L Wong, S Beare, N Hava, M Duggan, M Harrison
Background: Chemoradiation (CRT) or short-course radiotherapy (SCRT) are standard treatments for locally advanced rectal cancer (LARC). We evaluated the efficacy/safety of two neoadjuvant chemotherapy (NACT) regimens as an alternative prior to total mesorectal excision (TME). Methods/design: This multi-centre, phase II trial in patients with magnetic resonance imaging (MRI) defined high-risk LARC (>cT3b, cN2+ or extramural venous invasion) randomised patients (1:1) to FOLFOX + Bevacizumab (Arm 1) or FOLFOXIRI + bevacizumab (Arm 2) every 14 days for 6 cycles prior to surgery...
September 2018: Heliyon
https://www.readbyqxmd.com/read/30243484/short-course-radiotherapy-in-neoadjuvant-treatment-for-rectal-cancer-a-systematic-review-and-meta-analysis
#8
Bin Ma, Peng Gao, Yongxi Song, Xuanzhang Huang, Hongchi Wang, Qingzhou Xu, Shan Zhao, Zhenning Wang
BACKGROUND: To assess whether preoperative short-course radiotherapy (PSRT) could be the treatment of choice compared to preoperative long-course chemoradiotherapy (PLCRT) METHODS: The PubMed, Embase, and Web of Science Databases were searched to conduct a systematic review and meta-analysis. Perioperative and survival outcomes between PSRT and PLCRT were selected as end points for our meta-analysis. In addition, health-related quality-of-life outcomes were also systematically reviewed between PSRT and PLCRT...
August 11, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/30240527/short-course-carbon-ion-radiotherapy-for-hepatocellular-carcinoma-a-multi-institutional-retrospective-study
#9
Kei Shibuya, Tatsuya Ohno, Kazuki Terashima, Shingo Toyama, Shigeo Yasuda, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Kenji Nemoto, Tadashi Kamada, Takashi Nakano
BACKGROUND & AIMS: Carbon-ion radiation therapy has shown encouraging results in hepatocellular carcinoma patients in single-centre studies. We evaluated the effectiveness and safety of short-course carbon-ion radiation therapy for hepatocellular carcinoma in a multicentre study conducted by the Japan Carbon Ion Radiation Oncology Study Group. METHODS: Consecutive hepatocellular carcinoma patients who were treated with carbon-ion radiation therapy in four or fewer fractions at four Japanese institutions between April 2005 and November 2014 were analysed retrospectively...
September 21, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30220111/partially-ablative-radiotherapy-par-for-large-mass-tumors-using-simultaneous-integrated-boost-a-dose-escalation-feasibility-study
#10
Savino Cilla, Francesco Deodato, Anna Ianiro, Gabriella Macchia, Vincenzo Picardi, Milly Buwenge, Silvia Cammelli, Alice Zamagni, Vincenzo Valentini, Alessio G Morganti
PURPOSE: This study aimed to assess the feasibility to plan and deliver highly heterogeneous doses to symptomatic large tumors using volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB) during a short course palliative accelerated radiotherapy. METHODS: A patient with a large symptomatic chordoma infiltrating the right gluteal region was selected. A modified SIB treatment was implemented to irradiate the central volume of the tumor (boost target volume, BTV) up to 10 Gy/fraction in a dose escalation trial while maintaining the remaining tumor volume (planning target volume, PTV) and the surrounding healthy tissues within 5 Gy/fraction in twice daily fractions for two consecutive days...
September 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/30186977/activation-of-immune-responses-in-patients-with-relapsed-metastatic-head-and-neck-cancer-confront-phase-i-ii-trial-multimodality-immunotherapy-with-avelumab-short-course-radiotherapy-and-cyclophosphamide
#11
Marco C Merlano, Anna M Merlotti, Lisa Licitra, Nerina Denaro, Elena Fea, Danilo Galizia, Massimo Di Maio, Claudia Fruttero, Paola Curcio, Stefania Vecchio, Elvio G Russi, Renzo Corvò
Introduction and background: Second-line treatment of platinum-resistant relapsed/metastatic (R/M) head and neck cancer (HNC) is a currently unmet clinical need. Clinical trials showed improvement in overall survival and quality of life of R/M-HNC patients treated with anti-PD-1 regardless of the number of prior chemotherapy lines; however, the percentage of long-term survivors remains limited.This study aims to test the hypothesis that attacking the tumor microenvironment at multiple levels can increase immunogenicity of R/M-HNC without worsening the safety profile of immune checkpoint inhibitors...
August 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/30185419/smad7-promotes-healing-of-radiotherapy-induced-oral-mucositis-without-compromising-oral-cancer-therapy-in-a-xenograft-mouse-model
#12
Jingjing Luo, Li Bian, Melanie A Blevins, Donna Wang, Chao Liang, Danfeng Du, FangLong Wu, Barry Holwerda, Rui Zhao, David Raben, Hongmei Zhou, Christian Young, Xiao-Jing Wang
PURPOSE: We previously reported preventive and therapeutic effects of Smad7, a multifunctional protein, on radiation-induced mucositis in mice without promoting human oral cancer cell survival or migration in vitro. The current study aims to determine whether a Smad7-based biologic can treat existing oral mucositis during radiotherapy for oral cancer and whether this treatment compromises RT-induced cancer cell killing in neighboring oral cancer. EXPERIMENTAL DESIGN: We transplanted human oral cancer cells into the tongues of mice and applied craniofacial irradiation to simultaneously kill tumor cells and induce oral mucositis, thus modeling RT and mucositis in oral cancer patients...
September 5, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30143462/-image-guided-radiotherapy-contribution-and-patient-setup-for-anorectal-cancer-treatment
#13
REVIEW
I Masson, G Delpon, V Vendrely
Intensity-modulated radiation therapy is recommended in anal squamous cell carcinoma treatment and is increasingly used in rectal cancer. It adapts the dose to target volumes, with a high doses gradient. Intensity-modulated radiation therapy allows to reduce toxicity to critical normal structures and to consider dose-escalation studies or systemic treatment intensification. Image-guided radiation therapy is a warrant of quality for intensity-modulated radiation therapy, especially for successful delivery of the dose as planned...
October 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/30129043/margin-and-ptv-volume-reduction-using-a-population-based-library-of-plans-strategy-for-rectal-cancer-radiotherapy
#14
Chris Beekman, Baukelien van Triest, Suzanne van Beek, Jan-Jakob Sonke, Peter Remeijer
PURPOSE: Day-to-day shape variation in the rectum CTV results in considerable geometric uncertainties during rectal cancer radiotherapy. To ensure coverage a large CTV-to-PTV margin is required. The purpose of this study was to increase the accuracy of treatment delivery by building a population based library of planning CTVs for rectal cancer patients and to evaluate its potential for rectum PTV margin and PTV volume reduction. METHODS: Analysis was done retrospectively on 33 early-stage rectal cancer patients with daily repeat CTs who received short-course pre-operative radiotherapy in 5 fractions of 5 Gy...
August 20, 2018: Medical Physics
https://www.readbyqxmd.com/read/30121938/short-course-regimen-of-palliative-radiotherapy-in-complicated-bone-metastases-a-phase-i-ii-study-sharon-project
#15
Jenny Capuccini, Gabriella Macchia, Eleonora Farina, Milly Buwenge, Domenico Genovesi, Luciana Caravatta, Nam P Nguyen, Silvia Cammelli, Savino Cilla, Tigeneh Wondemagegnhu, A F M Kamal Uddin, Mostafà Aziz Sumon, Francesco Cellini, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
Metastases with soft tissues invasion, impending fractures or spinal cord compression (complicated bone metastases) represent a common clinical problem in advanced cancers and frequently lead to deterioration of patients' quality of life (QoL). A phase I-II study was planned to define the maximum tolerated dose (MTD) of a short-course radiotherapy (RT) and its efficacy in palliation of complicated bone metastases. A phase I trial was designed with three dose-escalation steps: 16, 18, and 20 Gy. Total dose at each level was delivered in 2 days, twice daily...
August 18, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/30116024/a-prospective-phase-ii-study-of-pre-operative-chemotherapy-then-short-course-radiotherapy-for-high-risk-rectal-cancer-copernicus
#16
Simon Gollins, Nicholas West, David Sebag-Montefiore, Shabbir Susnerwala, Stephen Falk, Nick Brown, Mark Saunders, Philip Quirke, Ruby Ray, Philip Parsons, Gareth Griffiths, Tim Maughan, Richard Adams, Chris Hurt
BACKGROUND: Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastases but is not standard of care. There are currently no biomarkers predicting long-term progression-free survival (PFS) benefit from NAC. PATIENTS AND METHODS: In this single arm phase II trial, patients with non-metastatic magnetic resonance imaging (MRI)-defined operable rectal adenocarcinoma at high risk of post-operative metastatic recurrence, received 8 weeks of oxaliplatin/fluorouracil NAC then short-course preoperative radiotherapy (SCPRT) before immediate surgery...
September 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30108013/-hypofractionad-radiotherapy-for-elderly-with-head-and-neck-cancer
#17
REVIEW
C Ortholan, A Auperin, C Mertens, H Le Caer, J Guigay
Thirty percent of patients with head and neck cancer are over 70 years. Radiotherapy approach in elderly is a challenge. On one hand, radiotherapy side effects, as well as the number of sessions required, could be a burden. On the other hand, omission of local treatment is not an option due to the symptoms of the tumor. Patients in good general condition may receive standard fractionnated radiotherapy. For frail patients unsuitable for standard fractionated radiotherapy, more convenient shorter course of radiotherapy are commonly used...
October 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/30092843/prospective-randomized-controlled-trial-to-compare-laparoscopic-distal-gastrectomy-d2-lymphadenectomy-plus-complete-mesogastrium-excision-d2-cme-with-conventional-d2-lymphadenectomy-for-locally-advanced-gastric-adenocarcinoma-study-protocol-for-a-randomized
#18
Jie Shen, Beibei Cao, Yatao Wang, Aitang Xiao, Jichao Qin, Jianhong Wu, Qun Yan, Yuanlong Hu, Chuanyong Yang, Zhixin Cao, Junbo Hu, Ping Yin, Daxing Xie, Jianping Gong
BACKGROUND: Although radical gastrectomy with D2 lymph node dissection has become the standard surgical approach for locally advanced gastric cancer, patients still have a poor prognosis after operation. Previously, we proposed laparoscopic distal gastrectomy (D2 lymphadenectomy plus complete mesogastrium excision [D2 + CME]) as an optimized surgical procedure for locally advanced gastric cancer. By dissection along the boundary of the mesogastrium, D2 + CME resected proximal segments of the dorsal mesogastrium completely with less blood loss, and it improved the short-term surgical outcome...
August 9, 2018: Trials
https://www.readbyqxmd.com/read/30079958/prognostic-implications-of-mri-detected-lateral-nodal-disease-and-extramural-vascular-invasion-in-rectal-cancer
#19
D P Schaap, A Ogura, J Nederend, M Maas, J S Cnossen, G J Creemers, I van Lijnschoten, G A P Nieuwenhuijzen, H J T Rutten, M Kusters
BACKGROUND: Lateral nodal disease in rectal cancer remains a subject of debate and is treated differently in the East and the West. The predictive value of lateral lymph node and MRI-detected extramural vascular invasion (mrEMVI) features on oncological outcomes was assessed in this study. METHODS: In this retrospective cohort study, data on patients with cT3-4 rectal cancer within 8 cm from the anal verge were considered over a 5-year period (2009-2013). Lateral lymph node size, malignant features and mrEMVI features were evaluated and related to oncological outcomes...
August 6, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/30077790/short-hypofractionated-radiotherapy-in-palliation-of-pediatric-malignancies-outcomes-and-toxicities
#20
Stanislav Lazarev, Brian H Kushner, Suzanne L Wolden
PURPOSE: Treatment strategies in palliation of pediatric cancer remain a significant challenge. In this study, we aimed to assess efficacy and safety of a short course of hypofractionated RT for metastatic, or recurrent childhood tumors. METHODS AND MATERIALS: A total of 104 lesions in 62 pediatric patients with metastatic or recurrent cancer were treated with a short hypofractionation schedule (>1 but ≤5 fractions; ≥3 Gy per fraction) between 2007 and 2017 in our institution...
August 2, 2018: International Journal of Radiation Oncology, Biology, Physics
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