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https://www.readbyqxmd.com/read/28945009/biomechanical-regulation-of-mesenchymal-stem-cells-for-cardiovascular-tissue-engineering
#1
REVIEW
Kayla Henderson, Andrew D Sligar, Victoria P Le, Jason Lee, Aaron B Baker
Mesenchymal stem cells (MSCs) are an appealing potential therapy for vascular diseases; however, many challenges remain in their clinical translation. While the use of biochemical, pharmacological, and substrate-mediated treatments to condition MSCs has been subjected to intense investigation, there has been far less exploration of using these treatments in combination with applied mechanical force for conditioning MSCs toward vascular phenotypes. This review summarizes the current understanding of the use of applied mechanical forces to differentiate MSCs into vascular cells and enhance their therapeutic potential for cardiovascular disease...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944939/there-is-no-remarkable-differences-between-the-pedicle-screw-and-hybrid-construct-about-the-correction-of-lenke-type-i-curves
#2
Ulaş Serarslan, Emin Alici, Ömer Akçali, Can Koşay, Meriç Unal, Alper Gultekin
AIM: Lenke type-1, primary main thoracic curve pattern, is the most common spinal deformity pattern in adolescent idiopathic scoliosis (AIS). Posterior spinal fusion with all screw instrumentation or hybrid type instrumentation has been shown to achieve reliable deformity correction. The aim of this study is to compare deformity correction success of segmental pedicle screw and hybrid instrumentation for the treatment of Lenke type-1 AIS curves. MATERIAL AND METHODS: Surgically treated Lenke type-1 scoliosis patients were retrospectively evaluated and data of 26 patients that treated with hybrid instrumentation were included into first group...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944867/succinate-promotes-skeletal-muscle-protein-synthesis-via-erk1-2-signaling-pathway
#3
Yexian Yuan, Yaqiong Xu, Jingren Xu, Bingqing Liang, Xingcai Cai, Canjun Zhu, Lina Wang, Songbo Wang, Xiaotong Zhu, Ping Gao, Xiuqi Wang, Yongliang Zhang, Qingyan Jiang, Gang Shu
It is well known that endurance training is effective to attenuate skeletal muscle atrophy. Succinate is a typical TCA metabolite, of which exercise could dramatically increase the content. The present study aimed to investigate the effect of succinate on protein synthesis in skeletal muscle, and try to delineate the underlying mechanism. The in vitro study revealed that succinate dose‑dependently increased protein synthesis in C2C12 myotube along with the enhancement of phosphorylation levels of AKT Serine/Threonine Kinase 1(Akt), mammalian target of rapamycin, S6, eukaryotic translation initiation factor 4E, 4E binding protein 1 and forkhead box O (FoxO) 3a...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944853/kisspeptin-inhibits-cancer-growth-and-metastasis-via-activation-of-eif2ak2
#4
Tae-Hun Kim, Sung-Gook Cho
Kisspeptin is a protein encoded by the KISS1 gene, which has been reported to suppress the metastatic capabilities of various types of cancer cells, through the activation of its G‑protein coupled receptor GPR54. However, the molecular mechanisms underlying the involvement of kisspeptin‑mediated signaling in the inhibition of cancer cell migration and invasion have yet to be elucidated. The present in vitro cell proliferation, migration and invasion assays and in vivo experimental metastasis studies demonstrated that kisspeptin‑induced eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) activation suppressed the metastatic capabilities of several types of cancer cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944851/microrna%C3%A2-96-regulates-the-proliferation-of-nucleus-pulposus-cells-by-targeting-arid2-akt-signaling
#5
Bo Tao, Jiaoyu Yi, Changzhao Huang, Wang Xu, Chao Qin, Lei Chen, Jincai Chen, Yan Gao, Ruiying Wang
The aberrant proliferation of nucleus pulposus (NP) cells has been reported to be implicated in the pathogenesis of intervertebral disc degeneration (IDD). Previous studies have demonstrated that microRNAs (miRNAs), which are a group of small noncoding RNAs, are critical regulators of cell proliferation in various pathologies. However, the role of miRNA‑96 (miR‑96) in the proliferation of NP cells remains to be determined. In the present study, reverse transcription‑quantitative polymerase chain reaction was used to investigate the expression of miR‑96 in NP tissues from patients with IDD and healthy tissues from patients with traumatic lumbar fracture as the control...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944715/balance-training-enhances-motor-coordination-during-a-perturbed-side-step-cutting-task
#6
Anderson Souza Oliveira, Priscila de Brito Silva, Morten Enemark Lund, Dario Farina, Uwe Gustav Kersting
Study Design Controlled laboratory study. Background Balance training (BTR) may improve motor coordination, however little is known about the changes in motor coordination during unexpected perturbations to postural control following BTR. Objectives To study the effects of BTR on motor coordination and knee mechanics during perturbed side-step cutting maneuvers in healthy adults. Methods Twenty-six healthy men were randomly assigned to a training group (TG) or control (CG). Before BTR, subjects performed unperturbed, 90° side-step cutting maneuvers and one unexpected perturbed cut (10-cm translation of a moveable platform)...
September 23, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28944618/comparison-of-algorithms-for-automated-femur-fracture-reduction
#7
Eduardo M Suero, Ralf Westphal, Musa Citak, Nael Hawi, Emmanouil Liodakis, Mohamed Omar, Christian Krettek, Timo Stuebig
PURPOSE: We designed an experiment to determine the comparative effectiveness of computer algorithms for performing automated long bone fracture reduction. METHODS: Automated reduction of 10 3D fracture models was performed using two computer algorithms, random sample matching (RANSAM) and Z-buffering (Z-Buffer), and one of five options of post-processing: none; iterative closest point algorithm (ICP); ICP-X1; ICP-X2; and ICP-X3. We measured the final alignment between the two fragments for each algorithm and post-processing option...
September 24, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28944609/hypertension-management-research-priorities-from-patients-caregivers-and-healthcare-providers-a-report-from-the-hypertension-canada-priority-setting-partnership-group
#8
Nadia Khan, Simon L Bacon, Samia Khan, Sara Perlmutter, Carline Gerlinsky, Mark Dermer, Lonni Johnson, Finderson Alves, Donna McLean, Andreas Laupacis, Mandy Pui, Angelique Berg, Felicia Flowitt
Patient- and stakeholder-oriented research is vital to improving the relevance of research. The authors aimed to identify the 10 most important research priorities of patients, caregivers, and healthcare providers (family physicians, nurses, nurse practitioners, pharmacists, and dietitians) for hypertension management. Using the James Lind Alliance approach, a national web-based survey asked patients, caregivers, and care providers to submit their unanswered questions on hypertension management. Questions already answered from randomized controlled trial evidence were removed...
September 25, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28944442/protein-folding-and-trna-biology
#9
REVIEW
Mónica Marín, Tamara Fernández-Calero, Ricardo Ehrlich
Polypeptides can fold into tertiary structures while they are synthesized by the ribosome. In addition to the amino acid sequence, protein folding is determined by several factors within the cell. Among others, the folding pathway of a nascent polypeptide can be affected by transient interactions with other proteins, ligands, or the ribosome, as well as by the translocation through membrane pores. Particularly, the translation machinery and the population of tRNA under different physiological or adaptive responses can dramatically affect protein folding...
September 24, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28944441/translation-and-cross-cultural-adaptation-with-preliminary-validation-of-gcos-24-for-use-in-spain
#10
Patricia Muñoz-Cabello, Sixto García-Miñaúr, Manuel Eliecer Espinel-Vallejo, Lorenzo Fernández-Franco, Alexandra Stephens, Fernando Santos-Simarro, Pablo Lapunzina-Badía, Marion McAllister
The aim in this study was to translate and cross-culturally adapt the Genetic Counseling Outcome Scale (GCOS-24) for use in Spain and to carry out a preliminary psychometric validation in a sample of Spanish patients. With oversight by an expert panel, forward and backward translations were conducted to create the draft Spanish GCOS-24. Fourteen patients were recruited from a clinical genetics service in Madrid, Spain, to participate in cognitive interviews designed to explore readability and interpretability of the draft...
September 25, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28944382/s-nitrosothiols-chemistry-and-reactions
#11
Caihong Zhang, Tyler D Biggs, Nelmi O Devarie-Baez, Shaomin Shuang, Chuan Dong, Ming Xian
The formation of S-nitrosothiols (SNO) in protein cysteine residues is an important post-translational modification elicited by nitric oxide (NO). This process is involved in virtually every class of cell signaling and has attracted considerable attention in redox biology. On the other hand, their unique structural characters make SNO potentially useful synthons. In this review, we summarized the fundamental chemical/physical properties of SNO. We also highlighted the reported chemical reactions of SNO, including the reactions with phosphine reagents, sulfinic acids, various nucleophiles, SNO-mediated radical additions, and the reactions of acyl SNO species...
September 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28944316/relationship-between-anti-depressant-use-and-lung-cancer-survival
#12
Adriana Zingone, Derek Brown, Elise D Bowman, Oscar Vidal, Julien Sage, Joel Neal, Bríd M Ryan
OBJECTIVES: In recent years, the anti-cancer properties of several commonly used drugs have been explored, with drugs such as aspirin and beta-blockers associated with improved cancer outcomes. Previous preclinical work demonstrated that tricyclic anti-depressants have antitumor efficacy in lung cancer. Our goal was to examine the association between anti-depressant use and survival in lung cancer. MATERIALS AND METHODS: We examined the association between use of common anti-depressants and survival in 1,097 lung cancer patients from the NCI-Maryland lung cancer study...
2017: Cancer Treat Res Commun
https://www.readbyqxmd.com/read/28944295/towards-precision-medicine-in-alzheimer-s-disease-deciphering-genetic-data-to-establish-informative-biomarkers
#13
Ornit Chiba-Falek, Michael W Lutz
INTRODUCTION: Developing biomarker tools for identification of individuals at high-risk for late-onset Alzheimer's disease (LOAD) is important for prognosis and early treatment. This review focuses on genetic factors and their potential role for precision medicine in LOAD. AREAS COVERED: APOEe4 is the strongest genetic risk factor for non-Mendelian LOAD, and the APOE-linkage disequilibrium (LD) region has produced the most significant association signal in multi-center genome-wide-association-studies (GWAS)...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/28944291/acceptability-of-chairside-screening-for-racial-ethnic-minority-older-adults-a-qualitative-study
#14
A P Greenblatt, I Estrada, E W Schrimshaw, S S Metcalf, C Kunzel, M E Northridge
An aging and more racially and ethnically diverse population, coupled with changes in the health care policy environment, is demanding that the dental profession both redirect and expand its focus. Challenges include providing comprehensive care for patients with complicated medical needs while improving access to care for underserved groups. The purpose of this study is to examine the acceptability of screening for hypertension and diabetes in the dental setting for African American, Puerto Rican, and Dominican older adults who attend senior centers in northern Manhattan, New York City...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28944237/next-generation-sequencing-reveals-the-mutational-landscape-of-clinically-diagnosed-usher-syndrome-copy-number-variations-phenocopies-a-predominant-target-for-translational-read-through-and-pex26-mutated-in-heimler-syndrome
#15
Christine Neuhaus, Tobias Eisenberger, Christian Decker, Sandra Nagl, Cornelia Blank, Markus Pfister, Ingo Kennerknecht, Cornelie Müller-Hofstede, Peter Charbel Issa, Raoul Heller, Bodo Beck, Klaus Rüther, Diana Mitter, Klaus Rohrschneider, Ute Steinhauer, Heike M Korbmacher, Dagmar Huhle, Solaf M Elsayed, Hesham M Taha, Shahid M Baig, Heidi Stöhr, Markus Preising, Susanne Markus, Fabian Moeller, Birgit Lorenz, Kerstin Nagel-Wolfrum, Arif O Khan, Hanno J Bolz
BACKGROUND: Combined retinal degeneration and sensorineural hearing impairment is mostly due to autosomal recessive Usher syndrome (USH1: congenital deafness, early retinitis pigmentosa (RP); USH2: progressive hearing impairment, RP). METHODS: Sanger sequencing and NGS of 112 genes (Usher syndrome, nonsyndromic deafness, overlapping conditions), MLPA, and array-CGH were conducted in 138 patients clinically diagnosed with Usher syndrome. RESULTS: A molecular diagnosis was achieved in 97% of both USH1 and USH2 patients, with biallelic mutations in 97% (USH1) and 90% (USH2), respectively...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944234/the-nextgen-study-patient-motivation-for-participation-in-genome-sequencing-for-carrier-status
#16
Tia L Kauffman, Stephanie A Irving, Michael C Leo, Marian J Gilmore, Patricia Himes, Carmit K McMullen, Elissa Morris, Jennifer Schneider, Benjamin S Wilfond, Katrina A B Goddard
BACKGROUND: While translational genomic sequencing research is increasing, few studies have been limited to healthy individuals; most have focused on patients with a disease or a strong family history of a disorder. The limited studies that have included healthy individuals have focused on the disclosure of medically actionable secondary results, rather than carrier status, to assess reproductive risks. To address this important gap, we conducted the NextGen study, which focuses on carrier status and medically actionable secondary findings in a population of women planning a pregnancy...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944064/de-novo-synthesis-of-alkyne-substituted-tryptophans-as-chemical-probes-for-protein-profiling-studies
#17
R N Nair, J J Rosnow, T A Murphree, M E Bowden, S R Lindemann, A T Wright
De novo synthesis of alkynalted tryptophan moieties as chemical probes for protein profilling studies, via an unexpected synthesis of Michael acceptor 12 is reported. Friedel Craft's alkylation of 12 and alkyne substituted indoles gave alkynalated tryptophan moieties, which perform as chemical probe by incorporating into actively translating Escherichia coli cells, whereby the alkyne moiety enables multimodal analyses through click chemistry mediated attachment of reporting groups.
April 1, 2017: Organic Chemistry Frontiers: An International Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28944015/signatures-of-selection-in-mammalian-clock-genes-with-coding-trinucleotide-repeats-implications-for-studying-the-genomics-of-high-pace-adaptation
#18
Melanie B Prentice, Jeff Bowman, Jillian L Lalor, Michelle M McKay, Lindsay A Thomson, Cristen M Watt, Andrew G McAdam, Dennis L Murray, Paul J Wilson
Climate change is predicted to affect the reproductive ecology of wildlife; however, we have yet to understand if and how species can adapt to the rapid pace of change. Clock genes are functional genes likely critical for adaptation to shifting seasonal conditions through shifts in timing cues. Many of these genes contain coding trinucleotide repeats, which offer the potential for higher rates of change than single nucleotide polymorphisms (SNPs) at coding sites, and, thus, may translate to faster rates of adaptation in changing environments...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943932/increased-expression-of-bpi-fold-containing-family-a-member-1-is-associated-with-metastasis-and-poor-prognosis-in-human-colorectal-carcinoma
#19
Huanan Wang, Dongmei Jiang, Wenlu Li, Shuang Wang
Bactericidal or permeability-increasing protein fold-containing family A member 1 (BPIFA1) has been demonstrated to be involved in inflammatory responses in the upper airway and the progression of non-small cell lung cancer. However, the expression levels of BPIFA1 and its clinical prognostic significance in colorectal carcinoma (CRC) has not yet been elucidated. Reverse transcription-polymerase chain reaction and immunohistochemistry were used to analyze the expression levels of BPIFA1 in CRC and normal mucosal tissues...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943874/a-genome-wide-prediction-and-identification-of-intergenic-small-rnas-by-comparative-analysis-in-mesorhizobium-huakuii-7653r
#20
Xie Fuli, Zhao Wenlong, Wang Xiao, Zhang Jing, Hao Baohai, Zou Zhengzheng, Ma Bin-Guang, Li Youguo
In bacteria, small non-coding RNAs (sRNAs) are critical regulators of cellular adaptation to changes in metabolism, physiology, or the external environment. In the last decade, more than 2000 of sRNA families have been reported in the Rfam database and have been shown to exert various regulatory functions in bacterial transcription and translation. However, little is known about sRNAs and their functions in Mesorhizobium. Here, we predicted putative sRNAs in the intergenic regions (IGRs) of M. huakuii 7653R by genome-wide comparisons with four related Mesorhizobial strains...
2017: Frontiers in Microbiology
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