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https://www.readbyqxmd.com/read/29023858/interleukin-1-gene-cluster-haplotype-analysis-in-the-chronic-outcome-prediction-of-the-hepatitis-b-virus-infection
#1
Bita Javan, Mohamad Reza Kalani, Majid Shahbazi
Hepatitis B virus (HBV) infection is well known as an important cause of the chronic liver disease. The screening of the genotype of certain cytokines might be helpful to predict the clinical outcome of an HBV infection. The present study investigates the relationship between the polymorphism and haplotypes of the Interleukin-1 (IL-1) gene family, including IL-1-alpha (IL-1A), IL-1-beta (IL-1B) and IL-1 receptor antagonist (IL-1RN), with chronic HBV infection. 297 chronic HBV and 333 matched on sex and age control individuals were genotyped using the standard sequence-specific- polymerase chain reaction primer (SSP-PCR) method...
October 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29023524/polymorphism-il-1rn-rs419598-reduces-the-susceptibility-to-generalized-periodontitis-in-a-population-of-european-descent
#2
Francisco Mesa, Esperanza Lanza, Llenalia García, Rafael Marfil-Alvarez, Antonio Magan-Fernandez
Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five periodontopathogenic bacteria and periodontal clinical variables. A cross-sectional analytic study was conducted in 123 patients with GCP, 60 patients with GAgP, and 20 controls...
2017: PloS One
https://www.readbyqxmd.com/read/29021606/higher-expression-of-toll-like-receptors-2-and-4-in-blood-cells-of-keratoconus-patiens
#3
Tomás Sobrino, Uxía Regueiro, Mercedes Malfeito, Alba Vieites-Prado, María Pérez-Mato, Francisco Campos, Isabel Lema
Inflammation may play a significant role in Keratoconus (KC), but the implication of immunity on this inflammatory response is unknown. Therefore, our aim was to determine the expression levels of Toll-like receptors 2 (TLR2) and 4 (TLR4) in monocytes and neutrophils from patients with KC and control subjects for demonstrating the role of innate immunity in KC. We also study the correlation between TLR2/TLR4 expression and serum levels of proinflammatory markers (IL-1β, IL-6, TNF-α, MMP-9 and NF-κB). Forty patients with bilateral KC (55% males; mean age; 33...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020403/cardiac-and-systemic-rejuvenation-after-cardiosphere-derived-cell-therapy-in-senescent-rats
#4
Lilian Grigorian-Shamagian, Weixin Liu, Soraya Fereydooni, Ryan C Middleton, Jackelyn Valle, Jae Hyung Cho, Eduardo Marbán
Aim: The aim is to assess the effects of CDCs on heart structure, function, gene expression, and systemic parameters in aged rats. Diastolic dysfunction is characteristic of aged hearts. Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the effects of CDCs on aging have not been evaluated. Methods and Results: We compared intra-cardiac injections of neonatal rat CDCs to vehicle (phosphate-buffered saline, PBS) in 21...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28989091/more-than-just-antibodies-protective-mechanisms-of-a-mucosal-vaccine-against-fish-pathogen-flavobacterium-columnare
#5
Dongdong Zhang, Wilawan Thongda, Chao Li, Honggang Zhao, Benjamin H Beck, Haitham Mohammed, Covadonga Arias, Eric Peatman
A recently developed attenuated vaccine for Flavobacterium columnare has been demonstrated to provide superior protection for channel catfish, Ictalurus punctatus, against genetically diverse columnaris isolates. We were interested in examining the mechanisms of this protection by comparing transcriptional responses to F. columnare challenge in vaccinated and unvaccinated juvenile catfish. Accordingly, 58 day old fingerling catfish (28 days post-vaccination or unvaccinated control) were challenged with a highly virulent F...
October 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28979180/the-effect-of-different-workplace-nanoparticles-on-the-immune-systems-of-employees
#6
Natalja Kurjane, Tija Zvagule, Jelena Reste, Zanna Martinsone, Ilona Pavlovska, Inese Martinsone, Ivars Vanadzins
Currently, nanoparticles are widely present in the environment and are being used in various industrial technologies. Nanoparticles affect immune functions, causing different immune responses. The aim of the current study was to evaluate several cytokines, interleukin (IL)-1b, IL-6, IL-8, tumour necrosis factor-a (TNF-α), interferon-γ, adhesive molecule sICAM-1, macrophage inhibitory protein 1a (MIP1a) and secretory immunoglobulin A, in nasal lavage fluid and in the peripheral blood of healthy subjects exposed to workplace nanoparticles...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28954414/alpha-lipoic-acid-downregulates-il-1%C3%AE-and-il-6-by-dna-hypermethylation-in-sk-n-be-neuroblastoma-cells
#7
Simona Dinicola, Sara Proietti, Alessandra Cucina, Mariano Bizzarri, Andrea Fuso
Alpha-lipoic acid (ALA) is a pleiotropic molecule with antioxidant and anti-inflammatory properties, of which the effects are exerted through the modulation of NF-kB. This nuclear factor, in fact, modulates different inflammatory cytokines, including IL-1b and IL-6, in different tissues and cell types. We recently showed that IL-1b and IL-6 DNA methylation is modulated in the brain of Alzheimer's disease patients, and that IL-1b expression is associated to DNA methylation in the brain of patients with tuberous sclerosis complex...
September 26, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28943632/differences-in-abca1-r219k-polymorphisms-and-serum-indexes-in-alzheimer-and-parkinson-diseases-in-northern-china
#8
Lagai Ya, Zuneng Lu
BACKGROUND ABCA1 R219K single-nucleotide polymorphisms (SNPs) was related to Alzheimer disease (AD) but not Parkinson disease (PD). Here, we analyzed the associations among ABCA1 R219K distribution, serum biomarkers, AD, and PD in a population in northern China. MATERIAL AND METHODS We used the Mini-Mental State Examination (MMSE) and the Hoehn and Yahr scale (H-Y) to evaluate AD and PD progression, separately. ABCA1 R219K was analyzed by matrix-assisted laser desorption ionization time of flight time mass spectrometry (MALDI-TOF-MS)...
September 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28942534/cholinergic-system-and-oxidative-stress-changes-in-the-brain-of-a-zebrafish-model-chronically-exposed-to-ethanol
#9
Jotele Fontana Agostini, Helena Cristina Zuehl Dal Toé, Karine Medeiros Vieira, Samira Leila Baldin, Naithan Ludian Fernandes Costa, Carolina Uribe Cruz, Larisse Longo, Marcel Marcos Machado, Themis Reverbel da Silveira, Patrícia Fernanda Schuck, Eduardo Pacheco Rico
Ethanol is a widely used drug, and excess or even moderate consumption of ethanol is associated with changes in several neurotransmitter systems, including the cholinergic system. The incidence of alcoholic dementia and its insults are well supported by multiple studies, although the mechanisms of neurotoxicity are still poorly understood. Considering that zebrafish have a complete central nervous system (CNS) and that several signaling systems have already been identified in zebrafish, this neurotoxicological model has become useful...
September 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28910378/neuroinflammation-myelin-and-behavior-temporal-patterns-following-mild-traumatic-brain-injury-in-mice
#10
Toufik Taib, Claire Leconte, Juliette Van Steenwinckel, Angelo H Cho, Bruno Palmier, Egle Torsello, Rene Lai Kuen, Somfieme Onyeomah, Karine Ecomard, Chiara Benedetto, Bérard Coqueran, Anne-Catherine Novak, Edwige Deou, Michel Plotkine, Pierre Gressens, Catherine Marchand-Leroux, Valérie C Besson
Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with neurological deficits. Neuroinflammation originating from microglial activation may participate in WMI and associated disorders. To date, there is little information on the time courses of these events after mild TBI. Therefore we investigated (i) neuroinflammation, (ii) WMI and (iii) behavioral disorders between 6 hours and 3 months after mild TBI. For that purpose, we used experimental mild TBI in mice induced by a controlled cortical impact...
2017: PloS One
https://www.readbyqxmd.com/read/28854912/development-and-validation-of-a-house-finch-interleukin-1%C3%AE-hfil-1%C3%AE-elisa-system
#11
Sungwon Kim, Myeongseon Park, Ariel E Leon, James S Adelman, Dana M Hawley, Rami A Dalloul
BACKGROUND: A unique clade of the bacterium Mycoplasma gallisepticum (MG), which causes chronic respiratory disease in poultry, has resulted in annual epidemics of conjunctivitis in North American house finches since the 1990s. Currently, few immunological tools have been validated for this songbird species. Interleukin-1β (IL-1β) is a prototypic multifunctional cytokine and can affect almost every cell type during Mycoplasma infection. The overall goal of this study was to develop and validate a direct ELISA assay for house finch IL-1β (HfIL-1β) using a cross-reactive chicken antibody...
August 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28846666/interleukin-6-il-6-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-single-nucleotide-polymorphisms-snps-inflammation-and-metabolism-in-gestational-diabetes-mellitus-in-inner-mongolia
#12
Jie Zhang, Haiyi Chi, Huiying Xiao, Xiaoyan Tian, Yilin Wang, Xia Yun, Yancheng Xu
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on the association of IL-65-72C/G and TNF-α -857C/T single nucleotide polymorphisms (SNPs), inflammatory biomarkers, and metabolic indexes in women with GDM, especially in the Inner Mongolia population. The aim of this study was to investigate the associations of IL-65-72C/G and TNF-α -857C/T SNPs, and inflammation and metabolic biomarkers in women with GDM pregnancies...
August 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28843910/diacerein-inhibits-estradiol-benzoate-induced-cervical-hyperkeratosis-in-female-rats
#13
Marwa M M Refaie, Maram El-Hussieny
Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervical hyperkeratosis induced by intramuscular injection of Estradiol benzoate (60μg/100g) 3 times per week for 4 weeks. We measured the serum levels of total cholesterol, uterine weights, uterine tissue malondialdehyde, total nitrites, superoxide dismutase activity, caspase-3, interleukin-1b immunoexpression and histopathology...
August 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28837706/a-dna-inducing-vlp-vaccine-designed-for-hiv-and-tested-in-mice
#14
Alexandre Calazans, Cesar Boggiano, Ross Lindsay
We developed a DNA vaccine that induces the formation of a VLP in vivo. This VLP was designed to elicit neutralizing antibodies, to induce better T-cell responses and to activate the innate immune system. Overall, 5 groups of 10 mice were electroporated with the following constructs: pVLP-LTR-GagPro [full], pVLP-GagPro [VLP wihout RNA], pVLP-LTR-Gag [VLP immature], pVLP-Gag and pVLP-EnvBG505 [regular DNA vaccine] and a mock group. We performed ICS on the mouse spleens and performed ELISA for ENV antibodies and a Luminex assay for inflammatory cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28801784/prior-repeated-stress-attenuates-cold-induced-immunomodulation-associated-with-browning-in-mesenteric-fat-of-rats
#15
P Vargovic, M Laukova, J Ukropec, G Manz, R Kvetnansky
Continuous exposure to cold leads to activation of adaptive thermogenesis in brown adipose tissue but also to induction of brown/beige cell phenotype in white adipose tissue. The aim of this work was to investigate whether prior exposure to immobilization (IMO) stress may affect immune response associated with adipocyte "browning" in mesenteric adipose tissue (mWAT). In the first experiment, Sprague-Dawley rats were exposed to acute (3 h) or prolonged (7 days) cold exposure (4 ± 1 °C). 7-day cold stimulated gene expression of uncoupling protein 1 and other "browning"-associated factors...
August 11, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28771187/herbal-supplement-in-a-buffer-for-dry-eye-syndrome-treatment
#16
Hung-Chang Chen, Zhi-Yu Chen, Tsung-Jen Wang, Victor J Drew, Ching-Li Tseng, Hsu-Wei Fang, Feng-Huei Lin
Dry eye syndrome (DES) is one of the most common types of ocular diseases. There is a major need to treat DES in a simple yet efficient way. Artificial tears (AT) are the most commonly used agents for treating DES, but are not very effective. Herbal extractions of ferulic acid (FA), an anti-oxidant agent, and kaempferol (KM), an anti-inflammatory reagent, were added to buffer solution (BS) to replace ATs for DES treatment. The cytotoxicity and anti-inflammatory effects were examined in vitro by co-culture with human corneal epithelial cells (HCECs) to obtain the optimal concentration of KM and FA for treating HCECs...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749954/metabolic-markers-during-pregnancy-and-their-association-with-maternal-and-newborn-weight-status
#17
Otilia Perichart-Perera, Cinthya Muñoz-Manrique, Angélica Reyes-López, Maricruz Tolentino-Dolores, Salvador Espino Y Sosa, Ma Cristina Ramírez-González
BACKGROUND/AIMS: Obesity during pregnancy increases the risk of adverse clinical outcomes and is associated with low-grade chronic inflammation. We describe maternal metabolic risk and inflammation by maternal weight status, and evaluate the association of metabolic and inflammatory markers with birthweight in a group of pregnant Mexican women. METHODS: This study derived from a prospective cohort of healthy pregnant women <14 weeks of gestation, receiving prenatal care at National Institute of Perinatology (Mexico, 2009-2013)...
2017: PloS One
https://www.readbyqxmd.com/read/28740674/does-the-usage-of-digital-chest-drainage-systems-reduce-pleural-inflammation-and-volume-of-pleural-effusion-following-oncologic-pulmonary-resection-a-prospective-randomized-trial
#18
Michèle De Waele, John Agzarian, Waël C Hanna, Colin Schieman, Christian J Finley, Joseph Macri, Laura Schneider, Terri Schnurr, Forough Farrokhyar, Katherine Radford, Parameswaran Nair, Yaron Shargall
BACKGROUND: Prolonged air leak and high-volume pleural drainage are the most common causes for delays in chest tube removal following lung resection. While digital pleural drainage systems have been successfully used in the management of post-operative air leak, their effect on pleural drainage and inflammation has not been studied before. We hypothesized that digital drainage systems (as compared to traditional analog continuous suction), using intermittent balanced suction, are associated with decreased pleural inflammation and postoperative drainage volumes, thus leading to earlier chest tube removal...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740480/cerebrospinal-fluid-and-microdialysis-cytokines-in-severe-traumatic-brain-injury-a-scoping-systematic-review
#19
REVIEW
Frederick A Zeiler, Eric Peter Thelin, Marek Czosnyka, Peter J Hutchinson, David K Menon, Adel Helmy
OBJECTIVE: To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS: Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Both were conducted in severe TBI (sTBI) patients only. DATA SOURCES: Articles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28739185/novel-atherogenic-pathways-from-the-differential-transcriptome-analysis-of-diabetic-epicardial-adipose-tissue
#20
COMPARATIVE STUDY
V Camarena, D Sant, M Mohseni, T Salerno, M L Zaleski, G Wang, G Iacobellis
BACKGROUND AND AIM: To evaluate the epicardial adipose tissue (EAT) transcriptome in comparison to subcutaneous fat (SAT) in coronary artery disease (CAD) and type 2 diabetes (T2DM). METHODS AND RESULTS: SAT and EAT samples were obtained from subjects with T2DM and CAD (n = 5) and those without CAD with or without T2DM (=3) undergoing elective cardiac surgery. RNA-sequencing analysis was performed in both EAT and SAT. Gene enrichment analysis was conducted to identify pathways affected by the differentially expressed genes...
August 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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