keyword
MENU ▼
Read by QxMD icon Read
search

Il-1b

keyword
https://www.readbyqxmd.com/read/29241030/expression-profiles-of-genes-involved-in-tlrs-and-nlrs-signaling-pathways-of-water-buffaloes-infected-with-fasciola-gigantica
#1
Fu-Kai Zhang, Jun-Ling Hou, Ai-Jiang Guo, Ai-Ling Tian, Zhao-An Sheng, Wen-Bin Zheng, Wei-Yi Huang, Hany M Elsheikha, Xing-Quan Zhu
Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like receptors (TLRs) and NOD-like receptors (NLRs) signaling pathways in buffaloes infected with 500F. gigantica metacercariae. Serum, liver and peripheral blood mononuclear cell (PBMC) samples were collected from infected and control buffaloes at 3, 10, 28, and 70days post infection (dpi)...
December 11, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29237457/the-role-of-src-erk1-2-kinases-in-inspiratory-resistive-breathing-induced-acute-lung-injury-and-inflammation
#2
Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis, Theodoros Vassilakopoulos
BACKGROUND: Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with large negative intrathoracic pressures, due to strenuous contractions of the inspiratory muscles. IRB is shown to induce lung injury in previously healthy animals. Src is a multifunctional kinase that is activated in the lung by mechanical stress. ERK1/2 kinase is a downstream target of Src. We hypothesized that Src is activated in the lung during IRB, mediates ERK1/2 activation and IRB-induced lung injury...
December 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29233180/distinct-cytokine-patterns-may-regulate-the-severity-of-neonatal-asphyxia-an-observational-study
#3
Anna Bajnok, László Berta, Csaba Orbán, Gábor Veres, Dénes Zádori, Hajnalka Barta, Ünőke Méder, László Vécsei, Tivadar Tulassay, Miklós Szabó, Gergely Toldi
BACKGROUND: Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels in moderate and severe asphyxia in order to identify players of the inflammatory response that may influence patient outcome. METHODS: We analyzed the data of 28 term neonates requiring moderate systemic hypothermia in a single-center observational study...
December 12, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29228441/correlation-between-individual-inflammation-genetic-profile-and-platelet-rich-plasma-efficacy-in-hair-follicle-regeneration-a-pilot-study-reveals-prognostic-value-of-il-1a-polymorphism
#4
F Rossano, S Di Martino, L Iodice, M Di Paolo, S Misso, R Tomeo, A M Marini, R Brugnone, S Marlino, A Santorelli, R Di Francia
OBJECTIVE: Hair loss generates severe psychosocial implications. To date, exploring the prognostic factors of possible clinical benefit of autologous blood concentrate platelet rich plasma (PRP) was failed. The aim of our pilot study was to explore the correlation between the individual inflammation genetic profile and PRP efficacy in the treatment of hair follicle regeneration. PATIENTS AND METHODS: 41 volunteers (25 men, 16 women) took part in this retrospective study...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29223534/systemic-recovery-and-therapeutic-effects-of-transplanted-allogenic-and-xenogenic-mesenchymal-stromal-cells-in-a-rat-blunt-chest-trauma-model
#5
Elisa Maria Amann, Markus Thomas Rojewski, Sinja Rodi, Daniel Fürst, Jörg Fiedler, Annette Palmer, Sonja Braumüller, Markus Huber-Lang, Hubert Schrezenmeier, Rolf Erwin Brenner
BACKGROUND: Effective therapy of Acute Lung Injury (ALI) is still a major scientific and clinical problem. To define novel therapeutic strategies for sequelae of blunt chest trauma (TxT) like ALI/Acute Respiratory Distress Syndrome, we have investigated the immunomodulatory and regenerative effects of a single dose of ex vivo expanded human or rat mesenchymal stromal cells (hMSCs/rMSCs) with or without priming, immediately after the induction of TxT in Wistar rats. METHODS: We analyzed the histological score of lung injury, the cell count of the broncho alveolar lavage fluid (BAL), the change in local and systemic cytokine level and the recovery of the administered cells 24 h and 5 days post trauma...
December 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29208671/cxcr4-is-a-potential-target-for-diagnostic-pet-ct-imaging-in-barrett-s-dysplasia-and-esophageal-adenocarcinoma
#6
Hsin-Yu Fang, Natasha Stephens Münch, Margret Schottelius, Jonas Ingermann, Haibo Liu, Michael Schauer, Stefan Stangl, Gabriele Multhoff, Katja Steiger, Carlos Gerngroß, Moritz Jesinghaus, Wilko Weichert, Anja A Kühl, Antonia R Sepulveda, Hans-Jürgen Wester, Timothy C Wang, Michael Quante
INTRODUCTION: Barrett's Esophagus (BE) represents an early stage in carcinogenesis leading to esophageal adenocarcinoma (EAC). Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of BE and EAC. METHODS: Here we utilized a IL-1b transgenic mouse model of BE and EAC and human patient imaging to analyse the importance of CXCR4 expressing cells during esophageal carcinogenesis. RESULTS: IL-1b overexpression induces chronic esophageal inflammation and recapitulates the progression to BE and EAC...
December 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29208272/biosynthesis-of-cerium-oxide-nanoparticles-and-their-effect-on-lipopolysaccharide-lps-induced-sepsis-mortality-and-associated-hepatic-dysfunction-in-male-sprague-dawley-rats
#7
Guoqiang Chen, Yunfei Xu
The fetal/life challenging Sepsis is an urgent medical disaster which have developed "blood poisoning". The sepsis is one of the disorders of organs which cause death in patients. The investigational models that mimicchemical change of sepsis in human bodywereessential. We have synthesized CeO2 NPs using eco-friendly method using plant extract. The characterization of synthesized CeO2 NPs was studied using UV-Vis, FTIR, XRD, SEM, EDX and TEM analysis. The results were confirmed that the synthesized CeO2 was in nano size with spherical shape...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#8
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29196001/allium-tuberosum-antidiabetic-and-hepatoprotective-activities
#9
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
Allium tuberosum (AT) is traditionally used for treating nocturnal emissions, abdominal pain, diarrhea, sexual dysfunction and asthma. This study aimed at investigating the antidiabetic and hepatoprotective activities of the butyl alcohol fraction from the methanolic extract of A. tuberosum. For the antidiabetic activity, rats were induced with diabetes by intraperitoneal injection of 150mg/kg alloxan and treated for 30days with AT extract (100, 200 and 400mg/kg). Animals were sacrificed after the study and the fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), HDL, malondialdehyde (MDA) catalase, superoxide dismutase and glutathione levels were determined...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29177583/identification-and-functional-analysis-of-the-novel-orf6-protein-of-porcine-circovirus-type-2-in-vitro
#10
Dongge Li, Jing Wang, Shangen Xu, Shanxia Cai, Chaojie Ao, Liurong Fang, Shaobo Xiao, Huanchun Chen, Yunbo Jiang
In the present study, the function of a novel ORF6 gene in the PCV2 genome was determined and functionally analyzed in vitro. ORF6 expression was demonstrated by indirect immunofluorescence in PCV2-infected cells. The antibody against ORF6 was detected in PCV2-infected pigs. The start codon of ORF6 was mutated and an infectious clone was used to create an ORF6-deficient mutant virus. Viral DNA replication curves and immunofluorescence analysis indicated that ORF6 is unnecessary for viral replication and ORF6 deletion reduces viral DNA replication in PK-15 cells...
November 25, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/29170045/astragalus-polysaccharides-inhibit-avian-infectious-bronchitis-virus-infection-by-regulating-viral-replication
#11
Pengju Zhang, Xuefeng Liu, Weixia Wang, Haiyan Liu, Xiaohui Liu, Xintao Li, Xinghong Wu
The avian coronavirus causes infectious bronchitis (IB), which is one of the most serious diseases affecting the avian industry worldwide. However, there are no effective strategies for controlling the IB virus (IBV) at present. Therefore, development of novel antiviral treatment strategies is urgently required. As reported, astragalus polysaccharides (APS) have potential antiviral effects against several viruses; however, the antiviral effect of APS against IBV remains unclear. In this study, we explored whether APS had the potential to inhibit IBV infectionby utilizing several in vitro experimental approaches...
November 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29111234/exacerbation-and-prolongation-of-psoriasiform-inflammation-in-diabetic-obese-mice-a-synergistic-role-of-cxcl5-and-er-stress
#12
Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Chikako Nishigori
Accumulating evidence suggests that psoriasis is frequently accompanied by metabolic disorders such as obesity and diabetes. However, the mechanisms underlying the association between increased psoriasis severity and concomitant metabolic syndrome have not been fully clarified. Herein, we show that imiquimod-induced psoriasiform inflammation was exacerbated and prolonged in diabetic obese mice compared to that in control mice, accompanied by remarkably increased lesional expressions of Cxcl5 and Il-1b. Notably, a large number of CXCL5(+) Ly6G(+) cells infiltrated the dermis and subcutaneous fat tissue of the diabetic obese mice...
October 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29109727/dexamethasone-and-monophosphoryl-lipid-a-induce-a-distinctive-profile-on-monocyte-derived-dendritic-cells-through-transcriptional-modulation-of-genes-associated-with-essential-processes-of-the-immune-response
#13
Paulina A García-González, Katina Schinnerling, Alejandro Sepúlveda-Gutiérrez, Jaxaira Maggi, Ahmed M Mehdi, Hendrik J Nel, Bárbara Pesce, Milton L Larrondo, Octavio Aravena, María C Molina, Diego Catalán, Ranjeny Thomas, Ricardo A Verdugo, Juan C Aguillón
There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a tolerogenic state are still poorly understood. Here, we studied the transcriptional profile of moDCs from healthy subjects, modulated with dexamethasone (Dex) and activated with monophosphoryl lipid A (MPLA), referred to as Dex-modulated and MPLA-activated DCs (DM-DCs), as an approach to identify molecular regulators and pathways associated with the induction of tolerogenic properties in tolDCs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29084047/infection-by-htlv-1-is-associated-with-high-levels-of-pro-inflammatory-cytokines-in-hiv-hcv-coinfected-patients
#14
Carlos Brites, Marcos Abrahão, Patrícia Bozza, Eduardo M Netto, André Lyra, Fabianna Bahia
OBJECTIVES: HIV, HCV, and HTLV-1 share the same routes of infection, making coinfection by these viruses a frequent finding in endemic areas. However, there is scarce information on the clinical / immunological consequences of triple infection. Coinfection by HTLV-1 is able to modulate cytokine´s production in HIV patients, but there is no data on the immune response of HIV-HCV-HTLV-1 infected patients METHODS:: we compared the plasma levels of 25 different cytokines in HIV-HCV patients, according to their serostatus to HTLV-1 infection...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29080879/-changes-in-laboratory-parameters-of-peripheral-blood-reflect-cell-and-protein-content-of-the-immune-system-in-bone-resorption
#15
O V Berdugina, K A Berdugin
The aim of this study was to investigate dynamic changes in the laboratory parameters of peripheral blood, reflecting cellular and protein composition of the immune system in bone resorption. The study involved 108 patients with degenerative-dystrophic and posttraumatic disorders of the hip joint before and after joint replacement surgery. Half of the cases resulted in bone resorption. Dynamic monitoring was performed up to 7.5 years. It included flow cytometry (Coulter Epics XL, USA) and enzyme immunoassay to determine the amount of immunocompetent cells, immunoglobulin class M, A, G, E, cytokines, acute phase proteins (C-reactive protein, fibrinogen, albumin, ceruloplasmin, haptoglobin), parameters of neutrophil functional activity (lactoferrin cationic protein, myeloperoxidase, superoxide anion production)...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29069743/determination-of-il-1b-rs16944-and-il-6-rs1800796-genetic-polymorphisms-in-iga-nephropathy-in-a-northwest-chinese-han-population
#16
Daofa Zhang, Maowei Xie, Xiaohong Yang, Yin Zhang, Yan Su, Yanni Wang, Haiyang Huang, Hui Han, Wenning Li, Keying Fu, Huiluan Su, Wentan Xu, Yeguang Han, Ru Wang, Pei Zhang, Wei Wu, Yun Huang, Daojun Chen, Tianbo Jin, Jiali Wei
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29068700/silibinin-reduces-the-impact-of-obesity-on-invasive-liver-cancer
#17
C Miethe, H Nix, R Martin, A R Hernandez, R S Price
Obesity is associated with non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Obesity and metabolic abnormalities resulting in low-grade inflammation can increase the risk of developing NASH and HCC. NASH, a risk factor for HCC, is characterized by increased inflammation, lipid accumulation, and liver injury. Obesogenic proteins modulate signaling pathways that induce physiological changes including lipogenesis, ROS, and inflammation. Silibinin, a polyphenol in milk thistle seed, has been shown to have anti-inflammatory properties...
October 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29067681/chitosan-triclosan-particles-modulate-inflammatory-signaling-in-gingival-fibroblasts
#18
L Pavez, N Tobar, C Chacón, R Arancibia, C Martínez, C Tapia, A Pastor, M González, J Martínez, P C Smith
BACKGROUND AND OBJECTIVES: An important goal of periodontal therapy is the modulation of the inflammatory response. To this end, several pharmacological agents have been evaluated. Triclosan corresponds to an antibacterial and anti-inflammatory agent currently used in periodontal therapy. Chitosan is a natural polymer that may act as a drug delivery agent and exerts antibacterial and anti-inflammatory activities. Therefore, an association between both molecules might be useful to prevent inflammation and tissue destruction in periodontal tissues...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29058588/effect-of-infla-kine-supplementation-on-the-gene-expression-of-inflammatory-markers-in-peripheral-mononuclear-cells-and-on-c-reactive-protein-in-blood
#19
Nina A Mikirova, Santosh Kesari, Thomas E Ichim, Neil H Riordan
BACKGROUND: Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer's disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lactobacillus fermentum extract, burdock seed (arctigenin), zinc, alpha lipoic acid, papaya enzyme and an enhanced absorption bio-curcumin complex (BCM-95®). METHODS: Infla-Kine was administered twice daily to 24 health volunteers for 4 weeks. Quantitative RT-PCR was used to assess mRNA transcripts of IL-1b, IL8, IL-6, NF-κB, and TNF-α from peripheral blood mononuclear cells (PBMC)...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29053818/effect-of-dietary-supplementation-of-nitrocompounds-on-salmonella-colonization-and-ileal-immune-gene-expression-in-laying-hens-challenged-with-salmonella-enteritidis
#20
Pratima Adhikari, D E Cosby, N A Cox, W K Kim
Foodborne disease caused by Salmonella Enteritidis (SE) is one of the important public health and economic concerns. A study was conducted to determine the effect of supplementation with 2-nitroethanol (NE) and 2-nitropropanol (NP) on Salmonella recovery of internal organs as well as on the immune gene expression in the ileum of laying hens. Thirty-six White Leghorns were orally gavaged with nalidixic acid resistant Salmonella Enteritidis (SENR). Hens were housed individually in wire-laying cages and randomly assigned to six dietary treatments: T1 = SENR unchallenged (negative control), T2 = SENR challenged (positive control), T3 = SENR challenged + 100 ppm NE, T4 = SENR challenged + 200 ppm NE, T5 = SENR challenged + 100 ppm NP, and T6 = SENR challenged + 200 ppm NP...
October 5, 2017: Poultry Science
keyword
keyword
15879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"