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https://www.readbyqxmd.com/read/29438197/elevated-liver-stiffness-is-linked-to-increased-biomarkers-of-inflammation-and-immune-activation-in-hiv-hcv-coinfected-patients
#1
Luz Maria Medrano, Pilar Garcia-Broncano, Juan Berenguer, Juan González-García, Ma Ángeles Jiménez-Sousa, Josep M Guardiola, Manuel Crespo, Carmen Quereda, José Sanz, Isabel Canorea, Ana Carrero, Victor Hontañón, Ma Ángeles Muñoz-Fernández, Salvador Resino
OBJECTIVES: Immune dysregulation is a hallmark of HIV and HCV infections. To evaluate the relationship between liver stiffness measure (LSM) and biomarkers of T cell activation, bacterial translocation, inflammation, endothelial dysfunction, and coagulopathy in HIV/HCV-coinfected patients. DESIGN: Cross-sectional study. METHODS: We studied 238 HIV/HCV-coinfected patients, 32 healthy controls and 39 HIV-monoinfected patients. Patients were stratified according to LSM into four groups: <12...
February 12, 2018: AIDS
https://www.readbyqxmd.com/read/29434599/rna-seq-analysis-of-il-1b-and-il-36-responses-in-epidermal-keratinocytes-identifies-a-shared-myd88-dependent-gene-signature
#2
William R Swindell, Maria A Beamer, Mrinal K Sarkar, Shannon Loftus, Joseph Fullmer, Xianying Xing, Nicole L Ward, Lam C Tsoi, Michelle J Kahlenberg, Yun Liang, Johann E Gudjonsson
IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Type I and II interferon genes exhibited time-dependent response patterns, with early induction (8 h) followed by no response or repression (24 h)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29425536/magnetic-iodixanol-%C3%A2-a-novel-contrast-agent-and-its-early-characterization
#3
M C Arokiaraj, E Menesson, N Feltin
AIMS: Contrast-induced nephropathy is a commonly encountered problem in clinical practice. The purpose of the study was to design and develop a novel contrast agent, which could be used to prevent contrast-induced nephropathy in the future. METHODS: In total, 20-220nm magnetic nanoparticles were conjugated with iodixanol, and their radio-opacity and magnetic properties were assessed thereafter. Scanning electron microscopy pictures were acquired. Thereafter, the nanoparticles conjugate was tested in cell culture (HUVEC cells), and Quantibody® assay was studied after cell treatment in 1:5 dilutions for 48h, compared with control...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29423077/integrating-the-dysregulated-inflammasome-based-molecular-functionome-in-the-malignant-transformation-of-endometriosis-associated-ovarian-carcinoma
#4
Chia-Ming Chang, Mong-Lien Wang, Kai-Hsi Lu, Yi-Ping Yang, Chi-Mou Juang, Peng-Hui Wang, Ren-Jun Hsu, Mu-Hsien Yu, Cheng-Chang Chang
The coexistence of endometriosis (ES) with ovarian clear cell carcinoma (CCC) or endometrioid carcinoma (EC) suggested that malignant transformation of ES leads to endometriosis associated ovarian carcinoma (EAOC). However, there is still lack of an integrating data analysis of the accumulated experimental data to provide the evidence supporting the hypothesis of EAOC transformation. Herein we used a function-based analytic model with the publicly available microarray datasets to investigate the expression profiling between ES, CCC, and EC...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398577/cell-death-inflammation-tumor-burden-and-proliferation-blood-biomarkers-predict-lung-cancer-radiotherapy-response-and-correlate-with-tumor-volume-and-proliferation-imaging
#5
Ahmed Salem, Hitesh Mistry, Alison Backen, Clare Hodgson, Pek Koh, Emma Dean, Lynsey Priest, Kate Haslett, Ioannis Trigonis, Alan Jackson, Marie-Claude Asselin, Caroline Dive, Andrew Renehan, Corinne Faivre-Finn, Fiona Blackhall
INTRODUCTION: There is an unmet need to develop noninvasive biomarkers to stratify patients in drug-radiotherapy trials. In this pilot study we investigated lung cancer radiotherapy response and toxicity blood biomarkers and correlated findings with tumor volume and proliferation imaging. PATIENTS AND METHODS: Blood samples were collected before and during (day 21) radiotherapy. Twenty-six cell-death, hypoxia, angiogenesis, inflammation, proliferation, invasion, and tumor-burden biomarkers were evaluated...
December 11, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29380171/java-tea-orthosiphon-stamineus-protected-against-osteoarthritis-by-mitigating-inflammation-and-cartilage-degradation-a-preclinical-study
#6
Rubiatul Adawiyah Bokhari, Nur Adeelah Che Ahmad Tantowi, Seng Fong Lau, Suhaila Mohamed
The effect of Orthosiphon stamineus aqueous (OSA) extract against osteoarthritis (OA) was investigated in explant cartilage culture and in postmenopausal OA rat model. Female rats were bilaterally ovariectomized (OVX). Osteoarthritis was induced after surgical recovery, by intra-articular injection of monosodium iodoacetate (MIA) into the right knee. Rats were grouped (n = 8) into: healthy sham control; non-treated OA; OA + diclofenac (positive control 5 mg/kg); and two doses OSA (150-300 mg/kg). After 4 weeks' treatment, rats were evaluated for OA-related parameters and biomarkers...
January 29, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29362226/elovl4-mediated-production-of-very-long-chain-ceramides-stabilizes-tight-junctions-and-prevents-diabetes-induced-retinal-vascular-permeability
#7
Nermin M Kady, Xuwen Liu, Todd A Lydic, Meesum H Syed, Svetlana Navitskaya, Qi Wang, Sandra S Hammer, Sandra O'Reilly, Chao Huang, Sergey S Seregin, Andrea Amalfitano, Vince A Chiodo, Sanford L Boye, William W Hauswirth, David A Antonetti, Julia V Busik
Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. While TJ proteins have been studied in detail, the role of lipids is largely unknown. We addressed the role of very long chain (VLC ≥26) ceramides in TJs using diabetes induced loss of blood-retinal barrier as a model. VLC fatty acids that incorporate into VLC ceramides are produced by elongase ELOVL4. ELOVL4 is significantly reduced in the diabetic retina. Overexpression of ELOVL4 significantly decreased basal permeability, inhibited VEGF and IL-1b induced permeability and prevented VEGF-induced decrease in occludin expression and border staining of TJ proteins; ZO-1 and claudin-5...
January 23, 2018: Diabetes
https://www.readbyqxmd.com/read/29356123/serum-cytokine-profiling-in-cats-with-acute-idiopathic-cystitis
#8
M Parys, V Yuzbasiyan-Gurkan, J M Kruger
BACKGROUND: Feline idiopathic cystitis (FIC) is a common lower urinary tract disorder of domestic cats that resembles interstitial cystitis/painful bladder syndrome (IC/PBS) in humans. Diagnosis of FIC is based on clinical signs and exclusion of other disorders because of a lack of specific pathologic findings or other objective biomarkers. Cytokines are potential noninvasive biomarkers to define the presence, severity, and progression of disease, and response to treatment. OBJECTIVES: The objective of this pilot study was to determine concentrations of selected cytokines in serum from healthy cats and cats with acute FIC...
January 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29351002/protective-effect-of-the-standardized-leaf-extract-of-ginkgo-biloba-egb761-against-hypertension-induced-renal-injury-in-rats
#9
Ahmed O Abdel-Zaher, Hanan S M Farghaly, Abeer E M El-Refaiy, Ahmed M Abd-Eldayem
BACKGROUND: Ginkgo biloba leaves extract has been widely used worldwide to protect against oxidative stress-induced cell damage and improves blood circulation. METHODS: The potential protective role of the standardized leaf extract of Ginkgo biloba (EGb761) on hypertension-induced renal injury was investigated in rats. Hypertension was induced in rats by L-NAME. RESULT: Repeated treatment with EGb761 produced progressive reductions in the systolic, diastolic and mean arterial blood pressure...
January 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29345045/the-in-vitro-release-of-cytokines-and-growth-factors-from-fibrin-membranes-produced-through-horizontal-centrifugation
#10
E S Lourenço, C F A B Mourão, P E C Leite, J M Granjeiro, M D Calasans-Maia, G G Alves
Platelet-rich fibrin (PRF) membranes are biomaterials widely used for therapeutic purposes, and canonically produced through the processing of peripheral blood with fixed-angle rotor centrifuges. In this work, we evaluate the in vitro stability and release of cytokines and growth factors when these biomaterials are produced with a horizontal swing-out clinical centrifuge. Membranes produced from the blood of 14 donors were morphologically evaluated by scanning electron microscopy and fluorescence microscopy, and their stability was assessed by photographic recording after incubation in culture medium for up to 28 days...
January 18, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29343616/rapamycin-activates-tgf-receptor-independently-of-its-ligand-implications-for-endothelial-dysfunction
#11
Ayumi A Miyakawa, Thais Girao-Silva, Jose E Krieger, Elazer R Edelman
Rapamycin, the macrolide immunosuppressant and active pharmaceutic in drug-eluting stents (DES), has a well-recognized anti-proliferative action that involves inhibition of the mTOR pathway after binding to the cytosolic protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFb. Human umbilical vein endothelial cells (HUVEC) were treated with rapamycin (10nmoL/L) and/or TGF-b RI kinase inhibitor (TGFRIi, 100nmoL/L) for 24 hours...
January 17, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29340244/an-exploratory-study-of-adolescent-response-to-fluoxetine-using-psychological-and-biological-predictors
#12
Ada H Zohar, Tamar Eilat, Maya Amitai, Michal Taler, Romi Bari, Alon Chen, Alan Apter, Avraham Weizman, Silvana Fennig
Background: Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. Methods: Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine...
2018: PeerJ
https://www.readbyqxmd.com/read/29338067/the-influence-of-delayed-cord-clamping-and-cord-milking-on-inflammatory-cytokines-in-umbilical-vein-and-neonatal-circulation
#13
George Daskalakis, Angeliki Papapanagiotou, Charalambos Siristatidis, Petros Drakakis, Ioanna Mole, Anastasia Barbouni, Athanasios G Papavassiliou, Vasilios Pergialiotis
The purpose of the present study was to compare the levels of tumor necrosis factor a (TNF-a), and interleukins (IL) 1, 6, 8 and 10 in the umbilical cord and neonatal circulation among neonates with early and late cord clamping MATERIAL AND METHODS: A consecutive series of 76 cases that had an uncomplicated pregnancy and an uneventful parturition was evaluated. In 40 cases delayed cord clamping was used and in the remaining 36 cases early cord clamping was practiced. Blood samples were collected from the umbilical vein immediately after cord clamping and at 24 hours from the median cubital or basilic vein of the neonate RESULTS: Significant differences were noted in the hematocrit and hemoglobin levels at 24 hours that favored delayed clamping...
January 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29333402/interleukin-1b-il-1b-31-and-il-1b-511-and-interleukin-1-receptor-antagonist-il-1ra-gene-polymorphisms-in-primary-immune-thrombocytopenia
#14
Deependra Kumar Yadav, Anil Kumar Tripathi, Divya Gupta, Saurabh Shukla, Aloukick Kumar Singh, Ashutosh Kumar, Jyotsna Agarwal, K N Prasad
Background: Immune thrombocytopenia (ITP) is an immune-mediated disease caused by autoantibodies against platelets membrane glycoproteins GPIIb/IIIa and GPIb/IX. The etiology of ITP remains unclear. This study evaluated the association of polymorphisms in interleukin ( IL ) -1B-31 , IL-1B-511 , and IL-1Ra with ITP. Methods: Genotyping of IL-1B-31 , IL-1B-511 , and IL-1Ra was performed in 118 ITP patients and 100 controls by polymerase chain reaction restriction fragment length polymorphism and detection of variable number tandem repeats...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333395/il-1b-31-and-il-1ra-polymorphisms-associated-with-increased-host-susceptibility-to-immune-thrompocytopenia
#15
EDITORIAL
Juwon Kim
No abstract text is available yet for this article.
December 2017: Blood Research
https://www.readbyqxmd.com/read/29317576/-protective-effect-of-taxifolin-on-h2o2-induced-%C3%A2-h9c2-cell-pyroptosis
#16
Yanqiong Ye, Xiaoli Wang, Qian Cai, Jian Zhuang, Xiaohua Tan, Wei He, Mingyi Zhao
To explore the effect of taxifolin on H2O2-induced pyroptosis in H9C2 cells and the possible mechanisms.
 Methods: The H9C2 cells was divided into 3 groups: a control group, a hydrogen peroxide (H2O2)group and a taxifolin group. The morphology of H9C2 cells was observed by inverted phase contrast microscope. The mitochondrial membrane potential was measured by JC-1 staining and flow cytometry. The alteration of the level of reactive oxygen species (ROS) was detected by specific mitochondrial probe. The protein levels of cysteinyl aspartate specific proteinase-1 (caspase-1)was determined by Western blot...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29304412/developmental-toxicity-and-potential-mechanisms-of-pyraoxystrobin-to-zebrafish-danio-rerio
#17
Hui Li, Song Yu, Fangjie Cao, Chengju Wang, Mingqi Zheng, Xuefeng Li, Lihong Qiu
As a newly developed, highly efficient strobilurin fungicide, pyraoxystrobin has been reported to be highly toxic to some aquatic organisms. However, the toxicity of pyraoxystrobin to different life stages of fish and the potential underlying mechanisms are still unknown. Hence, in the present study, the acute toxicity of pyraoxystrobin to different life stages of zebrafish (embryo, larva, and adult) was assessed. The developmental toxicity of pyraoxystrobin to zebrafish embryos and its effects on gene transcription in the embryo were also investigated...
January 2, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29288802/increasing-extracellular-cgmp-in-cerebellum-in-vivo-reduces-neuroinflammation-gabaergic-tone-and-motor-in-coordination-in-hyperammonemic-rats
#18
Andrea Cabrera-Pastor, Tiziano Balzano, Vicente Hernández-Rabaza, Michele Malaguarnera, Marta Llansola, Vicente Felipo
Hyperammonemia is a main contributor to cognitive impairment and motor in-coordination in patients with hepatic encephalopathy. Hyperammonemia-induced neuroinflammation mediates the neurological alterations in hepatic encephalopathy. Intracerebral administration of extracellular cGMP restores some but not all types of cognitive impairment. Motor in-coordination, is mainly due to increased GABAergic tone in cerebellum. We hypothesized that extracellular cGMP would restore motor coordination in hyperammonemic rats by normalizing GABAergic tone in cerebellum and that this would be mediated by reduction of neuroinflammation...
December 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29241030/expression-profiles-of-genes-involved-in-tlrs-and-nlrs-signaling-pathways-of-water-buffaloes-infected-with-fasciola-gigantica
#19
Fu-Kai Zhang, Jun-Ling Hou, Ai-Jiang Guo, Ai-Ling Tian, Zhao-An Sheng, Wen-Bin Zheng, Wei-Yi Huang, Hany M Elsheikha, Xing-Quan Zhu
Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like receptors (TLRs) and NOD-like receptors (NLRs) signaling pathways in buffaloes infected with 500F. gigantica metacercariae. Serum, liver and peripheral blood mononuclear cell (PBMC) samples were collected from infected and control buffaloes at 3, 10, 28, and 70days post infection (dpi)...
December 11, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29237457/the-role-of-src-erk1-2-kinases-in-inspiratory-resistive-breathing-induced-acute-lung-injury-and-inflammation
#20
Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis, Theodoros Vassilakopoulos
BACKGROUND: Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with large negative intrathoracic pressures, due to strenuous contractions of the inspiratory muscles. IRB is shown to induce lung injury in previously healthy animals. Src is a multifunctional kinase that is activated in the lung by mechanical stress. ERK1/2 kinase is a downstream target of Src. We hypothesized that Src is activated in the lung during IRB, mediates ERK1/2 activation and IRB-induced lung injury...
December 13, 2017: Respiratory Research
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