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https://www.readbyqxmd.com/read/28801784/prior-repeated-stress-attenuates-cold-induced-immunomodulation-associated-with-browning-in-mesenteric-fat-of-rats
#1
P Vargovic, M Laukova, J Ukropec, G Manz, R Kvetnansky
Continuous exposure to cold leads to activation of adaptive thermogenesis in brown adipose tissue but also to induction of brown/beige cell phenotype in white adipose tissue. The aim of this work was to investigate whether prior exposure to immobilization (IMO) stress may affect immune response associated with adipocyte "browning" in mesenteric adipose tissue (mWAT). In the first experiment, Sprague-Dawley rats were exposed to acute (3 h) or prolonged (7 days) cold exposure (4 ± 1 °C). 7-day cold stimulated gene expression of uncoupling protein 1 and other "browning"-associated factors...
August 11, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28771187/herbal-supplement-in-a-buffer-for-dry-eye-syndrome-treatment
#2
Hung-Chang Chen, Zhi-Yu Chen, Tsung-Jen Wang, Victor J Drew, Ching-Li Tseng, Hsu-Wei Fang, Feng-Huei Lin
Dry eye syndrome (DES) is one of the most common types of ocular diseases. There is a major need to treat DES in a simple yet efficient way. Artificial tears (AT) are the most commonly used agents for treating DES, but are not very effective. Herbal extractions of ferulic acid (FA), an anti-oxidant agent, and kaempferol (KM), an anti-inflammatory reagent, were added to buffer solution (BS) to replace ATs for DES treatment. The cytotoxicity and anti-inflammatory effects were examined in vitro by co-culture with human corneal epithelial cells (HCECs) to obtain the optimal concentration of KM and FA for treating HCECs...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749954/metabolic-markers-during-pregnancy-and-their-association-with-maternal-and-newborn-weight-status
#3
Otilia Perichart-Perera, Cinthya Muñoz-Manrique, Angélica Reyes-López, Maricruz Tolentino-Dolores, Salvador Espino Y Sosa, Ma Cristina Ramírez-González
BACKGROUND/AIMS: Obesity during pregnancy increases the risk of adverse clinical outcomes and is associated with low-grade chronic inflammation. We describe maternal metabolic risk and inflammation by maternal weight status, and evaluate the association of metabolic and inflammatory markers with birthweight in a group of pregnant Mexican women. METHODS: This study derived from a prospective cohort of healthy pregnant women <14 weeks of gestation, receiving prenatal care at National Institute of Perinatology (Mexico, 2009-2013)...
2017: PloS One
https://www.readbyqxmd.com/read/28740674/does-the-usage-of-digital-chest-drainage-systems-reduce-pleural-inflammation-and-volume-of-pleural-effusion-following-oncologic-pulmonary-resection-a-prospective-randomized-trial
#4
Michèle De Waele, John Agzarian, Waël C Hanna, Colin Schieman, Christian J Finley, Joseph Macri, Laura Schneider, Terri Schnurr, Forough Farrokhyar, Katherine Radford, Parameswaran Nair, Yaron Shargall
BACKGROUND: Prolonged air leak and high-volume pleural drainage are the most common causes for delays in chest tube removal following lung resection. While digital pleural drainage systems have been successfully used in the management of post-operative air leak, their effect on pleural drainage and inflammation has not been studied before. We hypothesized that digital drainage systems (as compared to traditional analog continuous suction), using intermittent balanced suction, are associated with decreased pleural inflammation and postoperative drainage volumes, thus leading to earlier chest tube removal...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740480/cerebrospinal-fluid-and-microdialysis-cytokines-in-severe-traumatic-brain-injury-a-scoping-systematic-review
#5
REVIEW
Frederick A Zeiler, Eric Peter Thelin, Marek Czosnyka, Peter J Hutchinson, David K Menon, Adel Helmy
OBJECTIVE: To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS: Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Both were conducted in severe TBI (sTBI) patients only. DATA SOURCES: Articles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28739185/novel-atherogenic-pathways-from-the-differential-transcriptome-analysis-of-diabetic-epicardial-adipose-tissue
#6
V Camarena, D Sant, M Mohseni, T Salerno, M L Zaleski, G Wang, G Iacobellis
BACKGROUND AND AIM: To evaluate the epicardial adipose tissue (EAT) transcriptome in comparison to subcutaneous fat (SAT) in coronary artery disease (CAD) and type 2 diabetes (T2DM). METHODS AND RESULTS: SAT and EAT samples were obtained from subjects with T2DM and CAD (n = 5) and those without CAD with or without T2DM (=3) undergoing elective cardiac surgery. RNA-sequencing analysis was performed in both EAT and SAT. Gene enrichment analysis was conducted to identify pathways affected by the differentially expressed genes...
June 10, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28738849/immune-suppression-of-igg-response-against-dairy-proteins-in-major-depression
#7
Leszek Rudzki, Dariusz Pawlak, Krystyna Pawlak, Napoleon Waszkiewicz, Aleksandra Małus, Beata Konarzewska, Mirosława Gałęcka, Anna Bartnicka, Lucyna Ostrowska, Agata Szulc
BACKGROUND: Interactions between the digestive system, brain functions and immunoglobulin G (IgG) mediated immunity against food antigens became recently a topic of growing interest in psychiatry research. Psychological stress can activate hypothalamic-pituitary-adrenal axis (HPA) with subsequent hypercortisolemia. It can also influence intestinal permeability and dynamics of IgG response. Major depression can by accompanied either by activation of inflammatory response or by immune suppression (e...
July 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28734553/dietary-inflammatory-index-and-liver-status-in-subjects-with-different-adiposity-levels-within-the-predimed-trial
#8
Irene Cantero, Itziar Abete, Nancy Babio, Fernando Arós, Dolores Corella, Ramón Estruch, Montse Fitó, James R Hebert, M Ángel Martínez-González, Xavier Pintó, M Puy Portillo, Miguel Ruiz-Canela, Nitin Shivappa, Julia Wärnberg, Enrique Gómez-Gracia, J Antoni Tur, Jordi Salas-Salvadó, M Angeles Zulet, J Alfredo Martínez
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted...
July 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28715807/amniotic-fluid-angiogenic-and-inflammatory-factor-profiling-in-foetal-down-syndrome
#9
Monika Zbucka-Kretowska, Karol Charkiewicz, Jan Czerniecki, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski
OBJECTIVES: Angiogenic factors are proteins that can potentially be related to certain foetal chromosomal abnormalities. The goal of this study was to determine the concentrations of 60 angiogenic factors in the amniotic fluid of women carrying foetuses with Down syndrome (DS). METHODS: After analysis of the karyotyping results, for the purpose of this study, we chose 12 women with foetal DS. For the control group, we selected 12 healthy patients with uncomplicated pregnancies (15-18 weeks of gestation) who delivered healthy newborns at term...
July 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28679471/postoperative-immune-response-and-surgical-stress-in-selective-neck-dissection-comparison-between-endoscopically-assisted-dissection-and-open-techniques-in-ct1-2n0-oral-squamous-cell-carcinoma
#10
Song Fan, Jiang-Long Zhong, Wei-Xiong Chen, Wei-Liang Chen, Qun-Xing Li, You-Yuan Wang, Zhao-Yu Lin, Han-Qing Zhang, Da-Ming Zhang, Xin Yu, Fa-Ya Liang, Xiao-Ming Huang, Eduardo Dias-Ribeiro, Yong Liu, Xiang-Hua Lin, Bin Zhou, Qi-Xiang Liang, Celso Koogi Sonoda, Jin-Song Li
BACKGROUND: Endoscopically assisted selective neck dissection (SND) has recently been applied in clinical N0 cases of oral squamous cell carcinoma (OSCC). However, nothing is known of the immune response after surgery. METHODS: A total of 60 patients with cT1-2N0 OSCC randomly underwent endoscopically assisted SND and open operations. The serum levels of IL-6, IL-8, IL-10, IL-1b, TNF-a, CRP, cortisol, ACTH, and growth hormone were analyzed before the start of the surgery (T0) and at 2 (T1), 6 (T2), 24 (T3), and 72 h (T4) after surgery...
December 7, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28672073/prediction-of-treatment-outcomes-to-exercise-in-patients-with-nonremitted-major-depressive-disorder
#11
Chad D Rethorst, Charles C South, A John Rush, Tracy L Greer, Madhukar H Trivedi
BACKGROUND: Only one-third of patients with major depressive disorder (MDD) achieve remission with initial treatment. Consequently, current clinical practice relies on a "trial-and-error" approach to identify an effective treatment for each patient. The purpose of this report was to determine whether we could identify a set of clinical and biological parameters with potential clinical utility for prescription of exercise for treatment of MDD in a secondary analysis of the Treatment with Exercise Augmentation in Depression (TREAD) trial...
July 3, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28669832/hyperbaric-oxygen-therapy-augments-tobramycin-efficacy-in-experimental-staphylococcus-aureus-endocarditis
#12
C J Lerche, L J Christophersen, M Kolpen, P R Nielsen, H Trøstrup, K Thomsen, O Hyldegaard, H Bundgaard, P Ø Jensen, N Høiby, C Moser
Staphylococcus aureus infective endocarditis (IE) is a serious disease with an in-hospital mortality of up to 40%. Improvements in the effects of antibiotics and host responses could potentially benefit outcomes. Hyperbaric oxygen therapy (HBOT) represents an adjunctive therapeutic option. In this study, the efficacy of HBOT in combination with tobramycin in S. aureus IE was evaluated. A rat model of S. aureus IE mimicking the bacterial load in humans was used. Infected rats treated subcutaneously with tobramycin were randomised into two groups: (i) HBOT twice daily (n = 13); or (ii) normobaric air breathing (non-HBOT) (n = 17)...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28666275/curcumin-protects-against-hepatic-ischemia-reperfusion-induced-injury-through-inhibiting-tlr4-nf-%C3%AE%C2%BAb-pathway
#13
Lu Wang, Ning Li, Dongdong Lin, Yunjin Zang
The TLR4/NF-κB pathway had important roles in hepatic ischemia/reperfusion (I/R) injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-κB pathway. Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant. In addition, curcumin ameliorated elevated TLR4 and NF-κB caused by hypoxia/reoxygenation stimulation in BRL-3A cells. In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-κB signaling pathway caused by hepatic I/R stimulation in liver tissues...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28646583/sebum-lipids-influence-macrophage-polarization-and-activation
#14
M Lovászi, M Mattii, K Eyerich, Attila Gácsi, Erzsébet Csányi, D Kovács, R Rühl, A Szegedi, L Kemény, M Ståhle, C C Zouboulis, S Eyerich, D Törőcsik
BACKGROUND: As lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. OBJECTIVE: To investigate if sebocytes could contribute to the differentiation, polarization and function of macrophages with their secreted lipids. METHODS: Oil-red-O lipid staining and Raman spectroscopy were used to assess the dermal lipid content and penetration. Immunohistochemistry was used to analyse the macrophage subsets...
June 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28646347/alendronate-treatment-induces-il-1b-expression-and-apoptosis-in-glioblastoma-cell-line
#15
Paola Maura Tricarico, Angeladine Epate, Fulvio Celsi, Sergio Crovella
Alendronate (ALD), one among the nitrogen-containing bisphosphonates (NBPs), is currently used for the treatment of many pathological conditions. Unfortunately, although generally tolerated, NBPs treatment has been associated with central nervous system (CNS) adverse outcomes, such as amnesia, hallucinations and visual disturbances. So, we analyzed the effect of ALD treatment in glial cells, the main sources of cholesterol for neurons and principal cells involved in the immunological defense of the brain. We treated a glial cell line (U87-MG) with increasing doses of ALD (0...
June 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28634425/a-transcriptional-regulatory-role-for-the-membrane-type-1-matrix-metalloproteinase-in-carcinogen-induced-inflammasome-gene-expression
#16
Samuel Sheehy, Borhane Annabi
Signal-transducing functions driven by the cytoplasmic domain of membrane type-1 matrix metalloproteinase (MT1-MMP) are believed to regulate many inflammation-associated cancer cell functions including migration, proliferation, and survival. Aside from upregulation of the inflammation biomarker cyclooxygenase-2 (COX-2) expression, MT1-MMP's role in relaying intracellular signals triggered by extracellular pro-inflammatory cues remains poorly understood. Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP...
2017: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/28631672/-the-influence-of-interleukin-gene-polymorphism-on-the-serum-cytokine-level-in-the-patients-presenting-with-chonic-suppurative-otitis-media
#17
E V Baike, Yu A Vitkovsky, A A Dutova
The objective of the present work was to study the influence of allelic variant associations of 1-beta interleukin (C3953T, &511C, T31C), interleukin-6 (C174G), and tumour necrosis factor-alpha (G308A) gene polymorphisms on the serum cytokine level in the patients presenting with chronic suppurative otitis media. A total of 299 patients at the age varying from 16 to 55 years with this condition divided into three groups were examined. Group 1 was comprised of 146 patients suffering from the tubotympanic form of chronic suppurative otitis media (CSOM)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28623311/identification-of-rare-genetic-variation-of-nlrp1-gene-in-familial-multiple-sclerosis
#18
Ales Maver, Polona Lavtar, Smiljana Ristić, Sanja Stopinšek, Saša Simčič, Keli Hočevar, Juraj Sepčić, Jelena Drulović, Tatjana Pekmezović, Ivana Novaković, Hodžić Alenka, Gorazd Rudolf, Saša Šega, Nada Starčević-Čizmarević, Anja Palandačić, Gordana Zamolo, Miljenko Kapović, Tina Likar, Borut Peterlin
The genetic etiology and the contribution of rare genetic variation in multiple sclerosis (MS) has not yet been elucidated. Although familial forms of MS have been described, no convincing rare and penetrant variants have been reported to date. We aimed to characterize the contribution of rare genetic variation in familial and sporadic MS and have identified a family with two sibs affected by concomitant MS and malignant melanoma (MM). We performed whole exome sequencing in this primary family and 38 multiplex MS families and 44 sporadic MS cases and performed transcriptional and immunologic assessment of the identified variants...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611262/relative-adrenal-insufficiency-is-associated-with-the-clinical-outcome-in-patients-with-stable-decompensated-cirrhosis
#19
Evangelos Cholongitas, Ioannis Goulis, Eirini Pagkalidou, Anna Haidich, Apostolos Karagiannis, Theodora Nakouti, Chrysoula Pipili, Theodora Oikonomou, Spyros Gerou, Evangelos Akriviadis
BACKGROUND: The clinical impact of relative adrenal insufficiency (AI) on patients with stable decompensated cirrhosis (DeCi) has not been yet elucidated. AIM: Explore the association between AI and outcome [death or liver transplantation (LT)] in patients with DeCi. MATERIAL AND METHODS: Patients with DeCi presenting no active complication have been included. Clinical and laboratory data, including serum levels of corticosteroid-binding globulin (CBG), interleukin (IL)-1b, IL-6 and tumor necrosis factor (TNFα) were recorded in each participant...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28595952/trans-resveratrol-enriched-maternal-diet-protects-the-immature-hippocampus-from-perinatal-asphyxia-in-rats
#20
Sebastian Isac, Anca Maria Panaitescu, Ana Spataru, Mara Iesanu, Alexandra Totan, Amalia Udriste, Natalia Cucu, Gheorghe Peltecu, Leon Zagrean, Ana-Maria Zagrean
Trans-resveratrol (tRESV), a polyphenol with antioxidant properties, is common in many food sources, hence easily accessible for study as a maternal dietary supplement in perinatal asphyxia (PA). Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause of neonatal morbidity. The purpose of this study is to identify new epigenetic mechanisms of brain inflammation and injury related to PA and to explore the benefit of tRESV enriched maternal diet...
July 13, 2017: Neuroscience Letters
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