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https://www.readbyqxmd.com/read/29682101/evaluation-of-mediators-associated-with-the-inflammatory-response-in-prostate-cancer-patients-undergoing-radiotherapy
#1
Nice Bedini, Alessandro Cicchetti, Federica Palorini, Tiziana Magnani, Valentina Zuco, Marzia Pennati, Elisa Campi, Paola Allavena, Samantha Pesce, Sergio Villa, Barbara Avuzzi, Sara Morlino, Maria Emanuela Visentin, Nadia Zaffaroni, Tiziana Rancati, Riccardo Valdagni
A recent "hot topic" in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy...
2018: Disease Markers
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#2
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29652312/-a-study-on-the-association-of-genes-for-pro-inflammatory-cytokines-and-depression
#3
T V Lezheiko, A V Andryushchenko, G I Korovaitseva, N V Kondratiev, M V Gabaeva, E V Krikova, V E Golimbet
AIM: To study the association between proinflammatory cytokine genes and depression. MATERIAL AND METHODS: IL-1B С-511T and TNF-a G-308A gene polymorphisms were studied in patients diagnosed with depression and age and sex-matched healthy controls. RESULTS AND CONCLUSION: The IL-1B С-511T and TNF-a G-308A polymorphisms were associated with depression; CC genotype (р=0,001, OR=1.9 CI 1,3-2,7) and GG genotype (р=0,001, OR=3,0 CI 1,8-4,9) were the risk factors...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29644893/activation-of-the-nfkb-pathway-alters-the-phenotype-of-mscs-in-the-tracheal-aspirates-of-preterm-infants-with-severe-bpd
#4
Tobias Reicherzer, Susanne Häffner, Tayyab Shahzad, Judith Gronbach, Josef Mysliwietz, Christoph Huebener, Uwe Hasbargen, Jan Gertheiss, Andreas Schulze, Saverio Bellusci, Rory E Morty, Anne Hilgendorff, Harald Ehrhardt
Mesenchymal stromal cells (MSCs) are released into the airways of preterm infants following lung injury. These cells display a pro-inflammatory phenotype and are associated with development of severe bronchopulmonary dysplasia (BPD). We aimed to characterize the functional properties of MSCs obtained from tracheal aspirates of 50 preterm infants who required invasive ventilation. Samples were separated by disease severity. The increased proliferative capacity of MSCs was associated with longer duration of mechanical ventilation and higher severity of BPD...
April 12, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29627479/classical-swine-fever-virus-induces-pyroptosis-in-the-peripheral-lymphoid-organs-of-infected-pigs
#5
Jin Yuan, Mengjiao Zhu, Shaofeng Deng, Shuangqi Fan, Hailuan Xu, Jiedan Liao, Peng Li, Jingfang Zheng, Mingqiu Zhao, Jinding Chen
Classical swine fever virus (CSFV) causes a highly lethal disease in pigs, which is characterized by immunosuppression. Leukopenia is known to be a possible mechanism of immunosuppression during CSFV infection. As a new and specialized form of cell death, pyroptosis is the key response of the innate immune system to pathogens, and is widely involved in the occurrence and development of infectious diseases. However, the relationship between CSFV and pyroptosis has not been explored. In this study, we investigated the occurrence of pyroptosis in pigs following CSFV infection...
April 5, 2018: Virus Research
https://www.readbyqxmd.com/read/29600800/hypertonic-saline-alleviates-brain-edema-after-traumatic-brain-injury-via-downregulation-of-aquaporin-4-in-rats
#6
Jian Yin, Haixiao Zhang, Huai Chen, Qingping Lv, Xuhong Jin
BACKGROUND Hypertonic saline (HS) has been successfully used for treatment of various forms of brain edema. Decreased expression of aquaporin (AQP)4 and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a and interleukin (IL)-1b have been linked to edema pathogenesis. This study examined the effect of 3% HS on brain edema in a rat model of traumatic brain injury (TBI). MATERIAL AND METHODS Sprague-Dawley rats were subjected to TBI induced by a controlled cortical impactor. The HS group was injected with 3% NaCl until the end of the study period...
March 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29595664/roles-of-t-follicular-helper-cells-in-the-pathogenesis-of-adenoidal-hypertrophy-combined-with-secretory-otitis-media
#7
Chunyan Feng, Qicheng Zhang, Guangquan Zhou, Jing Zhang, Yanshu Zhang
The aim of this study was to investigate the roles of T follicular helper (Tfh) cells in secretory otitis media (SOM) combined with adenoidal hypertrophy (AH).Patients with AH or AH combined with SOM admitted to the Yancheng No. 1 People's Hospital from December 2012 to December 2014 were included. Fourteen age-matched healthy individuals received physical examinations in the hospital served as control. The venous Tfh was determined using flow cytometry, and CD3 + CD4 + CXCR5 + T lymphocytes were defined as Tfh cells...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29593814/age-related-differences-in-function-and-structure-of-rat-livers-subjected-to-ischemia-reperfusion
#8
Małgorzata Trocha, Anna Merwid-Ląd, Małgorzata Pieśniewska, Joanna Kwiatkowska, Lidia Fereniec-Gołębiewska, Przemysław Kowalski, Adam Szeląg, Tomasz Sozański
Introduction: Liver function is affected during ischemia/reperfusion (IR). The current state of knowledge about liver aging processes during IR is incomplete. We evaluated the effects of aging on liver structure and function under IR conditions. Material and methods: Animals were divided into control (C-2) and ischemia/reperfusion (IR-2) groups of young rats (2-4 months old) and C-12 and IR-12 groups of old rats (12-14 months old). The livers from IR-2 and IR-12 groups were subjected to partial ischemia (60 min), followed by global reperfusion (4 h)...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29581620/genome-wide-association-study-for-pollinosis-identified-two-novel-loci-in-interleukin-il-1b-in-a-japanese-population
#9
Ryosuke Fujii, Asahi Hishida, Michael C Wu, Takaaki Kondo, Yuta Hattori, Mariko Naito, Kaori Endoh, Masahiro Nakatochi, Nobuyuki Hamajima, Michiaki Kubo, Kiyonori Kuriki, Kenji Wakai
The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29560933/-prognostic-significance-of-clinical-anthropometric-biochemical-metabolic-vascular-inflammatory-and-molecular-genetic-markers-in-the-development-of-the-first-ischemic-stroke
#10
V N Shishkova, T V Adasheva, A Yu Remenik, V N Valyaeva, V M Shklovsky
AIM: To study the relationship between clinical-anthropometric, biochemical, metabolic, vascular-inflammatory, molecular-genetic parameters and the development of the first ischemic stroke, and to develop a prognostic model for determining the probability of its occurrence. MATERIAL AND METHODS: The study included 196 first ischemic stroke patients and 119 healthy people matched for age, place of residence and nationality to the group of patients. The main anthropometric, clinical, biochemical, metabolic parameters and markers of vascular inflammation and endothelial dysfunction were assessed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29512786/dioscin-prevents-lps%C3%A2-induced-acute-lung-injury-through-inhibiting-the-tlr4-myd88-signaling-pathway-via-upregulation-of-hsp70
#11
Huiqing Zeng, Lijuan Yang, Xiaobin Zhang, Yan Chen, Jianghang Cai
Dioscin, as a type of important natural steroidal saponin, has widespread sources, primarily from the fenugreek plant, which is an important raw material in the production of synthetic steroid hormone drugs. Dioscin has anti‑tumor, anti‑inflammatory, antioxidant and other significant pharmacological effects with high medicinal value. The present work aimed to research the protective effect and underlying mechanisms by which dioscin prevents acute lung injury (ALI). Mice were injected with 5 mg/kg LPS to induce lung injury...
March 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29509495/inflammatory-and-apoptotic-signalling-pathways-and-concussion-severity-a-genetic-association-study
#12
Sarah Mc Fie, Shameemah Abrahams, Jon Patricios, Jason Suter, Michael Posthumus, Alison V September
The objective was to investigate the relationship between IL-1B rs16944, IL-6 rs1800795, and CASP8 rs3834129 genetic polymorphisms and concussion severity. Rugby players from high school, senior amateur, and professional teams completed a concussion severity questionnaire and donated a DNA sample. Participants (n = 163) were split into symptom severity groups around the median number and duration of symptoms. The frequency of participants with high symptom counts (more than five symptoms) increased across the IL-1B (C/C: 35%; C/T: 51%; T/T: 56%; P = 0...
March 6, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29501867/levetiracetam-mitigates-lipopolysaccharide-induced-jak2-stat3-and-tlr4-mapk-signaling-pathways-activation-in-a-rat-model-of-adjuvant-induced-arthritis
#13
Omnia Ahmed Mohamed Abed El-Gaphar, Amira M Abo-Youssef, Gouda Kamel Halal
Levetiracetam (LEV), a novel anti-epileptic drug that has been demonstrated with an anti-inflammatory effect, but the exact mechanisms of its action remain to be fully defined. The present study aimed to evaluate the possible effects of LEV on lipopolysaccharides (LPS)-induced Janus kinase-signal transducers and activators of transcription (JAK/STAT) as well as toll-like receptor 4 (TLR4)/ mitogen activated protein kinase (MAPK) signaling pathways activation in adjuvant induced arthritis (AIA). Rats were allocated into normal control, three arthritic control groups: Complete Freund's Adjuvant (CFA) (0...
March 1, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29479379/effects-of-preoperative-curcumin-on-the-inflammatory-response-during-mechanical-circulatory-support-a-porcine-model
#14
Peter Ma, Dmitry Tumin, Mary Cismowski, Joseph D Tobias, Daniel Gomez, Patrick McConnell, Aymen Naguib, Andrew R Yates, Peter Winch
Background: Curcumin is a polyphenol extracted from the turmeric plant which may have anti-inflammatory properties. We hypothesized that curcumin pretreatment would result in a reduction in inflammatory markers in a large animal model of extracorporeal support. Methods: A total of seven samples were obtained from three swine treated with curcumin and 16 samples were obtained from six swine in the control group (procedure terminated in two swine before last sample could be obtained)...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29466053/interplay-between-gut-microbiota-and-p66shc-affects-obesity-associated-insulin-resistance
#15
Stefano Ciciliot, Mattia Albiero, Stefano Campanaro, Nicol Poncina, Serena Tedesco, Valentina Scattolini, Francesca Dalla Costa, Andrea Cignarella, Monica Vettore, Iole Maria Di Gangi, Sara Bogialli, Angelo Avogaro, Gian Paolo Fadini
The 66 kDa isoform of the mammalian Shc gene promotes adipogenesis, and p66Shc-/- mice accumulate less body weight than wild-type (WT) mice. As the metabolic consequences of the leaner phenotype of p66Shc-/- mice is debated, we hypothesized that gut microbiota may be involved. We confirmed that p66Shc-/- mice gained less weight than WT mice when on a high-fat diet (HFD), but they were not protected from insulin resistance and glucose intolerance. p66Shc deletion significantly modified the composition of gut microbiota and their modification after an HFD...
February 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29438197/elevated-liver-stiffness-is-linked-to-increased-biomarkers-of-inflammation-and-immune-activation-in-hiv-hcv-coinfected-patients
#16
Luz Maria Medrano, Pilar Garcia-Broncano, Juan Berenguer, Juan González-García, Ma Ángeles Jiménez-Sousa, Josep M Guardiola, Manuel Crespo, Carmen Quereda, José Sanz, Isabel Canorea, Ana Carrero, Victor Hontañón, Ma Ángeles Muñoz-Fernández, Salvador Resino
OBJECTIVES: Immune dysregulation is a hallmark of HIV and HCV infections. To evaluate the relationship between liver stiffness measure (LSM) and biomarkers of T cell activation, bacterial translocation, inflammation, endothelial dysfunction, and coagulopathy in HIV/HCV-coinfected patients. DESIGN: Cross-sectional study. METHODS: We studied 238 HIV/HCV-coinfected patients, 32 healthy controls and 39 HIV-monoinfected patients. Patients were stratified according to LSM into four groups: <12...
February 12, 2018: AIDS
https://www.readbyqxmd.com/read/29434599/rna-seq-analysis-of-il-1b-and-il-36-responses-in-epidermal-keratinocytes-identifies-a-shared-myd88-dependent-gene-signature
#17
William R Swindell, Maria A Beamer, Mrinal K Sarkar, Shannon Loftus, Joseph Fullmer, Xianying Xing, Nicole L Ward, Lam C Tsoi, Michelle J Kahlenberg, Yun Liang, Johann E Gudjonsson
IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Type I and II interferon genes exhibited time-dependent response patterns, with early induction (8 h) followed by no response or repression (24 h)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29425536/magnetic-iodixanol-a-novel-contrast-agent-and-its-early-characterization
#18
M C Arokiaraj, E Menesson, N Feltin
AIMS: Contrast-induced nephropathy is a commonly encountered problem in clinical practice. The purpose of the study was to design and develop a novel contrast agent, which could be used to prevent contrast-induced nephropathy in the future. METHODS: In total, 20-220nm magnetic nanoparticles were conjugated with iodixanol, and their radio-opacity and magnetic properties were assessed thereafter. Scanning electron microscopy pictures were acquired. Thereafter, the nanoparticles conjugate was tested in cell culture (HUVEC cells), and Quantibody® assay was studied after cell treatment in 1:5 dilutions for 48h, compared with control...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29423077/integrating-the-dysregulated-inflammasome-based-molecular-functionome-in-the-malignant-transformation-of-endometriosis-associated-ovarian-carcinoma
#19
Chia-Ming Chang, Mong-Lien Wang, Kai-Hsi Lu, Yi-Ping Yang, Chi-Mou Juang, Peng-Hui Wang, Ren-Jun Hsu, Mu-Hsien Yu, Cheng-Chang Chang
The coexistence of endometriosis (ES) with ovarian clear cell carcinoma (CCC) or endometrioid carcinoma (EC) suggested that malignant transformation of ES leads to endometriosis associated ovarian carcinoma (EAOC). However, there is still lack of an integrating data analysis of the accumulated experimental data to provide the evidence supporting the hypothesis of EAOC transformation. Herein we used a function-based analytic model with the publicly available microarray datasets to investigate the expression profiling between ES, CCC, and EC...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398577/cell-death-inflammation-tumor-burden-and-proliferation-blood-biomarkers-predict-lung-cancer-radiotherapy-response-and-correlate-with-tumor-volume-and-proliferation-imaging
#20
Ahmed Salem, Hitesh Mistry, Alison Backen, Clare Hodgson, Pek Koh, Emma Dean, Lynsey Priest, Kate Haslett, Ioannis Trigonis, Alan Jackson, Marie-Claude Asselin, Caroline Dive, Andrew Renehan, Corinne Faivre-Finn, Fiona Blackhall
INTRODUCTION: There is an unmet need to develop noninvasive biomarkers to stratify patients in drug-radiotherapy trials. In this pilot study we investigated lung cancer radiotherapy response and toxicity blood biomarkers and correlated findings with tumor volume and proliferation imaging. PATIENTS AND METHODS: Blood samples were collected before and during (day 21) radiotherapy. Twenty-six cell-death, hypoxia, angiogenesis, inflammation, proliferation, invasion, and tumor-burden biomarkers were evaluated...
December 11, 2017: Clinical Lung Cancer
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