keyword
MENU ▼
Read by QxMD icon Read
search

Il-1b

keyword
https://www.readbyqxmd.com/read/28423679/association-of-il-1a-and-il-1b-polymorphisms-with-ankylosing-spondylitis-among-the-chinese-han-population-a-case-control-study
#1
Lei Li, Baolan Shi, Wenkai Zheng, Wenhua Xing, Yan Zhao, Feng Li, Daqi Xin, Tianbo Jin, Yong Zhu, Xuejun Yang
Ankylosing spondylitis (AS) is a complex and chronic inflammatory disease with a high heritage. Previous study has shown that IL-1A and IL-1B involved in inflammatory reaction. But little is known about single nucleotide polymorphisms (SNPs) of IL-1A and IL-1B associated with AS. We conducted a case-control study among 267 AS cases and 297 healthy controls from China. In the genetic model analysis, we found the "T" genotype of rs3783550 was associated with decreased AS risk in the dominant model (p = 0.044) and log-additive model (p = 0...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417590/calcitonin-gene-related-peptide-cgrp-a-novel-target-for-alzheimer-s-disease
#2
REVIEW
Yogendra Singh, Gaurav Gupta, Birendra Shrivastava, Rajiv Dahiya, Juhi Tiwari, Madhu Ashwathanarayana, Rakesh Kumar Sharma, Mohit Agrawal, Anurag Mishra, Kamal Dua
Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP) is a thirty-seven-amino acid regulatory neuropeptide resulting from different merging of the CGRP gene, which also includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor-stimulating peptide...
April 17, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28404639/cholesterol-crystallization-within-hepatocyte-lipid-droplets-and-its-role-in-murine-nash
#3
George N Ioannou, Savitha Subramanian, Alan Chait, W Geoffrey Haigh, Matthew M Yeh, Geoffrey C Farrell, Sum P Lee, Christopher Savard
We recently reported that cholesterol crystals form in hepatocyte lipid droplets (LDs) in human and experimental NASH. Herein, we assigned wild-type C57BL/6J mice to a high-fat (15%) diet for 6 months supplemented with 0%, 0.25%, 0.5%, 0.75%, or 1% dietary cholesterol. Increasing dietary cholesterol led to cholesterol loading of the liver, but not adipose tissue, resulting in fibrosing steatohepatitis at a dietary cholesterol concentration ≥0.5%, whereas mice on lower cholesterol diets developed only simple steatosis...
April 12, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28390203/lipopolysaccharide-and-lipoteichoic-acid-virulence-deactivation-by-stannous-fluoride
#4
Chris Haught, Sancai Xie, Ben Circello, Cheryl S Tansky, Deepa Khambe, Malgorzata Klukowska, Tom Huggins, Donald J White
OBJECTIVES: Oral bacterial pathogens promote gingivitis and periodontal disease. Bacterial endotoxins, also known as lipopolysaccharides (LPSs) and lipoteichoic acids (LTAs), are known to enhance bacterial pathogenicity through binding with Toll-like receptors (TLRs), a group of pattern recognition receptors critical to the activation of innate immunity, that are expressed on host cells. Both LPS and LTA contain lipophilic domains and anionic charges that may be susceptible to reactivity with stannous fluoride, a commonly used ingredient clinically proven for the treatment and prevention of gingivitis...
September 2016: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28389653/identification-of-igf-1-enhanced-cytokine-expressions-targeted-by-mir-181d-in-glioblastomas-via-an-integrative-mirna-mrna-regulatory-network-analysis
#5
Kuo-Hao Ho, Peng-Hsu Chen, Edward Hsi, Chwen-Ming Shih, Wei-Chiao Chang, Chia-Hsiung Cheng, Cheng-Wei Lin, Ku-Chung Chen
The insulin-like growth factor (IGF)-1 signaling is relevant in regulating cell growth and cytokine secretions by glioblastomas. MicroRNAs determine the cell fate in glioblastomas. However, relationships between IGF-1 signaling and miRNAs in glioblastoma pathogenesis are still unclear. Our aim was to validate the IGF-1-mediated mRNA/miRNA regulatory network in glioblastomas. Using in silico analyses of mRNA array and RNA sequencing data from The Cancer Genome Atlas (TCGA), we identified 32 core enrichment genes that were highly associated with IGF-1-promoted cytokine-cytokine receptor interactions...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381600/increased-neutrophil-gelatinase-associated-lipocalin-ngal-promotes-airway-remodelling-in-chronic-obstructive-pulmonary-disease
#6
Yujie Wang, Man Jia, Xiaoyi Yan, Limin Cao, Peter J Barnes, Ian M Adcock, Mao Huang, Xin Yao
Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from neutrophils may drive COPD epithelial-mesenchymal transition (EMT). NGAL expression was quantified in the lungs of COPD patients and bronchoalveolar lavage fluid (BALF) of ozone-treated mice. Reticular basement membrane (RBM) thickness and E-cadherin and α-smooth muscle actin (α-SMA) expression were determined in mice airways. Effects of cigarette smoke extract (CSE) and inflammatory factors on NGAL expression in human neutrophils as well as the effects of NGAL on airway structural cells was assessed...
April 5, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28357029/chronic-exposure-to-ethanol-causes-steatosis-and-inflammation-in-zebrafish-liver
#7
Ana Claudia Reis Schneider, Cleandra Gregório, Carolina Uribe-Cruz, Ranieli Guizzo, Tais Malysz, Maria Cristina Faccioni-Heuser, Larisse Longo, Themis Reverbel da Silveira
AIM: To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genes in zebrafish. METHODS: Zebrafish (n = 104), wild type, adult, male and female, were divided into two groups: Control and ethanol (0.05 v/v). The ethanol was directly added into water; tanks water were changed every two days and the ethanol replaced. The animals were fed twice a day with fish food until satiety. After two and four weeks of trial, livers were dissected, histological analysis (hematoxilin-eosin and Oil Red staining) and gene expression assessment of adiponectin, adiponectin receptor 2 (adipor2), sirtuin-1 (sirt-1), tumor necrosis factor-alpha (tnf-a), interleukin-1b (il-1b) and interleukin-10 (il-10) were performed...
March 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28356984/interleukin-1%C3%AE-activates-focal-adhesion-kinase-and-src-to-induce-matrix-metalloproteinase-9-production-and-invasion-of-mcf-7-breast-cancer-cells
#8
Naing Naing Mon, Takeshi Senga, Satoko Ito
Interleukin-1β (IL-1b) is a pleiotropic cytokine that is important in tumor progression and invasion. Matrix metalloproteinase-9 (MMP-9), which is a secreted matrix-degrading enzyme, is one of the key regulators of tumor invasion and metastasis. The current report indicated that IL-1b promotes MMP-9 production and cell invasion in non-metastatic MCF-7 breast cancer cells. IL-1b activated focal adhesion kinase (FAK) and proto-oncogene tyrosine-protein kinase Src (Src). Moreover, inhibiting the Src/FAK pathway reduced the IL-1b-induced production of MMP-9 and cell invasion...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28299811/the-role-of-interleukin-1b-and-its-antagonist-diacerein-in-estradiol-benzoate-induced-endometrial-hyperplasia-and-atypia-in-female-rats
#9
Marwa M M Refaie, Maram El-Hussieny
Endometrial hyperplasia (EH) is a common gynecological condition and may progress to carcinoma. We investigated the effect of diacerein (DIA) on estradiol benzoate (EB)-induced EH and atypia. DIA (50mg/kg/day) was administered orally to rats for 4 weeks, in the presence or absence of EH induced by intramuscular (im) injection of EB (60μg/100g) 3 times per week for 4 weeks. We measured levels of serum total cholesterol, uterine tissue malondialdehyde (MDA), total nitrites (NOx ), superoxide dismutase (SOD) activity, caspase-3, interleukin-1b (IL-1b) immunoexpressions and histopathology...
March 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28296282/sildenafil-reduces-neuroinflammation-in-cerebellum-restores-gabaergic-tone-and-improves-motor-in-coordination-in-rats-with-hepatic-encephalopathy
#10
Ana Agusti, Vicente Hernández-Rabaza, Tiziano Balzano, Lucas Taoro-Gonzalez, Andrea Ibañez-Grau, Andrea Cabrera-Pastor, Santos Fustero, Marta Llansola, Carmina Montoliu, Vicente Felipo
AIMS: Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in-coordination. Rats with HE due to portacaval shunts (PCS) show motor in-coordination. We hypothesized that in PCS rats: (i) Motor in-coordination would be due to enhanced GABAergic tone in cerebellum; (ii) increased GABAergic tone would be due to neuroinflammation; (iii) increasing cGMP would reduce neuroinflammation and GABAergic tone and restore motor coordination. To assess these hypotheses, we assessed if (i) treatment with sildenafil reduces neuroinflammation; (ii) reduced neuroinflammation is associated with reduced GABAergic tone and restored motor coordination...
May 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28207826/changes-of-plasma-cytokines-and-chemokines-expression-level-in-nasopharyngeal-carcinoma-patients-after-treatment-with-definitive-intensity-modulated-radiotherapy-imrt
#11
Ya-Bin Jin, Guo-Yi Zhang, Kai-Rong Lin, Xiang-Ping Chen, Jin-Huan Cui, Yue-Jian Wang, Wei Luo
BACKGROUND: Potential clinical application values of certain cytokines and chemokines that participate in the process of tumor growth, invasion, and metastasis have been reported. However, there still lack of biomarkers for a great many of malignancy. This study identified cytokines or chemokines involved in the occurrence and development of nasopharyngeal carcinoma (NPC), which might be a biomarker for noninvasive early diagnosis. METHODS: The plasma levels of 19 cytokines and chemokines were detected by the luminex liquid array-based multiplexed immunoassays in 39 NPC patients before and after treatment by definitive intensity-modulated radiotherapy (IMRT)...
2017: PloS One
https://www.readbyqxmd.com/read/28197807/telomere-length-in-the-gastric-mucosa-after-helicobacter-pylori-eradication-and-its-potential-role-in-the-gastric-carcinogenesis
#12
Tomomitsu Tahara, Sayumi Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
The molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication remain unclear. We examined the telomere length of gastric mucosa samples after successful H. pylori eradication in patients without and those with gastric cancer. Telomere length was measured by the real-time PCR among four different groups of biopsies: gastric body from subjects without history of H. pylori infection (Hp-: n = 23), gastric body from cancer-free subjects after H. pylori eradication (cancer-free body: n = 24), gastric body from early gastric cancer patients diagnosed after H...
February 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28194840/burst-spinal-cord-stimulation-increases-peripheral-antineuroinflammatory-interleukin-10-levels-in-failed-back-surgery-syndrome-patients-with-predominant-back-pain
#13
Thomas M Kinfe, Sajjad Muhammad, Carolina Link, Sandra Roeske, Shafqat R Chaudhry, Thomas L Yearwood
OBJECTIVES: Burst spinal cord stimulation (SCS) has been reported to reduce back pain and improve functional capacity in Failed Back Surgery Syndrome (FBSS). However, its mechanism of action is not completely understood. Systemic circulating cytokines have been associated with the development of chronic back pain. METHODS: This prospective, feasibility study enrolled 12 refractory FBSS patients with predominant back pain (70% of overall pain) suitable for Burst SCS...
February 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28193589/head-kidney-liver-and-skin-histopathology-and-gene-expression-in-gilthead-seabream-sparus-aurata-l-exposed-to-highly-polluted-marine-sediments-from-portman-bay-spain
#14
Said Ben Hamed, Francisco Guardiola, Alberto Cuesta, Salvadora Martínez, María José Martínez-Sánchez, Carmen Pérez-Sirvent, María Ángeles Esteban
Biomarkers have become crucial tools in modern environmental assessment as they can help to predict magnitude of pollution. The head-kidney (HK) and liver (hematopoietic and xenobiotic metabolism organs, respectively) are the key organs in all fish toxicological studies, although the skin has received less attention in this respect. The impact of two different types of polluted sediment collected from Portman Bay (Spain) on HK, liver and skin gene expression in gilthead seabream (Sparus aurata L.) exposed for two weeks to the sediments was determined by real time-PCR...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28174320/isolation-of-luteal-endothelial-cells-and-functional-interactions-with-t-lymphocytes
#15
Sadhat S Walusimbi, Lindy Wetzel, David Townson, Joy Pate
The objectives of this study were to optimize the isolation of luteal endothelial cells (LEC) and examine their functional interactions with autologous T lymphocytes. Analysis by flow cytometry showed that the purity of LEC isolated by filtration was nearly 90% as indicated by Bandeiraea simplicifolia (BS)-1 lectin binding. LEC expressed mRNA for progesterone receptor (PGR), prostaglandin receptors (PTGFR, PTGER2 and 4, and PTGIR), tumor necrosis factor receptors (TNFRSF1A&B) and interleukin (IL) 1B receptors (IL1R1&2)...
February 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28138240/plant-derived-pectin-nanocoatings-to-prevent-inflammatory-cellular-response-of-osteoblasts-following-porphyromonas-gingivalis-infection
#16
Anna Meresta, Justyna Folkert, Timo Gaber, Korneliusz Miksch, Frank Buttgereit, Jacqueline Detert, Nicole Pischon, Katarzyna Gurzawska
BACKGROUND: Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is) from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28129679/a-study-on-the-association-of-interleukin-1-cluster-with-genetic-risk-in-bipolar-i-disorder-in-iranian-patients-a-case-control-study
#17
Ali Talaei, Jalil Tavakkol Afshari, Mohammad Reza Fayyazi Bordbar, Hamidreza Pouryousof, Farhad Faridhosseini, Ali Saghebi, Amir Rezaei Ardani, Andisheh Talaei, Mohsen Tehrani
The pathogenesis of Bipolar I Disorder (BP-I) involves immune-mediated mechanisms, especially an imbalance in pro-inflammatory/anti-inflammatory cytokines in plasma or cerebrospinal fluid. Interleukin-1 (IL-1) gene cluster, coding some of these pro-inflammatory cytokines, might play a role in various neuropathologies related to neuron inflammation. The aim of the present study was to investigate the possible role of IL-1 gene cluster polymorphisms in determining the susceptibility to BP-I in Iranian population...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28127698/estrogen-attenuates-local-inflammasome-expression-and-activation-after-spinal-cord-injury
#18
Adib Zendedel, Fabian Mönnink, Gholamreza Hassanzadeh, Arash Zaminy, Malek Masoud Ansar, Pardes Habib, Alexander Slowik, Markus Kipp, Cordian Beyer
17-estradiol (E2) is a neuroprotective hormone with a high anti-inflammatory potential in different neurological disorders. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1b) and IL-18 mediated by caspase-1 which is under the control of an intracellular multiprotein complex called inflammasome. We recently described in a SCI model that between 24 and 72 h post-injury, most of inflammasome components including IL-18, IL-1b, NLRP3, ASC, and caspase-1 are upregulated...
January 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28111717/a-predictive-model-of-inflammatory-markers-and-patient-reported-symptoms-for-cachexia-in-newly-diagnosed-pancreatic-cancer-patients
#19
David R Fogelman, J Morris, L Xiao, M Hassan, S Vadhan, M Overman, S Javle, R Shroff, G Varadhachary, R Wolff, L Vence, A Maitra, C Cleeland, X S Wang
BACKGROUND: Cachexia is a frequent manifestation of pancreatic cancer, can limit a patient's ability to take chemotherapy, and is associated with shortened survival. We developed a model to predict the early onset of cachexia in advanced pancreatic cancer patients. METHODS: Patients with newly diagnosed, untreated metastatic or locally advanced pancreatic cancer were included. Serum cytokines were drawn prior to therapy. Patient symptoms were recorded using the M...
January 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28110439/combination-of-interleukin-1-polymorphism-and-helicobacter-pylori-infection-an-increased-risk-of-gastric-cancer-in-pakistani-population
#20
Yasir Raza, Adnan Khan, Asif Iqbal Khan, Saeed Khan, Shakeel Akhter, Muhammad Mubarak, Ayaz Ahmed, Shahana Urooj Kazmi
Helicobacter pylori is one of the major risk factors involved in the development ofgastritis and gastric cancer (GC). H. pylori infection leads to increased production of pro-inflammatory cytokines by the host. Carriage of specific polymorphisms in cytokine genes may be associated with host susceptibility to the development of GC. We investigated the role of host genetic factors including polymorphisms of IL-1B and IL-1RN in correlation with gastritis and GC in H. pylori infected Pakistani population. A total of 230 gastritis cases and 100 GC cases were genotyped for IL 1B-511 and IL-1RN penta-allelic variable number of tandem repeats (VNTRs)...
January 21, 2017: Pathology Oncology Research: POR
keyword
keyword
15879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"