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https://www.readbyqxmd.com/read/28079752/changes-in-dorsal-root-ganglion-gene-expression-in-response-to-spinal-cord-stimulation
#1
Dana M Tilley, David L Cedeño, Courtney A Kelley, Margaret DeMaegd, Ramsin Benyamin, Ricardo Vallejo
BACKGROUND AND OBJECTIVES: Spinal cord stimulation (SCS) has been shown to influence pain-related genes in the spinal cord directly under the stimulating electrodes. There is limited information regarding changes occurring at the dorsal root ganglion (DRG). This study evaluates gene expression in the DRG in response to SCS therapy. METHODS: Rats were randomized into experimental or control groups (n = 6 per group). Experimental animals underwent spared-nerve injury, implantation of lead, and continuous SCS (72 hours)...
January 11, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28070458/characterization-of-adipose-tissue-macrophages-and-adipose-derived-stem-cells-in-critical-wounds
#2
Bong-Sung Kim, Pathricia V Tilstam, Katrin Springenberg-Jung, Arne Hendrick Boecker, Corinna Schmitz, Daniel Heinrichs, Soo Seok Hwang, Jan Philipp Stromps, Bergita Ganse, Ruedger Kopp, Matthias Knobe, Juergen Bernhagen, Norbert Pallua, Richard Bucala
BACKGROUND: Subcutaneous adipose tissue is a rich source of adipose tissue macrophages and adipose-derived stem cells which both play a key role in wound repair. While macrophages can be divided into the classically-activated M1 and the alternatively-activated M2 phenotype, ASCs are characterized by the expression of specific stem cell markers. METHODS: In the present study, we have investigated the expression of common macrophage polarization and stem cell markers in acutely inflamed adipose tissue...
2017: PeerJ
https://www.readbyqxmd.com/read/28028364/nadph-oxidase-1-deficiency-offers-little-protection-in-salmonella-typhimurium-induced-typhlitis-in-mice
#3
Fong-Fong Chu, R Steven Esworthy, James H Doroshow, Binghui Shen
AIM: To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium (S. Tm) in a mouse model. METHODS: Eight-week-old male wild-type (WT) and Nox1 knockout (KO) C57BL6/J (B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28027994/variations-in-il-1r1-gene-influence-risk-for-hepatitis-b-virus-infection-of-children-in-a-han-chinese-population
#4
Jie Fan, Yiling Cai, Xin Huang, Yan Wang, Lihong Mu, Li Zhou
BACKGROUND/AIMS: Host genetic factors play an important role in the pathogenesis of hepatitis B virus (HBV) infection. However, the role of Interleukin1Receptor, Type I (IL-1R1) gene in HBV infection and breakthrough infection in children remains unclear. The aim of this study was to investigate the association between SNPs in IL-1 family and HBV infection and breakthrough infection in children. PATIENTS AND METHODS: A total of 627 Chinese children (274 HBV infected children and 353 controls) ages 6 months to 12 years were recruited from October 2013 to May 2015...
December 24, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28017802/signal-transduction-analysis-of-the-nlrp3-inflammasome-pathway-after-cellular-damage-and-its-paracrine-regulation
#5
Denise Veltman, Thessa Laeremans, Egle Passante, Heinrich J Huber
Activation of the NLRP3-inflammasome pathway and production of the inflammatory cytokine IL-1B after cellular damage caused by infarct or infection is a key process in several diseases such as acute myocardial infarction and inflammatory bowel disease. However, while the molecular triggers of the NLRP3-pathway after cellular damage are well known, the mechanisms that sustain or confine its activity are currently under investigation. We present here an Ordinary Differential Equation-based model that investigates the mechanisms of inflammasome activation and regulation in monocytes to predict IL-1β activation kinetics upon a two-step activation by Damage-Associate-Molecular-Particles (DAMP) and extracellular ATP...
December 22, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28017773/antileishmanial-activity-of-verbascoside-selective-arginase-inhibition-of-intracellular-amastigotes-of-leishmania-leishmania-amazonensis-with-resistance-induced-by-lps-plus-ifn-%C3%AE
#6
Claudia do Carmo Maquiaveli, Arina Lázaro Rochetti, Heidge Fukumasu, Paulo Cezar Vieira, Edson Roberto da Silva
Verbascoside is the main component of the traditional medicinal plants that were used against protozoa parasites that cause malaria and leishmaniasis. Previously, we have described verbascoside inhibition of Leishmania amazonensis arginase as well as its antileishmanial action against extracellular promastigotes. In this study, we have assessed arginase parasite inhibition in intracellular amastigotes. In addition, we verified whether verbascoside can influence the host defense against the parasite by measuring gene expression of cytokines IL-1b, IL-10, IL-18, TNF-α and murine macrophage arginase as well as nitric oxide synthase enzymes...
December 23, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27957319/blood-brain-barrier-and-intestinal-epithelial-barrier-alterations-in-autism-spectrum-disorders
#7
Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S Camhi, Sarah M Kadzielski, Timothy M Buie, Deanna L Kelly, Nicola Cascella, Alessio Fasano
BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27956075/natural-product-htp-screening-for-attenuation-of-cytokine-induced-neutrophil-chemo-attractants-cincs-and-no2-in-lps-ifn%C3%AE-activated-glioma-cells
#8
Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, Karam F A Soliman
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells...
January 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27908700/sex-dependent-effects-of-developmental-exposure-to-different-pesticides-on-spatial-learning-the-role-of-induced-neuroinflammation-in-the-hippocampus
#9
Belén Gómez-Giménez, Marta Llansola, Vicente Hernández-Rabaza, Andrea Cabrera-Pastor, Michele Malaguarnera, Ana Agusti, Vicente Felipo
The use of pesticides has been associated with impaired neurodevelopment in children. The aims of this work were to assess: 1) the effects on spatial learning of developmental exposure to pesticides 2) if the effects are sex-dependent and 3) if hippocampal neuroinflammation is associated with the impairment of spatial learning. We analyzed the effects of developmental exposure to four pesticides: chlorpyrifos, carbaryl, endosulfan and cypermethrin. Exposure was from gestational day 7 to post-natal day 21 and spatial learning and memory was assessed when the rats were young adults...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27890235/dermatologic-manifestations-of-monogenic-autoinflammatory-diseases
#10
REVIEW
Kyawt Win Shwin, Chyi-Chia Richard Lee, Raphaela Goldbach-Mansky
Autoinflammatory disorders are sterile inflammatory conditions characterized by episodes of early-onset fever, rash, and disease-specific patterns of organ inflammation. Gain-of-function mutations in innate danger-sensing pathways, including the inflammasomes and the nucleic acid sensing pathways, play critical roles in the pathogenesis of IL-1 and Type-I IFN-mediated disorders and point to an important role of excessive proinflammatory cytokine signaling, including interleukin (IL)-1b , Type-I interferons, IL-18, TNF and others in causing the organ specific immune dysregulation...
January 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/27862176/inflammasomes-hormesis-and-antioxidants-in-neuroinflammation-role-of-nrlp3-in-alzheimer-disease
#11
REVIEW
Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J Calabrese, Roberto Crea, Salvatore Cuzzocrea, Vittorio Calabrese
Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It represents the most prevalent cause of dementia, and its incidence rates exponentially increase with increasing age. The number of Americans living with AD is rapidly increasing. An estimated 5.4 million Americans of all ages have AD in 2016. One in nine people aged 65 and older has AD, and by midcentury, someone in the United States will develop the disease every 33 sec...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27859227/il-1b-rs16944-polymorphism-is-related-to-septic-shock-and-death
#12
María Ángeles Jiménez-Sousa, Luz M Medrano, Pilar Liu, Raquel Almansa, Amanda Fernández-Rodríguez, Esther Gómez-Sánchez, Lucía Rico, María Heredia-Rodríguez, Estefanía Gómez-Pesquera, Eduardo Tamayo, Salvador Resino
BACKGROUND: IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. MATERIALS AND METHODS: We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group)...
January 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27853420/reducing-peripheral-inflammation-with-infliximab-reduces-neuroinflammation-and-improves-cognition-in-rats-with-hepatic-encephalopathy
#13
Sherry Dadsetan, Tiziano Balzano, Jerónimo Forteza, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Vicente Hernandez-Rabaza, Sara Gil-Perotín, Laura Cubas-Núñez, José-Manuel García-Verdugo, Ana Agusti, Marta Llansola, Vicente Felipo
Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate cognitive impairment. Taking into account these data, we hypothesized that in rats with HE: (1) peripheral inflammation is a main contributor to neuroinflammation; (2) neuroinflammation in hippocampus impairs spatial learning by altering AMPA and/or NMDA receptors membrane expression; (3) reducing peripheral inflammation with infliximab (anti-TNF-a) would improve spatial learning; (4) this would be associated with reduced neuroinflammation and normalization of the membrane expression of glutamate receptors...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27824519/influences-of-il-1b-3953-c-t-and-mmp-9-1562c%C3%A2-t-gene-variants-on-myocardial-infarction-susceptibility-in-a-subset-of-the-iranian-population
#14
Abdolreza Daraei, Yaser Mansoori, Zahra Zendebad, Javad Tavakkoly-Bazzaz, Farzan Madadizadeh, Mohammad Mehdi Naghizadeh, Ali Arghavani, Behnam Mansoori
AIMS: IL-1b-3953 C>T and MMP-9-1562C>T variants have been shown to be linked to the development of myocardial infarction (MI), although previous studies have reported inconsistent results. The aim of the present study was to determine whether these genetic variations are associated with MI susceptibility in an Iranian population. METHODS: In the current study, 117 patients with MI and 120 control group members were selected as participants. Peripheral blood samples were taken from all the subjects for genomic DNA extraction...
January 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27806063/biomarker-profiles-in-women-with-pcos-and-pcos-offspring-a-pilot-study
#15
Nadine M P Daan, Maria P H Koster, Marlieke A de Wilde, Gerdien W Dalmeijer, Annemieke M V Evelein, Bart C J M Fauser, Wilco de Jager
OBJECTIVE: To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring. DESIGN: Cross-sectional comparison of serum biomarkers. SETTING: University Medical Center Utrecht. PATIENTS: Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30)...
2016: PloS One
https://www.readbyqxmd.com/read/27773978/insulin-resistance-and-inflammation-in-black-women-with-and-without-breast-cancer-cause-for-concern
#16
Kathleen A Griffith, Seon-Yoon Chung, Shijun Zhu, Alice S Ryan
OBJECTIVE: After chemotherapy for breast cancer, Black women gain more weight and have an increased mortality rate compared with White women. Our study objective was to compare biomarkers associated with obesity in Black women with and without a history of breast cancer. DESIGN: Case-control. SETTING: Academic/federal institution. PARTICIPANTS: Black women with a history of breast cancer (cases) and age-matched controls...
October 20, 2016: Ethnicity & Disease
https://www.readbyqxmd.com/read/27772795/association-of-tlr8-gene-rs3764880-polymorphisms-with-susceptibility-and-lipid-metabolism-and-inflammation-response-related-quantitative-traits-of-ischemic-stroke-in-southern-chinese-han-male-population
#17
Lian Gu, Jinying Zhou, Jinjing Tan, Junwei Yang, Tingting Shen, Haiyun Jiang, Qianli Tang
Inflammatory response and lipid metabolism influence the development of ischemic stroke (IS). TLRs have an important function in inflammation and lipid metabolism. To investigate association of TLR8 rs3764880 polymorphism with susceptibility of IS and the relationship between rs3764880 with inflammation response- and lipid metabolism-related quantitative traits, we conducted a case-control study in a Han Chinese population comprising 816 cases and 816 controls being matched for age and gender. The distribution of allele of TLR8 rs3764880 had statistical significance in male group (P=0...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27765923/il-1-drives-breast-cancer-growth-and-bone-metastasis-in-vivo
#18
Ingunn Holen, Diane V Lefley, Sheila E Francis, Sarah Rennicks, Steven Bradbury, Robert E Coleman, Penelope Ottewell
BACKGROUND: We have recently identified interleukin 1B (IL-1B) as a potential biomarker for predicting breast cancer patients at increased risk for developing bone metastasis. In mouse models, IL-1B and its receptor (IL-1R1) are upregulated in breast cancer cells that metastasise to bone compared with cells that do not. We have now investigated the functional role of IL-1 by blocking IL-1R signalling with the clinically licensed antagonist, anakinra. METHODOLOGY: 6-week old female BALB/c mice received a subcutaneous or intra-venous injection of MDA-MB-231-IV or MCF7 cells...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27764517/effect-of-recombinant-lactococcus-lactis-producing-myelin-peptides-on-neuroimmunological-changes-in-rats-with-experimental-allergic-encephalomyelitis
#19
K Kasarełło, A Szczepankowska, B Kwiatkowska-Patzer, A W Lipkowski, R Gadamski, D Sulejczak, M Łachwa, M Biały, J Bardowski
Multiple sclerosis (MS) is a human autoimmune neurodegenerative disease with an unknown etiology. Despite various therapies, there is no effective cure for MS. Since the mechanism of the disease is based on autoreactive T-cell responses directed against myelin antigens, oral tolerance is a promising approach for the MS treatment. Here, the experiments were performed to assess the impact of oral administration of recombinant Lactococcus lactis producing encephalogenic fragments of three myelin proteins: myelin basic protein, proteolipid protein, and myelin oligodendrocyte glycoprotein, on neuroimmunological changes in rats with experimental allergic encephalomyelitis (EAE) - an animal model of MS...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27762068/procalcitonin-and-cytokine-profiles-in-engraftment-syndrome-in-pediatric-stem-cell-transplantation
#20
Nirali N Shah, Theresa M Watson, Bonnie Yates, David J Liewehr, Seth M Steinberg, David Jacobsohn, Terry J Fry
BACKGROUND: Diagnosis of engraftment syndrome (ES) following allogeneic hematopoietic stem cell transplantation (HSCT) can be a challenge due to the systemic presentation and alternative etiologies. With a goal of establishing biomarkers to more accurately distinguish ES, we prospectively analyzed levels of cytokines during HSCT. PROCEDURES: We performed a prospective study of children ≤21 years who underwent allogeneic HSCT. Blood samples for interleukin (IL)-6, IL-8, IL-10, IL-1b, IL-12p70, interferon-γ, tumor necrosis factor alpha (TNF-α) and procalcitonin were obtained from each subject prior to conditioning, at day 0, and then biweekly through engraftment and at days 30, 60 and 100...
October 20, 2016: Pediatric Blood & Cancer
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