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https://www.readbyqxmd.com/read/28207826/changes-of-plasma-cytokines-and-chemokines-expression-level-in-nasopharyngeal-carcinoma-patients-after-treatment-with-definitive-intensity-modulated-radiotherapy-imrt
#1
Ya-Bin Jin, Guo-Yi Zhang, Kai-Rong Lin, Xiang-Ping Chen, Jin-Huan Cui, Yue-Jian Wang, Wei Luo
BACKGROUND: Potential clinical application values of certain cytokines and chemokines that participate in the process of tumor growth, invasion, and metastasis have been reported. However, there still lack of biomarkers for a great many of malignancy. This study identified cytokines or chemokines involved in the occurrence and development of nasopharyngeal carcinoma (NPC), which might be a biomarker for noninvasive early diagnosis. METHODS: The plasma levels of 19 cytokines and chemokines were detected by the luminex liquid array-based multiplexed immunoassays in 39 NPC patients before and after treatment by definitive intensity-modulated radiotherapy (IMRT)...
2017: PloS One
https://www.readbyqxmd.com/read/28197807/telomere-length-in-the-gastric-mucosa-after-helicobacter-pylori-eradication-and-its-potential-role-in-the-gastric-carcinogenesis
#2
Tomomitsu Tahara, Sayumi Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
The molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication remain unclear. We examined the telomere length of gastric mucosa samples after successful H. pylori eradication in patients without and those with gastric cancer. Telomere length was measured by the real-time PCR among four different groups of biopsies: gastric body from subjects without history of H. pylori infection (Hp-: n = 23), gastric body from cancer-free subjects after H. pylori eradication (cancer-free body: n = 24), gastric body from early gastric cancer patients diagnosed after H...
February 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28194840/burst-spinal-cord-stimulation-increases-peripheral-antineuroinflammatory-interleukin-10-levels-in-failed-back-surgery-syndrome-patients-with-predominant-back-pain
#3
Thomas M Kinfe, Sajjad Muhammad, Carolina Link, Sandra Roeske, Shafqat R Chaudhry, Thomas L Yearwood
OBJECTIVES: Burst spinal cord stimulation (SCS) has been reported to reduce back pain and improve functional capacity in Failed Back Surgery Syndrome (FBSS). However, its mechanism of action is not completely understood. Systemic circulating cytokines have been associated with the development of chronic back pain. METHODS: This prospective, feasibility study enrolled 12 refractory FBSS patients with predominant back pain (70% of overall pain) suitable for Burst SCS...
February 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28193589/head-kidney-liver-and-skin-histopathology-and-gene-expression-in-gilthead-seabream-sparus-aurata-l-exposed-to-highly-polluted-marine-sediments-from-portman-bay-spain
#4
Said Ben Hamed, Francisco Guardiola, Alberto Cuesta, Salvadora Martínez, María José Martínez-Sánchez, Carmen Pérez-Sirvent, María Ángeles Esteban
Biomarkers have become crucial tools in modern environmental assessment as they can help to predict magnitude of pollution. The head-kidney (HK) and liver (hematopoietic and xenobiotic metabolism organs, respectively) are the key organs in all fish toxicological studies, although the skin has received less attention in this respect. The impact of two different types of polluted sediment collected from Portman Bay (Spain) on HK, liver and skin gene expression in gilthead seabream (Sparus aurata L.) exposed for two weeks to the sediments was determined by real time-PCR...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28174320/isolation-of-luteal-endothelial-cells-and-functional-interactions-with-t-lymphocytes
#5
Sadhat S Walusimbi, Lindy Wetzel, David Townson, Joy Pate
The objectives of this study were to optimize the isolation of luteal endothelial cells (LEC) and examine their functional interactions with autologous T lymphocytes. Analysis by flow cytometry showed that the purity of LEC isolated by filtration was nearly 90% as indicated by Bandeiraea simplicifolia (BS)-1 lectin binding. LEC expressed mRNA for progesterone receptor (PGR), prostaglandin receptors (PTGFR, PTGER2 and 4, and PTGIR), tumor necrosis factor receptors (TNFRSF1A&B) and interleukin (IL) 1B receptors (IL1R1&2)...
February 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28138240/plant-derived-pectin-nanocoatings-to-prevent-inflammatory-cellular-response-of-osteoblasts-following-porphyromonas-gingivalis-infection
#6
Anna Meresta, Justyna Folkert, Timo Gaber, Korneliusz Miksch, Frank Buttgereit, Jacqueline Detert, Nicole Pischon, Katarzyna Gurzawska
BACKGROUND: Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is) from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28129679/a-study-on-the-association-of-interleukin-1-cluster-with-genetic-risk-in-bipolar-i-disorder-in-iranian-patients-a-case-control-study
#7
Ali Talaei, Jalil Tavakkol Afshari, Mohammad Reza Fayyazi Bordbar, Hamidreza Pouryousof, Farhad Faridhosseini, Ali Saghebi, Amir Rezaei Ardani, Andisheh Talaei, Mohsen Tehrani
The pathogenesis of Bipolar I Disorder (BP-I) involves immune-mediated mechanisms, especially an imbalance in pro-inflammatory/anti-inflammatory cytokines in plasma or cerebrospinal fluid. Interleukin-1 (IL-1) gene cluster, coding some of these pro-inflammatory cytokines, might play a role in various neuropathologies related to neuron inflammation. The aim of the present study was to investigate the possible role of IL-1 gene cluster polymorphisms in determining the susceptibility to BP-I in Iranian population...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28127698/estrogen-attenuates-local-inflammasome-expression-and-activation-after-spinal-cord-injury
#8
Adib Zendedel, Fabian Mönnink, Gholamreza Hassanzadeh, Arash Zaminy, Malek Masoud Ansar, Pardes Habib, Alexander Slowik, Markus Kipp, Cordian Beyer
17-estradiol (E2) is a neuroprotective hormone with a high anti-inflammatory potential in different neurological disorders. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1b) and IL-18 mediated by caspase-1 which is under the control of an intracellular multiprotein complex called inflammasome. We recently described in a SCI model that between 24 and 72 h post-injury, most of inflammasome components including IL-18, IL-1b, NLRP3, ASC, and caspase-1 are upregulated...
January 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28111717/a-predictive-model-of-inflammatory-markers-and-patient-reported-symptoms-for-cachexia-in-newly-diagnosed-pancreatic-cancer-patients
#9
David R Fogelman, J Morris, L Xiao, M Hassan, S Vadhan, M Overman, S Javle, R Shroff, G Varadhachary, R Wolff, L Vence, A Maitra, C Cleeland, X S Wang
BACKGROUND: Cachexia is a frequent manifestation of pancreatic cancer, can limit a patient's ability to take chemotherapy, and is associated with shortened survival. We developed a model to predict the early onset of cachexia in advanced pancreatic cancer patients. METHODS: Patients with newly diagnosed, untreated metastatic or locally advanced pancreatic cancer were included. Serum cytokines were drawn prior to therapy. Patient symptoms were recorded using the M...
January 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28110439/combination-of-interleukin-1-polymorphism-and-helicobacter-pylori-infection-an-increased-risk-of-gastric-cancer-in-pakistani-population
#10
Yasir Raza, Adnan Khan, Asif Iqbal Khan, Saeed Khan, Shakeel Akhter, Muhammad Mubarak, Ayaz Ahmed, Shahana Urooj Kazmi
Helicobacter pylori is one of the major risk factors involved in the development ofgastritis and gastric cancer (GC). H. pylori infection leads to increased production of pro-inflammatory cytokines by the host. Carriage of specific polymorphisms in cytokine genes may be associated with host susceptibility to the development of GC. We investigated the role of host genetic factors including polymorphisms of IL-1B and IL-1RN in correlation with gastritis and GC in H. pylori infected Pakistani population. A total of 230 gastritis cases and 100 GC cases were genotyped for IL 1B-511 and IL-1RN penta-allelic variable number of tandem repeats (VNTRs)...
January 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28103636/limited-excessive-voluntary-alcohol-drinking-leads-to-liver-dysfunction-in-mice
#11
Scott A Wegner, Katherine A Pollard, Viktor Kharazia, David Darevsky, Luz Perez, Sanjoy Roychowdhury, Allison Xu, Dorit Ron, Laura E Nagy, Frederic Woodward Hopf
BACKGROUND: Liver damage is a serious and sometimes fatal consequence of long-term alcohol intake, which progresses from early-stage fatty liver (steatosis) to later-stage steatohepatitis with inflammation and fibrosis/necrosis. However, very little is known about earlier stages of liver disruption that may occur in problem drinkers, those who drink excessively but are not dependent on alcohol. METHODS: We examined how repeated binge-like alcohol drinking in C57BL/6 mice altered liver function, as compared with a single binge-intake session and with repeated moderate alcohol consumption...
February 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28096525/toll-like-receptor-4-signaling-in-high-mobility-group-box-1-protein-1-mediated-the-suppression-of-regulatory-t-cells
#12
Chunyan Luo, Huiting Liu, Hu Wang, Jiajun Wang
BACKGROUND Treg cells play a central role in the suppression of immune response, and their suppressive capacity can be modulated by toll-like receptor (TLR) ligands. However, the detailed pathway of TLR ligand modulation is still unknown. The present study aimed to evaluate the effect of the high mobility group box-1 protein 1 (HMGB1) and lipopolysaccharide (LPS) on Treg cells through TLR4 signaling. MATERIAL AND METHODS Treg cells were purified from healthy human peripheral blood mononuclear cells (PBMCs) by magnetic-bead activity cell sorting (MACS), blocked by anti-TLR4 monoclonal antibody, and then incubated with different concentration of LPS or HMGB1...
January 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28079752/changes-in-dorsal-root-ganglion-gene-expression-in-response-to-spinal-cord-stimulation
#13
Dana M Tilley, David L Cedeño, Courtney A Kelley, Margaret DeMaegd, Ramsin Benyamin, Ricardo Vallejo
BACKGROUND AND OBJECTIVES: Spinal cord stimulation (SCS) has been shown to influence pain-related genes in the spinal cord directly under the stimulating electrodes. There is limited information regarding changes occurring at the dorsal root ganglion (DRG). This study evaluates gene expression in the DRG in response to SCS therapy. METHODS: Rats were randomized into experimental or control groups (n = 6 per group). Experimental animals underwent spared-nerve injury, implantation of lead, and continuous SCS (72 hours)...
March 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28070458/characterization-of-adipose-tissue-macrophages-and-adipose-derived-stem-cells-in-critical-wounds
#14
Bong-Sung Kim, Pathricia V Tilstam, Katrin Springenberg-Jung, Arne Hendrick Boecker, Corinna Schmitz, Daniel Heinrichs, Soo Seok Hwang, Jan Philipp Stromps, Bergita Ganse, Ruedger Kopp, Matthias Knobe, Juergen Bernhagen, Norbert Pallua, Richard Bucala
BACKGROUND: Subcutaneous adipose tissue is a rich source of adipose tissue macrophages and adipose-derived stem cells which both play a key role in wound repair. While macrophages can be divided into the classically-activated M1 and the alternatively-activated M2 phenotype, ASCs are characterized by the expression of specific stem cell markers. METHODS: In the present study, we have investigated the expression of common macrophage polarization and stem cell markers in acutely inflamed adipose tissue...
2017: PeerJ
https://www.readbyqxmd.com/read/28028364/nadph-oxidase-1-deficiency-offers-little-protection-in-salmonella-typhimurium-induced-typhlitis-in-mice
#15
Fong-Fong Chu, R Steven Esworthy, James H Doroshow, Binghui Shen
AIM: To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium (S. Tm) in a mouse model. METHODS: Eight-week-old male wild-type (WT) and Nox1 knockout (KO) C57BL6/J (B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28027994/variations-in-il-1r1-gene-influence-risk-for-hepatitis-b-virus-infection-of-children-in-a-han-chinese-population
#16
Jie Fan, Yiling Cai, Xin Huang, Yan Wang, Lihong Mu, Li Zhou
BACKGROUND/AIMS: Host genetic factors play an important role in the pathogenesis of hepatitis B virus (HBV) infection. However, the role of Interleukin1Receptor, Type I (IL-1R1) gene in HBV infection and breakthrough infection in children remains unclear. The aim of this study was to investigate the association between SNPs in IL-1 family and HBV infection and breakthrough infection in children. PATIENTS AND METHODS: A total of 627 Chinese children (274 HBV infected children and 353 controls) ages 6 months to 12 years were recruited from October 2013 to May 2015...
December 24, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28017802/signal-transduction-analysis-of-the-nlrp3-inflammasome-pathway-after-cellular-damage-and-its-paracrine-regulation
#17
Denise Veltman, Thessa Laeremans, Egle Passante, Heinrich J Huber
Activation of the NLRP3-inflammasome pathway and production of the inflammatory cytokine IL-1B after cellular damage caused by infarct or infection is a key process in several diseases such as acute myocardial infarction and inflammatory bowel disease. However, while the molecular triggers of the NLRP3-pathway after cellular damage are well known, the mechanisms that sustain or confine its activity are currently under investigation. We present here an Ordinary Differential Equation-based model that investigates the mechanisms of inflammasome activation and regulation in monocytes to predict IL-1β activation kinetics upon a two-step activation by Damage-Associate-Molecular-Particles (DAMP) and extracellular ATP...
December 22, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28017773/antileishmanial-activity-of-verbascoside-selective-arginase-inhibition-of-intracellular-amastigotes-of-leishmania-leishmania-amazonensis-with-resistance-induced-by-lps-plus-ifn-%C3%AE
#18
Claudia do Carmo Maquiaveli, Arina Lázaro Rochetti, Heidge Fukumasu, Paulo Cezar Vieira, Edson Roberto da Silva
Verbascoside is the main component of the traditional medicinal plants that were used against protozoa parasites that cause malaria and leishmaniasis. Previously, we have described verbascoside inhibition of Leishmania amazonensis arginase as well as its antileishmanial action against extracellular promastigotes. In this study, we have assessed arginase parasite inhibition in intracellular amastigotes. In addition, we verified whether verbascoside can influence the host defense against the parasite by measuring gene expression of cytokines IL-1b, IL-10, IL-18, TNF-α and murine macrophage arginase as well as nitric oxide synthase enzymes...
December 23, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27957319/blood-brain-barrier-and-intestinal-epithelial-barrier-alterations-in-autism-spectrum-disorders
#19
Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S Camhi, Sarah M Kadzielski, Timothy M Buie, Deanna L Kelly, Nicola Cascella, Alessio Fasano
BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27956075/natural-product-htp-screening-for-attenuation-of-cytokine-induced-neutrophil-chemo-attractants-cincs-and-no2-in-lps-ifn%C3%AE-activated-glioma-cells
#20
Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, Karam F A Soliman
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells...
January 15, 2017: Journal of Neuroimmunology
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