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Protein energy wasting hemodialysis

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https://www.readbyqxmd.com/read/30184517/amino-acid-profile-after-oral-nutritional-supplementation-in-hemodialysis-patients-with-protein-energy-wasting
#1
Sylwia Małgorzewicz, Grażyna Gałęzowska, Monika Cieszyńska-Semenowicz, Joanna Ratajczyk, Lidia Wolska, Przemysław Rutkowski, Magdalena Jankowska, Bolesław Rutkowski, Alicja Dębska-Ślizień
OBJECTIVES: Protein-energy wasting (PEW) is highly prevalent in patients on hemodialysis (HD). Oral nutritional supplementation (ONS) is recommended for malnourished patients on HD. The aim of this study was to evaluate ONS on plasma amino acid in HD patients with PEW. METHODS: Thirty-two HD patients with a mean age 59.1 ± 9.5 y with PEW were enrolled into the study. Patients were prescribed ONS (125 mL twice a day for 3 mo) together with dietary advice. The nutritional status was evaluated by means of body mass index, Subjective Global Assessment, and serum albumin and prealbumin levels...
July 11, 2018: Nutrition
https://www.readbyqxmd.com/read/30107974/pilot-study-of-the-effects-of-high-protein-meals-during-hemodialysis-on-intradialytic-hypotension-in-patients-undergoing-maintenance-hemodialysis
#2
Mun Sun Choi, Brandon Kistler, Gretchen N Wiese, Elizabeth R Stremke, Amy J Wright, Ranjani N Moorthi, Sharon M Moe, Kathleen M Hill Gallant
OBJECTIVE: Patients undergoing hemodialysis (HD) have high protein and energy requirements, and protein-energy wasting is common and associated with poor outcomes. Eating during dialysis may improve nutritional status by counteracting the catabolic effects of HD treatment; but eating during HD may be discouraged because of concerns of postprandial hypotension. However, little data are available to support this practice. In this study, we hypothesized that high-protein meals during HD do not lead to symptomatic intradialytic hypotension events...
August 11, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/30102329/hypoalbuminemia-a-price-worth-paying-for-improved-dialytic-removal-of-middle-molecular-weight-uremic-toxins
#3
Richard A Ward, Werner Beck, Angelito A Bernardo, Filipa C Alves, Peter Stenvinkel, Bengt Lindholm
Hemodiafiltration (HDF) increases the removal of middle-molecular-weight uremic toxins and may improve outcomes in patients with end-stage kidney disease (ESKD), but it requires complex equipment and comes with risks associated with infusion of large volumes of substitution solution. New high-flux hemodialysis membranes with improved diffusive permeability profiles do not have these limitations and offer an attractive alternative to HDF. However, both strategies are associated with increased albumin loss into the dialysate, raising concerns about the potential for decreased serum albumin concentrations that have been associated with poor outcomes in ESKD...
August 8, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30049915/-fragility-fractures-in-hemodialysis-patients-frailty-and-fragility-fractures-among-dialysis-patients
#4
Kenichi Akiyama, Norio Hanafusa
According to the current status of chronic dialysis therapy in Japan 2016, the average age at the time of dialysis initiation is 68.57 years for males and 71.19 years for females, which has been rising continuously. Frailty is a geriatric syndrome that is frequently seen in the elderly. It is known that frailty among dialysis patients are more common than the general population of the same age, and that frailty is associated with life prognosis. As eGFR decreases, BMD decreases and fracture risk increase, and dialysis patients are at the highest risk of fracture in CKD patients...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/30016788/the-unexpected-effects-of-l-carnitine-supplementation-on-lipid-metabolism-in-hemodialysis-patients
#5
Lea Katalinic, Branimir Krtalic, Bojan Jelakovic, Nikolina Basic-Jukic
BACKGROUND/AIMS: There is a growing body of evidence that the long-term hemodialysis (HD) treatment leads to disturbances of carnitine homeostasis but the results of L-carnitine supplementation in HD patients have been conflicting. In the present prospective study, we investigated the effectiveness of intravenous L-carnitine in mitigating dialysis-related protein-energy wasting (PEW) based on pre-treatment albumin levels. METHODS: Fifty patients (46% male, mean age 63±18...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30009545/managing-protein-energy-wasting-in-hemodialysis-patients-a-comparison-of-animal-and-plant-based-protein-foods
#6
REVIEW
David E St-Jules, David S Goldfarb, Collin J Popp, Mary Lou Pompeii, Scott E Liebman
Protein-energy wasting (PEW) is a major diet-related complication in hemodialysis (HD) patients. Nutrient-based dietary guidelines emphasize animal-based protein foods for preventing and managing PEW in HD patients. Although dietary protein intake is important for protein anabolism, other dietary factors contribute to PEW. In this article, we examine the diet-related etiologies of PEW in HD patients, and discuss how they may be affected differently by animal- and plant-based protein foods. In general, animal foods are superior sources of protein, but may contribute more to metabolic derangements that cause PEW...
July 15, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29983232/diagnostic-usefulness-of-the-protein-energy-wasting-score-in-prevalent-hemodialysis-patients
#7
Gloria Antón-Pérez, Ángelo Santana-Del-Pino, Fernando Henríquez-Palop, Tania Monzón, Ana Y Sánchez, Francisco Valga, Adelaida Morales-Umpierrez, Cesar García-Cantón, Jose C Rodríguez-Pérez, Juan J Carrero
OBJECTIVE: To study whether the score proposed by the International Society of Renal Nutrition and Metabolism to define the protein energy wasting (PEW) syndrome has diagnostic validity in patients undergoing dialysis. DESIGN AND METHODS: Cross-sectional study including 468 prevalent hemodialysis patients from Canary Islands, Spain. Individual PEW syndrome criteria and the number of PEW syndrome categories were related to other objective markers of PEW using linear and logistic regression analyses: subjective global assessment, handgrip strength, bioimpedance-assessed body composition, and levels of high-sensitivity C-reactive protein...
July 5, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29954825/how-i-treat-protein-energy-wasting-in-hemodialysis-patients
#8
Menaka Sarav, Csaba Pal Kovesdy
No abstract text is available yet for this article.
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29909606/dietary-protein-and-nutritional-supplements-in-conventional-hemodialysis
#9
Alice Sabatino, Giovanni Piotti, Carmela Cosola, Ilaria Gandolfini, Jeroen P Kooman, Enrico Fiaccadori
Protein energy wasting (PEW) is a condition commonly occurring among patients with ESRD on hemodialysis. PEW is characterized by depletion of protein and energy stores and is caused by multiple factors related to chronic kidney disease, acute and chronic comorbidities and by renal replacement therapy itself. Anorexia is central in the pathogenesis of PEW; it is frequently observed in these patients whose protein and energy intakes are typically lower than guidelines recommendations. If untreated, PEW invariably leads to major complications, and may activate a vicious circle with further worsening of nutritional status...
June 17, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29866494/noninvasive-evaluation-of-muscle-mass-by-ultrasonography-of-quadriceps-femoris-muscle-in-end-stage-renal-disease-patients-on-hemodialysis
#10
Alice Sabatino, Giuseppe Regolisti, Marco Delsante, Tommaso Di Motta, Chiara Cantarelli, Sarah Pioli, Giulia Grassi, Valentina Batini, Mariacristina Gregorini, Enrico Fiaccadori
BACKGROUND & AIMS: Protein-Energy Wasting (PEW) is a pathological condition of renal patients with advanced Chronic Kidney Disease characterized by a progressive reduction of energy and protein assets. Nutritional status assessment, especially for what concerns muscle mass, is essential for both the identification of patients at risk for the development of PEW, as well as monitoring the effects of nutritional interventions. Ultrasound methods are easily applicable at the bedside for quantitative assessment of skeletal muscle...
May 19, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29734150/association-between-increases-in-normalized-protein-catabolic-rate-and-increases-in-creatinine-generation-rate-in-dialysis-patients
#11
Norio Hanafusa, Daigo Kamei, Misao Tsukada, Naoko Miwa, Mizuki Komatsu, Shunji Shiohira, Masayuki Okazaki, Ryota Watanabe, Hiroshi Kawaguchi, Ken Tsuchiya, Kosaku Nitta
The older dialysis population is growing, and malnutrition and wasting syndrome are great concerns in this population. The management of these syndromes includes appropriate nutritional intake and physical activity. However, whether management in the form of an increase in protein intake has a beneficial effect on muscle mass has not been demonstrated. In this study, we investigated an association between changes of normalized protein catabolic rate (nPCR), as a proxy for protein intake and percent creatinine generation rate (%CGR), as a proxy for muscle mass in patients receiving hemodialysis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29731235/assessment-of-nutritional-status-in-children-with-chronic-kidney-disease-using-hand-grip-strength-tool
#12
Ashraf Mohamed Abd El Basset Bakr, Bothina Mohamed Hasaneen, Dina AbdelRasoul Helal Bassiouni
OBJECTIVE: Muscle status assessment is crucial for diagnosis of protein energy wasting PEW/cachexia in chronic kidney disease (CKD) population. Hand grip strength (HGS) has been used in muscle power assessment in adult CKD. However, no data is available about its usefulness in children with CKD. Hence, we aimed to study the reliability of HGS in reflecting the muscle power and thus, nutritional status in children with CKD. DESIGN AND METHODS: In this Observational cross sectional study we enrolled 73 CKD children; 45 had end stage kidney disease (ESKD) on hemodialysis (HD) and 28 had CKD but not on dialysis yet...
July 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29707907/secondary-hyperparathyroidism-and-protein-energy-wasting-in-end-stage-renal-disease
#13
REVIEW
Hirotaka Komaba, Masafumi Fukagawa
Protein-energy wasting (PEW), a syndrome involving adverse changes in nutrition and body composition, is a serious problem associated with morbidity and mortality in patients with end-stage renal disease (ESRD). The pathogenesis of PEW is multifactorial, and the underlying mechanisms are not fully understood. However, recent translational work has provided compelling evidence for a causal role of parathyroid hormone (PTH) in the pathogenesis of adipose tissue browning and increased energy expenditure, a critical component of PEW in ESRD...
June 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29691162/bioimpedance-spectroscopy-as-a-practical-tool-for-the-early-detection-and-prevention-of-protein-energy-wasting-in-hemodialysis-patients
#14
Marta Arias-Guillén, Eduardo Perez, Patricia Herrera, Bárbara Romano, Raquel Ojeda, Manel Vera, José Ríos, Néstor Fontseré, Francisco Maduell
OBJECTIVES: To evaluate whether body composition monitor (BCM) could be a practical instrument for nephrologists to assess nutritional status in patients on hemodialysis (HD) and whether it is more effective in identifying patients at highest risk of developing protein-energy wasting (PEW) alone or in combination with other tools currently used for that purpose. DESIGN: Observational cross-sectional study in 91 HD patients (60 ± 14 years, 70.3% male, 24 ± 4...
September 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29688512/greater-fluid-overload-and-lower-interdialytic-weight-gain-are-independently-associated-with-mortality-in-a-large-international-hemodialysis-population
#15
Manfred Hecking, Ulrich Moissl, Bernd Genser, Hugh Rayner, Indranil Dasgupta, Stefano Stuard, Andrea Stopper, Charles Chazot, Franklin W Maddux, Bernard Canaud, Friedrich K Port, Carmine Zoccali, Peter Wabel
Background: Fluid overload and interdialytic weight gain (IDWG) are discrete components of the dynamic fluid balance in haemodialysis patients. We aimed to disentangle their relationship, and the prognostic importance of two clinically distinct, bioimpedance spectroscopy (BIS)-derived measures, pre-dialysis and post-dialysis fluid overload (FOpre and FOpost) versus IDWG. Methods: We conducted a retrospective cohort study on 38 614 incident patients with one or more BIS measurement within 90 days of haemodialysis initiation (1 October 2010 through 28 February 2015)...
October 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29686466/nutrition-status-and-helicobacter-pylori-infection-in-patients-receiving-hemodialysis
#16
REVIEW
Mitsushige Sugimoto, Hideo Yasuda, Akira Andoh
Chronic kidney disease (CKD) patients receiving hemodialysis (HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting (PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori ( H. pylori ) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin levels that are seen in malnutrition...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29665664/-resting-metabolic-rate-estimated-by-bioelectrical-impedance-analysis-and-its-determinants-in-maintenance-hemodialysis-patients
#17
J J Da, H Y Peng, X Lin, Y Shen, J Q Zhao, S He, Y Zha
Objective: To explore the level of resting energy expenditure (REE) estimated by bioelectrical impedance analysis and the association of resting metabolic rate (RMR) with clinical related factors, and provide new ideas for improving protein energy wasting (PEW) in maintenance hemodialysis (MHD) patients. Methods: Seven hundred and sixty-five subjects receiving MHD between July 2015 and September 2016 in 11 hemodialysis centers in Guizhou province were enrolled in this cross-sectional study. Bioelectrical impedance analysis was used to measure RMR and body composition, such as lean body mass, fat mass and body cell mass (BCM)...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29471458/pro-the-rationale-for-dietary-therapy-for-patients-with-advanced-chronic-kidney-disease
#18
Joel D Kopple, Denis Fouque
Dietary treatment offers many benefits to patients with advanced chronic kidney disease (CKD) who are approaching the need for renal replacement therapy. A large number of these benefits are independent of whether diets slow the rate of progression of CKD. These diets are low in protein and many minerals, and provide adequate energy for the CKD patient. The diets can reduce accumulation of potentially toxic metabolic products derived from protein and amino acid degradation, maintain a healthier balance of body water, sodium, potassium, phosphorus, calcium and other minerals, and prevent or improve protein-energy wasting...
March 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29457529/n-terminal-pro-b-type-natriuretic-peptide-associated-with-2-year-mortality-from-both-cardiovascular-and-non-cardiovascular-origins-in-prevalent-chronic-hemodialysis-patients
#19
Chihiro Kawagoe, Yuji Sato, Tatsunori Toida, Hideto Nakagawa, Yasuhiro Yamashita, Akihiro Fukuda, Shuji Iwatsubo, Shouichi Fujimoto
N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) was a predictive marker of cardiovascular disease (CVD)-related death in chronic dialysis patients. NT-proBNP was also correlated with markers of inflammation, malnutrition and protein-energy wasting. We hypothesized whether NT-proBNP was also associated with non-CVD death in chronic dialysis patients. A prospective observational study for incidence of death in chronic dialysis patients was conducted. Prevalent chronic dialysis patients (n = 1310) were enrolled and followed for 24 months...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29362457/age-modifies-the-association-between-serum-obestatin-appetite-and-nutritional-status-in-maintenance-hemodialysis-patients
#20
Anna Katkov, Inna Sinuani, Ada Azar, Gregory Shapiro, Shai Efrati, Ilia Beberashvili
BACKGROUND/OBJECTIVES: Increased age is strongly associated with anorexia and protein-energy wasting (PEW) in maintenance hemodialysis (MHD) population. We hypothesized that the association of obestatin, a recently discovered anorexigenic gut hormone, with appetite and nutritional status differs by age groups. SUBJECTS/METHODS: We performed a cross-sectional study on 261MHD patients. Obestatin, acyl-ghrelin, markers of inflammation (CRP, IL-6, TNF-α) and nutrition (self-reported appetite, dietary intake, biochemical nutritional parameters, and body composition) were measured...
July 2018: European Journal of Clinical Nutrition
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