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Pulmonary metastasis of osteosarcoma

M A Clara-Altamirano, D Y García-Ortega, A Maciel-Miranda, H Martínez-Said, J L Martínez-Tlahuel, C H S Caro-Sánchez, G C García-Ruíz, M Cuellar-Hubbe
Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Axial computed tomography of the thorax revealed metastatic disease in the upper lobe of the left lung...
May 2018: Acta Ortopédica Mexicana
Jared I Baum, Owen T Skinner, Sarah E Boston
This report describes a domestic shorthair cat with fracture-associated osteosarcoma 11 years after injury. A left hind limb amputation was performed using coxofemoral disarticulation. No intravenous cytotoxic chemotherapy was used after surgery. Pulmonary metastasis was identified 3 months after amputation. Fracture-associated osteosarcoma may occur in the cat more than 10 years after initial injury.
October 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Yang Su, Yan Zhou, Yuan-Jue Sun, Ya-Ling Wang, Jun-Yi Yin, Yu-Jing Huang, Jian-Jun Zhang, Ai-Na He, Kun Han, Hui-Zhen Zhang, Yang Yao, Xiao-Bin Lv, Hai-Yan Hu
Osteosarcoma (OS), which is the most common primary malignant bone tumor, has a high incidence of pulmonary metastasis. CCL18 (C-C motif chemokine ligand 18), which is secreted by tumor-associated macrophages (TAMs), has been found to be increased in various tumors and is associated with tumor metastasis. However, the role of CCL18 in OS remains unclear. Here, we evaluated the effect of CCL18 on the OS cell lines MG63 and 143B and explored its potential mechanisms. We found that CCL18 enhanced the proliferation and migration of OS cells and upregulated UCA1 through transcription factor EP300...
November 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Jie Wang, Di Wang, Xiaohui Niu, Zhijie Wang, Cheng-Li Song, Zhen Huang, Ke-Neng Chen, Jianchun Duan, Hua Bai, Jiachen Xu, Jun Zhao, Yu Wang, Minglei Zhuo, X Sunney Xie, Xiaozheng Kang, Yanhua Tian, Liangliang Cai, Jie-Fei Han, Tongtong An, Yu Sun, Shugeng Gao, Jun Zhao, Jianming Ying, Luhua Wang, Jie He
Osteosarcoma (OS) is the most common primary bone malignancy, and the lung is the most frequent site of metastasis. The limited understanding of the tumoral heterogeneity and evolutionary process of genomic alterations in pulmonary metastatic osteosarcoma impedes development of novel therapeutic strategies. Here we systematically illustrate the genomic disparities between primary tumors (PT) and corresponding pulmonary metastatic tumors (MT) by multiregional whole-exome and whole-genome sequencing in 86 tumor regions from 10 OS patients...
November 2, 2018: Cancer Research
Xiaodong Chen, Min Deng, Xinshe Zhou, Xuyi Wang, Yuchen Ye, Jun Zhu, Huafeng Jiang, Xiaotian Chen, Wenju Zha
OBJECTIVE: Osteosarcoma (OS) is one of the most common malignancies of bone. This study was aimed to explore the anti-metastatic effect of euxanthone on OS. MATERIALS AND METHODS: Adhesion assay and Transwell assay were used to examine the effect of euxanthone on adhesion, migration and invasion of OS cells. COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone. PDCD4 knockdown and miR-21 mimic were applied to assess whether euxanthone suppresses the transactivation of c-jun via modulating miR-21-PDCD4 signaling...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Jie Xu, Wei Guo, Lu Xie
BACKGROUND: The combination of gemcitabine and docetaxel (GT) has been demonstrated to be effective against various types of solid tumors, including sarcoma. However, the regimen has not been confirmed in large, well-designed clinical trials in refractory metastatic osteosarcoma. METHODS: We retrospectively reviewed the records of patients with refractory metastatic osteosarcoma at Peking University People's Hospital who were treated with gemcitabine (1000 mg/m2 ) intravenously (IV) on Day 1 and Day 8, and docetaxel (75 mg/m2 ) IV on Day 8, repeated every 21 days...
October 16, 2018: BMC Cancer
Xiuxin Han, Fengting Liu, Chao Zhang, Zhiwu Ren, Lili Li, Guowen Wang
Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells and named them MG-63/Dox and HOS/Dox, respectively. The Dox resistant OS cells had greater invasion ability than that of parental cells. The expression of ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased in Dox resistant OS cells. Silencing of ZEB1 can attenuate the metastasis and increase Dox sensitivity of MG-63/Dox and HOS/Dox cells...
October 11, 2018: Biological Chemistry
Dylan C Dean, Shen Shen, Francis J Hornicek, Zhenfeng Duan
Although the investigation into biomarkers specific for pulmonary metastasis within osteosarcoma (OS) has recently expanded, their usage within the clinic remains sparse. The current screening protocol after any OS diagnosis includes a chest CT scan; however, metastatic lung nodules frequently go undetected and remain the primary cause of death in OS. Recently, screening technologies such as liquid biopsy and next-generation sequencing have revealed a promising array of biomarkers with predictive and diagnostic value for the pulmonary metastasis associated with OS...
August 31, 2018: Cancer Metastasis Reviews
María Tereza Nieto-Coronel, Allan David López-Vásquez, Diana Marroquín-Flores, Sandy Ruiz-Cruz, Jorge Luis Martínez-Tláhuel, Jaime De la Garza-Salazar
Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn't have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2-6.5%, increase to 10-15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died...
July 2018: Reports of Practical Oncology and Radiotherapy
Liping Wang, Peipei Li, Xue Xiao, Jingying Li, Juan Li, Huang-Hao Yang, Weihong Tan
Osteosarcoma (OS) is one of most malignant bone tumors in early adolescence, which is a highly metastatic cancer and pulmonary metastasis is the most common cause of death. Thus, the development of efficient approaches to discover potential compounds that target metastasis of OS remains a topic of considerable interest. In this study, subtractive Cell-SELEX was performed to screen OS metastasis specific DNA aptamers by using cell lines with similar tumorigenic potentials but opposite metastatic aggressiveness (highly metastatic 143B cells and non-metastatic U-2 OS cells as the target and negative cells, respectively)...
October 1, 2018: Talanta
Gehad Ahmed, Manal Zamzam, Ahmed Kamel, Sonia Ahmed, Asmaa Salama, Iman Zaki, Nehal Kamal, Maged Elshafiey
BACKGROUND: Complete metastasectomy is the best predictor of survival in patients with osteosarcoma pulmonary metastases. There has been some controversy in the literature regarding the prognostic significance of the timing of occurrence of lung metastasis. METHODS: We reviewed the clinical course of all osteosarcoma patients with pulmonary metastases treated by metastasectomy in our hospital from January 2008 through December 2016. Each patient who underwent metastasectomy was placed into one of three groups based on whether lung metastases were present at initial presentation (Group 1), developed during chemotherapy (Group 2), or appeared after completion of chemotherapy (Group 3)...
June 23, 2018: Journal of Pediatric Surgery
Lin Xie, Zhihong Yao, Ya Zhang, Dongqi Li, Fengdi Hu, Yedan Liao, Ling Zhou, Yonghong Zhou, Zeyong Huang, Zewei He, Lei Han, Yihao Yang, Zuozhang Yang
Osteosarcoma (OS) is the most common pediatric malignant bone tumor, and occurrence of pulmonary metastasis generally causes a rapid and fatal outcome. Here we aimed to provide clues for exploring the mechanism of tumorigenesis and pulmonary metastasis for OS by comprehensive analysis of microRNA (miRNA), long non-coding RNA (lncRNA), and mRNA expression in primary OS and OS pulmonary metastasis. In this study, deep sequencing with samples from primary OS (n = 3), pulmonary metastatic OS (n = 3), and normal controls (n = 3) was conducted and differentially expressed miRNAs (DEmiRNAs), lncRNAs (DElncRNAs), and mRNAs (DEmRNAs) between primary OS and normal controls as well as pulmonary metastatic and primary OS were identified...
July 10, 2018: Cell Death & Disease
Lin Du, Xiu-Guo Han, Bing Tu, Min-Qi Wang, Han Qiao, Shu-Hong Zhang, Qi-Ming Fan, Ting-Ting Tang
The loss of appropriate cell adhesion normally induces apoptosis via a process termed anoikis. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) in the cancer microenvironment on the anoikis resistance and pulmonary metastasis of osteosarcoma (OS) cells, and to evaluate the critical role of the interleukin (IL)-8/C-X-C chemokine receptor (CXCR) 1/Akt-signaling pathway in these processes. Metastatic OS subtype cells, which did or did not interact with MSC-conditioned medium (MSC-CM) in vitro, were isolated from the pulmonary site and named Saos2-lung-M...
June 18, 2018: Cell Death & Disease
Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun, Santosh Kamar, Ya Zhang, Yihao Yang, Cao Wang, Zuozhang Yang
The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers...
June 13, 2018: Cell Death & Disease
Yong Zhu, Lanhua Tang, Shushan Zhao, Buhua Sun, Liang Cheng, Yifu Tang, Zhongwei Luo, Zhangyuan Lin, Jianxi Zhu, Weihong Zhu, Ruibo Zhao, Bangbao Lu, Haitao Long
Osteosarcoma is the most common primary bone malignancy. Recently, studies showed chemokine receptor 4 (CXCR4) played a critical role in osteosarcoma. However, the regulation of CXCR4 is not fully understood. microRNAs are short, non-coding RNAs that play an important roles in post-transcriptional regulation of gene expression in a variety of diseases including osteosarcoma. miR-613 is a newly discovered miRNA and has been reported to function as a tumor suppressor in many cancers. In this study, we confirmed that both Stromal Cell-Derived Factor (SDF-1) and CXCR4 could be prognostic markers for osteosarcoma...
August 2018: Cancer Science
Daniel M Lerman
No abstract text is available yet for this article.
July 2018: Clinical Orthopaedics and related Research
Pooja Dhupkar, Nancy Gordon, John Stewart, Eugenie S Kleinerman
Osteosarcoma (OS) pulmonary metastasis translates into poor patient survival. The implication of PD-1-PD-L1 pathway in the context of NK cells and/or macrophages in OS is unknown. We investigated the effect of anti-PD-1 in OS lung metastasis and the role of NK cells and/or macrophages in anti-PD-1 responses. A human LM7 OS mouse model was used. Immunohistochemistry for tissues (PD-L1, caspase-3, Ki-67, NK cells, macrophages), and Western blotting for OS lung tumors (p-Stat3, p-Erk1/2) was performed. NK and macrophages were assessed using flow cytometry...
June 2018: Cancer Medicine
Kai Zhao, Shang-You Yang, Jun Geng, Xuan Gong, Weiming Gong, Lin Shen, Bin Ning
Investigate whether rAAV-anginex gene therapy combined with radiotherapy could decrease growth and pulmonary metastasis of osteosarcoma in mice and examine the mechanisms involved in this therapeutic strategy. During in vitro experiment, multiple treatment regimes (rAAV-eGFP, radiotherapy, rAAV-anginex, combination therapy) were applied to determine effects on proliferation of endothelial cells (ECs) and G-292 osteosarcoma cells. During in vivo analysis, the same multiple treatment regimes were applied to osteosarcoma tumor-bearing mice...
June 2018: Cancer Medicine
Gang Zheng, Abby Richmond, Chengbao Liu, Alexander Berrebi, Aparna Pallavajjala, Lisa Haley, Rebecca L Stone, Edward McCarthy, Russell Vang, Deyin Xing
Primary osteosarcoma (OS) of the uterus is distinctly rare. We report a case of primary uterine OS with pulmonary metastasis in a 74-yr-old woman. Histopathologic features of the uterine tumor were in keeping with a pure chondroblastic OS composed of neoplastic cells with osteoblastic/chondroblastic differentiation and neoplastic bone formation. Despite treatment with Doxorubicin and Olaratumab and later with palliative radiation therapy, the patient died 7 mo after hysterectomy due to multiple distant metastases...
April 6, 2018: International Journal of Gynecological Pathology
Caroline Maloney, Morris C Edelman, Michelle P Kallis, Samuel Z Soffer, Marc Symons, Bettie M Steinberg
BACKGROUND: Although metastasis is the major cause of mortality in patients with osteosarcoma, little is known about how micrometastases progress to gross metastatic disease. Clinically relevant animal models are necessary to facilitate development of new therapies to target indolent pulmonary metastases. Intratibial injection of human and murine osteosarcoma cell lines have been described as orthotopic models that develop spontaneous pulmonary metastasis over time. However, there is variability in reported injection techniques and metastatic efficiency...
July 2018: Clinical Orthopaedics and related Research
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