Francesca Lazzaroni, Jennifer M T A Meessen, Ying Sun, Silvia Lanfranconi, Elisa Scola, Quintino Giorgio D'Alessandris, Laura Tassi, Maria Rita Carriero, Marco Castori, Silvia Marino, Adriana Blanda, Enrico B Nicolis, Deborah Novelli, Roberta Calabrese, Nicolò M Agnelli, Barbara Bottazzi, Roberto Leone, Selene Mazzola, Silvia Besana, Carlotta Catozzi, Luigi Nezi, Maria G Lampugnani, Matteo Malinverno, Nastasja Grdseloff, Claudia J Rödel, Behnam Rezai Jahromi, Niccolò Bolli, Francesco Passamonti, Peetra U Magnusson, Salim Abdelilah-Seyfried, Elisabetta Dejana, Roberto Latini
BACKGROUND: Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression...
December 18, 2023: EBioMedicine