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https://www.readbyqxmd.com/read/30118535/tpte-and-tpte-qt-novel-markers-to-predict-sudden-cardiac-death-in-esrd
#1
Basil M Saour, Jeffrey H Wang, Michael P Lavelle, Roy O Mathew, Mandeep S Sidhu, William E Boden, Joseph D Sacco, Eric J Costanzo, Mohammad A Hossain, Tuhsar Vachharanji, Anas Alrefaee, Arif Asif
INTRODUCTION: Reliable markers to predict sudden cardiac death (SCD) in patients with end stage renal disease (ESRD) remain elusive, but echocardiogram (ECG) parameters may help stratify patients. Given their roles as markers for myocardial dispersion especially in high risk populations such as those with Brugada syndrome, we hypothesized that the Tpeak to Tend (TpTe) interval and TpTe/QT are independent risk factors for SCD in ESRD. METHODS: Retrospective chart review was conducted on a cohort of patients with ESRD starting hemodialysis...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30116507/the-effect-of-kidney-transplantation-on-speckled-tracking-echocardiography-findings-in-patients-on-hemodialysis
#2
Sahand Hamidi, Javad Kojuri, Armin Attar, Jamshid Roozbeh, Alireza Moaref, Mohammad Hossein Nikoo
Introduction: Cardiac dysfunction is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Previous studies have shown that kidney transplantation can reverse some of the gross changes in the myocardial structure such as left ventricular ejection fraction (LVEF) and volumes. Whether kidney transplantation can reverse the subtle and early myocardial changes in ESRD patients who do not suffer from gross alternations in myocardial function is not yet studied. The aim of this study was to answer this question...
2018: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/30116443/acute-hepatic-failure-and-epididymitis-in-a-hispanic-patient-with-active-systemic-lupus-erythematosus
#3
Beau M Bailey, Kenneth S Ramos, Alice Johnson, Charlene Mitchell
Systemic lupus erythematosus (SLE) is an autoimmune disease known to affect a variety of organ systems. Patients with SLE are more prone to developing common infections that can mimic the complications of SLE. As such, it is essential to differentiate complications of SLE from infection to ensure appropriate management and to improve morbidity and mortality of this patient population. Here we present a 24-year-old, Hispanic male, with SLE complicated by dialysis-dependent end-stage renal disease and dilated cardiomyopathy...
September 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30116371/impact-of-timing-of-initiation-of-dialysis-on-long-term-prognosis-of-patients-undergoing-hemodialysis
#4
Yumei Zhang, Chun Hu, Zhixiang Bian, Peihua Chen
There are a lot of controversies pertaining to correctness of timing for the initiation of dialysis in chronic kidney disease (CKD) patients. The present study was conducted to examine the potential association of initiation timing of dialyses with long-term prognosis in CKD patients. In total, 294 patients confirmed as end-stage renal disease (ESRD) were included as study subjects. According to the estimated glomerular filtration rate (eGFR) at initiation time, the patients were classified into four groups based on eGFR: ≥10...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30112255/atypical-presentation-of-cardiac-tamponade-as-a-cause-of-acute-liver-injury-case-report-and-review-of-literature
#5
REVIEW
Sarang Thaker, Cemal Yazici, Sean Koppe
Pericardial tamponade is a rare cause of acute liver injury due to the compressive effects of an effusion resulting in a poor cardiac output which ultimately leads to ischemia-induced injury. We present a patient with chronic hepatitis C infection and end-stage renal disease who was transferred to our center for further evaluation and management of acute liver injury after presenting to an outside hospital with left upper quadrant abdominal pain, nausea and vomiting. The patient was discovered to have tamponade physiology on transthoracic echocardiogram as an underlying cause of his acute liver injury despite lack of clinical tamponade features...
June 11, 2018: Curēus
https://www.readbyqxmd.com/read/30112209/projecting-the-burden-of-chronic-kidney-disease-in-a-developed-country-and-its-implications-on-public-health
#6
L Y Wong, A S T Liew, W T Weng, C K Lim, A Vathsala, M P H S Toh
Background: Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. This study projects the number of residents with CKD in Singapore by 2035 using a Markov model. Methods: A Markov model with nine mutually exclusive health states was developed according to the clinical course of CKD, based on a discrete time interval of 1 year. The model simulated the transition of cohorts across different health states from 2007 to 2035 using prevalence, incidence, mortality, disease transition, and disease detection rates...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/30110675/obstructive-sleep-apnea-increases-sudden-cardiac-death-in-incident-hemodialysis-patients
#7
Eric S Kerns, Esther D Kim, Lucy A Meoni, Stephen M Sozio, Bernard G Jaar, Michelle M Estrella, Rulan S Parekh, Ghada Bourjeily
BACKGROUND: Mortality in end-stage renal disease (ESRD) occurs predominantly from cardiovascular disease (CVD) and sudden cardiac death (SCD). Obstructive sleep apnea (OSA) is characterized by periodic airflow limitation associated with sleep arousal and oxygen desaturation and is prevalent in patients with ESRD. Whether OSA increases the risk for SCD, cardiovascular and all-cause mortality among hemodialysis patients remains unknown. METHODS: In a prospective cohort of 558 incident hemodialysis patients, we examined the association of OSA with all-cause mortality, cardiovascular mortality, and SCD using Cox proportional hazards models controlling for traditional CVD risk factors...
August 15, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/30104301/the-legacy-effect-in-type-2-diabetes-impact-of-early-glycemic-control-on-future-complications-the-diabetes-aging-study
#8
Neda Laiteerapong, Sandra A Ham, Yue Gao, Howard H Moffet, Jennifer Y Liu, Elbert S Huang, Andrew J Karter
OBJECTIVE: To examine for a legacy effect of early glycemic control on diabetic complications and death. RESEARCH DESIGN AND METHODS: This cohort study of managed care patients with newly diagnosed type 2 diabetes and 10 years of survival (1997-2013, average follow-up 13.0 years, N = 34,737) examined associations between HbA1c <6.5% (<48 mmol/mol), 6.5% to <7.0% (48 to <53 mmol/mol), 7.0% to <8.0% (53 to <64 mmol/mol), 8.0% to <9.0% (64 to <75 mmol/mol), or ≥9...
August 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30104041/development-and-validation-of-prediction-scores-for-early-mortality-at-transition-to-dialysis
#9
Yoshitsugu Obi, Danh V Nguyen, Hui Zhou, Melissa Soohoo, Lishi Zhang, Yanjun Chen, Elani Streja, John J Sim, Miklos Z Molnar, Connie M Rhee, Kevin C Abbott, Steven J Jacobsen, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
OBJECTIVE: To develop and validate a risk prediction model that would help individualize treatment and improve the shared decision-making process between clinicians and patients. PATIENTS AND METHODS: We developed a risk prediction tool for mortality during the first year of dialysis based on pre-end-stage renal disease characteristics in a cohort of 35,878 US veterans with incident end-stage renal disease who transitioned to dialysis treatment between October 1, 2007, and March 31, 2014 and then externally validated this tool among 4284 patients in the Kaiser Permanente Southern California (KPSC) health care system who transitioned to dialysis treatment between January 1, 2007, and September 30, 2015...
August 10, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/30099652/effects-of-probiotics-on-inflammation-and-uremic-toxins-among-patients-on-dialysis-a-systematic-review-and-meta-analysis
#10
Charat Thongprayoon, Wisit Kaewput, Spencer T Hatch, Tarun Bathini, Konika Sharma, Karn Wijarnpreecha, Patompong Ungprasert, Matthew D'Costa, Michael A Mao, Wisit Cheungpasitporn
BACKGROUND/OBJECTIVES: We performed this systematic review and meta-analysis to evaluate effects of probiotics on inflammation, uremic toxins, and gastrointestinal (GI) symptoms in end-stage renal disease (ESRD) patients. METHODS: A literature search was conducted utilizing MEDLINE, EMBASE, and Cochrane Database from inception through October 2017. We included studies that assessed assessing effects of probiotics on inflammatory markers, protein-bound uremic toxins (PBUTs), and GI symptoms in ESRD patients on dialysis...
August 11, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30099445/independent-association-of-overhydration-with-all-cause-and-cardiovascular-mortality-adjusted-for-global-left-ventricular-longitudinal-systolic-strain-and-e-e-ratio-in-maintenance-hemodialysis-patients
#11
Jiun-Chi Huang, Yi-Chun Tsai, Pei-Yu Wu, Jia-Jung Lee, Szu-Chia Chen, Yi-Wen Chiu, Ya-Ling Hsu, Jer-Ming Chang, Hung-Chun Chen
BACKGROUND/AIMS: Fluid overload is common and associated with morbidity and mortality in patients with end-stage renal disease. The relationship between fluid overload and cardiac function is complex, and whether fluid overload is associated with adverse outcomes in patients undergoing hemodialysis (HD) independently of systolic and diastolic function of the left ventricle (LV) remains unclear. METHODS: The present study aimed to investigate the relationship between overhydration and all-cause and cardiovascular (CV) mortality after adjusting for LV function in 178 maintenance HD patients...
August 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30097337/circulating-long-noncoding-rna-dkfzp434i0714-predicts-adverse-cardiovascular-outcomes-in-patients-with-end-stage-renal-disease
#12
Chun-Fu Lai, Yen-Ting Chen, Jian Gu, Jeanne M Nerbonne, Chin-Hsien Lin, Kai-Chien Yang
BACKGROUND: Cardiovascular (CV) diseases are major causes of mortality in uremic patients. Conventional risk factors fail to identify uremic patients with increased propensity for adverse CV outcomes. We aimed to test the hypothesis that circulating long noncoding RNAs (lncRNAs) could be a prognostic marker to predict adverse CV outcomes in uremic patients. METHODS AND RESULTS: Plasma lncRNAs were profiled in patients with end-stage renal disease (ESRD, n = 28) or chronic kidney disease (CKD, n = 8) and in healthy (n = 12) subjects by RNA sequencing...
August 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30096785/does-a-supplemental-low-protein-diet-decrease-mortality-and-adverse-events-after-commencing-dialysis-a-nationwide-cohort-study
#13
Chieh-Li Yen, Kun-Hua Tu, Ming-Shyan Lin, Su-Wei Chang, Pei-Chun Fan, Ching-Chung Hsiao, Chao-Yu Chen, Hsiang-Hao Hsu, Ya-Chun Tian, Chih-Hsiang Chang
BACKGROUND: A beneficial effect of a ketoanalogue-supplemented low-protein diet (sLPD) in postponing dialysis has been demonstrated in numerous previous studies. However, evidence regarding its effect on long-term survival is limited. Our study assessed the long-term outcomes of patients on an sLPD after commencing dialysis. METHODS: This retrospective study examined patients with new-onset end-stage renal disease with permanent dialysis between 2001 and 2013, extracted from Taiwan's National Health Insurance Research Database...
August 8, 2018: Nutrients
https://www.readbyqxmd.com/read/30095497/postdischarge-major-adverse-cardiovascular-events-of-icu-survivors-who-received-acute-renal-replacement-therapy
#14
Sehoon Park, Soojin Lee, Min Woo Kang, Kyungdo Han, Yaerim Kim, Jung Nam An, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Hai-Won Yoo, Hyeongsu Kim, Dong Ki Kim
OBJECTIVES: Long-term risk of a major adverse cardiovascular events in ICU survivors who underwent acute renal replacement therapy requires further investigation. DESIGN: Nationwide population-based study using the claims database of Korea. SETTING: Index admission cases of ICU survivors in government-designated tertiary hospitals PATIENTS: : The study group consisted of ICU survivors who underwent acute renal replacement therapy, and the control group consisted of those without acute renal replacement therapy...
August 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30095143/anca-associated-vasculitis-experience-of-a-tertiary-care-referral-center
#15
Rafia Chaudhry, Anum Bilal, Adam Austin, Swati Mehta, Loay Salman, Llewellyn Foulke, Paul Feustel, Roman Zuckerman, Arif Asif
BACKGROUND AND OBJECTIVES: Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis is a small vessel vasculitis with insufficient epidemiologic estimates in the United States. We aimed to determine demographic and clinical features of ANCA associated vasculitis patients presenting to a large tertiary care referral center in Upstate New York. Design, setting, participants, and measurements: A retrospective analysis of cases with pauci-immune GN on renal biopsy and clinical diagnosis of ANCA vasculitis presenting over 11 years was conducted...
August 9, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30093367/the-use-of-aspirin-to-reduce-the-risk-of-thrombotic-events-in-patients-with-end-stage-renal-disease-protocol-for-a-randomized-controlled-trial
#16
Tiago Lemos Cerqueira, Armando Fartolino Guerrero, Clara Krystal Pérez Fermin, Ricardo Wang, Evelin Elfriede Balbino, Janis L Breeze, Paola Gonzalez Mego, Daniele Argentina Silva, Walid Ezzeldin Omer, Nathalie Monique Vandevelde
BACKGROUND: End-stage renal disease (ESRD) is the last stage of chronic kidney disease, mainly caused by type 2 diabetes mellitus and characterized by an increased mortality risk related to cardiovascular disease. Low-dose aspirin (acetylsalicylic acid or ASA) seems to effectively prevent cardiovascular events in patients with ESRD. However, the number of interventional studies in this population remains limited and the mechanisms of aspirin-related bleeding remain poorly understood. Aspirin's efficacy and safety may be modified by the presence of type 2 diabetes mellitus or platelet hyperreactivity...
August 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30093259/prenatal-renal-parenchymal-area-as-a-predictor-of-early-end-stage-renal-disease-in-children-with-vesicoamniotic-shunting-for-lower-urinary-tract-obstruction
#17
Paulo Renato Marcelo Moscardi, Chryso P Katsoufis, Mona Jahromi, Ruben Blachman-Braun, Marissa J DeFreitas, Kristin Kozakowski, Miguel Castellan, Andrew Labbie, Rafael Gosalbez, Alireza Alam
BACKGROUND: Vesicoamniotic shunting (VAS) and other bladder drainage techniques for fetal lower urinary tract obstruction (LUTO) have been proven to ameliorate pulmonary hypoplasia and increase survival in patients with an initial poor prognosis. Currently there are limited prognostic tools available during gestation to evaluate and predict postnatal renal function. OBJECTIVE: The aim was to describe the prenatal growth of the renal parenchymal area (RPA) in patients with LUTO and determine its application as a predictor of renal function at one year of life...
July 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30084761/donor-nephrectomy-may-compromise-the-cardiovascular-system-a-retrospective-single-center-study
#18
Emrullah Söğütdelen, Tolga Yildirim, Hakan Bahadir Haberal, Uğur Canpolat, Tuncay Hazirolan, Hasan Serkan Doğan, Şeref Rahmi Yilmaz, Yunus Erdem, Fazil Tuncay Aki
OBJECTIVES: Our goal was to determine the short-term effects of donor nephrectomy on the cardiovascular system and to gain a better understanding of the recently recognized long-term increased risk of end-stage renal disease and cardiovascular mortality. MATERIALS AND METHODS: Living kidney donors who underwent donor nephrectomy between January 2010 and January 2015 at the Hacettepe University Transplantation Unit were retrospectively screened. Echocardiographic parameters, kidney volumes, and renal functions before nephrectomy were compared with measurements after nephrectomy...
August 6, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/30082059/personalized-management-of-bone-and-mineral-disorders-and-precision-medicine-in-end-stage-kidney-disease
#19
REVIEW
Anna Jovanovich, Jessica Kendrick
Chronic kidney disease mineral bone disorder (CKD-MBD) is common in end-stage renal disease and is associated with an increased risk of cardiovascular morbidity and mortality. Mainstays of treatment include decreasing serum phosphorus level toward the normal range with dietary interventions and phosphate binders and treating increased parathyroid hormone levels with activated vitamin D and/or calcimimetics. There is significant variation in serum levels of mineral metabolism markers, intestinal absorption of phosphorus, and therapeutic response among individual patients and subgroups of patients with end-stage renal disease...
July 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/30081159/metformin-is-associated-with-improved-survival-and-decreased-cardiac-events-with-no-impact-on-patency-and-limb-salvage-after-revascularization-for-peripheral-arterial-disease
#20
Sikandar Z Khan, Mariel Rivero, Gregory S Cherr, Linda M Harris, Maciej L Dryjski, Nader D Nader, Hasan H Dosluoglu
OBJECTIVE: The incidence of cardiovascular and limb-specific adverse outcomes is higher in PAD patients with diabetes. Metformin is associated with improved cardiovascular morbidity and mortality. However, the effect of metformin on limb-specific outcomes is unclear. The objective of this study was to assess the effect of metformin on outcomes following intervention for PAD. METHODS: Patients who underwent revascularization for chronic limb ischemia (Rutherford 3-6) between 06/2001-12/2014 were retrospectively identified...
August 3, 2018: Annals of Vascular Surgery
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