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https://www.readbyqxmd.com/read/28072703/screening-the-key-micrornas-and-transcription-factors-in-prostate-cancer-based-on-microrna-functional-synergistic-relationships
#1
Fan Feng, Jitao Wu, Zhenli Gao, Shengqiang Yu, Yuanshan Cui
Prostate cancer (PC) is a common neoplasm, and metastatic PC remains incurable. The study aims to screen key microRNAs (miRNAs) and transcription factors (TFs) involved in PC.The miRNA expression profile dataset (GSE45604) was downloaded from Gene Expression Omnibus database, including 50 PC and 10 normal specimens. Differentially expressed miRNAs (DEmiRNAs) were identified through limma package in R, and DEmiRNA-DEmiRNA co-regulation network was constructed based on the number of co-regulated target genes...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068922/functional-changes-in-mrna-expression-and-alternative-pre-mrna-splicing-associated-with-the-effects-of-nutrition-on-apoptosis-and-spermatogenesis-in-the-adult-testis
#2
Yongjuan Guan, Guanxiang Liang, Graeme B Martin, Le Luo Guan
BACKGROUND: The effects of nutrition on testis mass in the sexually mature male have long been known, however, the cellular and molecular processes of the testis response to nutrition was not fully understood. METHODS: We tested whether the defects in spermatogenesis and increases in germ cell apoptosis in the testis that are induced by under-nutrition are associated with changes in mRNA expression and pre-mRNA alternative splicing using groups of 8 male sheep fed for a 10% increase or 10% decrease in body mass over 65 days...
January 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28009602/ewsr1-fusions-with-creb-family-transcription-factors-define-a-novel-myxoid-mesenchymal-tumor-with-predilection-for-intracranial-location
#3
Yu-Chien Kao, Yun-Shao Sung, Lei Zhang, Chun-Liang Chen, Sumathi Vaiyapuri, Marc K Rosenblum, Cristina R Antonescu
Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland. We have recently encountered a group of 5 myxoid mesenchymal tumors positive for EWSR1 fusions with one of the CREB family member (ATF1, CREB1, and CREM), with histologic features distinct from any of the previously described pathologic entities...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27993161/circulating-cell-free-dna-based-epigenetic-assay-can-detect-early-breast-cancer
#4
Natsue Uehiro, Fumiaki Sato, Fengling Pu, Sunao Tanaka, Masahiro Kawashima, Kosuke Kawaguchi, Masahiro Sugimoto, Shigehira Saji, Masakazu Toi
BACKGROUND: Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness of cfDNA for early detection of cancer. Although aberrant DNA methylation in cfDNA has been reported for more than a decade, its diagnostic accuracy remains unsatisfactory for cancer screening. Thus, the aim of the present study was to develop a highly sensitive cfDNA-based system for detection of primary breast cancer (BC) using epigenetic biomarkers and digital PCR technology...
December 19, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27987522/-interleukin-2-signaling-pathway-regulating-molecules-in-systemic-lupus-erythematosus
#5
Q Guo, X Y Chen, Y Su
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease, which characterized by complex immunological abnormalities and multiple tissue and organ damages. The etiology and pathogenesis of SLE have not been entirely recognized. Genetic, environmental and viral infections and other factors might be related to the pathogenetic mechanisms of SLE. Interleukin-2 (IL-2) is a critical cytokine produced by T cells upon activation and is important for the generation of T regulatory cells and activation-induced cell death...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27907106/brain-transcriptional-profiles-of-male-alternative-reproductive-tactics-and-females-in-bluegill-sunfish
#6
Charlyn G Partridge, Matthew D MacManes, Rosemary Knapp, Bryan D Neff
Bluegill sunfish (Lepomis macrochirus) are one of the classic systems for studying male alternative reproductive tactics (ARTs) in teleost fishes. In this species, there are two distinct life histories: parental and cuckolder, encompassing three reproductive tactics, parental, satellite, and sneaker. The parental life history is fixed, whereas individuals who enter the cuckolder life history transition from sneaker to satellite tactic as they grow. For this study, we used RNAseq to characterize the brain transcriptome of the three male tactics and females during spawning to identify gene ontology (GO) categories and potential candidate genes associated with each tactic...
2016: PloS One
https://www.readbyqxmd.com/read/27889934/vascular-cell-transcriptomic-changes-to-exercise-training-differ-directionally-along-and-between-skeletal-muscle-arteriolar-trees
#7
M Harold Laughlin, Hsiao T Yang, Darla L Tharp, R Scott Rector, Jaume Padilla, Douglas K Bowles
EXT-induced arteriolar adaptations in skeletal muscle are heterogeneous because of spatial variations in muscle fiber type composition and fiber recruitment patterns during exercise. The purpose of this report is to summarize a series of experiments conducted to test the hypothesis that changes in vascular gene expression are signaled by alterations in shear stress resulting from increases in blood flow, muscle fiber type composition and fiber recruitment patterns. We also report results from a follow-up study of Ankrd23, one gene whose expression was changed by EXT...
November 27, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27822872/constitutive-expression-of-inducible-cyclic-adenosine-monophosphate-early-repressor-icer-in-cycling-quiescent-hematopoietic-cells-implications-for-aging-hematopoietic-stem-cells
#8
Steven J Greco, Ghassan Yehia, Julius A Potian, Carlos A Molina, Pranela Rameshwar
Despite extensive insights on the interaction between hematopoietic stem cells (HSCs) and the supporting bone marrow (BM) stroma in hematopoietic homeostasis there remains unanswered questions on HSC regulation. We report on the mechanism by which HSCs attain cycling quiescence by addressing a role for inducible cyclic AMP early repressor (ICER). ICER negatively transcriptional regulators of cAMP activators such as CREM and CREB. These activators can be induced by hematopoietic stimulators such as cytokines...
November 8, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27813452/cognitive-remediation-to-enhance-mobility-in-older-adults-the-crem-study
#9
Joe Verghese, Emmeline Ayers, Jeannette R Mahoney, Anne Ambrose, Cuiling Wang, Roee Holtzer
Mobility disabilities represent the most prevalent disability among seniors. Emerging evidence indicates that executive functions play an important role in maintaining mobility. However, the use of cognitive remediation programs to enhance mobility has not been investigated in a full-scale randomized control trial. The CREM study is a single-blind randomized control trial to examine the effect of computerized cognitive remediation versus computer-based health education training on mobility in 420 seniors. The primary outcome is change in gait speed during normal walking and walking-while-talking conditions from baseline to postintervention...
December 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27799548/ptpn22-contributes-to-exhaustion-of-t-lymphocytes-during-chronic-viral-infection
#10
Christian J Maine, John R Teijaro, Kristi Marquardt, Linda A Sherman
The protein encoded by the autoimmune-associated protein tyrosine phosphatase nonreceptor type 22 gene, PTPN22, has wide-ranging effects in immune cells including suppression of T-cell receptor signaling and promoting efficient production of type I interferons (IFN-I) by myeloid cells. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13 (LCMV cl13). The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNβ-induced IL-2 repressor, cAMP-responsive element modulator (CREM) is reduced...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27733803/the-expression-of-cyclic-adenosine-monophosphate-responsive-element-modulator-in-rat-sertoli-cells-following-seminal-extract-administration
#11
Muslim Akmal, Tongku Nizwan Siregar, Sri Wahyuni, Hamny, Mustafa Kamal Nasution, Wiwik Indriati, Budianto Panjaitan, Dwinna Aliza
AIM: This study aims to determine the effect of seminal vesicle extract on cyclic adenosine monophosphate responsive element modulator (CREM) expression in rat Sertoli cells. MATERIALS AND METHODS: This study examined the expression of CREM on 20 male rats (Rattus norvegicus) at 4 months of age, weighing 250-300 g. The rats were divided into four groups: K0, KP1, KP2, and KP3. K0 group was injected with 0.2 ml normal saline; KP1 was injected with 25 mg cloprostenol (Prostavet C, Virbac S...
September 2016: Veterinary World
https://www.readbyqxmd.com/read/27680869/icer-is-requisite-for-th17-differentiation
#12
Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo, Florencia Rosetti, Tanya N Mayadas, José C Crispín, Sean J Bradley, Tomohiro Koga, Michihito Kono, Maria P Karampetsou, Vasileios C Kyttaris, Klaus Tenbrock, George C Tsokos
Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the IL-6-STAT3 pathway and binds to the Il17a promoter, where it facilitates the accumulation of the canonical enhancer RORγt. In vitro differentiation from naive ICER/CREM-deficient CD4(+) T cells to Th17 cells is impaired but can be rescued by forced overexpression of ICER. Consistent with a role of Th17 cells in autoimmune and inflammatory diseases, ICER/CREM-deficient B6...
September 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27614313/sulfur-dioxide-inhalation-lowers-sperm-quality-and-alters-testicular-histology-via-increasing-expression-of-crem-and-act-proteins-in-rat-testes
#13
Jianhai Zhang, Fei Zheng, Chen Liang, Yuchen Zhu, Yan Shi, Yongli Han, Jundong Wang
Sulfur dioxide (SO2) is one of the main atmospheric pollutants worldwide, and is reported to be responsible for the formation of severe haze in China. Some studies have demonstrated a potential harmful effect of SO2 on the male reproductive system; however the underlying mechanism is still unknown. The purpose of this study is to investigate the roles of cytochrome P450 (P450), cAMP-responsive element modulator (CREM), and activator of CREM (ACT) in SO2-induced toxicity. Forty-eight male Wistar rats were randomly divided into an experimental and control group...
October 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27560004/expression-dynamics-relationships-and-transcriptional-regulations-of-diverse-transcripts-in-mouse-spermatogenic-cells
#14
Xiwen Lin, Miao Han, Lu Cheng, Jian Chen, Zhuqiang Zhang, Ting Shen, Min Wang, Bo Wen, Ting Ni, Chunsheng Han
Among all tissues of the metazoa, the transcritpome of testis displays the highest diversity and specificity. However, its composition and dynamics during spermatogenesis have not been fully understood. Here, we have identified 20,639 message RNAs (mRNAs), 7,168 long non-coding RNAs (lncRNAs) and 15,101 circular RNAs (circRNAs) in mouse spermatogenic cells, and found many of them were specifically expressed in testes. lncRNAs are significantly more testis-specific than mRNAs. At all stages, mRNAs are generally more abundant than lncRNAs, and linear transcripts are more abundant than circRNAs...
October 2, 2016: RNA Biology
https://www.readbyqxmd.com/read/27467390/rapid-extraction-and-identification-of-maitotoxin-and-ciguatoxin-like-toxins-from-caribbean-and-pacific-gambierdiscus-using-a-new-functional-bioassay
#15
Richard J Lewis, Marco Inserra, Irina Vetter, William C Holland, D Ransom Hardison, Patricia A Tester, R Wayne Litaker
BACKGROUND: Ciguatera is a circumtropical disease produced by polyether sodium channel toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible fish. Ciguatoxins, as well as potent water-soluble polyethers known as maitotoxins, are produced by certain dinoflagellate species in the genus Gambierdiscus and Fukuyoa spp. in the Pacific but little is known of the potential of related Caribbean species to produce these toxins. METHODS: We established a simplified procedure for extracting polyether toxins from Gambierdiscus and Fukuyoa spp...
2016: PloS One
https://www.readbyqxmd.com/read/27465138/piggybac-transposon-mediated-mutagenesis-in-rats-reveals-a-crucial-role-of-bbx-in-growth-and-male-fertility
#16
Chieh-Ying Wang, Ming-Chu Tang, Wen-Chi Chang, Kenryo Furushima, Chuan-Wei Jang, Richard R Behringer, Chun-Ming Chen
Bobby sox homolog (Bbx) is an evolutionally conserved gene, but its biological function remains elusive. Here, we characterized defects of Bbx mutant rats that were created by PiggyBac-mediated insertional mutagenesis. Smaller body size and male infertility were the two major phenotypes of homozygous Bbx mutants. Bbx expression profile analysis showed that Bbx was more highly expressed in the testis and pituitary gland than in other organs. Histology and hormonal gene expression analysis of control and Bbx-null pituitary glands showed that loss of Bbx appeared to be dispensable for pituitary histogenesis and the expression of major hormones...
September 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27430551/in-vitro-differentiation-of-rat-spermatogonia-into-round-spermatids-in-tissue-culture
#17
A Reda, M Hou, T R Winton, R E Chapin, O Söder, J-B Stukenborg
STUDY QUESTION: Do the organ culture conditions, previously defined for in vitro murine male germ cell differentiation, also result in differentiation of rat spermatogonia into post-meiotic germ cells exhibiting specific markers for haploid germ cells? SUMMARY ANSWER: We demonstrated the differentiation of rat spermatogonia into post-meiotic cells in vitro, with emphasis on exhibiting, protein markers described for round spermatids. WHAT IS KNOWN ALREADY: Full spermatogenesis in vitro from immature germ cells using an organ culture technique in mice was first reported 5 years ago...
September 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27419096/astragalus-membranaceus-augment-sperm-parameters-in-male-mice-associated-with-camp-responsive-element-modulator-and%C3%A2-activator-of-crem-in-testis
#18
Wonnam Kim, Do Rim Kim, Mun Seog Chang, Seong Kyu Park
Astragalus membranaceus BUNGE (AM; huáng qí) has been widely used as a medicinal herb for different kinds of diseases. AM treatment in vitro enhance sperm motility and ameliorates testicular toxicity, it has demonstrated the ability as a potential treatment for male infertility. In order to gain further insights on the molecular understanding of how AM enhances spermatogenesis, this study investigated whether AM has an affect on sperm parameters associated with cAMP response element modulator (CREM) and activator of CREM in testis (ACT) expression...
July 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27357293/evaluation-of-the-sebia-capillarys-3-tera-and-the-bio-rad-d-100-systems-for-the-measurement-of-hemoglobin-a1c
#19
Margaux Herpol, Katrien Lanckmans, Stefaan Van Neyghem, Pascale Clement, Stefanie Crevits, Kim De Crem, Frans K Gorus, Ilse Weets
OBJECTIVES: We evaluated the Bio-Rad (Irvine, CA) D-100 and the Sebia (Lisses, France) Capillarys 3 Tera for the measurement of hemoglobin A1c (HbA1c) in venous blood samples. METHODS: Whole-blood samples and control material were analyzed with the D-100 and Capillarys 3 Tera and compared with our routine method, HLC-723G7 (Tosoh, Tokyo, Japan). An evaluation protocol to test precision, trueness, linearity, carryover, and selectivity was set up according to Clinical and Laboratory Standards Institute guidelines...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27339408/the-monoglyceride-content-affects-the-self-assembly-behavior-rheological-properties-syringeability-and-mucoadhesion-of-in-situ-gelling-liquid-crystalline-phase
#20
Kariane M Nunes, Cristian C C Teixeira, Renata C K Kaminski, Victor H V Sarmento, Renê O Couto, Sandra H Pulcinelli, Osvaldo Freitas
This article reports the development of a precursor liquid crystalline system based on a mixture of monoglycerides (MO) and Cremophor(®) (CREM) that exhibits in situ gelation to a liquid crystalline phase. The effects of different MO/CREM ratios and the water content (WC) on several performance characteristics were investigated with a full factorial design. The formulations were characterized by polarized light microscopy, small-angle X-ray scattering, and water uptake assays. Rheological, syringeability, and mucoadhesion evaluation were also performed...
August 2016: Journal of Pharmaceutical Sciences
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