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Taro Irisawa, Tasuku Matsuyama, Taku Iwami, Tomoki Yamada, Koichi Hayakawa, Kazuhisa Yoshiya, Kazuo Noguchi, Tetsuro Nishimura, Toshifumi Uejima, Yoshiki Yagi, Takeyuki Kiguchi, Masafumi Kishimoto, Makoto Matsuura, Yasuyuki Hayashi, Taku Sogabe, Takaya Morooka, Tetsuhisa Kitamura, Takeshi Shimazu
BACKGROUND: It has been insufficiently investigated whether neurological function after out-of-hospital cardiac arrest (OHCA) would differ by 1 °C change in ordered target temperature of 33-36 °C among patients undergoing targeted temperature management (TTM) in the real-world setting. METHODS: This nationwide hospital-based observational study (The Japanese Association for Acute Medicine-OHCA Registry) conducted between June 2014 and December 2015 in Japan included OHCA patients aged ≥18 years who were treated with TTM...
October 11, 2018: Resuscitation
Marta Massanella, Maile Y Karris, Josué Pérez-Santiago, Christina Yek, Andrej Vitomirov, Sanjay R Mehta
BACKGROUND: HIV infection is associated with premature aging, and mitochondrial integrity is compromised during the aging process. Because mitochondrial toxicity is a consequence of antiretroviral therapies (ARTs), we hypothesized HIV and long-term ART would correlate with immunosenescence and mitochondrial DNA (mtDNA) pathology. SETTING: Thirteen older HIV-infected individuals (aged >40 years) with virologic suppression (stratified by duration of ART) were compared with 10 uninfected controls well-matched for age...
November 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Sérgio Antônio Batista-Dos-Santos, Daniel Roberto C Freitas, Milene Raiol, Gleyce F Cabral, Ana Cecília Feio, Marinete M Póvoa, Maristela G Cunha, Ândrea Ribeiro-Dos-Santos
BACKGROUND: Malaria can be transmitted by blood transfusion through donations collected from asymptomatic or parasitic donors. The parasites are released into the bloodstream during its life cycle and will therefore be present in donated blood by infected individuals. All cases of transfusion-transmitted malaria (TTM) notified since 2005 in Brazil were fatal. A good screening tool for Plasmodium spp. detection in blood units must have a high detection threshold, and the prevention of TTM relies entirely on the exclusion of potentially infected donors...
October 1, 2018: Malaria Journal
Akram Ranjbar, Sara Soleimani Asl, Farzin Firozian, Hamid Heidary Dartoti, Saman Seyedabadi, Masoumeh Taheri Azandariani, Maziar Ganji
Paraquat (PQ), as a widely used herbicide, enhances the formation of free radicals and oxidative stress. Cerium oxide nanoparticles (CeNPs) are one of the most utilized and effective nanoparticles having strong antioxidative properties and inhibiting free radicals. Here, we aimed to investigate the effects of CeNPs on brain oxidative toxic stress injury induced with PQ. The male rats were treated intraperitoneally daily with PQ (50 mg/kg/day) and CeNPs (15, 30, and 60 mg/kg/day) alone or in combination for 2 weeks...
October 3, 2018: Journal of Molecular Neuroscience: MN
Young Su Kim, Yang Hyun Cho, Kiick Sung, Jeong-Am Ryu, Chi Ryang Chung, Gee Young Suh, Jeong Hoon Yang, Ji-Hyuk Yang
PURPOSE: Target temperature management (TTM) and extracorporeal cardiopulmonary resuscitation (ECPR) have been established as important interventions during cardiopulmonary arrest. However, the impact of combined TTM and ECPR on clinical outcomes has not been studied in detail. METHODS: We reviewed the records of 245 patients who received extracorporeal life support (ECLS) between January 2012 and June 2015. Exclusion criteria were as follows: Extracorporeal life support performed for reasons other than cardiac arrest, age less than 18 years, and death within 24 hours...
October 1, 2018: Journal of Intensive Care Medicine
Peggy L Nguyen, Laith Alreshaid, Roy A Poblete, Geoffrey Konye, Jonathan Marehbian, Gene Sung
Out-of-hospital cardiac arrest (CA) remains a leading cause of sudden morbidity and mortality; however, outcomes have continued to improve in the era of targeted temperature management (TTM). In this review, we highlight the clinical use of TTM, and provide an updated summary of multimodality monitoring possible in a modern ICU. TTM is neuroprotective for survivors of CA by inhibiting multiple pathophysiologic processes caused by anoxic brain injury, with a final common pathway of neuronal death. Current guidelines recommend the use of TTM for out-of-hospital CA survivors who present with a shockable rhythm...
2018: Frontiers in Neurology
Arnaud J Noreña, Philippe Fournier, Alain Londero, Damien Ponsot, Nicolas Charpentier
Acoustic shocks and traumas sometimes result in a cluster of debilitating symptoms, including tinnitus, hyperacusis, ear fullness and tension, dizziness, and pain in and outside the ear. The mechanisms underlying this large variety of symptoms remain elusive. In this article, we elaborate on the hypothesis that the tensor tympani muscle (TTM), the trigeminal nerve (TGN), and the trigeminal cervical complex (TCC) play a central role in generating these symptoms. We argue that TTM overuse (due to the acoustic shock), TTM overload (due to muscle tension), and ultimately, TTM injury (due to hypoxia and "energy crisis") lead to inflammation, thereby activating the TGN, TCC, and cortex...
January 2018: Trends in Hearing
Muharrem Akin, Jan-Thorben Sieweke, Florian Zauner, Vera Garcheva, Jörn Tongers, L Christian Napp, Lars Friedrich, Jens Treptau, Max-Udo Bahntje, Ulrike Flierl, Daniel G Sedding, Johann Bauersachs, Andreas Schäfer
OBJECTIVES: This study sought to analyze the impact of mandatory therapeutic hypothermia and cardiac catheterization in the absence of overt noncardiac cause of arrest as part of the Hannover Cardiac Resuscitation Algorithm before intensive care admission. BACKGROUND: Despite advanced therapies, out-of-hospital cardiac arrest (OHCA) is still associated with high mortality rates. Recently, the TTM (Target Temperature Management 33°C Versus 36°C After Out-of-Hospital Cardiac Arrest)-trial caused severe uncertainty about the efficacy of and need for therapeutic hypothermia...
September 24, 2018: JACC. Cardiovascular Interventions
Fabrizio R Assis, M Emma G Bigelow, Raghuram Chava, Sunjeet Sidhu, Aravindan Kolandaivelu, Henry Halperin, Harikrishna Tandri
Targeted temperature management (TTM) is recommended as a standard of care for postcardiac arrest patients. Current TTM methods have significant limitations to be used in an ambulatory setting. We investigated the efficacy and safety of a novel noninvasive transnasal evaporative cooling device (CoolStat™). Eleven Yorkshire pigs underwent hypothermia therapy using the CoolStat device. CoolStat induces evaporative cooling by blowing dehumidified ambient air over the nasal turbinates in a unidirectional fashion...
September 20, 2018: Therapeutic Hypothermia and Temperature Management
Christian Wallmüller, Alexander Spiel, Fritz Sterz, Andreas Schober, Pia Hubner, Peter Stratil, Christoph Testori
BACKGROUND: In elder patients after out-of-hospital cardiac arrest diminished neurologic function as well as reduced neuronal plasticity may cause a low response to targeted temperature management (TTM). Therefore, we investigated the association between TTM (32°C to 34°C) and neurologic outcome in cardiac arrest survivors with respect to age. MATERIAL AND METHODS: This retrospective cohort study included patients 18 years of age or older suffering a witnessed out-of-hospital cardiac arrest with presumed cardiac cause, which remained comatose after return of spontaneous circulation...
September 14, 2018: European Journal of Clinical Investigation
Miyuki Tauchi, Maria Mercedes Tejada de Rink, Hiroshi Fujioka, Satoko Okayama, Kei-Ichiro Nakamura, Barbara Dietel, Stephan Achenbach, Rainer Kollmar, Stefan Schwab, Kazuo Ushijima, Hideki Harada
Targeted temperature management (TTM), or therapeutic hypothermia, is one of the most potent neuroprotective approaches after ischemic and traumatic brain injuries. TTM has been applied clinically with various methods, but effective achievement and maintenance of the target temperature remain challenging. Furthermore, timing of cooling and target body and brain temperature to optimize effectiveness for neuroprotection and to minimize side effects are yet to be standardized. Focal brain cooling is a potential strategy to minimize adverse effects of systemic TTM...
September 8, 2018: Therapeutic Hypothermia and Temperature Management
Anjoli Anand, Kimberly E Mace, Rebecca L Townsend, Susan Madison-Antenucci, Kacie E Grimm, Noel Espina, Paul Losco, Naomi W Lucchi, Hilda Rivera, Kathleen Breen, Kathrine R Tan, Paul M Arguin, Jennifer L White, Susan L Stramer
BACKGROUND: Transfusion-transmitted malaria (TTM) is a rare occurrence with serious consequences for the recipient. A case study is presented as an example of best practices for conducting a TTM investigation. CASE REPORT: A 15-year-old male with a history of sickle cell disease developed fever after a blood transfusion. He was diagnosed with Plasmodium falciparum malaria and was successfully treated. The American Red Cross, New York State Department of Health, and the Centers for Disease Control and Prevention investigated the eight donors who provided components to the transfusion...
September 2018: Transfusion
Alexander Thomas, James F Matthaei, François Baneyx
Rationally designed two-dimensional (2D) arrays that support the assembly of nanoscale components are of interest for catalysis, sensing, and biomedical applications. The computational redesign of a protein called TTM that undergoes calcium-induced self-assembly into nanostructured lattices capable of growing to dozens of micrometers are previously reported. The work demonstrates here that the N- and C-termini of the constituent monomers are solvent-accessible and that they can be modified with a hexahistidine extension, a gold-binding peptide, or a biotinylation tag to decorate nickel-nitriloacetic acid beads with self-assembled protein islands, conjugate gold nanoparticles to planar arrays, or control the immobilization density of avidin molecules onto 2D lattices through co-polymerization of biotinylated and wild type TTM monomers...
August 31, 2018: Biotechnology Journal
Minjung Kathy Chae, Sung Eun Lee, So Young Kang, Min Seob Sim
For better care of postcardiac arrest patients, objective serial assessments of brain injury severity are needed. We hypothesized that monitoring of cerebral energy metabolism based on arterio-jugular (AJ) differences of metabolites will provide serial details of brain injury and information about neurologic outcomes in patients. Measurements of lactate and glucose in addition to blood gas analyses were done every 6 hours from the radial artery and jugular bulb in postcardiac arrest patients throughout targeted temperature management (TTM)...
August 20, 2018: Therapeutic Hypothermia and Temperature Management
Jun Dang, Li Zhang, Yun Shao, Lijuan Mei, Zenggen Liu, Huilan Yue, Qilan Wang, Yanduo Tao
Traditional Tibetan medicine (TTM) has been valuable for the identification of new therapeutic leads. Nevertheless, reports about the chemical constituents of TTM are meager owing to the lack of suitable purification techniques. In this study, an off-line two-dimensional reversed-phase/hydrophilic interaction liquid chromatography (2D RP/HILIC) technique guided by on-line HPLC-DPPH has been established for the isolation of pure antioxidants from the extract of Dracocephalum heterophyllum. According to the chromatographic recognition outcome of the HPLC-DPPH system, the first-dimensional (1D) separation on the Megress C18 preparative column yielded 6 antioxidative fractions (61...
September 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Qiang Zhang, Zhijiang Qi, Bo Liu, Chunsheng Li
This study was aimed at a serial evaluation of the prognostic values of initial shockable rhythm, bystander cardiopulmonary resuscitation (CPR) and gender for neurological outcome and survival in adults treated with targeted temperature management (TTM) following cardiac arrest (CA). PubMed, Embase and the Cochrane Library were searched for eligible studies. Pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated to evaluate prognostic values using RevMan 5.3. The outcomes were favorable neurological outcome (defined as cerebral performance category of 1 and 2) and survival...
August 14, 2018: Heart & Lung: the Journal of Critical Care
Florian Ebner, Matt B A Harmon, Anders Aneman, Tobias Cronberg, Hans Friberg, Christian Hassager, Nicole Juffermans, Jesper Kjærgaard, Michael Kuiper, Niklas Mattsson, Paolo Pelosi, Susann Ullén, Johan Undén, Matt P Wise, Niklas Nielsen
BACKGROUND: Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined. METHODS: This is an exploratory post-hoc substudy of the Target Temperature Management (TTM) trial, including resuscitated OHCA patients, investigating the association between serial measurements of arterial partial carbon dioxide pressure (PaCO2 ) and neurological outcome at 6 months, defined by the Cerebral Performance Category (CPC) scale, dichotomized to good outcome (CPC 1 and 2) and poor outcome (CPC 3-5)...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
Ward Eertmans, Cornelia Genbrugge, Jolien Haesen, Carolien Drieskens, Jelle Demeestere, Margot Vander Laenen, Willem Boer, Dieter Mesotten, Jo Dens, Ludovic Ernon, Frank Jans, Cathy De Deyne
BACKGROUND: We previously validated simplified electroencephalogram (EEG) tracings obtained by a bispectral index (BIS) device against standard EEG. This retrospective study now investigated whether BIS EEG tracings can predict neurological outcome after cardiac arrest (CA). METHODS: Bilateral BIS monitoring (BIS VISTA™, Aspect Medical Systems, Inc. Norwood, USA) was started following intensive care unit admission. Six, 12, 18, 24, 36 and 48 h after targeted temperature management (TTM) at 33 °C was started, BIS EEG tracings were extracted and reviewed by two neurophysiologists for the presence of slow diffuse rhythm, burst suppression, cerebral inactivity and epileptic activity (defined as continuous, monomorphic, > 2 Hz generalized sharp activity or continuous, monomorphic, < 2 Hz generalized blunt activity)...
August 15, 2018: Neurocritical Care
Madhappan Santha Moorthy, Subramanian Bharathiraja, Panchanathan Manivasagan, Kang Dae Lee, Junghwan Oh
Mesoporous silica-based drug delivery carriers mostly require appropriate surface modifications to improve their drug delivery efficiency and to reduce their adverse side effects. In the present work, we have synthesised mesoporous silica nanoparticles and their surface was covered by using capping units such as tetrathio-maleimide (TTM) via a "host-guest" complexation mechanism for pH-responsive drug delivery applications. The surface-functionalised melamine (Mela) groups on the outer surface of the mesoporous silica nanoparticles act as "hosts" and the surface capped TTM units act as "guests" during the surface capping of the mesoporous silica nanoparticles via the "host-guest" complexation approach...
September 1, 2017: MedChemComm
Yeonho You, Jungsoo Park, Jinhong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Jinwoong Lee, Seungwhan Kim, Sunguk Cho, Sekwang Oh, Junwan Lee, Hongjoon Ahn, Byungkook Lee, Donghun Lee, Kiryang Na, Yongnam In, Chihwan Kwack, Jaein Lee
AIM: The optimal time to measure serum albumin concentration (SAC) to predict prognosis in cardiac arrest (CA) survivors has not been elucidated. We aimed to compare the relationships between time-related SAC, optic nerve sheath diameter (ONSD), intracranial pressure (ICP), and neurological prognosis in CA survivors. METHODS: We undertook a retrospective study examining CA patients treated with target temperature management (TTM). ICP was measured using cerebrospinal fluid (CSF) pressure and ONSD was obtained before TTM...
October 2018: Resuscitation
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