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Jun Dang, Li Zhang, Yun Shao, Lijuan Mei, Zenggen Liu, Huilan Yue, Qilan Wang, Yanduo Tao
Traditional Tibetan medicine (TTM) has been valuable for the identification of new therapeutic leads. Nevertheless, reports about the chemical constituents of TTM are meager owing to the lack of suitable purification techniques. In this study, an off-line two-dimensional reversed-phase/hydrophilic interaction liquid chromatography (2D RP/HILIC) technique guided by on-line HPLC-DPPH has been established for the isolation of pure antioxidants from the extract of Dracocephalum heterophyllum. According to the chromatographic recognition outcome of the HPLC-DPPH system, the first-dimensional (1D) separation on the Megress C18 preparative column yielded 6 antioxidative fractions (61...
August 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Qiang Zhang, Zhijiang Qi, Bo Liu, Chunsheng Li
This study was aimed at a serial evaluation of the prognostic values of initial shockable rhythm, bystander cardiopulmonary resuscitation (CPR) and gender for neurological outcome and survival in adults treated with targeted temperature management (TTM) following cardiac arrest (CA). PubMed, Embase and the Cochrane Library were searched for eligible studies. Pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated to evaluate prognostic values using RevMan 5.3. The outcomes were favorable neurological outcome (defined as cerebral performance category of 1 and 2) and survival...
August 14, 2018: Heart & Lung: the Journal of Critical Care
Florian Ebner, Matt B A Harmon, Anders Aneman, Tobias Cronberg, Hans Friberg, Christian Hassager, Nicole Juffermans, Jesper Kjærgaard, Michael Kuiper, Niklas Mattsson, Paolo Pelosi, Susann Ullén, Johan Undén, Matt P Wise, Niklas Nielsen
BACKGROUND: Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined. METHODS: This is an exploratory post-hoc substudy of the Target Temperature Management (TTM) trial, including resuscitated OHCA patients, investigating the association between serial measurements of arterial partial carbon dioxide pressure (PaCO2 ) and neurological outcome at 6 months, defined by the Cerebral Performance Category (CPC) scale, dichotomized to good outcome (CPC 1 and 2) and poor outcome (CPC 3-5)...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
Ward Eertmans, Cornelia Genbrugge, Jolien Haesen, Carolien Drieskens, Jelle Demeestere, Margot Vander Laenen, Willem Boer, Dieter Mesotten, Jo Dens, Ludovic Ernon, Frank Jans, Cathy De Deyne
BACKGROUND: We previously validated simplified electroencephalogram (EEG) tracings obtained by a bispectral index (BIS) device against standard EEG. This retrospective study now investigated whether BIS EEG tracings can predict neurological outcome after cardiac arrest (CA). METHODS: Bilateral BIS monitoring (BIS VISTA™, Aspect Medical Systems, Inc. Norwood, USA) was started following intensive care unit admission. Six, 12, 18, 24, 36 and 48 h after targeted temperature management (TTM) at 33 °C was started, BIS EEG tracings were extracted and reviewed by two neurophysiologists for the presence of slow diffuse rhythm, burst suppression, cerebral inactivity and epileptic activity (defined as continuous, monomorphic, > 2 Hz generalized sharp activity or continuous, monomorphic, < 2 Hz generalized blunt activity)...
August 15, 2018: Neurocritical Care
Madhappan Santha Moorthy, Subramanian Bharathiraja, Panchanathan Manivasagan, Kang Dae Lee, Junghwan Oh
Mesoporous silica-based drug delivery carriers mostly require appropriate surface modifications to improve their drug delivery efficiency and to reduce their adverse side effects. In the present work, we have synthesised mesoporous silica nanoparticles and their surface was covered by using capping units such as tetrathio-maleimide (TTM) via a "host-guest" complexation mechanism for pH-responsive drug delivery applications. The surface-functionalised melamine (Mela) groups on the outer surface of the mesoporous silica nanoparticles act as "hosts" and the surface capped TTM units act as "guests" during the surface capping of the mesoporous silica nanoparticles via the "host-guest" complexation approach...
September 1, 2017: MedChemComm
Yeonho You, Jungsoo Park, Jinhong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Jinwoong Lee, Seungwhan Kim, Sunguk Cho, Sekwang Oh, Junwan Lee, Hongjoon Ahn, Byungkook Lee, Donghun Lee, Kiryang Na, Yongnam In, Chihwan Kwack, Jaein Lee
AIM: The optimal time to measure serum albumin concentration (SAC) to predict prognosis in cardiac arrest (CA) survivors has not been elucidated. We aimed to compare the relationships between time-related SAC, optic nerve sheath diameter (ONSD), intracranial pressure (ICP), and neurological prognosis in CA survivors. METHODS: We undertook a retrospective study examining CA patients treated with target temperature management (TTM). ICP was measured using cerebrospinal fluid (CSF) pressure and ONSD was obtained before TTM...
August 4, 2018: Resuscitation
Radames J B Cordero, Vincent Robert, Gianluigi Cardinali, Ebuka S Arinze, Susanna M Thon, Arturo Casadevall
Pigmentation is a fundamental characteristic of living organisms that is used to absorb radiation energy and to regulate temperature. Since darker pigments absorb more radiation than lighter ones, they stream more heat, which can provide an adaptive advantage at higher latitudes and a disadvantage near the Tropics, because of the risk of overheating. This intuitive process of color-mediated thermoregulation, also known as the theory of thermal melanism (TTM), has been only tested in ectothermic animal models [1-8]...
July 27, 2018: Current Biology: CB
Teresa L May, Richard R Riker, David J Gagnon, Christine Duarte, Barbara McCrum, Clifford Hoover, David B Seder
AIM: Shivering may interfere with targeted temperature management (TTM) after cardiac arrest, contributing to secondary brain injury. Early identification of shivering is challenging with existing tools. We hypothesized that shivering detected by continuous surface sEMG monitoring would be validated with calorimetry and detected earlier than by intermittent clinical observation. METHODS: This prospective observational study enrolled a convenience sample of comatose adult cardiac arrest patients treated with TTM at 33 °C...
July 24, 2018: Resuscitation
Hyo Joon Kim, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Hyung Ki Moon, Kyung Woon Jeung, Seung Pill Choi, In Soo Cho, Chun Song Youn
PURPOSE: This study aimed to elucidate the association between the neutrophil-to-lymphocyte ratio (NLR) and neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM). MATERIALS AND METHODS: A retrospective study was performed on patients treated with TTM after OHCA. Patients were divided into two groups according to their calculated NLRs (NLR < 6 and NLR ≥ 6). The primary outcome was poor neurological outcome at 6 months as defined by a Cerebral Performance Category between 3 and 5...
July 18, 2018: Journal of Critical Care
M Depmann, M J C Eijkemans, S L Broer, F Ramezani Tehrani, M Solaymani-Dodaran, F Azizi, C B Lambalk, J F Randolph, S D Harlow, E W Freeman, M D Sammel, W M M Verschuren, Y T van der Schouw, B W Mol, F J M Broekmans
Context: Anti-Müllerian hormone based (AMH) age at menopause predictions remain cumbersome due to predictive inaccuracy. Objective: To perform an Individual Patient Data (IPD) meta-analysis, regarding AMH based menopause prediction. Data sources: A systematic literature search was performed using PubMed, Embase and Cochrane databases. Study selection: Prospective cohort studies regarding menopause prediction using serum AMH levels were selected by consensus discussion...
July 18, 2018: Journal of Clinical Endocrinology and Metabolism
Maodian Liu, Yipeng He, Zofia Baumann, Chenghao Yu, Shidong Ge, Xuejun Sun, Menghan Cheng, Huizhong Shen, Robert P Mason, Long Chen, Qianggong Zhang, Xuejun Wang
Highly elevated concentrations of total mercury (THg) and methylmercury (MeHg) were found in the municipal sewage in Tibet. Material flow analysis supports the hypothesis that these elevated concentrations are related to regular ingestion of Hg-containing Traditional Tibetan Medicine (TTM). In Tibet in 2015, a total of 3600 kg of THg was released from human body into the terrestrial environment as a result of TTM ingestion, amounting to 45% of the total THg release into the terrestrial environment in Tibet, hence substantially enhancing the environmental Hg burden...
August 7, 2018: Environmental Science & Technology
Se Hyun Oh, Hui Dong Kang, Sang Ku Jung, Sangchun Choi
Cerebral arterial gas embolism (CAGE) shows various manifestations according to the quantity of gas and the brain areas affected. The symptoms range from minor motor weakness, headache, and confusion to disorientation, convulsions, hemiparesis, unconsciousness, and coma. A 46-year-old man was transferred to our emergency department due to altered sensorium. Immediately after a controlled ascent from 33 m of seawater, he complained of shortness of breath and rigid extremities, lapsing into unconsciousness...
July 17, 2018: Therapeutic Hypothermia and Temperature Management
Patrik Gilje, Martin Frydland, John Bro-Jeppesen, Josef Dankiewicz, Hans Friberg, Malin Rundgren, Yvan Devaux, Pascal Stammet, Mariam Al-Mashat, Jonas Jögi, Jesper Kjaergaard, Christian Hassager, David Erlinge
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Meng Qi, Wenjin Chen, Yuehong Bao, Yueqiao Xu, Ning Wan
Targeted temperature management (TTM) is often used in neuro-critical care to minimize secondary neurologic injury and improve outcomes. Evidence-based implementation guideline of TTM was generated from clinical questions relevant to TTM implementation for neuro-critical care by experts recruited by the American Neuro-critical Care Society. Interpretation of this guideline would help the readers to understand the implementation of TTM, bring benefits to standardization of TTM application, and contribute to the solving of specific issues related to TTM implementation...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jeong Ho Park, Jae Hun Oh, Seung Pill Choi, Jung Hee Wee
BACKGROUND: Outcome prediction is crucial for out-of-hospital cardiac arrest (OHCA) survivors. Several attempts have been made to use the bispectral index (BIS) for this purpose. We aimed to investigate the prognostic power of the BIS during the early stage of targeted temperature management (TTM) after OHCA. METHODS: From Jan 2014 to Feb 2017, the BIS was determined in OHCA patients as soon as possible after the start of TTM. We injected a neuro-muscular blocking agent and recoded the BIS value and the time when the electromyographic (EMG) factor reached zero...
July 13, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Halvard Gautefall Hiis, Marie Victoire Cosson, Christen P Dahl, Arnt E Fiane, Finn Olav Levy, Geir Øystein Andersen, Kurt Allen Krobert
Targeted temperature management (TTM) is part of the standardized treatment for cardiac arrest patients. Hypothermia decreases cerebral oxygen consumption and induces bradycardia, thus, increasing the heart rate may be considered to maintain cardiac output. We hypothesized that increasing heart rate during hypothermia would impair diastolic function. Human left ventricular trabeculae obtained from explanted hearts of patients with terminal heart failure were stimulated at 0.5 Hz and contraction-relaxation cycles recorded...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Hormoz Sanaeinasab, Mohsen Saffari, Firouz Valipour, Hassan Reza Alipour, Mojtaba Sepandi, Faten Al Zaben, Harold G Koenig
PURPOSE: Lack of knowledge about computer ergonomics predisposes users to musculoskeletal and visual disorders. The present study examined the effect of a trans-theoretical model (TTM)-based educational program on work-related posture in office computer users. METHODS: This experimental study examined 102 hospital personnel whose primary job involved working at a computer. Participants were randomized to intervention and control groups. An educational intervention based on TTM was conducted over five sessions...
July 9, 2018: International Archives of Occupational and Environmental Health
Zirui Huang, Jun Zhang, Jinsong Wu, Xiaoge Liu, Jianghui Xu, Jianfeng Zhang, Pengmin Qin, Rui Dai, Zhong Yang, Ying Mao, Anthony G Hudetz, Georg Northoff
Variability quenching is a widespread neural phenomenon in which trial-to-trial variability (TTV) of neural activity is reduced by repeated presentations of a sensory stimulus. However, its neural mechanism and functional significance remain poorly understood. Recurrent network dynamics are suggested as a candidate mechanism of TTV, and they play a key role in consciousness. We thus asked whether the variability-quenching phenomenon is related to the level of consciousness. We hypothesized that TTV reduction would be compromised during reduced level of consciousness by propofol anesthetics...
July 4, 2018: Human Brain Mapping
Jörg Peter, Kathrin Klingert, Wilfried Klingert, Karolin Thiel, Alfred Königsrainer, Christian Grasshoff, Wolfgang Rosenstiel, Martin Schenk
BACKGROUND: Management of a patient's body temperature is an important aspect of care that should be addressed by targeted temperature management (TTM). Often, non-invasive methods like forced-air blankets are used. Especially in the operating room this management may be a subsidiary and repetitive task requiring constant observation of the patient's body temperature and adaption using the limited set of available settings. Thus, automation of TTM is a feasible target to improve patient outcome and reduce caregiver workload...
July 3, 2018: BMC Anesthesiology
Alireza Rahimi, Mozhdeh Hashemzadeh, Firoozeh Zare-Farashbandi, Amir Mansur Alavi Naeini, Akbar Hasanzadeh
BACKGROUND/AIM: Today, the problem of obesity is a chronic condition that affects all age groups in developed and developing countries. Since adolescence is a transitional period and behavioral patterns formed in this period affect people in their adult years, attention to obesity and extra weight in this age group is more important than other groups. Therefore, this study aims to investigate the effects of nutrition education course on awareness of female 1st -year high school students of Isfahan based on transtheoretical model ( TTM) of behavioral change...
2018: Journal of Education and Health Promotion
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