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Da-Cheng Hao, Pei-Gen Xiao, Chang Liu
Around 70-80% of drugs used in traditional Tibetan medicine (TTM) come from Qinghai Tibet Plateau, the majority of which are plants. The biological and medicinal culture diversity on Qinghai Tibet Plateau are amazing and constitute a less tapped resource for innovative drug research and development. Meanwhile, the problem of the exhausting Tibetan medicine resources is worrying. Here, the latest awareness, as well as the gaps of the traditional Tibetan medicinal plant issues in drug development and clinical usage of TTM compounds, was systematically reviewed and highlighted...
November 30, 2018: Future Medicinal Chemistry
Cecilia Andréll, Josef Dankiewicz, Christian Hassager, Janneke Horn, Jesper Kjærgaard, Matilde Winther-Jensen, Matt P Wise, Niklas Nielsen, Pascal Stammet, Hans Friberg
BACKGROUND: The majority of out-of-hospital cardiac arrests (OHCAs) occur at place residence, which is associated with worse outcomes in unselected prehospital populations. Our aim was to investigate whether location of arrest was associated with outcome in a selected group of initial survivors admitted to intensive care. METHODS: This is a post-hoc analysis of the Targeted Temperature Management after cardiac arrest trial (TTM trial), a multicenter controlled trial, randomizing 950 OHCA patients to an intervention of 33°C or 36°C...
November 22, 2018: Minerva Anestesiologica
Mohammad Jafferany, Arsh Patel
Trichotillomania (TTM) is a disorder characterized by recurrent episodes of hair pulling that affects a growing and diverse patient population. The behavior is a result of conscious or unconscious stimuli aimed at alleviating stress. TTM can be diagnosed, typically by a psychiatrist or dermatologist, with various assessment tools and scales. Although researchers continue to discover new pharmacologic regimens and nonpharmacologic therapies, there is no single, effective, US Food and Drug Administration-approved option available for patients...
November 22, 2018: Primary Care Companion to CNS Disorders
Benjamin N Cragun, Frances Hite Philp, John O'Neill, Matthew R Noorbakhsh, Rachel P Tindall, Allan S Philp, Michael F Ditillo
Therapeutic hypothermia (TH) and targeted temperature management (TTM) have been shown to improve outcomes in survivors of cardiac arrest, but prior research has excluded trauma and postoperative patients. We sought to determine whether TH/TTM is safe in trauma and surgical patients. A retrospective cohort study was conducted at a single level I trauma center reviewing adults presenting as a traumatic arrest or cardiac arrest in the postoperative period with a Glasgow Coma Scale <8 after return of circulation who were treated with either TH or TTM...
November 22, 2018: Therapeutic Hypothermia and Temperature Management
Ram Gowda, Matthew Jaffa, Neeraj Badjatia
Different mechanisms explain thermoregulatory dysfunction following ischemic stroke, hemorrhagic stroke, and traumatic brain injury. Temperature instability following brain injury likely involves hypothalamic injury, pathologic changes in cerebral blood flow, metabolic derangement, and a neurogenic inflammatory response. Although targeted temperature management (TTM) exerts pleiotropic effects, the heterogeneity of brain injury has hindered identification of patient subsets most likely to benefit from TTM. Early optimism about TTM's role in brain injury has been tempered by the failure of successive clinical trials to show improved patient outcomes...
2018: Handbook of Clinical Neurology
Sini Saarinen, Ari Salo, James Boyd, Päivi Laukkanen-Nevala, Catharina Silfvast, Ilkka Virkkunen, Tom Silfvast
BACKGROUND: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) with pulseless electrical activity (PEA) as initial cardiac rhythm are not always treated in intensive care units (ICUs): some are admitted to high dependency units with various level of care, others to ordinary wards. Aim of this study was to describe the factors determining level of hospital care after OHCA with PEA, post-resuscitation care and survival. METHODS: Adult OHCA patients with PEA (n = 221), who were resuscitated in southern Finland between 2010 and 2013 were included, provided patient survived to hospital admission...
November 19, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Kirk von Sternberg, Carlo C DiClemente, Mary M Velasquez
Using data from Project CHOICES, a randomized controlled trial to test an intervention to prevent alcohol-exposed pregnancies, this study examined process of change profiles composed of Transtheoretical Model of Change (TTM) constructs for alcohol. The primary purpose was to identify a profile of TTM variables associated with reduced drinking. Participants (n = 570) were women at risk of an alcohol-exposed pregnancy recruited from high risk settings. Profile analyses compared end-of-treatment (i.e., 3 months postintake) TTM construct mean profiles for women who reduced drinking to below NIAAA-defined risk levels1 (changers) with women who continued to drink at risk levels (nonchangers) at the 9-month follow-up...
November 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Sharaf Khan, Chad M Meyers, Suzanne Bentley, Alex F Manini
INTRODUCTION: Drug overdose is the leading cause of non-traumatic out-of-hospital cardiac arrest (OHCA) among young adults. This study investigates whether targeted temperature management (TTM) improves hospital survival from presumed overdose-related cardiac arrest. METHODS: Retrospective chart review of consecutive cardiac arrests presenting to an urban tertiary care hospital ED from 2011 to 2015. ED patients with cardiac arrest were included if < 50 years old, and excluded if there was a non-overdose etiology (e...
November 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Aditya K Gupta, Rachel R Mays
Purpose: Onychomycosis is a nail disorder that is increasing in prevalence worldwide. The psychological and social limitations caused by onychomycosis can potentially undermine the work and social lives of those experiencing these negative effects. This review aimed to evaluate the randomized controlled trials (RCTs) available in the current literature on the impact onychomycosis has on quality of life (QoL). Methods: A systematic review was performed using the databases PubMed, PsycINFO, Scopus, ClinicalTrials...
October 2018: Skin Appendage Disorders
Zhiyuan Cui, Shaofeng Ye, Lu Wang, Haoqing Guo, Ablikim Obolda, Shengzhi Dong, Yingxin Chen, Xin Ai, Alim Abdurahman, Ming Zhang, Lei Wang, Feng Li
A new luminescent radical, tris-2,4,6-trichlorophenylmethyl-1,5-diazarcarbazole (TTM-DACz), was synthesized and characterized. The photoluminescence quantum yield of TTM-DACz in solid 1,3,5-tris(1-phenyl-1H-benzimidazol-2-yl)benzene matrix film (5 wt %) is as high as 57.0%. Organic light-emitting diodes (OLEDs) employing TTM-DACz as the emitter were fabricated. By rational design of the device structure and host-guest doping system, external quantum efficiency (EQE) of up to 10.6% of the optimized device with a red CIE chromaticity of (0...
November 15, 2018: Journal of Physical Chemistry Letters
S Meißner, S Nuding, J Schröder, K Werdan, H Ebelt
BACKGROUND: According to ILCOR (International Liaison Committee on Resuscitation) recommendations (released in 2003), use of therapeutic hypothermia is recommended for unconscious adult patients who have survived a cardiac arrest regardless of the initial monitored cardiac rhythm. Thereby, the treatment goal is to achieve and maintain a body temperature of 32-34 °C for a period of 12-24 h. According to the October 2015 recommendations of the European Resuscitation Council (ERC), targeted temperature management (TTM) remains part of treatment, but, as an option, it is advised that the targeted body temperature be 36 °C rather than 32-34 °C...
November 5, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Christophe Henri Valdemar Duez, Birger Johnsen, Mads Qvist Ebbesen, Marie Bu Kvaløy, Anders Morten Grejs, Anni Nørgaard Jeppesen, Eldar Søreide, Jørgen Feldbæk Nielsen, Hans Kirkegaard
OBJECTIVE: To test if prognostic performance is affected by prolonged targeted temperature management (TTM) in comatose out-of-hospital cardiac arrest patients using two recently proposed EEG pattern classification models. METHODS: In this sub-study of the "Target Temperature Management for 48 vs. 24 hours and Neurologic Outcome after Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial", EEGs of 20-30 minutes duration were collected 24 h and 48 h after reaching the target temperature of 33 ± 1 °C...
October 31, 2018: Resuscitation
Kazuhiro P Izawa, Koichiro Oka
This study aimed to determine differences in sitting behavior time (SBT) and health-related quality of life (HRQOL) based on application of the transtheoretical model (TTM) to exercise behavior in overseas-dwelling Japanese. SBT, HRQOL, and various sociodemographic factors were measured in 108 Japanese living in Ipoh, Malaysia. Subjects were classified into the non-exercise (NE), preparation (P), and exercise (E) groups. Workday, non-workday, and total-day SBTs were identified by self-reported questionnaire...
January 2018: Gerontology & Geriatric Medicine
Mattias Bohm, Gisela Lilja, Hafrún Finnbogadóttir, Tobias Cronberg, Johan Undén, Hans Friberg, Jesper Kjærgaard, Niklas Nielsen, Matt P Wise, Eva Åkerman
AIM: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. METHODS: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2® (SF-36v2® ) at a structured follow-up 6 months after out-of-hospital cardiac arrest (OHCA)...
October 29, 2018: Resuscitation
Maryam Khazaee-Pool, Leila Jahangiry, Tahereh Pashaei, Farhad Ramezani-Badr, Haidar Nadrian, Koen Ponnet
BACKGROUND: Drug misuse is a major problem that has an extreme negative effect on people's health. Methamphetamine (MA) is frequently used by young adults, despite its harmful consequences. The Transtheoretical Model (TTM) has been known to be very effective in explaining both the achievement and cessation of several health-related behaviors. Therefore, in this study, the TTM was used toward the domain of immoderate MA use among young adults. This study aimed to test the validity and reliability of a decisional balance scale for MA use in young adults...
October 29, 2018: Substance Abuse Treatment, Prevention, and Policy
Xi Liu, Zhi-Gang Yang, Yue Gao, Lin-Jun Xie, Li Jiang, Bi-Yue Hu, Kai-Yue Diao, Ke Shi, Hua-Yan Xu, Meng-Ting Shen, Yan Ren, Ying-Kun Guo
BACKGROUND: Early detection of subclinical myocardial dysfunction in patients with diabetes mellitus (DM) is essential for recommending therapeutic interventions that can prevent or reverse heart failure, thereby improving the prognosis in such patients. This study aims to quantitatively evaluate left ventricular (LV) myocardial deformation and perfusion using cardiovascular magnetic resonance (CMR) imaging in patients with type 2 diabetes mellitus (T2DM), and to investigate the association between LV subclinical myocardial dysfunction and coronary microvascular perfusion...
October 30, 2018: Cardiovascular Diabetology
Ahmed Jerôme Romain, Catherine Bortolon, Mathieu Gourlan, Marion Carayol, Emmanuelle Decker, Olivier Lareyre, Grégory Ninot, Julie Boiché, Paquito Bernard
Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model (TTM)-based interventions on physical activity (PA) varied according to the following criteria: (1) interventions targeted the actual stages of change (SOCs) or did not; (2) participants were selected according to their SOC or were not; and (3) its theoretical constructs (decisional balance, temptation, self-efficacy, processes of change). Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically identified...
January 2018: Journal of Sport and Health Science
Samuel A Shabtaie, Alan Sugrue, Nicholas Y Tan, Samuel Asirvatham, David L Hayes
PURPOSE: The evolution of heart rhythm monitoring technology over the past few decades has seen a decline in the use and need of transtelephonic monitoring (TTM). We sought to establish a predicted date for the sun setting of TTM at our institution, as well as establish the current demographics of the patients still using this technology. METHODS: We retrospectively reviewed all patients with permanent pacemakers receiving routine device follow-up at our institution (Mayo Clinic-Rochester) between 2015 and 2018...
October 23, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Esteban Lopez-de-Sa, Miriam Juarez, Eduardo Armada, José C Sanchez-Salado, Pedro L Sanchez, Pablo Loma-Osorio, Alessandro Sionis, Maria C Monedero, Manuel Martinez-Sellés, Juán C Martín-Benitez, Albert Ariza, Aitor Uribarri, José M Garcia-Acuña, Patricia Villa, Pablo J Perez, Christian Storm, Anne Dee, Jose L Lopez-Sendon
PURPOSE: To obtain initial data on the effect of different levels of targeted temperature management (TTM) in out-of-hospital cardiac arrest (OHCA). METHODS: We designed a multicentre pilot trial with 1:1:1 randomization to either 32 °C (n = 52), 33 °C (n = 49) or 34 °C (n = 49), via endovascular cooling devices during a 24-h period in comatose survivors of witnessed OHCA and initial shockable rhythm. The primary endpoint was the percentage of subjects surviving with good neurologic outcome defined by a modified Rankin Scale (mRS) score of ≤ 3, blindly assessed at 90 days...
November 2018: Intensive Care Medicine
Taro Irisawa, Tasuku Matsuyama, Taku Iwami, Tomoki Yamada, Koichi Hayakawa, Kazuhisa Yoshiya, Kazuo Noguchi, Tetsuro Nishimura, Toshifumi Uejima, Yoshiki Yagi, Takeyuki Kiguchi, Masafumi Kishimoto, Makoto Matsuura, Yasuyuki Hayashi, Taku Sogabe, Takaya Morooka, Tetsuhisa Kitamura, Takeshi Shimazu
BACKGROUND: It has been insufficiently investigated whether neurological function after out-of-hospital cardiac arrest (OHCA) would differ by 1 °C change in ordered target temperature of 33-36 °C among patients undergoing targeted temperature management (TTM) in the real-world setting. METHODS: This nationwide hospital-based observational study (The Japanese Association for Acute Medicine-OHCA Registry) conducted between June 2014 and December 2015 in Japan included OHCA patients aged ≥18 years who were treated with TTM...
October 11, 2018: Resuscitation
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