Michael M Safaee, Varun B Dwaraka, Justin M Lee, Marissa Fury, Tavis L Mendez, Ryan Smith, Jue Lin, Dana L Smith, John F Burke, Justin K Scheer, Hannah Went, Christopher P Ames
OBJECTIVE: Surgery for spinal deformity has the potential to improve pain, disability, function, self-image, and mental health. These surgical procedures carry significant risk and require careful selection, optimization, and risk assessment. Epigenetic clocks are age estimation tools derived by measuring the methylation patterns of specific DNA regions. The study of biological age in the adult deformity population has the potential to shed insight onto the molecular basis of frailty and to improve current risk assessment tools...
December 1, 2023: Journal of Neurosurgery. Spine