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https://www.readbyqxmd.com/read/30321391/structural-basis-for-dna-break-recognition-by-artd2-parp2
#1
Ezeogo Obaji, Teemu Haikarainen, Lari Lehtiö
Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and other proteins, initiating a cascade of events leading to DNA repair. In contrast to ARTD1, the founding member of the enzyme family, ARTD2 does not have specialized zinc-fingers for detecting DNA damage. The domain organization of ARTD2 includes disordered N-terminus, WGR and catalytic domains. However, the N-terminus of ARTD2 is not strictly required for the DNA dependent activity...
October 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30320422/evaluation-of-radiopacity-of-luting-cements-submitted-to-different-aging-procedures
#2
Rafael B Junqueira, Rodrigo F Carvalho, Felipe Agf Yamamoto, Solange M Almeida, Francielle S Verner
PURPOSE: To evaluate the radiopacity of luting cements submitted to different aging procedures. MATERIALS AND METHODS: Twenty discs (1 × 4 mm) of each of the following cements were prepared: zinc phosphate, RelyX Luting 2, Variolink 2, AllCem, RelyX U200, Multilink, Panavia F2.0 and RelyX ARC. Then, they were randomly divided into 2 groups (n = 10/group), according to the aging procedure: thermal cycling group and water storage group. Before and after aging procedures, specimens were x-rayed with an aluminum step-wedge (11 steps, 1 mm thick each) and 3 dental slices (1 mm thick)...
October 15, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/30310898/influence-of-the-metals-and-ligands-in-dinuclear-complexes-on-phosphopeptide-sequencing-by-electron-transfer-dissociation-tandem-mass-spectrometry
#3
Daiki Asakawa, Akio Miyazato, Frédéric Rosu, Valérie Gabelica
Phosphorylation is one of the most important protein modifications, and electron-transfer dissociation tandem mass spectrometry (ETD-MS/MS) is a potentially useful method for the sequencing of phosphopeptides, including determination of the phosphorylation site. Notably, ETD-MS/MS typically provides useful information when the precursor contains more than three positive charges. It is not yet used as an analysis method for large-scale phosphopeptide production due to difficulties occurring in the production of acidic phosphopeptides having more than three positive charges...
October 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30286279/zinc-incorporated-microporous-for-mild-catalytic-hydrolysis-of-gamma-valerolactone-a-new-selective-route-for-biomass-conversion
#4
Wei-Che Lin, Lin Ye, Simson Wu, Ben Lo, Yung-Kang Peng, Pu Zhao, Ian Mcpherson, Edman Shik Chi Tsang
Gamma-valerolactone (GVL) is regarded as a key platform molecule in the production of fine chemicals such as pentenoic acid (PA) from biomass. Although PA is believed to be the key intermediate in solid acid catalyzed reactions of GVL, due to subsequent facile decarboxylation reactions, further alkene products were formed. Here, by tailoring the acidity of Brønsted acid sites in an alumino-phosphate (AlPO) molecular sieve via incorporation of Zn2+ into the framework, we access a new selective, high yield catalytic route for GVL conversion to PA...
October 4, 2018: ChemSusChem
https://www.readbyqxmd.com/read/30277746/substrate-profile-of-the-phosphotriesterase-homology-protein-from-escherichia-coli
#5
Venkatesh Nemmara, Dao Feng Xiang, Alexander Fedorov, Elena V Fedorov, Jeffrey B Bonanno, Steven C Almo, Frank M Raushel
The phosphotriesterase homology protein (PHP) from Escherichia coli is a member of a family of proteins that is related to phosphotriestrase (PTE), a bacterial enzyme from cog1735 with unusual substrate specificity towards the hydrolysis of synthetic organic phosphates and phosphonates. PHP was cloned, purified to homogeneity, and functionally characterized. The three-dimensional structure of PHP was determined at a resolution of 1.84 Å with zinc and phosphate ions in the active site. The protein folds as a distorted (β/α)8-barrel and possesses a binuclear metal center in the active site...
October 2, 2018: Biochemistry
https://www.readbyqxmd.com/read/30275506/superoxide-dismutase-activity-enabled-by-a-redox-active-ligand-rather-than-metal
#6
Meghan B Ward, Andreas Scheitler, Meng Yu, Laura Senft, Annika S Zillmann, John D Gorden, Dean D Schwartz, Ivana Ivanović-Burmazović, Christian R Goldsmith
Reactive oxygen species are integral to many physiological processes. Although their roles are still being elucidated, they seem to be linked to a variety of disorders and may represent promising drug targets. Mimics of superoxide dismutases, which catalyse the decomposition of O2 •- to H2 O2 and O2 , have traditionally used redox-active metals, which are toxic outside of a tightly coordinating ligand. Purely organic antioxidants have also been investigated but generally require stoichiometric, rather than catalytic, doses...
October 1, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/30274184/influence-of-luting-materials-on-the-retention-of-cemented-implant-supported-crowns-an-in-vitro-study
#7
Ella A Naumova, Felix Roth, Berit Geis, Christine Baulig, Wolfgang H Arnold, Andree Piwowarczyk
The retention force of cemented crowns on implant abutments with various luting materials was evaluated. Cobalt⁻chromium crowns were cemented onto tapered titanium abutments (Camlog) with eugenol-free temporary cement (RelyX TempBond NE), composite-based temporary cement (Bifix Temp), zinc phosphate cement (Harvard Cement), glass-ionomer cements (Meron, Fuji I), and resin-modified glass-ionomer cements (Fuji II, Fuji Plus, Ketac Cem Plus). Specimen aging via hydrostress was performed in artificial saliva at 37 °C for 14 days (S1), followed by hydrothermal stress with thermocycling (S2)...
September 28, 2018: Materials
https://www.readbyqxmd.com/read/30273782/environmental-pollution-and-toxic-substances-cellular-apoptosis-as-a-key-parameter-in-a-sensible-model-like-fish
#8
REVIEW
Hossein AnvariFar, A K Amirkolaie, Ali M Jalali, H K Miandare, Alaa H Sayed, Sema İşisağ Üçüncü, Hossein Ouraji, Marcello Ceci, Nicla Romano
The industrial wastes, sewage effluents, agricultural run-off and decomposition of biological waste may cause high environmental concentration of chemicals that can interfere with the cell cycle activating the programmed process of cells death (apoptosis). In order to provide a detailed understanding of environmental pollutants-induced apoptosis, here we reviewed the current knowledge on the interactions of environmental chemicals and programmed cell death. Metals (aluminum, arsenic, cadmium, chromium, cobalt, zinc, copper, mercury and silver) as well as other chemicals including bleached kraft pulp mill effluent (BKME), persistent organic pollutants (POPs), and pesticides (organo-phosphated, organo-chlorinated, carbamates, phyretroids and biopesticides) were evaluated in relation to apoptotic pathways, heat shock proteins and metallothioneins...
September 22, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/30270484/znf185-derived-peptide-induces-fertility-suppression-in-mice
#9
Shutong Fan, Yuhan Zhao, Zhiwei Pan, Zhiqin Gao, Zumu Liang, Zhifang Pan, Weiguo Feng
Zinc finger protein 185 (ZNF185) belongs to the ZNF family and is involved in male reproduction. However, it is unclear whether ZNF185 may be a target candidate for contraceptive vaccines. In this study, antigenic peptides derived from ZNF185 were prepared, and their immune contraceptive effects were investigated using mice. Results from enzyme-linked immunosorbent assay (ELISAs) showed that peptide immunization induced an antibody titre increase that reached a peak in week 12. Peptide-3 and peptide-4 were then chosen for subsequent experiments...
October 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30240432/phosphate-solubilizing-bacteria-with-glucose-dehydrogenase-gene-for-phosphorus-uptake-and-beneficial-effects-on-wheat
#10
Muhammad Suleman, Sumera Yasmin, Maria Rasul, Mahreen Yahya, Babar Manzoor Atta, Muhammad Sajjad Mirza
The aim of this study was to isolate, characterize and use phosphate solubilizing bacteria to enhance the bioavailability of insoluble Ca-phosphate for wheat plants. For this purpose, 15 phosphorus solubilizing bacteria (PSB) were isolated from wheat rhizospheric soils of Peshawar and southern Punjab region, Pakistan. These isolates were identified using light microscopy and 16S rRNA gene. Among the isolated bacteria, two strains (Pseudomonas sp. MS16 and Enterobacter sp. MS32) were the efficient P solubilizers based on their P solubilization activity determined qualitatively (solubilization index 3...
2018: PloS One
https://www.readbyqxmd.com/read/30231201/zinc-coordinated-cationic-polymers-break-up-the-paradox-between-low-molecular-weight-and-high-transfection-efficacy
#11
Shuai Liu, Huiting Jia, Jixiang Yang, Jianping Pan, Huiyun Liang, Liheng Zeng, Hao Zhou, Jiatong Chen, Tianying Guo
Cationic polymers have emerged as appealing nonviral gene vectors for decades, which, however, suffer from the paradox between low molecular weight and high transfection efficacy. Low molecular weight cationic polymers (LCPs) are well cell tolerated but are perplexed by orders-of-magnitude less efficacy compared to their macromolecular counterparts. The deficiency mainly lies in weak DNA binding of polymers and difficulty in endosomal escape of formulated polyplexes. Herein, we demonstrate that, through zinc (Zn) coordinated modification of LCPs, the high transfection efficiency and low molecular weight (thus low cytotoxicity) can be achieved simultaneously...
October 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30226742/calcium-phosphate-nanoparticles-as-intrinsic-inorganic-antimicrobials-the-antibacterial-effect
#12
Victoria M Wu, Sean Tang, Vuk Uskoković
Cheap and simple to make, calcium phosphate (CP), thanks to its unusual functional pleiotropy, belongs to the new wave of abundant and naturally accessible nanomaterials applicable as a means to various technological ends. It is used in a number of industries, including the biomedical, but its intrinsic antibacterial activity in the nanoparticle form has not been sufficiently explored to date. In this study, we report on this intrinsic antibacterial effect exhibited by two distinct CP phases: an amorphous CP (ACP) and hydroxyapatite (HAp)...
September 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30218229/mineral-density-changes-in-bovine-carious-dentin-after-treatment-with-bioactive-dental-cements-a-comparative-micro-ct-study
#13
Aline Borburema Neves, Tamiris Gomes Bergstrom, Andréa Fonseca-Gonçalves, Thais Maria Pires Dos Santos, Ricardo Tadeu Lopes, Aline de Almeida Neves
OBJECTIVES: To evaluate the potential of conventional glass ionomer cement (GIC), Biodentine™, MTA, and Portland cement to induce mineral density changes in carious dentin compared to zinc oxide eugenol control cement (ZOE). MATERIALS AND METHODS: Fifty blocks of bovine root dentin were prepared and a biofilm model using ATCC strains of S.mutans, S.sobrinus, and L.casei was used to promote artificial dentin lesions. After demineralization, the blocks were randomly divided into the five cement groups...
September 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30212894/distinctive-structural-basis-for-dna-recognition-by-the-fission-yeast-zn2cys6-transcription-factor-pho7-and-its-role-in-phosphate-homeostasis
#14
Angad Garg, Yehuda Goldgur, Beate Schwer, Stewart Shuman
Pho7, a member of the Zn2Cys6 family of fungal transcription factors, is the key transcriptional activator underlying fission yeast phosphate homeostasis, a physiological response to phosphate starvation in which the pho1, pho84 and tgp1 genes are upregulated. Here, we delineated a minimized 61-amino-acid Pho7 DNA-binding domain (DBD) and determined the 1.7 Å crystal structure of the DBD at its target site in the tgp1 promoter. Two distinctive features of the Pho7 DBD are: it binds DNA as a monomer, unlike most other fungal zinc-cluster factors that bind as homodimers; and it makes extensive interactions with its asymmetric target sequence over a 14-bp footprint that entails hydrogen bonding to 13 individual bases within, and remote from, the CGG triplet typically recognized by other Zn2Cys6 DBDs...
September 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30208598/novel-porous-phosphorus%C3%A2-calcium%C3%A2-magnesium-coatings-on-titanium-with-copper-or-zinc-obtained-by-dc-plasma-electrolytic-oxidation-fabrication-and-characterization
#15
Krzysztof Rokosz, Tadeusz Hryniewicz, Sofia Gaiaschi, Patrick Chapon, Steinar Raaen, Dalibor Matýsek, Łukasz Dudek, Kornel Pietrzak
In this paper, the characteristics of new porous coatings fabricated at three voltages in electrolytes based on H₃PO₄ with calcium nitrate tetrahydrate, magnesium nitrate hexahydrate, and copper(II) nitrate trihydrate are presented. The SEM, energy dispersive spectroscopy (EDS), glow discharge optical emission spectroscopy (GDOES), X-ray photoelectron spectroscopy (XPS), and XRD techniques for coating identification were used. It was found that the higher the plasma electrolytic oxidation (PEO) (micro arc oxidation (MAO)) voltage, the thicker the porous coating with higher amounts of built-in elements coming from the electrolyte and more amorphous phase with signals from crystalline Ca(H₂PO₄)₂∙H₂O and/or Ti(HPO₄)₂∙H₂O...
September 11, 2018: Materials
https://www.readbyqxmd.com/read/30196463/influence-of-phosphate-amendment-and-zinc-foliar-application-on-heavy-metal-accumulation-in-wheat-and-on-soil-extractability-impacted-by-a-lead-smelter-near-jiyuan-china
#16
Weiqin Xing, Enze Cao, Kirk G Scheckel, Xiaoming Bai, Liping Li
Higher concentrations of Pb and Cd in wheat grains harvested in several lead-smelting-polluted areas in northern China have been reported. This field experiment was conducted to investigate the effect of phosphate amendment and Zn foliar application on the accumulation of Pb and Cd in wheat grains grown in a lead-smelting impacted area in Jiyuan in northern China. The soil (total Pb and Cd are 261 and 2.65 mg kg-1 , respectively) was amended with superphosphate at P:Pb ratios (mol:mol) of 1.90 or 2.57 either during wheat (Triticum aestivum L...
November 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30194387/mechanism-s-of-action-of-heavy-metals-to-investigate-the-regulation-of-plastidic-glucose-6-phosphate-dehydrogenase
#17
Alessia De Lillo, Manuela Cardi, Simone Landi, Sergio Esposito
The regulation of recombinant plastidic glucose-6P dehydrogenase from Populus trichocarpa (PtP2-G6PDH - EC 1.1.1.49) was investigated by exposing wild type and mutagenized isoforms to heavy metals. Nickel and Cadmium caused a marked decrease in PtP2-G6PDH WT activity, suggesting their poisoning effect on plant enzymes; Lead (Pb++ ) was substantially ineffective. Copper (Cu++ ) and Zinc (Zn++ ) exposition resulted in strongest decrease in enzyme activity, thus suggesting a physiological competition with Magnesium, a well-known activator of G6PDH activity...
September 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30193182/mechanical-and-biological-performance-of-axially-loaded-novel-bio-nanocomposite-sandwich-plate-type-implant-coated-by-biological-polymer-thin-film
#18
S Sahmani, S Saber-Samandari, M Shahali, H Joneidi Yekta, F Aghadavoudi, A H Montazeran, M M Aghdam, A Khandan
Post-surgical infection is one of the essential problems in bone scaffolds that is usually treated with antibiotics. This issue may be related to the poor blood supply for bone tissue due to high concentrations of drug. In the current study, the effect of zinc oxide (ZnO) nanoparticles on the antibacterial behavior of the nanocrystalline hydroxyapatite (n-HA) scaffolds coated by gelatin-ibuprofen (GN-IBO) is evaluated. To this end, the bio-nanocomposite scaffolds are fabricated via the space holder technique and then characterized with the aid of X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM)...
August 24, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/30177593/restoration-strategies-of-endodontically-treated-teeth-among-dental-practitioners-in-saudi-arabia-a-nationwide-pilot-survey
#19
Abdulrahman Alenzi, Abdulaziz Samran, Ahlam Samran, Mohammad Zakaria Nassani, Mustafa Naseem, Zohaib Khurshid, Mutlu Özcan
The purpose of this study was to determine dental practitioners' opinions, techniques, and materials used for the restoration of endodontically treated teeth (ETT) in Saudi Arabia. A comprehensive nationwide survey regarding treatment strategies of ETT, on the post types and material used for core foundations were distributed either by email or by hard copies to general dentists in different parts of Saudi Arabia (North, South, West, East, and Center). Descriptive statistics were used to analyze the responses to the questions...
September 3, 2018: Dentistry journal
https://www.readbyqxmd.com/read/30171723/comparison-between-the-effect-of-human-wharton-s-jelly-derived-mesenchymal-stem-cells-and-levetiracetam-on-brain-infarcts-in-rats
#20
Dalia M Abd El Motteleb, Samia Hussein, Mai M Hasan, Hala Mosaad
BACKGROUND: Stroke represents one of the major causes of death worldwide. Neuroprotection remains an important goal of stroke therapy. Stem cell therapeutic effect is attributed to the neuroprotective effect and the regulation of the oxidant stress. Levetiracetam (LEV), a second-generation antiepileptic drug, was reported to confer neuronal protection after cerebral ischemia reperfusion. AIM: To investigate the effect of human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) and LEV on the size of brain infarcts, the histological structure, the neurotrophic, and the antioxidant gene expression in middle cerebral artery occlusion in rats...
September 1, 2018: Journal of Cellular Biochemistry
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