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Pavan M V Raja, Gibran L Esquenazi, Kourtney D Wright, Cathren E Gowenlock, Bruce E Brinson, Shirin Alexander, Daniel R Jones, Varun Shenoy Gangoli, Andrew R Barron
The electromigration behaviour of raw and acid purified single walled carbon nanotubes (SWCNTs) in dilute aqueous systems (0.0034 mg mL-1), in the absence of surfactant, with the addition of either 0.85 M acetic acid or 0.1 M CuSO4, was evaluated using a 2-inch copper cathode and either a 2-inch copper or 0.5-inch platinum anode. The results showed that the electromigration of raw SWCNTs (with a high catalyst residue) in the presence of CuSO4 resulted in the formation of a Cu-SWCNT composite material at the cathode...
October 16, 2018: Nanoscale
Imen Ammous, Omar Hadj Said, Mejdi Boukari, Imen Zhioua, Khalil Errais, Raja Zhioua
Cranial nerves palsy associated with preeclampsia is reported in literature. Facial and abducens palsies were the most nerve disorders described. Only eleven cases have been reported in the literature. We report the case of a 27-years-old patient who presented abducens nerve palsy in immediately after the delivery of severe pre-eclampsia. No specific pathology was found. Symptoms of abducens nerve palsy have resolved spontaneously by controlling blood pressure after delivery.
January 2018: La Tunisie Médicale
Raja Kalaiarasi, Avvaru Satya Kiran, Chellappa Vijayakumar, Ramakrishnan Venkataramanan, Manusrut Manusrut, Ravi Prabhu
Introduction Facial nerve has the longest and complex course in its bony canal. The anatomical variations make the nerve prone to injury during mastoid surgeries. Having a thorough anatomical knowledge and its variations is must for the surgeons to avoid injury to this vital structure and for the safe surgery. The objective of the study was to describe the anatomical variations of intratemporal portion of facial nerve. Materials and methods The study was conducted in the department of otorhinolaryngology in the temporal bone dissection laboratory of a tertiary health care centre...
August 2, 2018: Curēus
S Kumar, K Raja, S Gnanasekaran, B Pottakkat
Intussusception in adolescents is usually idiopathic in nature. A 17-year-old woman with diffuse large B cell lymphoma presented with signs of intestinal obstruction after initiation of induction chemotherapy. On evaluation, the patient was diagnosed to have ileoileal intussusception with intestinal lymphangiectasia as the lead point. Intestinal lymphangiectasia as a rare cause for intussusception and its relationship with lymphoma is discussed in this case report.
October 16, 2018: Annals of the Royal College of Surgeons of England
Mansi Gandhi, Desikan Rajagopal, Sampath Parthasarathy, Sudhakaran Raja, Sheng-Tung Huang, Annamalai Senthil Kumar
Most of the common redox mediators such as organic dyes and cyanide ligand-associated metal complex systems that have been used for various electrochemical applications are hazardous nature. Sesamol, a vital nutrient that exists in natural products like sesame seeds and oil, shows several therapeutic benefits including anticancer, antidiabetic, cardiovascular protective properties, etc. Herein, we introduce a new electrochemical redox platform based on a sesamol derivative, sesamol-quinone (Ses-Qn; oxidized sesamol), prepared by the in situ electrochemical oxidation method on a carbon nanoblack chemically modified glassy carbon electrode surface (GCE/CB@Ses-Qn) in pH 7 phosphate buffer solution, for nontoxic and sustainable electrochemical, electroanalytical, and bioelectroanalytical applications...
September 30, 2018: ACS Omega
David E Gerber, M Shaalan Beg, Farjana Fattah, Arthur E Frankel, Oluwatomilade Fatunde, Yull Arriaga, Jonathan E Dowell, Ajit Bisen, Richard D Leff, Claudia C Meek, William C Putnam, Raja Reddy Kallem, Indhumathy Subramaniyan, Ying Dong, Joyce Bolluyt, Venetia Sarode, Xin Luo, Yang Xie, Brian Schwartz, David A Boothman
BACKGROUND: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron oxidoreductase expressed in multiple tumour types. ARQ 761 is a β-lapachone (β-lap) analogue that exploits the unique elevation of NQO1 found in solid tumours to cause tumour-specific cell death. METHODS: We performed a 3+3 dose escalation study of 3 schedules (weekly, every other week, 2/3 weeks) of ARQ 761 in patients with refractory advanced solid tumours. Tumour tissue was analysed for NQO1 expression...
October 15, 2018: British Journal of Cancer
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. METHODS AND RESULTS: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012...
October 12, 2018: ESC Heart Failure
Tamir Ailon, Jin Tee, Neil Manson, Hamilton Hall, Ken Thomas, Y Raja Rampersaud, Albert Yee, Nicolas Dea, Andrew Glennie, Chris Bailey, Sean Christie, Michael H Weber, Andrew Nataraj, Jerome Paquet, Mike Johnson, Jonathan Norton, Henry Ahn, Greg McIntosh, Charles G Fisher
STUDY DESIGN: Retrospective review of results from a prospectively collected Canadian cohort in comparison to published literature. OBJECTIVES: (1) To investigate whether patients in a universal health care system (HCS) have different outcomes than those in a multi-tier HCS in surgical management of degenerative spondylolisthesis (DS). (2) To identify independent factors predictive of outcome in surgical DS patients. SUMMARY OF BACKGROUND DATA: Canada has a national health insurance program with unique properties...
October 9, 2018: Spine Journal: Official Journal of the North American Spine Society
Komagan Prabhu Nakkeeran, Poornima Ravi, Guruprasad Thulasi Doss, Krishna Kumar Raja
PURPOSE: This study was performed to compare the efficacy and comfort of the inferior alveolar nerve (IAN) block and the Vazirani-Akinosi (VA) nerve block when administered by dental trainees. MATERIALS AND METHODS: In this prospective, randomized controlled trial, patients requiring extraction of mandibular teeth received either the conventional IAN block (IAN group) or VA nerve block (VA group). Objective parameters evaluated included ease of locating landmarks, incidence of positive aspiration, and failure rate...
September 18, 2018: Journal of Oral and Maxillofacial Surgery
Raja Bhaskara Rajasekaran, Dheenadhayalan Jayaramaraju, Hari Venkataramani, Devendra Agraharam, Raja Sabapathy Shanmuganathan, Rajasekaran Shanmuganathan
Reconstruction of large defects following trauma in the distal femur are a surgical challenge. These cases usually require multiple procedures and are associated with poor functional outcomes. We managed a post-traumatic distal femur defect of 16 cm using the modified Capanna's technique - combination of a vascularised free fibula and an allograft - and achieved a successful union at 6 months and also a good functional outcome with knee flexion of 100°. The patient received a vascularised free fibula which was pegged into an allograft which was sculptured to bridge the defect...
October 2018: Trauma Case Reports
Tom Tirer, Raja Giryes
Inverse problems appear in many applications, such as image deblurring and inpainting. The common approach to address them is to design a specific algorithm for each problem. The Plug-and-Play (P&P) framework, which has been recently introduced, allows solving general inverse problems by leveraging the impressive capabilities of existing denoising algorithms. While this fresh strategy has found many applications, a burdensome parameter tuning is often required in order to obtain high-quality results. In this work, we propose an alternative method for solving inverse problems using off-the-shelf denoisers, which requires less parameter tuning...
October 11, 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Ilamathi Raja, Vikram Kumar, Hariharan Sabapathy, Manoharan Kumariah, Kasthuri Rajendran, Jebasingh Tennyson
sRNAs are a class of gene regulators in bacteria, playing a central role in its response to environmental changes. Bioinformatic prediction facilitates the identification of sRNAs expressed at different conditions. We propose a novel method of prediction of sRNAs from the genome of Agrobacterium based on PWM matrix of conditional sigma factors. sRNAs predicted from the genome are integrated with the virulence specific transcriptome data to identify putative sRNAs that are over expressed during Agrobacterial virulence induction...
October 11, 2018: FEMS Microbiology Letters
Jiří Hrdý, Kateřina Vlasáková, Viktor Černý, Lenka Súkeníková, Olga Novotná, Petra Petrásková, Kristýna Boráková, Rája Lodinová-Žádníková, Libuše Kolářová, Ludmila Prokešová
The growing knowledge of the key role of microbiota in the maturation of neonatal immune system suggests that manipulation of microbiota could be exploited in hampering allergy development. In this study, Escherichia coli O83:K24:H31 (EcO83) was administered to newborns that were followed prospectively. Several immunological characteristics (cytokines, specific IgE, total T regulatory cells (Treg) and subpopulation of natural Treg (nTreg) and induced Treg (iTreg)) were tested in peripheral blood of eight year old children...
October 10, 2018: European Journal of Immunology
Anne-Sophie Sillesen, Anna Axelsson Raja, Christian Pihl, Ruth Ottilia Birgitta Vøgg, Morten Hedegaard, Pernille Emmersen, Karin Sundberg, Ann Tabor, Cathrine Vedel, Helle Zingenberg, Charlotte Kruse, Charlotte Wilken-Jensen, Tina Holm Nielsen, Finn Stener Jørgensen, Dorthe Lisbeth Jeppesen, Lars Søndergaard, Pia R Kamstrup, Børge G Nordestgaard, Ruth Frikke-Schmidt, Niels Vejlstrup, Heather A Boyd, Henning Bundgaard, Kasper Iversen
Congenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and functional cardiac abnormalities...
October 10, 2018: European Journal of Epidemiology
You Li, Yongying Ruan, Matthew T Kasson, Edward L Stanley, Conrad P D T Gillett, Andrew J Johnson, Mengna Zhang, Jiri Hulcr
Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae and Platypodinae) rely on a symbiosis with fungi for their nutrition. Symbiotic fungi are preserved and transported in specialized storage structures called mycangia. Although pivotal in the symbiosis, mycangia have been notoriously difficult to study, given their minute size and membranous structure. We compared the application of novel visualization methods for the study of mycangia, namely micro-computed tomography (micro-CT) and laser ablation tomography (LATscan) with traditional paraffin sectioning...
September 1, 2018: Journal of Insect Science
Kavita Raja, Molly Antony, S Harikrishnan
Introduction: Infective endocarditis (IE) is an infection of the heart valves with an aggregation of bacteria in a fibrin plaque called vegetation. Aims and Objectives: This is a retrospective study of all infective endocarditis cases due to alpha haemolytic streptococci and enterococci. Methods: All cases of infective endocarditis cases due to alpha haemolytic streptococci and enterococci in a period of three years from 1st January 2010 to 31st December 2012 were included...
October 2018: Indian Journal of Pathology & Microbiology
Matthew T Patrick, Philip E Stuart, Kalpana Raja, Johann E Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M Kang, Gerald G Krueger, Henry W Lim, Proton Rahman, Cheryl F Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J Voorhees, Gonçalo R Abecasis, Dafna D Gladman, Rajan P Nair, James T Elder, Lam C Tsoi
Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in ~30% of psoriasis patients. Currently, no systematic strategy is available that utilizes the differences in genetic architecture between PsA and cutaneous-only psoriasis (PsC) to assess PsA risk before symptoms appear. Here, we introduce a computational pipeline for predicting PsA among psoriasis patients using data from six cohorts with >7000 genotyped PsA and PsC patients. We identify 9 new loci for psoriasis or its subtypes and achieve 0...
October 9, 2018: Nature Communications
Pierre Lemaire, Gwénaëlle Duhil de Bénazé, Dick Mul, Sabine Heger, Wilma Oostdijk, Raja Brauner
BACKGROUND: A previous single-center study established a mathematical model for predicting the adult height (AH) in girls with idiopathic central precocious puberty (CPP). OBJECTIVE: To perform internal and external validations by comparing the actual AH to the calculated AH established by this model and to update it. METHODS: The original formula, calculated AH (cm) = 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1...
2018: PloS One
Kumara Raja Sundar
CONTEXT: Kaiser Permanente's Care Management Institute created a screening tool, Your Current Life Situation (YCLS), which primarily is used to identify social needs for populations at risk of high health care utilization. OBJECTIVE: This frontline improvement project was designed to address key stakeholder concerns about implementing universal screening for social needs using the YCLS in a primary care clinic. METHODS: I conducted a rapid stakeholder analysis through informal conversations to identify the most important concerns...
October 5, 2018: Permanente Journal
Monika Garg, Deepak Khandelwal, Vivek Aggarwal, Kiran B Raja, Sanjay Kalra, Bhoopendra Agarwal, Deep Dutta
Introduction: Data on ultrasound elastography (USE) are scant from India. This study aimed to compare the sensitivity and specificity of USE with thyroid ultrasonography (USG) and fine-needle aspiration (FNA) as preoperative predictor of malignancy, using postoperative histopathology as gold standard. Materials and Methods: Consecutive patients with thyroid swelling/goiter underwent thyroid USG followed by USE. Patients with pure cystic nodules or eggshell calcification were excluded...
September 2018: Indian Journal of Endocrinology and Metabolism
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