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Nathalie I Caversaccio, Maria D Reina Caro, Raja Prince, Martin Müller, Clayton S Lewis, Vladimir Y Bogdanov, Jean-François Dufour, Anne Angelillo-Scherrer
OBJECTIVES: In patients with chronic liver diseases, hypercoagulability can contribute to the progression of fibrosis and complications of cirrhosis. Tissue factor (TF) is a transmembrane glycoprotein that initiates the extrinsic pathway of blood coagulation. Recent investigations have established that TF is elevated in patients with pancreatic cancer, blood disorders, diabetes, and cardiovascular disease. Alternatively spliced tissue factor (asTF), a secreted form of TF, induces angiogenesis and exhibits low-level procoagulant activity...
August 14, 2018: European Journal of Gastroenterology & Hepatology
Adnan I Qureshi, Nishath Naseem, Muhammad A Saleem, Anvita Potluri, Faisal Raja, Shawn S Wallery
BACKGROUND AND OBJECTIVE: No reliable estimates of headaches following catheter-based cerebral angiography are available. We performed an observational cohort study to ascertain the frequency and type of headaches following catheter-based cerebral angiography. MATERIALS AND METHODS: Consecutive patients who underwent cerebral angiography through the transfemoral (or infrequently radial) route were included. Each patient underwent a brief neurological assessment after the procedure and more detailed assessment was performed if any patient reported occurrence of a headache...
August 16, 2018: Headache
Balasubramani Govindasamy, Deepak Paramasivam, Aiswarya Dilipkumar, Karthik Raja Ramalingam, Kamaraj Chinnaperumal, Perumal Pachiappan
Presently, the discovery of effective drugs and pesticides from eco-friendly biological sources is an important challenge in the field of life sciences. The present research was aimed for standardizing an innovative approach in the evaluation of the biological potentiality of the metabolites of fish-associated bacteria. We have identified 17 skin-associated bacteria from the freshwater fish, giant danio, Devario aquipinnatus. They were screened through biofilm forming and extracellular enzyme producing ability...
August 15, 2018: Environmental Science and Pollution Research International
Asmat Ullah, Raja Hussain Ali, Ayesha Isani Majeed, Khurram Liaqat, Pashmina Wiqar Shah, Bushra Khan, Muhammad Bilal, Muhammad Umair, Wasim Ahmad
Mesoaxial syndactyly is characterized by fusion of the central digits. The disorder segregates in autosomal recessive pattern and mapped on human chromosome 17p13.3. Homozygous missense mutations in the BHLHA9 have been reported to cause mesoaxial synostotic syndactyly with phalangeal reduction (MSSD). In the present study, we have investigated a family segregating mesoaxial synostotic syndactyly with phalangeal reduction (MSSD) in autosomal recessive manner. Genotyping using microsatellite markers followed by Sanger sequencing revealed a homozygous deletion and insertion mutation (NM_001164405: c...
August 11, 2018: European Journal of Medical Genetics
Viswas Raja Solomon, Carolina Gonzalez, Elahe Alizadeh, Wendy Bernhard, Siddesh V Hartimath, Kris Barreto, Clarence Ronald Geyer, Humphrey Fonge
Bifunctional chelators (BFCs) are covalently linked to biologically active targeting molecules and radiolabeled with radiometals. Technetium-99 m (99m Tc) is the most widely used isotope in nuclear medicine because of its excellent physical properties. The objective of this study was to synthesize and characterize a novel BFC that allows for the labeling of antibodies and antibody fragments using the 99m Tc(CO)3 + core which forms a very stable complex with 99m Tc in the +1 oxidation sate. This study reports the synthesis of a BFC 1-pyrrolidinyl-2,5-dione-11-(bis((1-(carboxymethyl)-1H-imidazol-2-yl)methyl)amino)undecanoic acid (SAAC-CIM NHS ester), and the in vitro and in vivo evaluation of 99m Tc(CO)3 -SAAC-CIM-DLO6-(scFv)2 (99m Tc(CO)3 -DLO6-(scFv)2 ), a domain I/II-specific anti-epidermal growth factor receptor I (anti-EGFR) antibody fragment...
August 6, 2018: European Journal of Medicinal Chemistry
Sharifah Nur Hidayah Syed Mazlan, Mohd Shukuri Mohamad Ali, Raja Noor Zaliha Raja Abd Rahman, Suriana Sabri, Mohd Anuar Jonet, Leow Thean Chor
GDSL esterase J15 (EstJ15) is a member of Family II of lipolytic enzyme. The enzyme was further classified in subgroup SGNH hydrolase due to the presence of highly conserve motif, Ser-Gly-Asn-His in four conserved blocks I, II, III, and V, respectively. X-ray quality crystal of EstJ15 was obtained from optimized formulation containing 0.10 M ammonium sulphate, 0.15 M sodium cacodylate trihydrate pH 6.5, and 20% PEG 8000. The crystal structure of EstJ15 was solved at 1.38 Å with one molecule per asymmetric unit...
August 10, 2018: International Journal of Biological Macromolecules
Daniel A Del Vecchio, Nathaniel L Villanueva, Raja Mohan, Bret Johnson, Dinah Wan, Aniketh Venkataram, Rod Rohrich
BACKGROUND: The intraoperative mortality and overall complication rate for gluteal augmentation with fat transplantation is unacceptably high. The current controversy among experts regarding safety is whether fat should be placed within the gluteus muscle or only limited to the subcutaneous space. The purpose of the present study is to test the hypothesis that under certain pressures, fat injected within the gluteal muscle can actually migrate out of the muscle and into a deeper plane containing critical neurovascular structures, via the process of Deep Intramuscular Migration...
August 10, 2018: Plastic and Reconstructive Surgery
Moaaz Soliman, Fatima Neemuchwala, Amanda Sankar, Rama Jasty, Raja Rabah, Antonia P Popova, Erika A Newman
A 14-year-old male patient presented with a nonproductive cough, weight loss, fatigue, and malaise. A chest radiograph showed large bilateral cavitary lung lesions in both upper and lower lobes that failed to improve with antibiotics and anti-inflammatory medications. Infectious and rheumatologic work-ups were negative. Thoracoscopic lung biopsies were diagnostic for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The patient received combination chemotherapy and immunotherapy based on current treatment standards with an excellent clinical response...
August 10, 2018: Journal of Pediatric Hematology/oncology
Madhur Upadhyay, Raja Shah, Sachin Agarwal, Meenakshi Vishwanath, Po-Jung Chen, Takafumi Asaki, Donald Peterson
A proper understanding of the force system created by various orthodontic appliances can make treatment of patients efficient and predictable. Reducing the complicated multi-bracket appliances to a simple two-bracket system for the purpose of force system evaluation will be the first step in this direction. However, much of the orthodontic biomechanics in this regard is confined to 2D experimental studies, computer modeling/analysis or theoretical extrapolation of existing models. The objective of this protocol is to design, construct and validate an in vitro 3D model capable of measuring the forces and moments generated by an archwire with a V-bend placed between two brackets...
July 24, 2018: Journal of Visualized Experiments: JoVE
Raja R R Singareddy, Shabana Chandrasekaran, Balamurugan Annamalai, Pratyush Ranjan
This article contains firm-level data on 1) aggregated corporate governance score, and 2) financial data for the period 2010-2017. The study includes 626 companies from 6 Asian countries: China, India, Indonesia, Japan, South Korea and Thailand. Aggregated corporate governance score is calculated using 13 firm-level attributes: board size, board independence, CEO duality, board meeting attendance, independence of audit committee, auditor ratification, independence of compensation committee, independence of nomination committee, shareholder-approved poison pill, dual class unequal voting rights of common shares, staged board, diversity of board and board duration...
October 2018: Data in Brief
Brian J Yun, Robert M Rodriguez, Anand M Prabhakar, David A Peak, DaMarcus E Baymon, Ali S Raja
INTRODUCTION: Increased use of computed tomography (CT) during injury-related Emergency Department (ED) visits has been reported, despite increased awareness of CT radiation exposure risks. We investigated national trends in the use of chest CT during injury-related ED visits between 2012 and 2015. METHODS: Analyzing injury-related ED visits from the 2012-2015 United States (U.S.) National Hospital Ambulatory Medical Care Survey (NHAMCS), we determined the percentage of visits that had a chest CT and the diagnostic yield of these chest CTs for clinically-significant findings...
August 8, 2018: American Journal of Emergency Medicine
Jerin Mathew, Kavitha Raja, Febin P Baby, Basima Barikkal
BACKGROUND: In most developing countries, accessibility for people using walking aids is limited due to architectural and environmental barriers. As observed from anecdotal accounts, even a minor orthopaedic injury/disorder may restrict a person's ambulation due to fatigue associated with using walking aids. Hence this study was undertaken with the following objective. OBJECTIVE: to estimate the magnitude of energy consumption using energy expenditure index (EEI) during gait under different conditions...
July 2018: Journal of Bodywork and Movement Therapies
Laure Monteillet, Monika Gjorgjieva, Marine Silva, Vincent Verzieux, Linda Imikirene, Adeline Duchampt, Hervé Guillou, Gilles Mithieux, Fabienne Rajas
OBJECTIVE: Ectopic lipid accumulation in the liver and kidneys is a hallmark of metabolic diseases leading to non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). Moreover, recent data have highlighted a strong correlation between NAFLD and CKD incidences. In this study, we use two mouse models of hepatic steatosis or CKD, each initiated independently of the other upon the suppression of glucose production specifically in the liver or kidneys, to elucidate the mechanisms underlying the development of CKD in the context of NAFLD-like pathology...
August 1, 2018: Molecular Metabolism
Fagen Zhang, Tim Erskine, Joanna Klapacz, Raja Settivari, Sue Marty
While the HPLC/UV (high performance liquid chromatography coupled with ultra-violet spectrometry)-based DPRA (Direct Peptide Reactivity Assay) identifies dermal sensitizers with approximately 80% accuracy, the low selectivity and sensitivity of the HPLC/UV-based DPRA poses challenges to accurately identify the sensitization potential of certain chemicals. In this study, a high performance liquid chromatography coupled with tandem mass spectrometry (HPLC/MS-MS)-based DPRA was developed and validated according to the test guideline (OECD TG 442C)...
August 9, 2018: Journal of Pharmacological and Toxicological Methods
Kamran Ali, Josephine Cockerill, Daniel Zahra, Haroon S Qazi, Ulfat Raja, Khurram Ataullah
AIMS: To evaluate the self-perceived preparedness to practice of final year dental undergraduate students in three dental institutions. METHODS: Dental undergraduate students in their final year from three dental institutions in Pakistan were invited to participate in an online study to assess self-perceived preparedness using a validated preparedness assessment scale. RESULTS: In total, 134 students responded to the questionnaire yielding a response rate of 72%...
August 11, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
Archana Raja, Malte Selig, Gunnar Berghäuser, Jaeeun Yu, Heather M Hill, Albert F Rigosi, Louis E Brus, Andreas Knorr, Tony F Heinz, Ermin Malic, Alexey Chernikov
Layered transition metal dichalcogenides exhibit the emergence of a direct bandgap at the monolayer limit, along with pronounced excitonic effects. In these materials, interaction with phonons is the dominant mechanism that limits the exciton coherence lifetime and determines exciton diffusion under most experimental conditions. However, the fundamental changes in the exciton-phonon interaction are not well understood as the material undergoes the transition from a direct to an indirect gap semiconductor. Here, we address this question through optical spectroscopy and microscopic theory...
August 10, 2018: Nano Letters
Majji Shankar, Koushik Ghosh, Kallol Mukherjee, Raja K Rit, Akhila K Sahoo
With the aid of a transformable sulfoximine directing group, unprecedented one-pot unsymmetrical double annulations {[4 + 2] and [4 + 2]} of hetero(arenes) with alkynes are revealed under Ru(II) catalysis. Functionalization of both ortho-C-H bonds of (hetero)arene is reflected in the building of unusual 6,6-fused pyranoisoquinoline skeletons. Construction of four [(C-C)-(C-N) and (C-C)-(C-O)] bonds occurs in one step under single catalytic conditions. The challenging unsymmetrical double annulations of both o-C-H bonds of arenes with two distinct alkynes is effectively demonstrated...
August 10, 2018: Organic Letters
Mubashir Hussain, Naveed Iqbal Raja, Muhammad Iqbal, Muhammad Ejaz, Sumaira Aslam, Abd-Ur Rehman, Uneeza Javaid
The biosynthesis of silver nanoparticles (AgNPs) is substantial for its applications in different fields. The Moringa oleifera leaves were used as reducing and stabilising agent for the biosynthesis of AgNPs. The synthesised AgNPs were characterised through UV-visible spectroscopy, zeta analyser, scanning electron microscopy (SEM) and energy dispersive Xray (EDX). In this study, effects of the synthesised AgNPs were also evaluated on nucellus tissues germination frequency and biochemical parameters of plant tissues...
August 2018: IET Nanobiotechnology
Nicholas V Colin, Raja A Cholan, Bhavaya Sachdeva, Benjamin E Nealy, Michael L Parchman, David A Dorr
Objective: To understand the impact of varying measurement period on the calculation of electronic Clinical Quality Measures (eCQMs). Background: eCQMs have increased in importance in value-based programs, but accurate and timely measurement has been slow. This has required flexibility in key measure characteristics, including measurement period, the timeframe the measurement covers. The effects of variable measurement periods on accuracy and variability are not clear...
July 19, 2018: EGEMS
Rajiv Raja, Michael Kuziora, Philip Brohawn, Brandon W Higgs, Ashok Gupta, Phillip A Dennis, Koustubh Ranade
PURPOSE: Immunotherapy has transformed the treatment of many solid tumors, with some patients deriving long-term benefit, but how to identify such patients remains unclear. Somatic mutations detected in circulating tumor DNA (ctDNA) from plasma can be an indicator of disease progression, response to therapy and clonality of primary and metastatic lesions. Hence, ctDNA analysis can provide a valuable noninvasive and tumor-specific marker for longitudinal monitoring of tumor burden. We explored the use of ctDNA to predict survival on durvalumab, an anti-PD-L1 therapy...
August 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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