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Benjamin M Vincent, Daniel F Tardiff, Jeff S Piotrowski, Rebecca Aron, Matthew C Lucas, Chee Yeun Chung, Helene Bacherman, YiQun Chen, Michelle Pires, Radha Subramaniam, Dimple B Doshi, Heather Sadlish, Waseem K Raja, Eric J Solís, Vikram Khurana, Bertrand Le Bourdonnec, Robert H Scannevin, Kenneth J Rhodes
The lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity of targets for therapeutic intervention. Here we used an integrated discovery paradigm to identify a new therapeutic target for diseases caused by α-synuclein (α-syn), a small lipid-binding protein that misfolds and aggregates in Parkinson's disease and other disorders. Using unbiased phenotypic screening, we identified a series of compounds that were cytoprotective against α-syn-mediated toxicity by inhibiting the highly conserved enzyme stearoyl-CoA desaturase (SCD)...
December 4, 2018: Cell Reports
Junaid Raja, Johannes M Ludwig, Scott N Gettinger, Kurt A Schalper, Hyun S Kim
BACKGROUND: Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. This therapy offers a multimodal approach to specifically and effectively target and destroy malignant cells, though a barrier oncoviral therapies have faced is a limited therapeutic response to currently delivery techniques...
December 4, 2018: Journal for Immunotherapy of Cancer
Raja Gnanadev, Joe Iwanaga, Rod J Oskouian, Marios Loukas, R Shane Tubbs
Henle's ligament was first described by German physician and anatomist, Friedrich Henle, in 1871. This review article will cover Henle's original description of the ligament, historical changes in terminology, embryological studies of the ligament, and the clinical significance of Henle's ligament. This article has a particular focus on the variation in the terminology of this structure and the implications of this.
September 26, 2018: Curēus
Raja Gnanadev, Joe Iwanaga, Marios Loukas, R Shane Tubbs
The hyoid contributes to many biomechanical processes including swallowing. Additionally, the hyoid bone has been studied for over a century in an effort to catalog and categorize many observed biometric differences. This has led to the hyoid being a major structure involved in forensic pathology. In this paper, we discuss a very unusual finding of an adult female hyoid bone.
September 26, 2018: Curēus
Anis Haddad, Olfa Zoukar, Houda Mhabrich, Awatef Hajjeji, Raja Faleh
In recent years, the incidence of placenta accreta and associated complications has increased significantly. The authors report the case of a pregnant woman in the 5th month of pregnancy for premature rupture of the membranes. The placenta was inserted low. The evolution was marked spontaneous work followed by the expulsion of the fetus. The delivery of the placenta was haemorrhagic and incomplete. Ultrasonic testing showed a placental fragment integrated in the thickness of the myometrium. Conservative treatment with methotrexate was published a few days later and MRI showed that the anterior uterine sac was filled with blood clots associated with pelvic effusion...
2018: Case Reports in Obstetrics and Gynecology
Ruikang Zhang, Raja Chouket, Marie-Aude Plamont, Zsolt Kelemen, Agathe Espagne, Alison G Tebo, Arnaud Gautier, Lionel Gissot, Jean-Denis Faure, Ludovic Jullien, Vincent Croquette, Thomas Le Saux
Macroscale fluorescence imaging is increasingly used to observe biological samples. However, it may suffer from spectral interferences that originate from ambient light or autofluorescence of the sample or its support. In this manuscript, we built a simple and inexpensive fluorescence macroscope, which has been used to evaluate the performance of Speed OPIOM (Out of Phase Imaging after Optical Modulation), which is a reference-free dynamic contrast protocol, to selectively image reversibly photoswitchable fluorophores as labels against detrimental autofluorescence and ambient light...
2018: Light, Science & Applications
Michael J McKay, Jeffery Craig, Paul Kalitsis, Sergei Kozlov, Sandra Verschoor, Phillip Chen, Pavel Lobachevsky, Raja Vasireddy, Yuqian Yan, Jacinta Ryan, George McGillivray, Ravi Savarirayan, Martin F Lavin, Robert G Ramsay, Huiling Xu
PURPOSE: Roberts Syndrome (RBS) is a rare recessively-transmitted developmental disorder characterized by growth retardation, craniofacial abnormalities and truncation of limbs. All affected individuals to date have mutations in the ESCO2 (Establishment of cohesion 2) gene, a key regulator of the cohesin complex, which is involved in sister chromatid cohesion and DNA double-strand break (dsb) repair. Here we characterize DNA damage responses (DDRs) for the first time in a RBS-affected family...
November 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Kamya Raja
No abstract text is available yet for this article.
January 2019: Journal of Public Health Management and Practice: JPHMP
Shahzad G Raja, Sheena Garg, Melissa Rochon, Siobhan Daley, Fabio De Robertis, Toufan Bahrami
Background: Minimally invasive direct coronary artery bypass (MIDCAB) grafting is regarded as an alternative to conventional coronary artery bypass grafting (CABG) through full sternotomy, particularly for patients with isolated proximal left anterior descending (LAD) artery stenosis deemed unsuitable for percutaneous coronary intervention. However, the technically demanding nature of the procedure and lack of long-term published outcomes have precluded its universal adoption. We report the comparative short-term outcomes and long-term survival of MIDCAB and conventional CABG through full sternotomy for grafting of isolated LAD...
September 2018: Annals of Cardiothoracic Surgery
Shahzad G Raja, Mohsin Uzzaman, Sheena Garg, Gowthanan Santhirakumaran, Michelle Lee, Manish K Soni, Habib Khan
Background: In the contemporary era of drug-eluting stents (DES) the issue of optimal revascularization strategy for patients with isolated disease of the left anterior descending (LAD) artery has gained more significance. We aimed to evaluate the current best evidence on the subject by performing a systematic review and meta-analysis of the studies comparing minimally invasive direct coronary artery bypass (MIDCAB) grafting with DES in patients with isolated LAD disease. Methods: A literature search was conducted from 1966 through March 2018 using MEDLINE, EMBASE, and other scientific databases to identify relevant articles...
September 2018: Annals of Cardiothoracic Surgery
Marwa Ferchichi, Raja Jouini, Imen Ayari, Wafa Koubaa, Aschraf Chadli-Debbiche, Ehsen BenBrahim
Background: Ampullary carcinomas are rare and dominated by adenocarcinomas. They account for only 0.5% of all gastrointestinal malignancies. Ampullary adenocarcinoma (AAC) with pancreaticobiliary (PB) histology has a worse outcome than that with intestinal (IT) histology. The mixed subtype contains the two epitheliums. This subclassification remains a challenge for pathologists and induces a reasonable level of disagreement. Genetic features of these subtypes are unclear. In this study, we aimed to reclassify AAC cases then to evaluate differences in prognostic, pathological and molecular parameters including mutational status of three oncogenes between these subtypes...
October 2018: Journal of Gastrointestinal Oncology
Emanuela Taioli, Wil Lieberman-Cribbin, Shoshana Rosenzweig, Maaike A G van Gerwen, Bian Liu, Raja M Flores
Background: The comparative effectiveness of stereotactic body radiation therapy (SBRT) and wedge resection in the treatment of early stage lung cancer is still under debate. This meta-analysis compares the 5-year overall survival (OS) of wedge resection and SBRT in patients with stage I non-small cell lung cancer (NSCLC). Methods: Original research articles published between 1995 and 2017 were identified through the National Library of Medicine and National Institutes of Health PubMed database and through the reference lists of reviewed articles...
October 2018: Journal of Thoracic Disease
Girish R Nair, Suresh Ss Raja
Bacillus is an important genus as it is a source for antibiotics, enzymes, and probiotics. Therefore, several studies are targeted on this genus in order to understand its diversity abundance in different soil environments. In present study, we investigated the diversity of Bacillus at species level using culturable approach in soils collected at different climatic zones of India and identified 20 prominent members of genus Bacillus species that are able to grow in different media types under same culture conditions...
2018: Microbiology Insights
Narayanamurthy Sundaramurthy, Manimaran Ramachandran, Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj, Praveen Ganesh Natarajan
No abstract text is available yet for this article.
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj, Narayanamurthy Sundaramurthy, Manimaran Ramachandran
No abstract text is available yet for this article.
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Ajeesh Sankaran, Praveen Bhardwaj, Hari Venkatramani, Shanmuganathan Raja Sabapathy
While brachial plexus palsy sustained due to birth trauma is well known, congenital palsies are decidedly rare. We report such a case caused by congenital varicella syndrome, with associated congenital Horner's syndrome and heterochromia iridis. The surprising juxtaposition of a classic upper plexus palsy and a Horner's syndrome raises points of interest. Similar reports in literature are reviewed, and the genesis of a very characteristic group of findings is discussed.
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
P W Crous, M J Wingfield, T I Burgess, G E St J Hardy, J Gené, J Guarro, I G Baseia, D García, L F P Gusmão, C M Souza-Motta, R Thangavel, S Adamčík, A Barili, C W Barnes, J D P Bezerra, J J Bordallo, J F Cano-Lira, R J V de Oliveira, E Ercole, V Hubka, I Iturrieta-González, A Kubátová, M P Martín, P-A Moreau, A Morte, M E Ordoñez, A Rodríguez, A M Stchigel, A Vizzini, J Abdollahzadeh, V P Abreu, K Adamčíková, G M R Albuquerque, A V Alexandrova, E Álvarez Duarte, C Armstrong-Cho, S Banniza, R N Barbosa, J-M Bellanger, J L Bezerra, T S Cabral, M Caboň, E Caicedo, T Cantillo, A J Carnegie, L T Carmo, R F Castañeda-Ruiz, C R Clement, A Čmoková, L B Conceição, R H S F Cruz, U Damm, B D B da Silva, G A da Silva, R M F da Silva, A L C M de A Santiago, L F de Oliveira, C A F de Souza, F Déniel, B Dima, G Dong, J Edwards, C R Félix, J Fournier, T B Gibertoni, K Hosaka, T Iturriaga, M Jadan, J-L Jany, Ž Jurjević, M Kolařík, I Kušan, M F Landell, T R Leite Cordeiro, D X Lima, M Loizides, S Luo, A R Machado, H Madrid, O M C Magalhães, P Marinho, N Matočec, A Mešić, A N Miller, O V Morozova, R P Neves, K Nonaka, A Nováková, N H Oberlies, J R C Oliveira-Filho, T G L Oliveira, V Papp, O L Pereira, G Perrone, S W Peterson, T H G Pham, H A Raja, D B Raudabaugh, J Řehulka, E Rodríguez-Andrade, M Saba, A Schauflerová, R G Shivas, G Simonini, J P Z Siqueira, J O Sousa, V Stajsic, T Svetasheva, Y P Tan, Z Tkalčec, S Ullah, P Valente, N Valenzuela-Lopez, M Abrinbana, D A Viana Marques, P T W Wong, V Xavier de Lima, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Australia , Chaetopsina eucalypti on Eucalyptus leaf litter, Colletotrichum cobbittiense from Cordyline stricta × C. australis hybrid, Cyanodermella banksiae on Banksia ericifolia subsp. macrantha, Discosia macrozamiae on Macrozamia miquelii, Elsinoë banksiigena on Banksia marginata, Elsinoë elaeocarpi on Elaeocarpus sp., Elsinoë leucopogonis on Leucopogon sp., Helminthosporium livistonae on Livistona australis , Idriellomyces eucalypti (incl...
December 2018: Persoonia
Teruaki Iyama, Mustafa N Okur, Tyler Golato, Daniel R McNeill, Huiming Lu, Royce Hamilton, Aishwarya Raja, Vilhelm A Bohr, David M Wilson
Cockayne syndrome (CS) is an inherited disorder that involves photosensitivity, developmental defects, progressive degeneration and characteristics of premature aging. Evidence indicates primarily nuclear roles for the major CS proteins, CSA and CSB, specifically in DNA repair and RNA transcription. We reveal herein a complex regulation of CSB targeting that involves three major consensus signals: NLS1 (aa467-481), which directs nuclear and nucleolar localization in cooperation with NoLS1 (aa302-341), and NLS2 (aa1038-1055), which seemingly optimizes nuclear enrichment...
November 30, 2018: Scientific Reports
Cheryl McQuire, Raja Mukherjee, Lisa Hurt, Andrea Higgins, Giles Greene, Daniel Farewell, Alison Kemp, Shantini Paranjothy
Fetal alcohol spectrum disorders (FASDs) are lifelong disabilities caused by prenatal alcohol exposure. Prenatal alcohol use is common in the UK, but FASD prevalence was unknown. Prevalence estimates are essential for informing FASD prevention, identification and support. We applied novel screening algorithms to existing data to estimate the screening prevalence of FASD. Data were from a population-based cohort study (ALSPAC), which recruited pregnant women with expected delivery dates between 1991 and 1992 from the Bristol area of the UK...
November 27, 2018: Preventive Medicine
Maneesha K Suresh, Raja Biswas, Lalitha Biswas
Staphylococcus aureus (S. aureus) readily forms biofilms on prosthetic devices such as the pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are recalcitrant to antibiotic therapy and pose a serious burden in the healthcare setting as they drastically increase the treatment cost and morbidity of the patient. Prevention and treatment of staphylococcal biofilms has therefore been an area of active research for the past two decades. While catheters coated with different antiseptics and antibiotics capable of preventing S...
November 27, 2018: International Journal of Medical Microbiology: IJMM
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