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L-methylfolate schizophrenia

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https://www.readbyqxmd.com/read/29212788/l-methylfolate-cannot-yet-be-recommended-as-an-add-on-treatment-in-schizophrenia
#1
COMMENT
Błażej Misiak
No abstract text is available yet for this article.
February 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28597528/enhancement-of-recovery-from-mental-illness-with-l-methylfolate-supplementation
#2
REVIEW
Gerald Martone
People suffering from depression, schizophrenia, and dementia often have measurably lower levels of serum folate compared to people not experiencing psychiatric disorders. Augmentation of SSRI and SNRI antidepressant medications with l-methylfolate has been demonstrated to increase their effectiveness and onset of action. Even the use of l-methylfolate as a stand-alone monotherapy has been observed to exert antidepressant properties. The role of folate in mental illness has been known for many decades, but the strategic use of l-methylfolate supplementation has not yet been accepted as a standard regimen...
April 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28289280/biochemical-physiological-and-clinical-effects-of-l-methylfolate-in-schizophrenia-a-randomized-controlled-trial
#3
J L Roffman, L J Petruzzi, A S Tanner, H E Brown, H Eryilmaz, N F Ho, M Giegold, N J Silverstein, T Bottiglieri, D S Manoach, J W Smoller, D C Henderson, D C Goff
Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizophrenia. In this randomized, double-blind trial, outpatients with schizophrenia (n=55) received l-methylfolate 15 mg or placebo for 12 weeks. Patients were maintained on stable doses of antipsychotic medications...
February 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/27520898/effectiveness-of-add-on-l-methylfolate-therapy-in-a-complex-psychiatric-illness-with-mthfr-c677-t-genetic-polymorphism
#4
Shailesh Jha, Pankaj Kumar, Rajesh Kumar, Aparna Das
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism. Many studies have demonstrated an association between MTHFR C677 T variant with depression, schizophrenia and bipolar disorder as one of them being comorbid to other. This has justified the use of folate supplement in psychiatric disorders mainly depression but still not in various other comorbid complex psychiatric disorders. Here we have tried to show how the l-methylfolate in conjunction with the conventional psychotropic drugs can be useful in a state of such complex psychiatric phenomenon and comorbid diagnosis with genetic polymorphism of MTHFR C677 T mutation...
August 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/1974941/enhancement-of-recovery-from-psychiatric-illness-by-methylfolate
#5
RANDOMIZED CONTROLLED TRIAL
P S Godfrey, B K Toone, M W Carney, T G Flynn, T Bottiglieri, M Laundy, I Chanarin, E H Reynolds
41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial of methylfolate, 15 mg daily, for 6 months in addition to standard psychotropic treatment. Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery. The differences in outcome scores between methylfolate and placebo groups became greater with time...
August 18, 1990: Lancet
https://www.readbyqxmd.com/read/1773245/enhancement-of-recovery-from-psychiatric-illness-by-methylfolate
#6
A Procter
"41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial of methylfolate, 15 mg daily, for 6 months in addition to standard psychotropic treatment. Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery. The differences in outcome scores between methylfolate and placebo groups became greater with time...
August 1991: British Journal of Psychiatry: the Journal of Mental Science
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